ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	KLHL20
Symbol Alias	KLEIP, KHLHX
Approved Name	kelch-like 20 (Drosophila)
Location	1q25.1
Position	chr1:173684080-173755840, +
External Links	HGNC: 25056 Entrez Gene: 27252 Ensembl: ENSG00000076321 UCSC: uc001gjc.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
1q25.1	chr1:172900000-176000000	1 (1/0/0)

Gene related GO terms (count: 19)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 19)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0015629	actin cytoskeleton	Cellular Component	TAS[10888605]	26
GO:0009986	cell surface	Cellular Component	IDA[12493773]	70
GO:0007010	cytoskeleton organization	Biological Process	TAS[10888605]	12
GO:0005794	Golgi apparatus	Cellular Component		157
GO:0005737	cytoplasm	Cellular Component		690
GO:0005730	nucleolus	Cellular Component		243
GO:0005634	nucleus	Cellular Component		770
GO:0005515	protein binding	Molecular Function		910
GO:0004842	ubiquitin-protein ligase activity	Molecular Function		52
GO:0003779	actin binding	Molecular Function		46
GO:0048471	perinuclear region of cytoplasm	Cellular Component		87
GO:0043161	proteasomal ubiquitin-dependent protein catabolic process	Biological Process		16
GO:0044444	cytoplasmic part	Cellular Component		4
GO:0035455	response to interferon-alpha	Biological Process		1
GO:0043066	negative regulation of apoptotic process	Biological Process		77
GO:0019964	interferon-gamma binding	Molecular Function		1
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component		5
GO:0016567	protein ubiquitination	Biological Process		41
GO:0016605	PML body	Cellular Component		10

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with KLHL20 (count: 53)

