ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Region Report

Basic Info
Region Name 11q
Chromosome Position chr11:53700000-135006516
#studies (significant/non-significant/trend)  2(1/1/0)

Region related studies (count: 2)
Reference Markers Statistical Values Author Comments Result of Statistical Analysis
Hebebrand J, 2006 D11S4176 LOD score=0.41 LOD score=0.41 identified nominal evidence for linkage identified nominal evidence for linkage Non-significant
Jain, M., 2012 rs677642, rs877137, rs754672, rs965560 G(LPHN3)-G(rs677642, 11q)-G(rs877137, 11q), P-value<0.000005...... G(LPHN3)-G(rs677642, 11q)-G(rs877137, 11q), P-value<0.000005, OR(95%CI)=4.47(2.30-8.69); G(LPHN3)-else(11q), P-value(corrected)<0.005 in the case-control sample; Paisa: P-value=0.0027, OR(95%CI)=3.14(1.49-6.62) for C-GG haplotype; P-value=0.1661, OR(95%CI)=1.46(0.85-2.51) for G-else haplotype; P-value=0.0943, OR(95%CI)=0.73(0.51-1.06) for else-GG haplotype; German: P-value=0.0706, OR(95%CI)=1.91(0.95-3.84) for G-GG haplotype, P-value=0.6505, OR(95%CI)=1.11(0.72-1.71) for G-else haplotype; P-value=0.0449, OR(95%CI)=0.69(0.48-0.99) for else-GG haplotype; US1: P-value=0.1014, OR(95%CI)=3.1(0.8-1.2) for G-GG haplotype; P-value=0.5955, OR(95%CI)=1.23(0.58-2.59) for G-else haplotype; P-value=0.4139, OR(95%CI)=0.77(0.4-1.45) for else-GG haplotype; US2: P-value=0.0432, OR(95%CI)=2.28(1.03-5.08) for G-AG haplotype; P-value=0.2279, OR(95%CI)=0.82(0.59-1.13) for G-else haplotype; P-value=0.1306, OR(95%CI)=0.72(0.46-1.13) for else-AG haplotype; meta-analysis: interaction, P-value<0.00001; LPHN3 only, P-value=0.7111, P-value<0.001 for haplotype only. More... We focused on 4q-11q interaction to determine that single-nu...... We focused on 4q-11q interaction to determine that single-nucleotide polymorphisms (SNPs) harbored in the LPHN3 gene interact with SNPs spanning the 11q region that contains DRD2 and NCAM1 genes, to double the risk of developing ADHD. More... Significant

Region related genes (count: 1135)

Literature-origin genes (count: 15)

Genes from other sources Help (count: 1120)

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