ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	XRCC5
Symbol Alias	KU80, KARP-1, Ku86, KUB2
Approved Name	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
Previous Name	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kD)
Name Alias	Ku autoantigen, 80kDa
Location	2q35
Position	chr2:216972187-217071026, +
External Links	HGNC: 12833 Entrez Gene: 7520 Ensembl: ENSG00000079246 UCSC: uc002vfy.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
2q35	chr2:215300000-221500000	1 (1/0/0)

Gene related GO terms (count: 32)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 32)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000723	telomere maintenance	Biological Process	TAS[15824061]	10
GO:0003677	DNA binding	Molecular Function	NAS[1537839]	220
GO:0003690	double-stranded DNA binding	Molecular Function	TAS[7957065]	17
GO:0000783	nuclear telomere cap complex	Cellular Component	TAS[15100233]	3
GO:0000784	nuclear chromosome, telomeric region	Cellular Component	IDA[10535943]	2
GO:0005515	protein binding	Molecular Function		910
GO:0005524	ATP binding	Molecular Function		228
GO:0003691	double-stranded telomeric DNA binding	Molecular Function	IDA[10409678]	1
GO:0004003	ATP-dependent DNA helicase activity	Molecular Function		4
GO:0042162	telomeric DNA binding	Molecular Function	IDA[10535943]	4
GO:0043066	negative regulation of apoptotic process	Biological Process		77
GO:0016032	viral reproduction	Biological Process		57
GO:0031625	ubiquitin protein ligase binding	Molecular Function		23
GO:0008022	protein C-terminus binding	Molecular Function	IPI[10783163]	32
GO:0008283	cell proliferation	Biological Process		60
GO:0006310	DNA recombination	Biological Process		14
GO:0006351	transcription, DNA-dependent	Biological Process		247
GO:0006302	double-strand break repair	Biological Process		11
GO:0006303	double-strand break repair via nonhomologous end joining	Biological Process	TAS[15824061]	4
GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex	Cellular Component		1
GO:0006281	DNA repair	Biological Process		62
GO:0005730	nucleolus	Cellular Component		243
GO:0005737	cytoplasm	Cellular Component		690
GO:0005634	nucleus	Cellular Component		770
GO:0005654	nucleoplasm	Cellular Component		183
GO:0070419	nonhomologous end joining complex	Cellular Component		2
GO:0060218	hematopoietic stem cell differentiation	Biological Process		1
GO:0051575	5'-deoxyribose-5-phosphate lyase activity	Molecular Function		2
GO:0050769	positive regulation of neurogenesis	Biological Process		4
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process	IMP[8621488]	64
GO:0044212	transcription regulatory region DNA binding	Molecular Function	IDA[18809223]	23
GO:0043564	Ku70:Ku80 complex	Cellular Component		1

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03450	Non-homologous end-joining	4	Nonhomologous end joining (NHEJ) eliminates DNA double-stran...... Nonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX complex in yeast), processing of ends, and recruitment of the DNA ligase IV (LIG4)-XRCC4 complex, which brings about ligation. A recent study shows that bacteria accomplish NHEJ using just two proteins (Ku and DNA ligase), whereas eukaryotes require many factors. NHEJ repairs DSBs at all stages of the cell cycle, bringing about the ligation of two DNA DSBs without the need for sequence homology, and so is error-prone. More...

