ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MED4
Previous Symbol	VDRIP
Symbol Alias	HSPC126, DRIP36, TRAP36
Approved Name	mediator complex subunit 4
Previous Name	vitamin D receptor interacting protein, "mediator of RNA polymerase II transcription, subunit 4 homolog (S. cerevisiae)"
Location	13q14.12
Position	chr13:48627459-48669267, -
External Links	HGNC: 17903 Entrez Gene: 29079 Ensembl: ENSG00000136146 UCSC: uc001vby.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 18)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0035257	nuclear hormone receptor binding	Molecular Function		30

GO terms by database search (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004872	receptor activity	Molecular Function	IDA[12218053]	36
GO:0003712	transcription cofactor activity	Molecular Function	IDA[12218053]	17
GO:0001104	RNA polymerase II transcription cofactor activity	Molecular Function	IDA[10882111]	16
GO:0005730	nucleolus	Cellular Component		243
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005634	nucleus	Cellular Component		770
GO:0005515	protein binding	Molecular Function	IPI[15175163]	910
GO:0016592	mediator complex	Cellular Component	IDA[14638676]	17
GO:0010467	gene expression	Biological Process		140
GO:0006367	transcription initiation from RNA polymerase II promoter	Biological Process	IDA[12218053]	42
GO:0006366	transcription from RNA polymerase II promoter	Biological Process	IDA[10882111]	62
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	IDA[10198638]	80
GO:0042809	vitamin D receptor binding	Molecular Function	NAS[10235266]	11
GO:0046966	thyroid hormone receptor binding	Molecular Function	IDA[10198638]	18
GO:0030518	intracellular steroid hormone receptor signaling pathway	Biological Process	IDA[11867769]	10
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	Molecular Function	NAS[10235266]	19
GO:0030521	androgen receptor signaling pathway	Biological Process	IDA[12218053]	16

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with MED4 (count: 64)

