ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	HOXB1
Previous Symbol	HOX2, HOX2I
Approved Name	homeobox B1
Previous Name	homeo box B1
Location	17q21.32
Position	chr17:46606797-46608359, -
External Links	HGNC: 5111 Entrez Gene: 3211 Ensembl: ENSG00000120094 UCSC: uc002ink.1
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Stergiakouli E., 2012	One of the top 20 independent SNPs with P=0.00000654 locates upstream relative to this gene.	Trend

Gene related SNPs (count: 2)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs11079828	Chr17:46609103(Fwd)	upstream_gene_variant	1(0/0/1)

LD-proxies (count: 1)

rs_ID	Location	Functional Annotation
rs10853100	Chr17:46602432(Fwd)	downstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 18)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0021612	facial nerve structural organization	Biological Process		2
GO:0021754	facial nucleus development	Biological Process		2
GO:0021570	rhombomere 4 development	Biological Process		2
GO:0021571	rhombomere 5 development	Biological Process		2
GO:0048704	embryonic skeletal system morphogenesis	Biological Process		9
GO:0043565	sequence-specific DNA binding	Molecular Function		72
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process		131
GO:0006351	transcription, DNA-dependent	Biological Process		247
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	TAS[10052460]	158
GO:0005730	nucleolus	Cellular Component		243
GO:0005737	cytoplasm	Cellular Component		690
GO:0009952	anterior/posterior pattern specification	Biological Process		26
GO:0019904	protein domain specific binding	Molecular Function	IPI[10052460]	40
GO:0007275	multicellular organismal development	Biological Process	NAS[10052460]	71
GO:0007389	pattern specification process	Biological Process	TAS[10052460]	13
GO:0005634	nucleus	Cellular Component		770
GO:0003700	sequence-specific DNA binding transcription factor activity	Molecular Function		132
GO:0003677	DNA binding	Molecular Function	IDA[10052460]	220

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with HOXB1 (count: 99)

