ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CPSF7
Symbol Alias	FLJ12529
Approved Name	cleavage and polyadenylation specific factor 7, 59kDa
Name Alias	pre mRNA cleavage factor I, 59 kDa subunit
Location	11q12.2
Position	chr11:61170120-61197464, -
External Links	HGNC: 30098 Entrez Gene: 79869 Ensembl: ENSG00000149532 UCSC: uc001nrp.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 14)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006397	mRNA processing	Biological Process		50
GO:0008380	RNA splicing	Biological Process		65
GO:0006366	transcription from RNA polymerase II promoter	Biological Process		62
GO:0006369	termination of RNA polymerase II transcription	Biological Process		14
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005849	mRNA cleavage factor complex	Cellular Component		2
GO:0005515	protein binding	Molecular Function	IPI[16713569]	910
GO:0005634	nucleus	Cellular Component		770
GO:0000398	mRNA splicing, via spliceosome	Biological Process		54
GO:0003723	RNA binding	Molecular Function		104
GO:0000166	nucleotide binding	Molecular Function		73
GO:0051262	protein tetramerization	Biological Process		6
GO:0031124	mRNA 3'-end processing	Biological Process		8
GO:0010467	gene expression	Biological Process		140

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03015	mRNA surveillance pathway	17	The mRNA surveillance pathway is a quality control mechanism...... The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins. More...

Genes shared at least 5 GO terms with CPSF7 (count: 57)