Genes shared at least 5 GO terms with XRCC5 (count: 149)

Gene Symbol	Pathway Count	Pathway List
MRE11A	13	DNA binding; double-stranded DNA binding; protein binding; ATP-dependent DNA helicase activity; protein C-terminus binding; cell proliferation; DNA recombination; double-strand break repair; double-strand break repair via nonhomologous end joining; DNA repair; nucleolus; nucleus; nucleoplasm;
MEN1	10	double-stranded DNA binding; protein binding; transcription, DNA-dependent; DNA repair; nucleolus; cytoplasm; nucleus; nucleoplasm; negative regulation of transcription, DNA-dependent; transcription regulatory region DNA binding;
FEN1	9	telomere maintenance; DNA binding; double-stranded DNA binding; protein binding; double-strand break repair; DNA repair; nucleolus; nucleus; nucleoplasm;
TERF2IP	9	telomere maintenance; nuclear telomere cap complex; nuclear chromosome, telomeric region; protein binding; telomeric DNA binding; transcription, DNA-dependent; cytoplasm; nucleus; nucleoplasm;
ATXN1	9	DNA binding; protein binding; protein C-terminus binding; transcription, DNA-dependent; nucleolus; cytoplasm; nucleus; nucleoplasm; negative regulation of transcription, DNA-dependent;
HINFP	9	DNA binding; protein binding; transcription, DNA-dependent; DNA repair; nucleolus; nucleus; nucleoplasm; negative regulation of transcription, DNA-dependent; transcription regulatory region DNA binding;
RELA	9	DNA binding; protein binding; negative regulation of apoptotic process; ubiquitin protein ligase binding; cytoplasm; nucleus; nucleoplasm; negative regulation of transcription, DNA-dependent; transcription regulatory region DNA binding;
ATM	8	telomere maintenance; DNA binding; protein binding; ATP binding; negative regulation of apoptotic process; double-strand break repair; DNA repair; nucleoplasm;
CHD1L	8	DNA binding; protein binding; ATP binding; ATP-dependent DNA helicase activity; DNA repair; nucleolus; cytoplasm; nucleus;
DHX9	8	DNA binding; protein binding; ATP binding; ATP-dependent DNA helicase activity; nucleolus; cytoplasm; nucleus; nucleoplasm;
HMGA1	8	DNA binding; protein binding; viral reproduction; transcription, DNA-dependent; nucleus; nucleoplasm; 5'-deoxyribose-5-phosphate lyase activity; negative regulation of transcription, DNA-dependent;
IGHMBP2	8	DNA binding; protein binding; ATP binding; DNA recombination; transcription, DNA-dependent; DNA repair; cytoplasm; nucleus;
MAPK1	8	DNA binding; protein binding; ATP binding; transcription, DNA-dependent; nucleolus; cytoplasm; nucleus; nucleoplasm;
RBPJ	8	DNA binding; protein binding; DNA recombination; nucleolus; cytoplasm; nucleus; nucleoplasm; negative regulation of transcription, DNA-dependent;
SSRP1	8	DNA binding; protein binding; viral reproduction; DNA repair; nucleolus; cytoplasm; nucleus; nucleoplasm;
GSK3B	8	protein binding; ATP binding; negative regulation of apoptotic process; ubiquitin protein ligase binding; nucleolus; cytoplasm; nucleus; negative regulation of transcription, DNA-dependent;
KDM1A	8	protein binding; negative regulation of apoptotic process; cell proliferation; transcription, DNA-dependent; nucleus; nucleoplasm; negative regulation of transcription, DNA-dependent; transcription regulatory region DNA binding;
SMC1A	8	protein binding; ATP binding; DNA recombination; DNA repair; nucleolus; cytoplasm; nucleus; nucleoplasm;
BCLAF1	7	DNA binding; protein binding; transcription, DNA-dependent; nucleolus; cytoplasm; nucleus; negative regulation of transcription, DNA-dependent;
TAF13	7	DNA binding; protein binding; viral reproduction; protein C-terminus binding; nucleolus; nucleus; nucleoplasm;
ZNF263	7	DNA binding; viral reproduction; transcription, DNA-dependent; nucleolus; cytoplasm; nucleus; negative regulation of transcription, DNA-dependent;
DAXX	7	protein binding; ubiquitin protein ligase binding; transcription, DNA-dependent; nucleolus; cytoplasm; nucleus; negative regulation of transcription, DNA-dependent;
TFAP2A	7	protein binding; negative regulation of apoptotic process; nucleolus; cytoplasm; nucleus; negative regulation of transcription, DNA-dependent; transcription regulatory region DNA binding;
