ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	KAT5
Previous Symbol	HTATIP
Symbol Alias	TIP60, PLIP, cPLA2, HTATIP1, ESA1
Approved Name	K(lysine) acetyltransferase 5
Previous Name	HIV-1 Tat interactive protein, 60kDa
Name Alias	Tat interacting protein, 60kDa, "K-acetyltransferase 5"
Location	11q13
Position	chr11:65479467-65487075, +
External Links	HGNC: 5275 Entrez Gene: 10524 Ensembl: ENSG00000172977 UCSC: uc001ofk.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 27)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 27)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006351	transcription, DNA-dependent	Biological Process		247
GO:0006302	double-strand break repair	Biological Process	IMP[10966108]	11
GO:0005829	cytosol	Cellular Component		447
GO:0005730	nucleolus	Cellular Component	IDA[16387653]	243
GO:0005667	transcription factor complex	Cellular Component		51
GO:0005634	nucleus	Cellular Component		770
GO:0005515	protein binding	Molecular Function		910
GO:0004402	histone acetyltransferase activity	Molecular Function	IDA[14966270]	9
GO:0035267	NuA4 histone acetyltransferase complex	Cellular Component	IDA[14966270]	1
GO:0032777	Piccolo NuA4 histone acetyltransferase complex	Cellular Component	IDA[14966270]	1
GO:0032703	negative regulation of interleukin-2 production	Biological Process	IDA[17360565]	2
GO:0032403	protein complex binding	Molecular Function		27
GO:0030521	androgen receptor signaling pathway	Biological Process	NAS[15572661]	16
GO:0019048	virus-host interaction	Biological Process		54
GO:0016573	histone acetylation	Biological Process	IDA[10966108]	2
GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	Biological Process	IDA[14966270]	1
GO:0000785	chromatin	Cellular Component		13
GO:0003713	transcription coactivator activity	Molecular Function	IDA[14966270]; TAS[17360565]	52
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	IMP[17360565]	78
GO:0046872	metal ion binding	Molecular Function		170
GO:0048471	perinuclear region of cytoplasm	Cellular Component		87
GO:0050681	androgen receptor binding	Molecular Function	NAS[15572661]	10
GO:0070491	repressing transcription factor binding	Molecular Function	IPI[17360565]	2
GO:0040008	regulation of growth	Biological Process		5
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process	IDA[17360565]	64
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	IDA[14966270]; NAS[15572661]	80
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process		131

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with KAT5 (count: 101)

Gene Symbol	Pathway Count	Pathway List
RELA	10	cytosol; transcription factor complex; nucleus; protein binding; protein complex binding; virus-host interaction; repressing transcription factor binding; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
DAXX	9	transcription, DNA-dependent; cytosol; nucleolus; nucleus; protein binding; androgen receptor signaling pathway; virus-host interaction; androgen receptor binding; negative regulation of transcription, DNA-dependent;
MEN1	9	transcription, DNA-dependent; cytosol; nucleolus; nucleus; protein binding; chromatin; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
NRIP1	9	transcription, DNA-dependent; nucleus; protein binding; androgen receptor signaling pathway; transcription coactivator activity; negative regulation of transcription from RNA polymerase II promoter; androgen receptor binding; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
SNW1	9	nucleolus; nucleus; protein binding; virus-host interaction; chromatin; transcription coactivator activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
HMGA1	8	transcription, DNA-dependent; cytosol; transcription factor complex; nucleus; protein binding; virus-host interaction; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent;
KDM1A	8	transcription, DNA-dependent; transcription factor complex; nucleus; protein binding; negative regulation of transcription from RNA polymerase II promoter; androgen receptor binding; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
ID2	8	cytosol; nucleolus; nucleus; protein binding; chromatin; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent;
RAN	8	cytosol; protein binding; androgen receptor signaling pathway; virus-host interaction; chromatin; transcription coactivator activity; androgen receptor binding; positive regulation of transcription, DNA-dependent;
MED1	8	nucleolus; nucleus; protein binding; androgen receptor signaling pathway; transcription coactivator activity; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
TFAP2A	8	nucleolus; nucleus; protein binding; transcription coactivator activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
HINFP	7	transcription, DNA-dependent; nucleolus; nucleus; protein binding; transcription coactivator activity; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent;
HSPA8	7	transcription, DNA-dependent; cytosol; nucleolus; nucleus; protein binding; virus-host interaction; negative regulation of transcription, DNA-dependent;
LPIN1	7	transcription, DNA-dependent; cytosol; transcription factor complex; nucleus; transcription coactivator activity; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
MAPK1	7	transcription, DNA-dependent; cytosol; nucleolus; nucleus; protein binding; virus-host interaction; positive regulation of transcription, DNA-dependent;
SMARCB1	7	transcription, DNA-dependent; nucleolus; nucleus; protein binding; virus-host interaction; transcription coactivator activity; positive regulation of transcription from RNA polymerase II promoter;