Gene Symbol	Pathway Count	Pathway List
U2AF1	12	mRNA processing; RNA splicing; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; nucleoplasm; protein binding; nucleus; mRNA splicing, via spliceosome; RNA binding; nucleotide binding; mRNA 3'-end processing; gene expression;
NCBP1	11	mRNA processing; RNA splicing; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; nucleoplasm; protein binding; nucleus; mRNA splicing, via spliceosome; RNA binding; mRNA 3'-end processing; gene expression;
U2AF2	11	mRNA processing; RNA splicing; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; nucleoplasm; protein binding; mRNA splicing, via spliceosome; RNA binding; nucleotide binding; mRNA 3'-end processing; gene expression;
CPSF3	10	mRNA processing; RNA splicing; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; nucleoplasm; protein binding; mRNA splicing, via spliceosome; RNA binding; mRNA 3'-end processing; gene expression;
HNRNPA2B1	9	mRNA processing; RNA splicing; nucleoplasm; protein binding; nucleus; mRNA splicing, via spliceosome; RNA binding; nucleotide binding; gene expression;
PCF11	9	mRNA processing; RNA splicing; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; nucleoplasm; mRNA cleavage factor complex; mRNA splicing, via spliceosome; mRNA 3'-end processing; gene expression;
SNRPG	9	mRNA processing; RNA splicing; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; nucleoplasm; protein binding; mRNA splicing, via spliceosome; RNA binding; gene expression;
CLP1	8	mRNA processing; RNA splicing; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; nucleoplasm; mRNA splicing, via spliceosome; mRNA 3'-end processing; gene expression;
HNRNPA1	8	mRNA processing; RNA splicing; nucleoplasm; nucleus; mRNA splicing, via spliceosome; RNA binding; nucleotide binding; gene expression;
SF3A1	8	mRNA processing; RNA splicing; nucleoplasm; protein binding; nucleus; mRNA splicing, via spliceosome; RNA binding; gene expression;
SF3B4	8	mRNA processing; RNA splicing; nucleoplasm; protein binding; mRNA splicing, via spliceosome; RNA binding; nucleotide binding; gene expression;
SNRPB	8	mRNA processing; RNA splicing; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; nucleoplasm; protein binding; mRNA splicing, via spliceosome; gene expression;
SNRPD3	8	mRNA processing; RNA splicing; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; nucleoplasm; protein binding; mRNA splicing, via spliceosome; gene expression;
SNRPF	8	mRNA processing; RNA splicing; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; nucleoplasm; mRNA splicing, via spliceosome; RNA binding; gene expression;
FUS	8	RNA splicing; nucleoplasm; protein binding; nucleus; mRNA splicing, via spliceosome; RNA binding; nucleotide binding; gene expression;
HNRNPH1	8	RNA splicing; nucleoplasm; protein binding; nucleus; mRNA splicing, via spliceosome; RNA binding; nucleotide binding; gene expression;
EFTUD2	7	mRNA processing; RNA splicing; nucleoplasm; protein binding; nucleus; mRNA splicing, via spliceosome; gene expression;
LSM11	7	mRNA processing; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; nucleoplasm; protein binding; nucleus; gene expression;
PRPF8	7	mRNA processing; RNA splicing; nucleoplasm; protein binding; mRNA splicing, via spliceosome; RNA binding; gene expression;
RBM4	7	mRNA processing; RNA splicing; nucleoplasm; protein binding; nucleus; RNA binding; nucleotide binding;
SF3A3	7	mRNA processing; RNA splicing; nucleoplasm; protein binding; nucleus; mRNA splicing, via spliceosome; gene expression;
SNRPB2	7	mRNA processing; RNA splicing; nucleoplasm; protein binding; mRNA splicing, via spliceosome; nucleotide binding; gene expression;
TARDBP	7	mRNA processing; RNA splicing; transcription from RNA polymerase II promoter; protein binding; nucleus; RNA binding; nucleotide binding;
CDC40	7	RNA splicing; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; nucleoplasm; mRNA splicing, via spliceosome; mRNA 3'-end processing; gene expression;
HNRNPC	7	RNA splicing; nucleoplasm; protein binding; mRNA splicing, via spliceosome; RNA binding; nucleotide binding; gene expression;
POLR2G	7	RNA splicing; transcription from RNA polymerase II promoter; nucleoplasm; nucleus; mRNA splicing, via spliceosome; RNA binding; gene expression;
PRPF6	7	RNA splicing; nucleoplasm; protein binding; nucleus; mRNA splicing, via spliceosome; RNA binding; gene expression;
SNRPA	7	RNA splicing; nucleoplasm; protein binding; mRNA splicing, via spliceosome; RNA binding; nucleotide binding; gene expression;
SNRPD1	7	RNA splicing; nucleoplasm; protein binding; nucleus; mRNA splicing, via spliceosome; RNA binding; gene expression;
RBFOX1	6	mRNA processing; RNA splicing; protein binding; nucleus; RNA binding; nucleotide binding;
SF3B2	6	mRNA processing; RNA splicing; nucleoplasm; nucleus; mRNA splicing, via spliceosome; gene expression;
CD2BP2	6	RNA splicing; nucleoplasm; protein binding; nucleus; mRNA splicing, via spliceosome; gene expression;
DDX23	6	RNA splicing; nucleoplasm; protein binding; nucleus; mRNA splicing, via spliceosome; gene expression;
DHX9	6	RNA splicing; nucleoplasm; protein binding; nucleus; mRNA splicing, via spliceosome; gene expression;
PRPF4	6	RNA splicing; nucleoplasm; protein binding; nucleus; mRNA splicing, via spliceosome; gene expression;
SMC1A	6	RNA splicing; nucleoplasm; protein binding; nucleus; mRNA splicing, via spliceosome; gene expression;
SNRNP200	6	RNA splicing; nucleoplasm; protein binding; nucleus; mRNA splicing, via spliceosome; gene expression;
SNRPA1	6	RNA splicing; nucleoplasm; protein binding; mRNA splicing, via spliceosome; RNA binding; gene expression;
CELF1	5	mRNA processing; protein binding; nucleus; RNA binding; nucleotide binding;
HSPA8	5	mRNA processing; RNA splicing; protein binding; nucleus; gene expression;
LSM4	5	mRNA processing; RNA splicing; protein binding; RNA binding; gene expression;
SCAF8	5	mRNA processing; RNA splicing; nucleus; RNA binding; nucleotide binding;
SF3A2	5	mRNA processing; RNA splicing; nucleoplasm; mRNA splicing, via spliceosome; gene expression;
SF3B3	5	mRNA processing; RNA splicing; nucleoplasm; mRNA splicing, via spliceosome; gene expression;
SMNDC1	5	mRNA processing; RNA splicing; protein binding; nucleus; RNA binding;
SNRNP35	5	mRNA processing; RNA splicing; nucleus; RNA binding; nucleotide binding;
SRSF8	5	mRNA processing; RNA splicing; nucleus; RNA binding; nucleotide binding;
ZCRB1	5	mRNA processing; RNA splicing; nucleoplasm; RNA binding; nucleotide binding;
DHX8	5	RNA splicing; protein binding; nucleus; mRNA splicing, via spliceosome; RNA binding;
SNRPD2	5	RNA splicing; nucleoplasm; protein binding; mRNA splicing, via spliceosome; gene expression;
TXNL4A	5	RNA splicing; nucleoplasm; protein binding; mRNA splicing, via spliceosome; gene expression;
MED4	5	transcription from RNA polymerase II promoter; nucleoplasm; protein binding; nucleus; gene expression;
NCOR1	5	transcription from RNA polymerase II promoter; nucleoplasm; protein binding; nucleus; gene expression;
SSRP1	5	transcription from RNA polymerase II promoter; nucleoplasm; protein binding; nucleus; gene expression;
TAF10	5	transcription from RNA polymerase II promoter; nucleoplasm; protein binding; nucleus; gene expression;
TAF13	5	transcription from RNA polymerase II promoter; nucleoplasm; protein binding; nucleus; gene expression;
SNW1	5	nucleoplasm; protein binding; nucleus; mRNA splicing, via spliceosome; gene expression;

Genes shared at least 2 KEGG pathways with CPSF7 (count: 0)

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Region: chr11:61170120..61197464 View in gBrowse