ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	IKZF1
Previous Symbol	ZNFN1A1
Symbol Alias	hIk-1, LyF-1, Hs.54452, IKAROS
Approved Name	IKAROS family zinc finger 1 (Ikaros)
Previous Name	zinc finger protein, subfamily 1A, 1 (Ikaros)
Location	7pter-7qter
Position	chr7:50343720-50472799, +
External Links	HGNC: 13176 Entrez Gene: 10320 Ensembl: ENSG00000185811 UCSC: uc003tow.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy

Gene related studies (count: 0)

Gene related SNPs (count: 3)

Literature-origin SNPs (count: 0)

LD-proxies (count: 3)

rs_ID	Location	Functional Annotation
rs7455944	Chr7:50449114(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant
rs6962370	Chr7:50454736(Fwd)	intron_variant; nc_transcript_variant
rs7797772	Chr7:50460208(Fwd)	intron_variant; nc_transcript_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 26)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 26)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process		131
GO:0046982	protein heterodimerization activity	Molecular Function		68
GO:0043565	sequence-specific DNA binding	Molecular Function		72
GO:0045660	positive regulation of neutrophil differentiation	Biological Process		1
GO:0048541	Peyer's patch development	Biological Process		3
GO:0048732	gland development	Biological Process		2
GO:0048535	lymph node development	Biological Process		3
GO:0048538	thymus development	Biological Process		14
GO:0051138	positive regulation of NK T cell differentiation	Biological Process		1
GO:0060041	retina development in camera-type eye	Biological Process		8
GO:0003700	sequence-specific DNA binding transcription factor activity	Molecular Function		132
GO:0003677	DNA binding	Molecular Function	TAS[8543809]	220
GO:0001779	natural killer cell differentiation	Biological Process		2
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process		78
GO:0006351	transcription, DNA-dependent	Biological Process		247
GO:0005737	cytoplasm	Cellular Component		690
GO:0005721	centromeric heterochromatin	Cellular Component		3
GO:0005634	nucleus	Cellular Component		770
GO:0016568	chromatin modification	Biological Process		16
GO:0008270	zinc ion binding	Molecular Function		323
GO:0007498	mesoderm development	Biological Process	TAS[8543809]	9
GO:0007049	cell cycle	Biological Process		31
GO:0040018	positive regulation of multicellular organism growth	Biological Process		6
GO:0030900	forebrain development	Biological Process		9
GO:0030217	T cell differentiation	Biological Process		5
GO:0030183	B cell differentiation	Biological Process		8

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with IKZF1 (count: 91)

