ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	NR5A1
Previous Symbol	FTZF1
Symbol Alias	FTZ1, SF-1, ELP, AD4BP
Approved Name	nuclear receptor subfamily 5, group A, member 1
Location	9q33
Position	chr9:127243515-127269709, -
External Links	HGNC: 7983 Entrez Gene: 2516 Ensembl: ENSG00000136931 UCSC: uc004boo.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q33	chr9:117700000-130300000	2 (1/1/0)

Gene related GO terms (count: 31)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 31)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0008584	male gonad development	Biological Process		7
GO:0008270	zinc ion binding	Molecular Function		323
GO:0010259	multicellular organismal aging	Biological Process		4
GO:0009888	tissue development	Biological Process		4
GO:0006367	transcription initiation from RNA polymerase II promoter	Biological Process		42
GO:0005654	nucleoplasm	Cellular Component		183
GO:0007538	primary sex determination	Biological Process	TAS[9590178]	1
GO:0007267	cell-cell signaling	Biological Process	TAS[10369247]	38
GO:0005515	protein binding	Molecular Function	IPI[14701856]	910
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	Molecular Function	TAS[8205615]	6
GO:0005634	nucleus	Cellular Component	IDA[10848616]	770
GO:0005543	phospholipid binding	Molecular Function	IDA[17664281]	61
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	Molecular Function		15
GO:0003690	double-stranded DNA binding	Molecular Function		17
GO:0003713	transcription coactivator activity	Molecular Function	TAS[8205615]	52
GO:0003707	steroid hormone receptor activity	Molecular Function		9
GO:0001553	luteinization	Biological Process		1
GO:0003677	DNA binding	Molecular Function	IDA[10567391]	220
GO:0003682	chromatin binding	Molecular Function		48
GO:2000020	positive regulation of male gonad development	Biological Process		1
GO:2000195	negative regulation of female gonad development	Biological Process		1
GO:0050810	regulation of steroid biosynthetic process	Biological Process	TAS[10567391]	2
GO:0051457	maintenance of protein location in nucleus	Biological Process		2
GO:0030154	cell differentiation	Biological Process		51
GO:0030325	adrenal gland development	Biological Process		3
GO:0010467	gene expression	Biological Process		140
GO:0019899	enzyme binding	Molecular Function	IPI[17664281]	47
GO:0043565	sequence-specific DNA binding	Molecular Function		72
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IMP[17664281]	131
GO:0030522	intracellular receptor mediated signaling pathway	Biological Process	TAS[8205615]	6
GO:0042445	hormone metabolic process	Biological Process		1

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with NR5A1 (count: 87)