Gene Symbol	Pathway Count	Pathway List
HOXA1	11	facial nerve structural organization; facial nucleus development; rhombomere 4 development; rhombomere 5 development; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; anterior/posterior pattern specification; multicellular organismal development; nucleus; sequence-specific DNA binding transcription factor activity;
HOXA5	8	embryonic skeletal system morphogenesis; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; anterior/posterior pattern specification; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding;
FOXD4	8	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; nucleolus; multicellular organismal development; pattern specification process; nucleus; sequence-specific DNA binding transcription factor activity;
TBX1	8	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; anterior/posterior pattern specification; pattern specification process; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding;
HOXA3	7	embryonic skeletal system morphogenesis; sequence-specific DNA binding; transcription, DNA-dependent; nucleolus; anterior/posterior pattern specification; nucleus; sequence-specific DNA binding transcription factor activity;
HOXA7	7	embryonic skeletal system morphogenesis; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; anterior/posterior pattern specification; nucleus; sequence-specific DNA binding transcription factor activity;
MEN1	7	embryonic skeletal system morphogenesis; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; nucleolus; cytoplasm; nucleus;
FOXL1	7	sequence-specific DNA binding; regulation of transcription, DNA-dependent; multicellular organismal development; pattern specification process; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding;
HNF1B	7	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; nucleolus; anterior/posterior pattern specification; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding;
HOXA11	7	sequence-specific DNA binding; transcription, DNA-dependent; nucleolus; cytoplasm; anterior/posterior pattern specification; multicellular organismal development; sequence-specific DNA binding transcription factor activity;
HOXA2	7	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; nucleolus; anterior/posterior pattern specification; nucleus; sequence-specific DNA binding transcription factor activity;
HOXA9	7	sequence-specific DNA binding; transcription, DNA-dependent; cytoplasm; anterior/posterior pattern specification; multicellular organismal development; nucleus; sequence-specific DNA binding transcription factor activity;
IKZF1	7	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding;
POU2F3	7	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; nucleolus; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity;
ZNF263	7	transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleolus; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding;
HOXA4	6	embryonic skeletal system morphogenesis; sequence-specific DNA binding; transcription, DNA-dependent; anterior/posterior pattern specification; nucleus; sequence-specific DNA binding transcription factor activity;
HOXA6	6	embryonic skeletal system morphogenesis; sequence-specific DNA binding; transcription, DNA-dependent; anterior/posterior pattern specification; nucleus; sequence-specific DNA binding transcription factor activity;
BSX	6	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity;
ETS1	6	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding;
FOXE1	6	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; pattern specification process; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding;
FOXP1	6	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; nucleolus; cytoplasm; pattern specification process; nucleus;
HES1	6	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding;
HOXA13	6	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding;
LMX1B	6	sequence-specific DNA binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; multicellular organismal development; nucleus; sequence-specific DNA binding transcription factor activity;
RELA	6	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding;
SREBF1	6	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding;
ATXN1	6	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; nucleolus; cytoplasm; nucleus; DNA binding;
RBPJ	6	positive regulation of transcription from RNA polymerase II promoter; nucleolus; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding;
TFEB	6	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; regulation of transcription, DNA-dependent; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity;
FLII	6	transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleolus; cytoplasm; multicellular organismal development; nucleus;
GRHL1	6	transcription, DNA-dependent; regulation of transcription, DNA-dependent; cytoplasm; multicellular organismal development; nucleus; DNA binding;
HINFP	6	transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleolus; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding;
TCF25	6	transcription, DNA-dependent; nucleolus; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding;
ZNF367	6	transcription, DNA-dependent; nucleolus; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding;
ZNF521	6	transcription, DNA-dependent; regulation of transcription, DNA-dependent; protein domain specific binding; multicellular organismal development; nucleus; DNA binding;
ZNF74	6	transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleolus; multicellular organismal development; nucleus; DNA binding;
ZNF77	6	transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleolus; cytoplasm; nucleus; DNA binding;
RREB1	6	regulation of transcription, DNA-dependent; cytoplasm; multicellular organismal development; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding;
TAF4B	6	regulation of transcription, DNA-dependent; nucleolus; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding;
HOXB3	5	embryonic skeletal system morphogenesis; transcription, DNA-dependent; anterior/posterior pattern specification; nucleus; sequence-specific DNA binding transcription factor activity;
CREBZF	5	sequence-specific DNA binding; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding;
DRAP1	5	sequence-specific DNA binding; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding;
ESRRA	5	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; protein domain specific binding; nucleus; DNA binding;
FOXF1	5	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; pattern specification process; nucleus; DNA binding;
FOXG1	5	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; nucleus; DNA binding;
FOXP2	5	sequence-specific DNA binding; cytoplasm; pattern specification process; sequence-specific DNA binding transcription factor activity; DNA binding;
HEY2	5	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity;
HOXA10	5	sequence-specific DNA binding; transcription, DNA-dependent; anterior/posterior pattern specification; multicellular organismal development; sequence-specific DNA binding transcription factor activity;
IRX3	5	sequence-specific DNA binding; transcription, DNA-dependent; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity;
LHX1	5	sequence-specific DNA binding; anterior/posterior pattern specification; pattern specification process; nucleus; sequence-specific DNA binding transcription factor activity;
LHX2	5	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity;
MAF	5	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity;
MTA2	5	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; nucleolus; nucleus; sequence-specific DNA binding transcription factor activity;
MTA3	5	sequence-specific DNA binding; nucleolus; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity;
NCOR1	5	sequence-specific DNA binding; transcription, DNA-dependent; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity;
NR4A2	5	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; cytoplasm; nucleus;
ONECUT2	5	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity;
PGR	5	sequence-specific DNA binding; nucleolus; cytoplasm; nucleus; DNA binding;
PKNOX2	5	sequence-specific DNA binding; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding;
PRDM1	5	sequence-specific DNA binding; transcription, DNA-dependent; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity;
RAX	5	sequence-specific DNA binding; transcription, DNA-dependent; pattern specification process; nucleus; sequence-specific DNA binding transcription factor activity;
TFAP2A	5	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; nucleolus; cytoplasm; nucleus;
TSHZ2	5	sequence-specific DNA binding; transcription, DNA-dependent; multicellular organismal development; nucleus; sequence-specific DNA binding transcription factor activity;
ZNF24	5	sequence-specific DNA binding; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding;
AATF	5	positive regulation of transcription from RNA polymerase II promoter; nucleolus; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity;
ARID3C	5	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; cytoplasm; nucleus; DNA binding;
BCL11A	5	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; regulation of transcription, DNA-dependent; cytoplasm; nucleus;
CLOCK	5	positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; nucleolus; nucleus; sequence-specific DNA binding transcription factor activity;
E2F5	5	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; cytoplasm; sequence-specific DNA binding transcription factor activity; DNA binding;
HSF2	5	positive regulation of transcription from RNA polymerase II promoter; nucleolus; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity;
MYB	5	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; DNA binding;
RPS6KA4	5	positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; nucleolus; cytoplasm; nucleus;
BANP	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; multicellular organismal development; nucleus; DNA binding;
BARX1	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; anterior/posterior pattern specification; multicellular organismal development; sequence-specific DNA binding transcription factor activity;
BCLAF1	5	transcription, DNA-dependent; nucleolus; cytoplasm; nucleus; DNA binding;
CDCA7L	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleolus; cytoplasm; nucleus;
CTNND1	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; cytoplasm; protein domain specific binding; nucleus;
CTNND2	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; cytoplasm; multicellular organismal development; nucleus;
DAXX	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleolus; cytoplasm; nucleus;
DPF2	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleolus; cytoplasm; nucleus;
EBF1	5	transcription, DNA-dependent; multicellular organismal development; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding;
HMGA1	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding;
IGHMBP2	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; cytoplasm; nucleus; DNA binding;
MAPK1	5	transcription, DNA-dependent; nucleolus; cytoplasm; nucleus; DNA binding;
NPAS3	5	transcription, DNA-dependent; nucleolus; cytoplasm; nucleus; DNA binding;
PSPC1	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleolus; cytoplasm; nucleus;
SCYL1	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; cytoplasm; nucleus; DNA binding;
TRIM22	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity;
XRCC5	5	transcription, DNA-dependent; nucleolus; cytoplasm; nucleus; DNA binding;
ZBTB34	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleolus; nucleus; DNA binding;
ZBTB9	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleolus; nucleus; DNA binding;
ZFP37	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding;
ZNF169	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding;
ZNF215	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding;
ZNF396	5	transcription, DNA-dependent; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding;
ZNF397	5	transcription, DNA-dependent; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding;
ZNF70	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding;
SSRP1	5	regulation of transcription, DNA-dependent; nucleolus; cytoplasm; nucleus; DNA binding;
ZFR	5	nucleolus; cytoplasm; multicellular organismal development; nucleus; DNA binding;

Genes shared at least 2 KEGG pathways with HOXB1 (count: 0)

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Region: chr17:46606797..46608359 View in gBrowse