Gene Symbol	Pathway Count	Pathway List
BCL11A	8	positive regulation of transcription from RNA polymerase II promoter; protein heterodimerization activity; transcription, DNA-dependent; cytoplasm; nucleus; zinc ion binding; T cell differentiation; B cell differentiation;
HES1	8	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; thymus development; sequence-specific DNA binding transcription factor activity; DNA binding; negative regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus;
TBX1	8	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; thymus development; sequence-specific DNA binding transcription factor activity; DNA binding; transcription, DNA-dependent; nucleus; mesoderm development;
FOXE1	7	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; thymus development; sequence-specific DNA binding transcription factor activity; DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleus;
HNF1B	7	positive regulation of transcription from RNA polymerase II promoter; protein heterodimerization activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleus;
HOXB1	7	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; DNA binding; transcription, DNA-dependent; cytoplasm; nucleus;
LHX2	7	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; nucleus; zinc ion binding; mesoderm development;
MYB	7	positive regulation of transcription from RNA polymerase II promoter; thymus development; sequence-specific DNA binding transcription factor activity; DNA binding; negative regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; B cell differentiation;
NR4A2	7	positive regulation of transcription from RNA polymerase II promoter; protein heterodimerization activity; sequence-specific DNA binding; transcription, DNA-dependent; cytoplasm; nucleus; zinc ion binding;
SREBF1	7	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; DNA binding; negative regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; nucleus;
DRAP1	7	protein heterodimerization activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; DNA binding; negative regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; nucleus;
NCOR1	7	sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; cytoplasm; nucleus; chromatin modification;
PRDM1	7	sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; cytoplasm; nucleus; zinc ion binding;
BSX	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; cytoplasm; nucleus;
ETS1	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; DNA binding; transcription, DNA-dependent; nucleus;
FOXC2	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; nucleus; mesoderm development;
FOXP1	6	positive regulation of transcription from RNA polymerase II promoter; protein heterodimerization activity; sequence-specific DNA binding; cytoplasm; nucleus; zinc ion binding;
HEY2	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus;
HOXA13	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; DNA binding; transcription, DNA-dependent; nucleus;
HOXA2	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; nucleus;
HOXA5	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; DNA binding; transcription, DNA-dependent; nucleus;
HOXA7	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; nucleus;
ISL1	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus; zinc ion binding;
MAF	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus;
MEN1	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; cytoplasm; nucleus;
MTA2	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; nucleus; zinc ion binding;
POU2F3	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; cytoplasm; nucleus;
RBPJ	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; DNA binding; negative regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus;
RELA	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; DNA binding; cytoplasm; nucleus;
TFEB	6	positive regulation of transcription from RNA polymerase II promoter; protein heterodimerization activity; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; cytoplasm; nucleus;
FOXP2	6	protein heterodimerization activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; DNA binding; cytoplasm; zinc ion binding;
IRX3	6	sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; cytoplasm; nucleus; mesoderm development;
ZNF24	6	sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; DNA binding; transcription, DNA-dependent; nucleus; zinc ion binding;
PHF1	6	sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; cytoplasm; nucleus; chromatin modification; zinc ion binding;
TCF25	6	sequence-specific DNA binding transcription factor activity; DNA binding; negative regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; cytoplasm; nucleus;
ZNF189	6	sequence-specific DNA binding transcription factor activity; DNA binding; negative regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; nucleus; zinc ion binding;
ZNF263	6	sequence-specific DNA binding transcription factor activity; DNA binding; transcription, DNA-dependent; cytoplasm; nucleus; zinc ion binding;
ZNF367	6	sequence-specific DNA binding transcription factor activity; DNA binding; transcription, DNA-dependent; cytoplasm; nucleus; zinc ion binding;
ZNF396	6	sequence-specific DNA binding transcription factor activity; DNA binding; transcription, DNA-dependent; cytoplasm; nucleus; zinc ion binding;
ZNF397	6	sequence-specific DNA binding transcription factor activity; DNA binding; transcription, DNA-dependent; cytoplasm; nucleus; zinc ion binding;
ARID3C	5	positive regulation of transcription from RNA polymerase II promoter; DNA binding; transcription, DNA-dependent; cytoplasm; nucleus;
ATXN1	5	positive regulation of transcription from RNA polymerase II promoter; DNA binding; transcription, DNA-dependent; cytoplasm; nucleus;
