ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	AATF
Symbol Alias	DED, CHE-1, CHE1
Approved Name	apoptosis antagonizing transcription factor
Location	17q12
Position	chr17:35306175-35414171, +
External Links	HGNC: 19235 Entrez Gene: 26574 Ensembl: ENSG00000108270 UCSC: uc002hni.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 3)

ID	Location	Size	Band	Type	Inheritance
CNV_Elia[2010]_191	chr17:31889664-33323543 (NCBI Build 35 (hg17))	1774728	17q12	Deletion (hemizygous)	Paternal
CNV_Williams[2010]_7	chr17:31964475-33297438 (NCBI Build 36.1 (hg18))	1278621	17q12	Gain	Paternal
CNV_Williams[2010]_8	chr17:31979521-33318471 (NCBI Build 36.1 (hg18))	1276993	17q12	Loss

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 22)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 22)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0032929	negative regulation of superoxide anion generation	Biological Process	IDA[15207272]	1
GO:0040016	embryonic cleavage	Biological Process		1
GO:0042254	ribosome biogenesis	Biological Process		5
GO:0042985	negative regulation of amyloid precursor protein biosynthetic process	Biological Process		1
GO:0006915	apoptotic process	Biological Process		111
GO:0006974	response to DNA damage stimulus	Biological Process	IEP[18049476]	37
GO:0007155	cell adhesion	Biological Process		86
GO:0007346	regulation of mitotic cell cycle	Biological Process		6
GO:0048156	tau protein binding	Molecular Function		3
GO:2000378	negative regulation of reactive oxygen species metabolic process	Biological Process	IDA[15207272]	4
GO:0043066	negative regulation of apoptotic process	Biological Process	IMP[15207272]	77
GO:0043522	leucine zipper domain binding	Molecular Function	IPI[14627703]	1
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA[18049476]	131
GO:0048011	nerve growth factor receptor signaling pathway	Biological Process		42
GO:0005730	nucleolus	Cellular Component		243
GO:0005634	nucleus	Cellular Component		770
GO:0005515	protein binding	Molecular Function	IPI[17157788]	910
GO:0003700	sequence-specific DNA binding transcription factor activity	Molecular Function	IDA[10580117]	132
GO:0005925	focal adhesion	Cellular Component		26
GO:0005813	centrosome	Cellular Component		71
GO:0005794	Golgi apparatus	Cellular Component		157
GO:0005737	cytoplasm	Cellular Component	IDA[15207272]	690

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with AATF (count: 69)