GSK3B	7	cytosol; nucleolus; nucleus; protein binding; perinuclear region of cytoplasm; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
UBE3A	7	cytosol; nucleus; protein binding; androgen receptor signaling pathway; virus-host interaction; transcription coactivator activity; positive regulation of transcription from RNA polymerase II promoter;
HNF1B	7	nucleolus; transcription factor complex; nucleus; protein binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
NCOA6	7	nucleolus; transcription factor complex; nucleus; protein binding; transcription coactivator activity; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
THRAP3	7	nucleolus; nucleus; protein binding; androgen receptor signaling pathway; transcription coactivator activity; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
ATXN1	6	transcription, DNA-dependent; nucleolus; nucleus; protein binding; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
ETS1	6	transcription, DNA-dependent; transcription factor complex; nucleus; protein binding; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
MYB	6	transcription, DNA-dependent; protein binding; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
NEDD4L	6	transcription, DNA-dependent; cytosol; nucleus; protein binding; virus-host interaction; negative regulation of transcription from RNA polymerase II promoter;
POU2F3	6	transcription, DNA-dependent; nucleolus; transcription factor complex; nucleus; protein binding; positive regulation of transcription from RNA polymerase II promoter;
SRCAP	6	transcription, DNA-dependent; nucleus; histone acetyltransferase activity; virus-host interaction; histone acetylation; transcription coactivator activity;
SREBF1	6	transcription, DNA-dependent; nucleus; protein binding; protein complex binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
SUB1	6	transcription, DNA-dependent; nucleolus; transcription factor complex; nucleus; protein binding; transcription coactivator activity;
XRCC5	6	transcription, DNA-dependent; double-strand break repair; nucleolus; nucleus; protein binding; negative regulation of transcription, DNA-dependent;
ARRB1	6	cytosol; nucleus; protein binding; histone acetyltransferase activity; chromatin; positive regulation of transcription from RNA polymerase II promoter;
CLOCK	6	cytosol; nucleolus; transcription factor complex; nucleus; histone acetyltransferase activity; positive regulation of transcription from RNA polymerase II promoter;
IRF7	6	cytosol; nucleus; protein binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
MAPK3	6	cytosol; nucleolus; nucleus; protein binding; virus-host interaction; positive regulation of transcription from RNA polymerase II promoter;
PAFAH1B1	6	cytosol; nucleolus; nucleus; protein binding; protein complex binding; perinuclear region of cytoplasm;
PDE2A	6	cytosol; nucleus; protein binding; negative regulation of transcription from RNA polymerase II promoter; metal ion binding; perinuclear region of cytoplasm;
PSMC3	6	cytosol; nucleus; protein binding; virus-host interaction; transcription coactivator activity; perinuclear region of cytoplasm;
YAP1	6	cytosol; transcription factor complex; nucleus; protein binding; transcription coactivator activity; positive regulation of transcription from RNA polymerase II promoter;
MTA2	6	nucleolus; transcription factor complex; nucleus; protein binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
RBPJ	6	nucleolus; nucleus; protein binding; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
FOXE1	6	transcription factor complex; nucleus; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
GATA6	6	transcription factor complex; nucleus; protein binding; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
MED17	6	transcription factor complex; nucleus; androgen receptor signaling pathway; transcription coactivator activity; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
STRN3	6	nucleus; protein binding; protein complex binding; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
APBB1	5	transcription, DNA-dependent; double-strand break repair; nucleus; protein binding; positive regulation of transcription, DNA-dependent;
BCL9L	5	transcription, DNA-dependent; nucleolus; nucleus; transcription coactivator activity; positive regulation of transcription from RNA polymerase II promoter;
BCLAF1	5	transcription, DNA-dependent; nucleolus; nucleus; protein binding; negative regulation of transcription, DNA-dependent;
BIRC2	5	transcription, DNA-dependent; cytosol; nucleus; protein binding; transcription coactivator activity;
CBX3	5	transcription, DNA-dependent; nucleus; protein binding; chromatin; negative regulation of transcription, DNA-dependent;
CNOT6	5	transcription, DNA-dependent; cytosol; nucleus; protein binding; metal ion binding;
ELK3	5	transcription, DNA-dependent; nucleolus; nucleus; protein binding; negative regulation of transcription, DNA-dependent;
HOXA2	5	transcription, DNA-dependent; nucleolus; nucleus; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
HOXA7	5	transcription, DNA-dependent; nucleus; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
MMS19	5	transcription, DNA-dependent; nucleus; protein binding; transcription coactivator activity; positive regulation of transcription, DNA-dependent;
NCOR1	5	transcription, DNA-dependent; transcription factor complex; nucleus; protein binding; negative regulation of transcription from RNA polymerase II promoter;
NCOR2	5	transcription, DNA-dependent; nucleolus; nucleus; protein binding; negative regulation of transcription from RNA polymerase II promoter;
NPAT	5	transcription, DNA-dependent; nucleus; protein binding; transcription coactivator activity; positive regulation of transcription, DNA-dependent;