Gene Symbol	Pathway Count	Pathway List
ESRRA	12	zinc ion binding; transcription initiation from RNA polymerase II promoter; nucleoplasm; protein binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; nucleus; steroid hormone receptor activity; DNA binding; gene expression; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; intracellular receptor mediated signaling pathway;
PGR	12	zinc ion binding; transcription initiation from RNA polymerase II promoter; nucleoplasm; cell-cell signaling; protein binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; nucleus; steroid hormone receptor activity; DNA binding; gene expression; enzyme binding; sequence-specific DNA binding;
NR4A2	11	zinc ion binding; transcription initiation from RNA polymerase II promoter; nucleoplasm; protein binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; nucleus; steroid hormone receptor activity; gene expression; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; intracellular receptor mediated signaling pathway;
RORA	10	zinc ion binding; transcription initiation from RNA polymerase II promoter; nucleoplasm; protein binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; steroid hormone receptor activity; gene expression; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; intracellular receptor mediated signaling pathway;
NR6A1	9	zinc ion binding; transcription initiation from RNA polymerase II promoter; nucleoplasm; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; steroid hormone receptor activity; DNA binding; gene expression; sequence-specific DNA binding; intracellular receptor mediated signaling pathway;
MEN1	9	transcription initiation from RNA polymerase II promoter; nucleoplasm; protein binding; nucleus; double-stranded DNA binding; chromatin binding; gene expression; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
GATA6	8	male gonad development; zinc ion binding; nucleoplasm; protein binding; nucleus; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; chromatin binding; positive regulation of transcription from RNA polymerase II promoter;
HINFP	8	zinc ion binding; nucleoplasm; protein binding; nucleus; transcription coactivator activity; DNA binding; chromatin binding; enzyme binding;
NR4A3	8	zinc ion binding; transcription initiation from RNA polymerase II promoter; nucleoplasm; nucleus; steroid hormone receptor activity; DNA binding; gene expression; sequence-specific DNA binding;
FOXG1	8	tissue development; protein binding; nucleus; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; double-stranded DNA binding; DNA binding; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
MED1	8	transcription initiation from RNA polymerase II promoter; nucleoplasm; protein binding; nucleus; transcription coactivator activity; chromatin binding; gene expression; positive regulation of transcription from RNA polymerase II promoter;
NCOA6	8	transcription initiation from RNA polymerase II promoter; nucleoplasm; protein binding; nucleus; transcription coactivator activity; chromatin binding; enzyme binding; positive regulation of transcription from RNA polymerase II promoter;
YAP1	8	transcription initiation from RNA polymerase II promoter; nucleoplasm; protein binding; nucleus; transcription coactivator activity; chromatin binding; gene expression; positive regulation of transcription from RNA polymerase II promoter;
RELA	8	nucleoplasm; protein binding; nucleus; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; DNA binding; chromatin binding; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
FOXP1	7	zinc ion binding; nucleus; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; double-stranded DNA binding; chromatin binding; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
NR3C2	7	zinc ion binding; transcription initiation from RNA polymerase II promoter; nucleoplasm; protein binding; steroid hormone receptor activity; gene expression; sequence-specific DNA binding;
FOXF1	7	tissue development; nucleus; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; double-stranded DNA binding; DNA binding; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
MAML1	7	transcription initiation from RNA polymerase II promoter; nucleoplasm; protein binding; nucleus; transcription coactivator activity; gene expression; positive regulation of transcription from RNA polymerase II promoter;
MED12	7	transcription initiation from RNA polymerase II promoter; nucleoplasm; nucleus; transcription coactivator activity; chromatin binding; gene expression; positive regulation of transcription from RNA polymerase II promoter;
NCOR1	7	transcription initiation from RNA polymerase II promoter; nucleoplasm; protein binding; nucleus; chromatin binding; gene expression; sequence-specific DNA binding;
NCOR2	7	transcription initiation from RNA polymerase II promoter; nucleoplasm; protein binding; nucleus; DNA binding; chromatin binding; gene expression;
RBPJ	7	transcription initiation from RNA polymerase II promoter; nucleoplasm; protein binding; nucleus; DNA binding; gene expression; positive regulation of transcription from RNA polymerase II promoter;
SNW1	7	transcription initiation from RNA polymerase II promoter; nucleoplasm; protein binding; nucleus; transcription coactivator activity; gene expression; positive regulation of transcription from RNA polymerase II promoter;
TAF10	7	transcription initiation from RNA polymerase II promoter; nucleoplasm; protein binding; nucleus; transcription coactivator activity; gene expression; enzyme binding;
FOXP2	6	zinc ion binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; double-stranded DNA binding; DNA binding; chromatin binding; sequence-specific DNA binding;
FUS	6	zinc ion binding; nucleoplasm; protein binding; nucleus; DNA binding; gene expression;
MTA2	6	zinc ion binding; protein binding; nucleus; chromatin binding; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
E2F5	6	transcription initiation from RNA polymerase II promoter; nucleoplasm; protein binding; DNA binding; gene expression; positive regulation of transcription from RNA polymerase II promoter;
MAML2	6	transcription initiation from RNA polymerase II promoter; nucleoplasm; nucleus; transcription coactivator activity; gene expression; positive regulation of transcription from RNA polymerase II promoter;
MED13	6	transcription initiation from RNA polymerase II promoter; nucleoplasm; nucleus; transcription coactivator activity; gene expression; positive regulation of transcription from RNA polymerase II promoter;
MED14	6	transcription initiation from RNA polymerase II promoter; nucleoplasm; nucleus; transcription coactivator activity; gene expression; positive regulation of transcription from RNA polymerase II promoter;
MED17	6	transcription initiation from RNA polymerase II promoter; nucleoplasm; nucleus; transcription coactivator activity; gene expression; positive regulation of transcription from RNA polymerase II promoter;