TP53BP1	7	protein binding; telomeric DNA binding; double-strand break repair; DNA repair; cytoplasm; nucleus; nucleoplasm;
YAP1	7	protein binding; negative regulation of apoptotic process; cell proliferation; cytoplasm; nucleus; nucleoplasm; transcription regulatory region DNA binding;
POLA2	6	telomere maintenance; DNA binding; nucleolus; cytoplasm; nucleus; nucleoplasm;
POLD3	6	telomere maintenance; protein binding; DNA repair; nucleolus; nucleus; nucleoplasm;
TINF2	6	telomere maintenance; DNA binding; nuclear telomere cap complex; protein binding; telomeric DNA binding; nucleoplasm;
DDB1	6	DNA binding; protein binding; DNA repair; cytoplasm; nucleus; nucleoplasm;
FUS	6	DNA binding; protein binding; nucleolus; cytoplasm; nucleus; nucleoplasm;
H2AFX	6	DNA binding; protein binding; double-strand break repair; DNA repair; nucleus; nucleoplasm;
HNF1B	6	DNA binding; protein binding; negative regulation of apoptotic process; nucleolus; nucleus; transcription regulatory region DNA binding;
NCOR2	6	DNA binding; protein binding; transcription, DNA-dependent; nucleolus; nucleus; nucleoplasm;
NFRKB	6	DNA binding; protein binding; DNA recombination; DNA repair; nucleolus; nucleus;
NHEJ1	6	DNA binding; protein binding; DNA recombination; double-strand break repair via nonhomologous end joining; nucleus; nonhomologous end joining complex;
PGR	6	DNA binding; protein binding; nucleolus; cytoplasm; nucleus; nucleoplasm;
TAF4B	6	DNA binding; viral reproduction; nucleolus; cytoplasm; nucleus; nucleoplasm;
TCF25	6	DNA binding; protein binding; transcription, DNA-dependent; nucleolus; cytoplasm; nucleus;
ZNF24	6	DNA binding; protein binding; viral reproduction; transcription, DNA-dependent; nucleus; negative regulation of transcription, DNA-dependent;
DAB2	6	protein binding; negative regulation of apoptotic process; protein C-terminus binding; cell proliferation; nucleus; negative regulation of transcription, DNA-dependent;
ERBB2	6	protein binding; ATP binding; protein C-terminus binding; cell proliferation; transcription, DNA-dependent; nucleus;
GATA6	6	protein binding; negative regulation of apoptotic process; nucleus; nucleoplasm; negative regulation of transcription, DNA-dependent; transcription regulatory region DNA binding;
HSPA8	6	protein binding; ATP binding; transcription, DNA-dependent; nucleolus; nucleus; negative regulation of transcription, DNA-dependent;
INO80E	6	protein binding; DNA recombination; transcription, DNA-dependent; DNA repair; nucleolus; nucleus;
KAT5	6	protein binding; transcription, DNA-dependent; double-strand break repair; nucleolus; nucleus; negative regulation of transcription, DNA-dependent;
NCOA6	6	protein binding; DNA recombination; DNA repair; nucleolus; nucleus; nucleoplasm;
NCOR1	6	protein binding; transcription, DNA-dependent; cytoplasm; nucleus; nucleoplasm; transcription regulatory region DNA binding;
PLK1	6	protein binding; ATP binding; negative regulation of apoptotic process; cell proliferation; nucleus; nucleoplasm;
PRKAA1	6	protein binding; ATP binding; negative regulation of apoptotic process; protein C-terminus binding; transcription, DNA-dependent; nucleus;
PSMC3	6	protein binding; ATP binding; viral reproduction; cytoplasm; nucleus; nucleoplasm;
RAD23B	6	protein binding; DNA repair; nucleolus; cytoplasm; nucleus; nucleoplasm;
RAD9A	6	protein binding; DNA repair; nucleolus; cytoplasm; nucleus; nucleoplasm;
RCC1	6	protein binding; viral reproduction; nucleolus; cytoplasm; nucleus; nucleoplasm;
SMC2	6	protein binding; ATP binding; DNA recombination; DNA repair; cytoplasm; nucleus;
SMC3	6	protein binding; ATP binding; DNA repair; cytoplasm; nucleus; nucleoplasm;
SNW1	6	protein binding; nucleolus; nucleus; nucleoplasm; positive regulation of neurogenesis; negative regulation of transcription, DNA-dependent;
USP28	6	protein binding; cell proliferation; DNA repair; nucleolus; nucleus; nucleoplasm;
POLD4	5	telomere maintenance; protein binding; DNA repair; nucleus; nucleoplasm;
POLE	5	telomere maintenance; DNA binding; DNA repair; nucleus; nucleoplasm;