NSD1	5	transcription, DNA-dependent; nucleus; negative regulation of transcription from RNA polymerase II promoter; androgen receptor binding; positive regulation of transcription, DNA-dependent;
PHF2	5	transcription, DNA-dependent; nucleolus; nucleus; protein binding; transcription coactivator activity;
PRKAA1	5	transcription, DNA-dependent; cytosol; nucleus; protein binding; metal ion binding;
PRKCB	5	transcription, DNA-dependent; cytosol; nucleus; protein binding; androgen receptor binding;
RNF2	5	transcription, DNA-dependent; nucleolus; nucleus; protein binding; negative regulation of transcription from RNA polymerase II promoter;
SMARCD3	5	transcription, DNA-dependent; nucleus; protein binding; transcription coactivator activity; positive regulation of transcription, DNA-dependent;
TCF25	5	transcription, DNA-dependent; nucleolus; nucleus; protein binding; negative regulation of transcription from RNA polymerase II promoter;
UBB	5	transcription, DNA-dependent; cytosol; protein binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
UBC	5	transcription, DNA-dependent; cytosol; protein binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
UTF1	5	transcription, DNA-dependent; nucleus; protein binding; transcription coactivator activity; positive regulation of transcription from RNA polymerase II promoter;
ZBTB16	5	transcription, DNA-dependent; nucleus; protein binding; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent;
ZNF423	5	transcription, DNA-dependent; nucleus; protein binding; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent;
TP53BP1	5	double-strand break repair; nucleus; protein binding; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
AIP	5	cytosol; nucleolus; nucleus; protein binding; transcription coactivator activity;
ALKBH8	5	cytosol; nucleolus; nucleus; protein binding; metal ion binding;
CDK5RAP2	5	cytosol; protein binding; protein complex binding; perinuclear region of cytoplasm; positive regulation of transcription, DNA-dependent;
IRF8	5	cytosol; nucleus; protein binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent;
MALT1	5	cytosol; nucleolus; nucleus; protein binding; perinuclear region of cytoplasm;
PDCD4	5	cytosol; nucleolus; nucleus; protein binding; negative regulation of transcription, DNA-dependent;
PPM1F	5	cytosol; protein binding; metal ion binding; perinuclear region of cytoplasm; negative regulation of transcription, DNA-dependent;
PPP1CA	5	cytosol; nucleolus; nucleus; protein binding; metal ion binding;
PRKD1	5	cytosol; nucleus; protein binding; metal ion binding; positive regulation of transcription from RNA polymerase II promoter;
XPO1	5	cytosol; nucleolus; protein binding; virus-host interaction; negative regulation of transcription from RNA polymerase II promoter;
FOXP1	5	nucleolus; transcription factor complex; nucleus; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
MAML1	5	nucleolus; nucleus; protein binding; transcription coactivator activity; positive regulation of transcription from RNA polymerase II promoter;
MED4	5	nucleolus; nucleus; protein binding; androgen receptor signaling pathway; positive regulation of transcription, DNA-dependent;
RBM14	5	nucleolus; transcription factor complex; nucleus; protein binding; positive regulation of transcription from RNA polymerase II promoter;
RNF20	5	nucleolus; nucleus; protein binding; transcription coactivator activity; positive regulation of transcription, DNA-dependent;
SUPT3H	5	nucleolus; nucleus; histone acetyltransferase activity; transcription coactivator activity; positive regulation of transcription, DNA-dependent;
FOXC2	5	transcription factor complex; nucleus; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
FOXF1	5	transcription factor complex; nucleus; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
FOXG1	5	transcription factor complex; nucleus; protein binding; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
KLF4	5	transcription factor complex; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
FLCN	5	nucleus; protein binding; protein complex binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
HES1	5	nucleus; protein binding; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
HEY2	5	nucleus; protein binding; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
MED12	5	nucleus; androgen receptor signaling pathway; transcription coactivator activity; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
MED13	5	nucleus; androgen receptor signaling pathway; transcription coactivator activity; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
MED14	5	nucleus; androgen receptor signaling pathway; transcription coactivator activity; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
PRPF6	5	nucleus; protein binding; transcription coactivator activity; androgen receptor binding; positive regulation of transcription from RNA polymerase II promoter;
TAF10	5	nucleus; protein binding; histone acetyltransferase activity; transcription coactivator activity; perinuclear region of cytoplasm;
USP2	5	nucleus; protein binding; negative regulation of transcription from RNA polymerase II promoter; metal ion binding; perinuclear region of cytoplasm;
SPI1	5	protein binding; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
TGFB1I1	5	protein binding; androgen receptor signaling pathway; transcription coactivator activity; androgen receptor binding; positive regulation of transcription, DNA-dependent;

Genes shared at least 2 KEGG pathways with KAT5 (count: 0)

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Region: chr11:65479467..65487075 View in gBrowse