BARX2	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; DNA binding; negative regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent;
E2F5	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; DNA binding; transcription, DNA-dependent; cytoplasm;
ESRRA	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; DNA binding; nucleus; zinc ion binding;
FOXF1	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleus;
FOXG1	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; DNA binding; nucleus; forebrain development;
GATA6	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; nucleus; zinc ion binding;
HOXA1	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; nucleus;
IRF7	5	positive regulation of transcription from RNA polymerase II promoter; DNA binding; negative regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus;
KDM1A	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; nucleus;
LPIN1	5	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; cytoplasm; nucleus;
MEIS2	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; nucleus;
NR5A1	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; DNA binding; nucleus; zinc ion binding;
ONECUT2	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; nucleus;
STRN3	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus;
TFAP2A	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus;
VEGFA	5	positive regulation of transcription from RNA polymerase II promoter; protein heterodimerization activity; negative regulation of transcription from RNA polymerase II promoter; cytoplasm; mesoderm development;
ZNF462	5	positive regulation of transcription from RNA polymerase II promoter; DNA binding; transcription, DNA-dependent; nucleus; zinc ion binding;
TAF4B	5	protein heterodimerization activity; sequence-specific DNA binding transcription factor activity; DNA binding; cytoplasm; nucleus;
CREBZF	5	sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; DNA binding; transcription, DNA-dependent; nucleus;
HOXA3	5	sequence-specific DNA binding; thymus development; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; nucleus;
HOXA9	5	sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; cytoplasm; nucleus;
LHX6	5	sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; nucleus; zinc ion binding;
LMX1B	5	sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; nucleus; zinc ion binding;
MTA3	5	sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; cytoplasm; nucleus; zinc ion binding;
PGR	5	sequence-specific DNA binding; DNA binding; cytoplasm; nucleus; zinc ion binding;
PKNOX2	5	sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; DNA binding; cytoplasm; nucleus;
TSHZ2	5	sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; nucleus; zinc ion binding;
ID2	5	Peyer's patch development; natural killer cell differentiation; negative regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus;
HINFP	5	sequence-specific DNA binding transcription factor activity; DNA binding; transcription, DNA-dependent; nucleus; zinc ion binding;
MYT1L	5	sequence-specific DNA binding transcription factor activity; DNA binding; transcription, DNA-dependent; nucleus; zinc ion binding;
RREB1	5	sequence-specific DNA binding transcription factor activity; DNA binding; cytoplasm; nucleus; zinc ion binding;
SP4	5	sequence-specific DNA binding transcription factor activity; DNA binding; transcription, DNA-dependent; nucleus; zinc ion binding;
TBX6	5	sequence-specific DNA binding transcription factor activity; DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; mesoderm development;
TRIM22	5	sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; cytoplasm; nucleus; zinc ion binding;
ZFP37	5	sequence-specific DNA binding transcription factor activity; DNA binding; transcription, DNA-dependent; nucleus; zinc ion binding;
ZNF169	5	sequence-specific DNA binding transcription factor activity; DNA binding; transcription, DNA-dependent; nucleus; zinc ion binding;
ZNF202	5	sequence-specific DNA binding transcription factor activity; DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; zinc ion binding;
ZNF215	5	sequence-specific DNA binding transcription factor activity; DNA binding; transcription, DNA-dependent; nucleus; zinc ion binding;
ZNF287	5	sequence-specific DNA binding transcription factor activity; DNA binding; transcription, DNA-dependent; nucleus; zinc ion binding;
ZNF483	5	sequence-specific DNA binding transcription factor activity; DNA binding; transcription, DNA-dependent; nucleus; zinc ion binding;
ZNF70	5	sequence-specific DNA binding transcription factor activity; DNA binding; transcription, DNA-dependent; nucleus; zinc ion binding;
ZNF75CP	5	sequence-specific DNA binding transcription factor activity; DNA binding; transcription, DNA-dependent; nucleus; zinc ion binding;
ZSCAN29	5	sequence-specific DNA binding transcription factor activity; DNA binding; transcription, DNA-dependent; nucleus; zinc ion binding;
ZSCAN30	5	sequence-specific DNA binding transcription factor activity; DNA binding; transcription, DNA-dependent; nucleus; zinc ion binding;
BANP	5	DNA binding; transcription, DNA-dependent; nucleus; chromatin modification; cell cycle;
GFI1B	5	DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; chromatin modification; zinc ion binding;
IGHMBP2	5	DNA binding; transcription, DNA-dependent; cytoplasm; nucleus; zinc ion binding;
MAPK1	5	DNA binding; transcription, DNA-dependent; cytoplasm; nucleus; cell cycle;
ZNF77	5	DNA binding; transcription, DNA-dependent; cytoplasm; nucleus; zinc ion binding;

Genes shared at least 2 KEGG pathways with IKZF1 (count: 0)

View in gBrowse

Region: chr7:50343720..50472799 View in gBrowse