Gene Symbol	Pathway Count	Pathway List
MED1	17	receptor activity; transcription cofactor activity; RNA polymerase II transcription cofactor activity; nucleolus; nucleoplasm; nucleus; protein binding; mediator complex; gene expression; transcription initiation from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; vitamin D receptor binding; thyroid hormone receptor binding; intracellular steroid hormone receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; androgen receptor signaling pathway;
MED30	16	receptor activity; transcription cofactor activity; RNA polymerase II transcription cofactor activity; nucleoplasm; nucleus; protein binding; mediator complex; gene expression; transcription initiation from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; vitamin D receptor binding; thyroid hormone receptor binding; intracellular steroid hormone receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; androgen receptor signaling pathway;
MED12	15	receptor activity; transcription cofactor activity; RNA polymerase II transcription cofactor activity; nucleoplasm; nucleus; mediator complex; gene expression; transcription initiation from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; vitamin D receptor binding; thyroid hormone receptor binding; intracellular steroid hormone receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; androgen receptor signaling pathway;
MED13	15	receptor activity; transcription cofactor activity; RNA polymerase II transcription cofactor activity; nucleoplasm; nucleus; mediator complex; gene expression; transcription initiation from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; vitamin D receptor binding; thyroid hormone receptor binding; intracellular steroid hormone receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; androgen receptor signaling pathway;
MED14	15	receptor activity; transcription cofactor activity; RNA polymerase II transcription cofactor activity; nucleoplasm; nucleus; mediator complex; gene expression; transcription initiation from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; vitamin D receptor binding; thyroid hormone receptor binding; intracellular steroid hormone receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; androgen receptor signaling pathway;
MED17	15	receptor activity; transcription cofactor activity; RNA polymerase II transcription cofactor activity; nucleoplasm; nucleus; mediator complex; gene expression; transcription initiation from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; vitamin D receptor binding; thyroid hormone receptor binding; intracellular steroid hormone receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; androgen receptor signaling pathway;
MED24	15	receptor activity; transcription cofactor activity; RNA polymerase II transcription cofactor activity; nucleoplasm; nucleus; mediator complex; gene expression; transcription initiation from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; vitamin D receptor binding; thyroid hormone receptor binding; intracellular steroid hormone receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; androgen receptor signaling pathway;
THRAP3	15	receptor activity; transcription cofactor activity; RNA polymerase II transcription cofactor activity; nucleolus; nucleus; protein binding; mediator complex; transcription initiation from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; vitamin D receptor binding; thyroid hormone receptor binding; intracellular steroid hormone receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; androgen receptor signaling pathway;
MED16	14	receptor activity; transcription cofactor activity; nucleoplasm; nucleus; mediator complex; gene expression; transcription initiation from RNA polymerase II promoter; transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; vitamin D receptor binding; thyroid hormone receptor binding; intracellular steroid hormone receptor signaling pathway; nuclear hormone receptor binding; androgen receptor signaling pathway;
NCOA6	9	nucleolus; nucleoplasm; nucleus; protein binding; transcription initiation from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; thyroid hormone receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding;
SNW1	8	nucleolus; nucleoplasm; nucleus; protein binding; gene expression; transcription initiation from RNA polymerase II promoter; vitamin D receptor binding; nuclear hormone receptor binding;
MED15	7	RNA polymerase II transcription cofactor activity; nucleoplasm; nucleus; protein binding; mediator complex; gene expression; transcription initiation from RNA polymerase II promoter;
TAF13	7	nucleolus; nucleoplasm; nucleus; protein binding; gene expression; transcription initiation from RNA polymerase II promoter; transcription from RNA polymerase II promoter;
NCOR1	7	nucleoplasm; nucleus; protein binding; gene expression; transcription initiation from RNA polymerase II promoter; transcription from RNA polymerase II promoter; thyroid hormone receptor binding;
MED7	6	RNA polymerase II transcription cofactor activity; nucleoplasm; protein binding; mediator complex; gene expression; transcription initiation from RNA polymerase II promoter;
RBM14	6	RNA polymerase II transcription cofactor activity; nucleolus; nucleus; protein binding; mediator complex; ligand-dependent nuclear receptor transcription coactivator activity;
MAML1	6	nucleolus; nucleoplasm; nucleus; protein binding; gene expression; transcription initiation from RNA polymerase II promoter;