CREBZF	5	DNA binding; protein binding; transcription, DNA-dependent; nucleus; negative regulation of transcription, DNA-dependent;
E2F5	5	DNA binding; protein binding; transcription, DNA-dependent; cytoplasm; nucleoplasm;
FOXG1	5	DNA binding; double-stranded DNA binding; protein binding; nucleus; negative regulation of transcription, DNA-dependent;
GRHL1	5	DNA binding; transcription, DNA-dependent; cytoplasm; nucleus; nucleoplasm;
HES1	5	DNA binding; protein binding; cytoplasm; nucleus; negative regulation of transcription, DNA-dependent;
HOXB1	5	DNA binding; transcription, DNA-dependent; nucleolus; cytoplasm; nucleus;
IRF7	5	DNA binding; protein binding; cytoplasm; nucleus; nucleoplasm;
KIF22	5	DNA binding; ATP binding; DNA repair; cytoplasm; nucleus;
MUS81	5	DNA binding; protein binding; DNA recombination; DNA repair; nucleolus;
NCBP1	5	DNA binding; protein binding; viral reproduction; nucleus; nucleoplasm;
NPAS3	5	DNA binding; transcription, DNA-dependent; nucleolus; cytoplasm; nucleus;
NR5A1	5	DNA binding; double-stranded DNA binding; protein binding; nucleus; nucleoplasm;
PALB2	5	DNA binding; protein binding; negative regulation of apoptotic process; DNA repair; nucleoplasm;
PRPF19	5	DNA binding; protein binding; DNA repair; cytoplasm; nucleus;
SCYL1	5	DNA binding; ATP binding; transcription, DNA-dependent; cytoplasm; nucleus;
TNFAIP3	5	DNA binding; protein binding; negative regulation of apoptotic process; cytoplasm; nucleus;
ZBTB16	5	DNA binding; protein binding; transcription, DNA-dependent; nucleus; negative regulation of transcription, DNA-dependent;
ZFR	5	DNA binding; protein binding; nucleolus; cytoplasm; nucleus;
ZNF367	5	DNA binding; transcription, DNA-dependent; nucleolus; cytoplasm; nucleus;
ZNF396	5	DNA binding; viral reproduction; transcription, DNA-dependent; cytoplasm; nucleus;
ZNF397	5	DNA binding; viral reproduction; transcription, DNA-dependent; cytoplasm; nucleus;
ZNF423	5	DNA binding; protein binding; transcription, DNA-dependent; nucleus; negative regulation of transcription, DNA-dependent;
ZNF77	5	DNA binding; transcription, DNA-dependent; nucleolus; cytoplasm; nucleus;
FOXP1	5	double-stranded DNA binding; nucleolus; cytoplasm; nucleus; negative regulation of transcription, DNA-dependent;
AATF	5	protein binding; negative regulation of apoptotic process; nucleolus; cytoplasm; nucleus;
APBB1	5	protein binding; transcription, DNA-dependent; double-strand break repair; cytoplasm; nucleus;
ARRB1	5	protein binding; ubiquitin protein ligase binding; cytoplasm; nucleus; transcription regulatory region DNA binding;
ATXN2	5	protein binding; protein C-terminus binding; nucleolus; cytoplasm; nucleus;
BAIAP2	5	protein binding; protein C-terminus binding; nucleolus; cytoplasm; nucleus;
BARD1	5	protein binding; negative regulation of apoptotic process; DNA repair; cytoplasm; nucleus;
BNIP3	5	protein binding; negative regulation of apoptotic process; cytoplasm; nucleus; nucleoplasm;
BRMS1	5	protein binding; transcription, DNA-dependent; cytoplasm; nucleus; negative regulation of transcription, DNA-dependent;
CBFA2T3	5	protein binding; cell proliferation; transcription, DNA-dependent; nucleolus; nucleoplasm;
CCDC85B	5	protein binding; transcription, DNA-dependent; cytoplasm; nucleus; negative regulation of transcription, DNA-dependent;
CDCA5	5	protein binding; double-strand break repair; nucleolus; cytoplasm; nucleus;
CEP164	5	protein binding; DNA repair; nucleolus; cytoplasm; nucleus;
CHEK1	5	protein binding; ATP binding; DNA repair; nucleus; nucleoplasm;
CUL5	5	protein binding; viral reproduction; ubiquitin protein ligase binding; cell proliferation; nucleus;
DDX23	5	protein binding; ATP binding; nucleolus; nucleus; nucleoplasm;
DGCR8	5	protein binding; nucleolus; cytoplasm; nucleus; nucleoplasm;
EFTUD2	5	protein binding; nucleolus; cytoplasm; nucleus; nucleoplasm;
ELK3	5	protein binding; transcription, DNA-dependent; nucleolus; nucleus; negative regulation of transcription, DNA-dependent;
FANCA	5	protein binding; DNA repair; cytoplasm; nucleus; nucleoplasm;
FANCC	5	protein binding; DNA repair; cytoplasm; nucleus; nucleoplasm;
FLII	5	protein binding; transcription, DNA-dependent; nucleolus; cytoplasm; nucleus;