Gene Symbol	Pathway Count	Pathway List
MALT1	8	cytoplasm; nucleolus; nucleus; protein binding; ubiquitin-protein ligase activity; perinuclear region of cytoplasm; negative regulation of apoptotic process; protein ubiquitination;
SNCA	7	actin cytoskeleton; Golgi apparatus; cytoplasm; nucleus; protein binding; perinuclear region of cytoplasm; negative regulation of apoptotic process;
CRYAB	6	cell surface; Golgi apparatus; cytoplasm; nucleus; protein binding; negative regulation of apoptotic process;
CFL1	6	cytoskeleton organization; cytoplasm; nucleus; protein binding; actin binding; negative regulation of apoptotic process;
AATF	6	Golgi apparatus; cytoplasm; nucleolus; nucleus; protein binding; negative regulation of apoptotic process;
ATXN2	6	Golgi apparatus; cytoplasm; nucleolus; nucleus; protein binding; perinuclear region of cytoplasm;
PARK2	6	Golgi apparatus; cytoplasm; nucleus; protein binding; ubiquitin-protein ligase activity; perinuclear region of cytoplasm;
TFAP2A	6	Golgi apparatus; cytoplasm; nucleolus; nucleus; protein binding; negative regulation of apoptotic process;
TRIM5	6	Golgi apparatus; cytoplasm; nucleolus; nucleus; protein binding; ubiquitin-protein ligase activity;
BARD1	6	cytoplasm; nucleus; protein binding; ubiquitin-protein ligase activity; negative regulation of apoptotic process; protein ubiquitination;
CBL	6	cytoplasm; nucleus; protein binding; ubiquitin-protein ligase activity; negative regulation of apoptotic process; protein ubiquitination;
CRBN	6	cytoplasm; nucleolus; nucleus; protein binding; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination;
GSK3B	6	cytoplasm; nucleolus; nucleus; protein binding; perinuclear region of cytoplasm; negative regulation of apoptotic process;
RCHY1	6	cytoplasm; nucleolus; nucleus; protein binding; ubiquitin-protein ligase activity; protein ubiquitination;
TRIM32	6	cytoplasm; nucleus; protein binding; ubiquitin-protein ligase activity; negative regulation of apoptotic process; protein ubiquitination;
WWP1	6	cytoplasm; nucleus; protein binding; ubiquitin-protein ligase activity; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination;
ARPC2	5	actin cytoskeleton; Golgi apparatus; cytoplasm; protein binding; actin binding;
BAIAP2	5	actin cytoskeleton; cytoplasm; nucleolus; nucleus; protein binding;
HNRNPH1	5	actin cytoskeleton; cytoplasm; nucleolus; nucleus; protein binding;
ACHE	5	cell surface; Golgi apparatus; nucleus; protein binding; perinuclear region of cytoplasm;
SORT1	5	cell surface; Golgi apparatus; cytoplasm; perinuclear region of cytoplasm; negative regulation of apoptotic process;
BIRC6	5	Golgi apparatus; protein binding; ubiquitin-protein ligase activity; negative regulation of apoptotic process; protein ubiquitination;
CEP57	5	Golgi apparatus; cytoplasm; nucleolus; nucleus; protein binding;
COG3	5	Golgi apparatus; cytoplasm; nucleolus; nucleus; protein binding;
G2E3	5	Golgi apparatus; cytoplasm; nucleolus; ubiquitin-protein ligase activity; negative regulation of apoptotic process;
MAPK1	5	Golgi apparatus; cytoplasm; nucleolus; nucleus; protein binding;
PDE2A	5	Golgi apparatus; cytoplasm; nucleus; protein binding; perinuclear region of cytoplasm;
SART1	5	Golgi apparatus; cytoplasm; nucleolus; nucleus; protein binding;
ARRB1	5	cytoplasm; nucleus; protein binding; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination;
ARRB2	5	cytoplasm; nucleus; protein binding; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination;
BIRC3	5	cytoplasm; nucleus; protein binding; ubiquitin-protein ligase activity; negative regulation of apoptotic process;
DAXX	5	cytoplasm; nucleolus; nucleus; protein binding; PML body;
FHOD3	5	cytoplasm; nucleolus; nucleus; protein binding; actin binding;
FLII	5	cytoplasm; nucleolus; nucleus; protein binding; actin binding;
HERC2	5	cytoplasm; nucleus; protein binding; ubiquitin-protein ligase activity; protein ubiquitination;
HERC5	5	cytoplasm; nucleus; protein binding; ubiquitin-protein ligase activity; perinuclear region of cytoplasm;
KLHL7	5	cytoplasm; nucleolus; nucleus; Cul3-RING ubiquitin ligase complex; protein ubiquitination;
KRT18	5	cytoplasm; nucleolus; protein binding; perinuclear region of cytoplasm; negative regulation of apoptotic process;
NEDD4L	5	cytoplasm; nucleus; protein binding; ubiquitin-protein ligase activity; protein ubiquitination;
NF2	5	cytoplasm; nucleolus; nucleus; protein binding; perinuclear region of cytoplasm;
PAFAH1B1	5	cytoplasm; nucleolus; nucleus; protein binding; perinuclear region of cytoplasm;
RAD23B	5	cytoplasm; nucleolus; nucleus; protein binding; proteasomal ubiquitin-dependent protein catabolic process;
RFWD2	5	cytoplasm; nucleolus; nucleus; protein binding; protein ubiquitination;
RFWD3	5	cytoplasm; nucleus; ubiquitin-protein ligase activity; protein ubiquitination; PML body;
RNF40	5	cytoplasm; nucleolus; nucleus; protein binding; ubiquitin-protein ligase activity;
TDP2	5	cytoplasm; nucleolus; nucleus; protein binding; PML body;
TNFAIP3	5	cytoplasm; nucleus; protein binding; ubiquitin-protein ligase activity; negative regulation of apoptotic process;
TRIP12	5	cytoplasm; nucleus; protein binding; ubiquitin-protein ligase activity; protein ubiquitination;
XRCC5	5	cytoplasm; nucleolus; nucleus; protein binding; negative regulation of apoptotic process;
SYVN1	5	nucleolus; nucleus; protein binding; negative regulation of apoptotic process; protein ubiquitination;
BIRC2	5	nucleus; protein binding; ubiquitin-protein ligase activity; proteasomal ubiquitin-dependent protein catabolic process; negative regulation of apoptotic process;
FBXO25	5	nucleus; protein binding; ubiquitin-protein ligase activity; actin binding; protein ubiquitination;
KCTD13	5	nucleus; ubiquitin-protein ligase activity; proteasomal ubiquitin-dependent protein catabolic process; Cul3-RING ubiquitin ligase complex; protein ubiquitination;

Genes shared at least 2 KEGG pathways with KLHL20 (count: 0)

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Region: chr1:173684080..173755840 View in gBrowse