MEN1	6	nucleolus; nucleoplasm; nucleus; protein binding; gene expression; transcription initiation from RNA polymerase II promoter;
NCOR2	6	nucleolus; nucleoplasm; nucleus; protein binding; gene expression; transcription initiation from RNA polymerase II promoter;
PGR	6	nucleolus; nucleoplasm; nucleus; protein binding; gene expression; transcription initiation from RNA polymerase II promoter;
RBPJ	6	nucleolus; nucleoplasm; nucleus; protein binding; gene expression; transcription initiation from RNA polymerase II promoter;
SSRP1	6	nucleolus; nucleoplasm; nucleus; protein binding; gene expression; transcription from RNA polymerase II promoter;
TAF4B	6	nucleolus; nucleoplasm; nucleus; gene expression; transcription initiation from RNA polymerase II promoter; transcription from RNA polymerase II promoter;
U2AF1	6	nucleolus; nucleoplasm; nucleus; protein binding; gene expression; transcription from RNA polymerase II promoter;
HMGA1	6	nucleoplasm; nucleus; protein binding; positive regulation of transcription, DNA-dependent; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding;
SMARCD3	6	nucleoplasm; nucleus; protein binding; positive regulation of transcription, DNA-dependent; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding;
TAF10	6	nucleoplasm; nucleus; protein binding; gene expression; transcription initiation from RNA polymerase II promoter; transcription from RNA polymerase II promoter;
NSD1	5	transcription cofactor activity; nucleus; positive regulation of transcription, DNA-dependent; thyroid hormone receptor binding; nuclear hormone receptor binding;
PPARGC1B	5	RNA polymerase II transcription cofactor activity; nucleus; mediator complex; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding;
TP53BP1	5	RNA polymerase II transcription cofactor activity; nucleoplasm; nucleus; protein binding; positive regulation of transcription, DNA-dependent;
DAXX	5	nucleolus; nucleus; protein binding; nuclear hormone receptor binding; androgen receptor signaling pathway;
DDX23	5	nucleolus; nucleoplasm; nucleus; protein binding; gene expression;
DGCR8	5	nucleolus; nucleoplasm; nucleus; protein binding; gene expression;
DHX9	5	nucleolus; nucleoplasm; nucleus; protein binding; gene expression;
EFTUD2	5	nucleolus; nucleoplasm; nucleus; protein binding; gene expression;
FUS	5	nucleolus; nucleoplasm; nucleus; protein binding; gene expression;
HINFP	5	nucleolus; nucleoplasm; nucleus; protein binding; positive regulation of transcription, DNA-dependent;
HNRNPA2B1	5	nucleolus; nucleoplasm; nucleus; protein binding; gene expression;
HNRNPH1	5	nucleolus; nucleoplasm; nucleus; protein binding; gene expression;
KAT5	5	nucleolus; nucleus; protein binding; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway;
MAPK1	5	nucleolus; nucleoplasm; nucleus; protein binding; positive regulation of transcription, DNA-dependent;
MAPK3	5	nucleolus; nucleoplasm; nucleus; protein binding; gene expression;
PRPF4	5	nucleolus; nucleoplasm; nucleus; protein binding; gene expression;
SF3A1	5	nucleolus; nucleoplasm; nucleus; protein binding; gene expression;
SF3A3	5	nucleolus; nucleoplasm; nucleus; protein binding; gene expression;
SMC1A	5	nucleolus; nucleoplasm; nucleus; protein binding; gene expression;
SNRNP200	5	nucleolus; nucleoplasm; nucleus; protein binding; gene expression;
TFAP2A	5	nucleolus; nucleus; protein binding; transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent;
CPSF7	5	nucleoplasm; nucleus; protein binding; gene expression; transcription from RNA polymerase II promoter;
ESRRA	5	nucleoplasm; nucleus; protein binding; gene expression; transcription initiation from RNA polymerase II promoter;
IRF7	5	nucleoplasm; nucleus; protein binding; transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent;
LSM11	5	nucleoplasm; nucleus; protein binding; gene expression; transcription from RNA polymerase II promoter;
MED23	5	nucleoplasm; protein binding; mediator complex; gene expression; transcription initiation from RNA polymerase II promoter;
NCBP1	5	nucleoplasm; nucleus; protein binding; gene expression; transcription from RNA polymerase II promoter;
NEDD4L	5	nucleoplasm; nucleus; protein binding; gene expression; transcription initiation from RNA polymerase II promoter;
NR4A2	5	nucleoplasm; nucleus; protein binding; gene expression; transcription initiation from RNA polymerase II promoter;
NR5A1	5	nucleoplasm; nucleus; protein binding; gene expression; transcription initiation from RNA polymerase II promoter;
POLR2G	5	nucleoplasm; nucleus; gene expression; transcription initiation from RNA polymerase II promoter; transcription from RNA polymerase II promoter;
PRPF6	5	nucleoplasm; nucleus; protein binding; gene expression; nuclear hormone receptor binding;
RAN	5	nucleoplasm; protein binding; gene expression; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway;
TRIP12	5	nucleoplasm; nucleus; protein binding; thyroid hormone receptor binding; nuclear hormone receptor binding;
YAP1	5	nucleoplasm; nucleus; protein binding; gene expression; transcription initiation from RNA polymerase II promoter;
NRIP1	5	nucleus; protein binding; positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding; androgen receptor signaling pathway;
TGFB1I1	5	protein binding; transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding; androgen receptor signaling pathway;

Genes shared at least 2 KEGG pathways with MED4 (count: 0)

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Region: chr13:48627459..48669267 View in gBrowse