FLT4	5	protein binding; ATP binding; negative regulation of apoptotic process; cytoplasm; nucleus;
HERC2	5	protein binding; ubiquitin protein ligase binding; DNA repair; cytoplasm; nucleus;
HNRNPA2B1	5	protein binding; nucleolus; cytoplasm; nucleus; nucleoplasm;
HNRNPH1	5	protein binding; nucleolus; cytoplasm; nucleus; nucleoplasm;
HSPA5	5	protein binding; ATP binding; negative regulation of apoptotic process; ubiquitin protein ligase binding; nucleus;
IARS	5	protein binding; ATP binding; nucleolus; cytoplasm; nucleus;
ID2	5	protein binding; nucleolus; cytoplasm; nucleus; negative regulation of transcription, DNA-dependent;
KLHL20	5	protein binding; negative regulation of apoptotic process; nucleolus; cytoplasm; nucleus;
MALT1	5	protein binding; negative regulation of apoptotic process; nucleolus; cytoplasm; nucleus;
MAPK3	5	protein binding; ATP binding; nucleolus; nucleus; nucleoplasm;
MAPK7	5	protein binding; ATP binding; negative regulation of apoptotic process; nucleus; nucleoplasm;
MED1	5	protein binding; negative regulation of apoptotic process; nucleolus; nucleus; nucleoplasm;
MMS19	5	protein binding; transcription, DNA-dependent; DNA repair; cytoplasm; nucleus;
NDNL2	5	protein binding; DNA recombination; DNA repair; cytoplasm; nucleus;
NEDD4L	5	protein binding; transcription, DNA-dependent; cytoplasm; nucleus; nucleoplasm;
NR4A2	5	protein binding; transcription, DNA-dependent; cytoplasm; nucleus; nucleoplasm;
NUMA1	5	protein binding; nucleolus; cytoplasm; nucleus; nucleoplasm;
NUP62	5	protein binding; negative regulation of apoptotic process; viral reproduction; transcription, DNA-dependent; cytoplasm;
PDCD4	5	protein binding; nucleolus; cytoplasm; nucleus; negative regulation of transcription, DNA-dependent;
POU2F3	5	protein binding; transcription, DNA-dependent; nucleolus; cytoplasm; nucleus;
PRKCB	5	protein binding; ATP binding; transcription, DNA-dependent; cytoplasm; nucleus;
PRKD1	5	protein binding; ATP binding; cell proliferation; cytoplasm; nucleus;
PSPC1	5	protein binding; transcription, DNA-dependent; nucleolus; cytoplasm; nucleus;
RAD1	5	protein binding; DNA repair; nucleolus; nucleus; nucleoplasm;
RBM14	5	protein binding; DNA recombination; DNA repair; nucleolus; nucleus;
RBM4	5	protein binding; nucleolus; cytoplasm; nucleus; nucleoplasm;
RFWD2	5	protein binding; nucleolus; cytoplasm; nucleus; nucleoplasm;
RNF40	5	protein binding; ubiquitin protein ligase binding; nucleolus; cytoplasm; nucleus;
RPS6KA4	5	protein binding; ATP binding; nucleolus; cytoplasm; nucleus;
RRP8	5	protein binding; transcription, DNA-dependent; nucleolus; cytoplasm; nucleus;
SAP18	5	protein binding; transcription, DNA-dependent; nucleolus; cytoplasm; nucleus;
SART1	5	protein binding; nucleolus; cytoplasm; nucleus; nucleoplasm;
SMARCB1	5	protein binding; transcription, DNA-dependent; nucleolus; nucleus; nucleoplasm;
SMARCD3	5	protein binding; transcription, DNA-dependent; cytoplasm; nucleus; nucleoplasm;
SMG1	5	protein binding; ATP binding; DNA repair; cytoplasm; nucleus;
SNRNP200	5	protein binding; ATP binding; nucleolus; nucleus; nucleoplasm;
STRN3	5	protein binding; cytoplasm; nucleus; nucleoplasm; negative regulation of transcription, DNA-dependent;
TAF10	5	protein binding; viral reproduction; cytoplasm; nucleus; nucleoplasm;
TDP2	5	protein binding; double-strand break repair; nucleolus; cytoplasm; nucleus;
TRIM32	5	protein binding; negative regulation of apoptotic process; cytoplasm; nucleus; positive regulation of neurogenesis;
TRIP12	5	protein binding; DNA repair; cytoplasm; nucleus; nucleoplasm;
UBB	5	protein binding; viral reproduction; transcription, DNA-dependent; DNA repair; nucleoplasm;
UBC	5	protein binding; viral reproduction; transcription, DNA-dependent; DNA repair; nucleoplasm;
XPO1	5	protein binding; viral reproduction; nucleolus; cytoplasm; nucleoplasm;
MPHOSPH8	5	transcription, DNA-dependent; nucleolus; cytoplasm; nucleus; negative regulation of transcription, DNA-dependent;

Genes shared at least 2 KEGG pathways with XRCC5 (count: 0)

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Region: chr2:216972187..217071026 View in gBrowse