TAF13	6	transcription initiation from RNA polymerase II promoter; nucleoplasm; protein binding; nucleus; DNA binding; gene expression;
KDM1A	6	nucleoplasm; protein binding; nucleus; chromatin binding; enzyme binding; positive regulation of transcription from RNA polymerase II promoter;
PRPF6	6	nucleoplasm; protein binding; nucleus; transcription coactivator activity; gene expression; positive regulation of transcription from RNA polymerase II promoter;
SMARCB1	6	nucleoplasm; protein binding; nucleus; transcription coactivator activity; cell differentiation; positive regulation of transcription from RNA polymerase II promoter;
SSRP1	6	nucleoplasm; protein binding; nucleus; DNA binding; chromatin binding; gene expression;
HNF1B	6	protein binding; nucleus; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; DNA binding; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
SREBF1	6	protein binding; nucleus; DNA binding; chromatin binding; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
TFAP2A	6	protein binding; nucleus; transcription coactivator activity; chromatin binding; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
FOXE1	6	nucleus; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; double-stranded DNA binding; DNA binding; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
UTF1	5	male gonad development; protein binding; nucleus; transcription coactivator activity; positive regulation of transcription from RNA polymerase II promoter;
CBFA2T3	5	zinc ion binding; nucleoplasm; protein binding; chromatin binding; positive regulation of transcription from RNA polymerase II promoter;
IKZF1	5	zinc ion binding; nucleus; DNA binding; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
KLF13	5	zinc ion binding; protein binding; nucleus; DNA binding; positive regulation of transcription from RNA polymerase II promoter;
POLE	5	zinc ion binding; nucleoplasm; nucleus; DNA binding; chromatin binding;
POLR1A	5	zinc ion binding; nucleoplasm; protein binding; DNA binding; gene expression;
RBM4	5	zinc ion binding; nucleoplasm; protein binding; nucleus; cell differentiation;
RNF20	5	zinc ion binding; protein binding; nucleus; transcription coactivator activity; chromatin binding;
SF3A3	5	zinc ion binding; nucleoplasm; protein binding; nucleus; gene expression;
SQSTM1	5	zinc ion binding; nucleoplasm; protein binding; cell differentiation; positive regulation of transcription from RNA polymerase II promoter;
U2AF1	5	zinc ion binding; nucleoplasm; protein binding; nucleus; gene expression;
ZNF24	5	zinc ion binding; protein binding; nucleus; DNA binding; sequence-specific DNA binding;
ZNF423	5	zinc ion binding; protein binding; nucleus; DNA binding; cell differentiation;
MED15	5	transcription initiation from RNA polymerase II promoter; nucleoplasm; protein binding; nucleus; gene expression;
MED16	5	transcription initiation from RNA polymerase II promoter; nucleoplasm; nucleus; transcription coactivator activity; gene expression;
MED23	5	transcription initiation from RNA polymerase II promoter; nucleoplasm; protein binding; transcription coactivator activity; gene expression;
MED30	5	transcription initiation from RNA polymerase II promoter; nucleoplasm; protein binding; nucleus; gene expression;
MED4	5	transcription initiation from RNA polymerase II promoter; nucleoplasm; protein binding; nucleus; gene expression;
MED7	5	transcription initiation from RNA polymerase II promoter; nucleoplasm; protein binding; transcription coactivator activity; gene expression;
NEDD4L	5	transcription initiation from RNA polymerase II promoter; nucleoplasm; protein binding; nucleus; gene expression;
TAF4B	5	transcription initiation from RNA polymerase II promoter; nucleoplasm; nucleus; DNA binding; gene expression;
THRAP3	5	transcription initiation from RNA polymerase II promoter; protein binding; nucleus; transcription coactivator activity; positive regulation of transcription from RNA polymerase II promoter;
UBB	5	transcription initiation from RNA polymerase II promoter; nucleoplasm; protein binding; gene expression; positive regulation of transcription from RNA polymerase II promoter;
UBC	5	transcription initiation from RNA polymerase II promoter; nucleoplasm; protein binding; gene expression; positive regulation of transcription from RNA polymerase II promoter;
ATF6	5	nucleoplasm; protein binding; nucleus; transcription coactivator activity; sequence-specific DNA binding;
ATXN1	5	nucleoplasm; protein binding; nucleus; DNA binding; positive regulation of transcription from RNA polymerase II promoter;
DHX9	5	nucleoplasm; protein binding; nucleus; DNA binding; gene expression;
FEN1	5	nucleoplasm; protein binding; nucleus; double-stranded DNA binding; DNA binding;
H2AFX	5	nucleoplasm; protein binding; nucleus; DNA binding; enzyme binding;
HMGA1	5	nucleoplasm; protein binding; nucleus; DNA binding; enzyme binding;
IRF7	5	nucleoplasm; protein binding; nucleus; DNA binding; positive regulation of transcription from RNA polymerase II promoter;
MAPK3	5	nucleoplasm; protein binding; nucleus; gene expression; positive regulation of transcription from RNA polymerase II promoter;
MAPK7	5	nucleoplasm; protein binding; nucleus; cell differentiation; positive regulation of transcription from RNA polymerase II promoter;
MRE11A	5	nucleoplasm; protein binding; nucleus; double-stranded DNA binding; DNA binding;
NCBP1	5	nucleoplasm; protein binding; nucleus; DNA binding; gene expression;
PSMC3	5	nucleoplasm; protein binding; nucleus; transcription coactivator activity; gene expression;
RAN	5	nucleoplasm; protein binding; transcription coactivator activity; chromatin binding; gene expression;
SMC1A	5	nucleoplasm; protein binding; nucleus; chromatin binding; gene expression;
XRCC5	5	nucleoplasm; protein binding; nucleus; double-stranded DNA binding; DNA binding;
APOA1	5	protein binding; nucleus; phospholipid binding; adrenal gland development; enzyme binding;
ETS1	5	protein binding; nucleus; DNA binding; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
HES1	5	protein binding; nucleus; DNA binding; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
HOXA5	5	protein binding; nucleus; DNA binding; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
FOXC2	5	nucleus; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; double-stranded DNA binding; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
FOXD4	5	nucleus; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; double-stranded DNA binding; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter;
FOXL1	5	nucleus; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; double-stranded DNA binding; DNA binding; sequence-specific DNA binding;

Genes shared at least 2 KEGG pathways with NR5A1 (count: 0)

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Region: chr9:127243515..127269709 View in gBrowse