Gene Symbol	Pathway Count	Pathway List
MAPK1	9	apoptotic process; response to DNA damage stimulus; nerve growth factor receptor signaling pathway; nucleolus; nucleus; protein binding; focal adhesion; Golgi apparatus; cytoplasm;
MAPK3	9	apoptotic process; response to DNA damage stimulus; positive regulation of transcription from RNA polymerase II promoter; nerve growth factor receptor signaling pathway; nucleolus; nucleus; protein binding; focal adhesion; Golgi apparatus;
GSK3B	9	tau protein binding; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter; nerve growth factor receptor signaling pathway; nucleolus; nucleus; protein binding; centrosome; cytoplasm;
TFAP2A	9	negative regulation of reactive oxygen species metabolic process; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter; nucleolus; nucleus; protein binding; centrosome; Golgi apparatus; cytoplasm;
APC	8	apoptotic process; response to DNA damage stimulus; cell adhesion; negative regulation of apoptotic process; nucleus; protein binding; centrosome; cytoplasm;
RELA	7	negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter; nerve growth factor receptor signaling pathway; nucleus; protein binding; sequence-specific DNA binding transcription factor activity; cytoplasm;
BIRC3	6	apoptotic process; negative regulation of reactive oxygen species metabolic process; negative regulation of apoptotic process; nucleus; protein binding; cytoplasm;
GATA6	6	apoptotic process; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; sequence-specific DNA binding transcription factor activity;
MAPK7	6	apoptotic process; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter; nerve growth factor receptor signaling pathway; nucleus; protein binding;
PERP	6	apoptotic process; cell adhesion; nucleolus; nucleus; Golgi apparatus; cytoplasm;
PRKD1	6	apoptotic process; positive regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; Golgi apparatus; cytoplasm;
WWOX	6	apoptotic process; positive regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; Golgi apparatus; cytoplasm;
MEN1	6	response to DNA damage stimulus; positive regulation of transcription from RNA polymerase II promoter; nucleolus; nucleus; protein binding; cytoplasm;
YAP1	6	response to DNA damage stimulus; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; cytoplasm;
HES1	6	cell adhesion; positive regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; sequence-specific DNA binding transcription factor activity; cytoplasm;
SNCA	6	tau protein binding; negative regulation of apoptotic process; nucleus; protein binding; Golgi apparatus; cytoplasm;
CRYAB	6	negative regulation of reactive oxygen species metabolic process; negative regulation of apoptotic process; nucleus; protein binding; Golgi apparatus; cytoplasm;
HNF1B	6	negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter; nucleolus; nucleus; protein binding; sequence-specific DNA binding transcription factor activity;
KLHL20	6	negative regulation of apoptotic process; nucleolus; nucleus; protein binding; Golgi apparatus; cytoplasm;
POU2F3	6	positive regulation of transcription from RNA polymerase II promoter; nucleolus; nucleus; protein binding; sequence-specific DNA binding transcription factor activity; cytoplasm;
RBPJ	6	positive regulation of transcription from RNA polymerase II promoter; nucleolus; nucleus; protein binding; sequence-specific DNA binding transcription factor activity; cytoplasm;
STRN3	6	positive regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; sequence-specific DNA binding transcription factor activity; Golgi apparatus; cytoplasm;
CEP57	6	nucleolus; nucleus; protein binding; centrosome; Golgi apparatus; cytoplasm;
FLII	6	nucleolus; nucleus; protein binding; focal adhesion; centrosome; cytoplasm;
RFWD2	6	nucleolus; nucleus; protein binding; focal adhesion; centrosome; cytoplasm;
APBB1	5	apoptotic process; response to DNA damage stimulus; nucleus; protein binding; cytoplasm;
API5	5	apoptotic process; negative regulation of apoptotic process; nucleolus; nucleus; cytoplasm;
ARHGEF2	5	apoptotic process; negative regulation of apoptotic process; nerve growth factor receptor signaling pathway; protein binding; Golgi apparatus;
BNIP3	5	apoptotic process; negative regulation of apoptotic process; nucleus; protein binding; cytoplasm;
DAXX	5	apoptotic process; nucleolus; nucleus; protein binding; cytoplasm;
EGLN3	5	apoptotic process; response to DNA damage stimulus; nucleus; protein binding; cytoplasm;
G2E3	5	apoptotic process; negative regulation of apoptotic process; nucleolus; Golgi apparatus; cytoplasm;
KRT18	5	apoptotic process; negative regulation of apoptotic process; nucleolus; protein binding; cytoplasm;
MLL	5	apoptotic process; positive regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; sequence-specific DNA binding transcription factor activity;
NEK6	5	apoptotic process; regulation of mitotic cell cycle; nucleus; protein binding; cytoplasm;
PAK1	5	apoptotic process; protein binding; focal adhesion; Golgi apparatus; cytoplasm;
PDCD4	5	apoptotic process; nucleolus; nucleus; protein binding; cytoplasm;
TAOK2	5	apoptotic process; response to DNA damage stimulus; nucleolus; nucleus; cytoplasm;
ALKBH8	5	response to DNA damage stimulus; nucleolus; nucleus; protein binding; cytoplasm;
BARD1	5	response to DNA damage stimulus; negative regulation of apoptotic process; nucleus; protein binding; cytoplasm;
CHD1L	5	response to DNA damage stimulus; nucleolus; nucleus; protein binding; cytoplasm;
IRF7	5	response to DNA damage stimulus; positive regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; cytoplasm;
NCOA6	5	response to DNA damage stimulus; positive regulation of transcription from RNA polymerase II promoter; nucleolus; nucleus; protein binding;
RAD9A	5	response to DNA damage stimulus; nucleolus; nucleus; protein binding; cytoplasm;
TP53BP1	5	response to DNA damage stimulus; positive regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; cytoplasm;
ADAM17	5	cell adhesion; nerve growth factor receptor signaling pathway; protein binding; focal adhesion; cytoplasm;
BCAR1	5	cell adhesion; nerve growth factor receptor signaling pathway; protein binding; focal adhesion; cytoplasm;
LPXN	5	cell adhesion; nucleus; protein binding; focal adhesion; cytoplasm;
PLK1	5	regulation of mitotic cell cycle; negative regulation of apoptotic process; nucleus; protein binding; centrosome;
CBL	5	negative regulation of apoptotic process; nucleus; protein binding; sequence-specific DNA binding transcription factor activity; cytoplasm;
KDM1A	5	negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; sequence-specific DNA binding transcription factor activity;
MALT1	5	negative regulation of apoptotic process; nucleolus; nucleus; protein binding; cytoplasm;
MED1	5	negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter; nucleolus; nucleus; protein binding;
TNFAIP3	5	negative regulation of apoptotic process; nucleus; protein binding; centrosome; cytoplasm;
XRCC5	5	negative regulation of apoptotic process; nucleolus; nucleus; protein binding; cytoplasm;
ATXN1	5	positive regulation of transcription from RNA polymerase II promoter; nucleolus; nucleus; protein binding; cytoplasm;
HEY2	5	positive regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; sequence-specific DNA binding transcription factor activity; cytoplasm;
HOXB1	5	positive regulation of transcription from RNA polymerase II promoter; nucleolus; nucleus; sequence-specific DNA binding transcription factor activity; cytoplasm;
HSF2	5	positive regulation of transcription from RNA polymerase II promoter; nucleolus; nucleus; sequence-specific DNA binding transcription factor activity; cytoplasm;
MTA2	5	positive regulation of transcription from RNA polymerase II promoter; nucleolus; nucleus; protein binding; sequence-specific DNA binding transcription factor activity;
RPS6KA4	5	positive regulation of transcription from RNA polymerase II promoter; nucleolus; nucleus; protein binding; cytoplasm;
ATXN2	5	nucleolus; nucleus; protein binding; Golgi apparatus; cytoplasm;
CEP164	5	nucleolus; nucleus; protein binding; centrosome; cytoplasm;
COG3	5	nucleolus; nucleus; protein binding; Golgi apparatus; cytoplasm;
DHX9	5	nucleolus; nucleus; protein binding; centrosome; cytoplasm;
PAFAH1B1	5	nucleolus; nucleus; protein binding; centrosome; cytoplasm;
SART1	5	nucleolus; nucleus; protein binding; Golgi apparatus; cytoplasm;
TCF25	5	nucleolus; nucleus; protein binding; sequence-specific DNA binding transcription factor activity; cytoplasm;
TRIM5	5	nucleolus; nucleus; protein binding; Golgi apparatus; cytoplasm;

Genes shared at least 2 KEGG pathways with AATF (count: 0)

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Region: chr17:35306175..35414171 View in gBrowse