ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	NCBP1
Previous Symbol	NCBP
Symbol Alias	CBP80, Sto1
Approved Name	nuclear cap binding protein subunit 1, 80kDa
Previous Name	nuclear cap binding protein subunit 1, 80kD
Location	9q34.1
Position	chr9:100395705-100436030, +
External Links	HGNC: 7658 Entrez Gene: 4686 Ensembl: ENSG00000136937 UCSC: uc004axq.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q22	chr9:90400000-102600000	3 (1/1/1)

Gene related GO terms (count: 31)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 31)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006379	mRNA cleavage	Biological Process	IDA[9342333]	4
GO:0006397	mRNA processing	Biological Process		50
GO:0006369	termination of RNA polymerase II transcription	Biological Process		14
GO:0006370	7-methylguanosine mRNA capping	Biological Process	IDA[12434151]	3
GO:0006366	transcription from RNA polymerase II promoter	Biological Process		62
GO:0006368	transcription elongation from RNA polymerase II promoter	Biological Process		10
GO:0005829	cytosol	Cellular Component		447
GO:0005845	mRNA cap binding complex	Cellular Component	IDA[9342333]	2
GO:0005634	nucleus	Cellular Component	IDA[19648179]	770
GO:0005654	nucleoplasm	Cellular Component		183
GO:0003723	RNA binding	Molecular Function	TAS[8069914]	104
GO:0005515	protein binding	Molecular Function	IPI[18423201]	910
GO:0000398	mRNA splicing, via spliceosome	Biological Process		54
GO:0003677	DNA binding	Molecular Function		220
GO:0000339	RNA cap binding	Molecular Function	TAS[8069914]	1
GO:0000387	spliceosomal snRNP assembly	Biological Process		10
GO:0050434	positive regulation of viral transcription	Biological Process		6
GO:0034660	ncRNA metabolic process	Biological Process		8
GO:0031442	positive regulation of mRNA 3'-end processing	Biological Process	IDA[9342333]	1
GO:0031124	mRNA 3'-end processing	Biological Process		8
GO:0031047	gene silencing by RNA	Biological Process		2
GO:0030529	ribonucleoprotein complex	Cellular Component	IDA[17289661]	23
GO:0016071	mRNA metabolic process	Biological Process		34
GO:0016070	RNA metabolic process	Biological Process		46
GO:0016032	viral reproduction	Biological Process		57
GO:0010467	gene expression	Biological Process		140
GO:0008380	RNA splicing	Biological Process		65
GO:0008334	histone mRNA metabolic process	Biological Process		6
GO:0006446	regulation of translational initiation	Biological Process	IDA[11551508]	3
GO:0006406	mRNA export from nucleus	Biological Process	IMP[17190602]	12
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	Biological Process	IDA[11551508]; IMP[18369367]	16

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03040	Spliceosome	47	After transcription, eukaryotic mRNA precursors contain prot...... After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified. More...
hsa03015	mRNA surveillance pathway	17	The mRNA surveillance pathway is a quality control mechanism...... The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins. More...
hsa03013	RNA transport	15	RNA transport from the nucleus to the cytoplasm is fundamen...... RNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) via mobile export receptors. The majority of RNAs, such as tRNAs, rRNAs, and U snRNAs, are transported by specific export receptors, which belong to the karyopherin-beta family proteins. A feature of karyopherins is their regulation by the small GTPase Ran. However, general mRNA export is mechanistically different. Nuclear export of mRNAs is functionally coupled to different steps in gene expression processes, such as transcription, splicing, 3'-end formation and even translation. More...

Genes shared at least 5 GO terms with NCBP1 (count: 114)

Gene Symbol	Pathway Count	Pathway List
SNRPG	14	mRNA processing; termination of RNA polymerase II transcription; transcription from RNA polymerase II promoter; cytosol; nucleoplasm; RNA binding; protein binding; mRNA splicing, via spliceosome; spliceosomal snRNP assembly; ncRNA metabolic process; RNA metabolic process; gene expression; RNA splicing; histone mRNA metabolic process;
CPSF3	13	mRNA cleavage; mRNA processing; termination of RNA polymerase II transcription; transcription from RNA polymerase II promoter; nucleoplasm; RNA binding; protein binding; mRNA splicing, via spliceosome; mRNA 3'-end processing; ribonucleoprotein complex; gene expression; RNA splicing; mRNA export from nucleus;
SNRPB	13	mRNA processing; termination of RNA polymerase II transcription; transcription from RNA polymerase II promoter; cytosol; nucleoplasm; protein binding; mRNA splicing, via spliceosome; spliceosomal snRNP assembly; ncRNA metabolic process; RNA metabolic process; gene expression; RNA splicing; histone mRNA metabolic process;
SNRPD3	13	mRNA processing; termination of RNA polymerase II transcription; transcription from RNA polymerase II promoter; cytosol; nucleoplasm; protein binding; mRNA splicing, via spliceosome; spliceosomal snRNP assembly; ncRNA metabolic process; RNA metabolic process; gene expression; RNA splicing; histone mRNA metabolic process;
SNRPF	13	mRNA processing; termination of RNA polymerase II transcription; transcription from RNA polymerase II promoter; cytosol; nucleoplasm; RNA binding; mRNA splicing, via spliceosome; spliceosomal snRNP assembly; ncRNA metabolic process; RNA metabolic process; gene expression; RNA splicing; histone mRNA metabolic process;
U2AF1	12	mRNA processing; termination of RNA polymerase II transcription; transcription from RNA polymerase II promoter; nucleus; nucleoplasm; RNA binding; protein binding; mRNA splicing, via spliceosome; mRNA 3'-end processing; gene expression; RNA splicing; mRNA export from nucleus;
CPSF7	11	mRNA processing; termination of RNA polymerase II transcription; transcription from RNA polymerase II promoter; nucleus; nucleoplasm; RNA binding; protein binding; mRNA splicing, via spliceosome; mRNA 3'-end processing; gene expression; RNA splicing;
U2AF2	11	mRNA processing; termination of RNA polymerase II transcription; transcription from RNA polymerase II promoter; nucleoplasm; RNA binding; protein binding; mRNA splicing, via spliceosome; mRNA 3'-end processing; gene expression; RNA splicing; mRNA export from nucleus;
POLR2G	11	7-methylguanosine mRNA capping; transcription from RNA polymerase II promoter; transcription elongation from RNA polymerase II promoter; nucleus; nucleoplasm; RNA binding; mRNA splicing, via spliceosome; positive regulation of viral transcription; viral reproduction; gene expression; RNA splicing;
SNRPD1	11	cytosol; nucleus; nucleoplasm; RNA binding; protein binding; mRNA splicing, via spliceosome; spliceosomal snRNP assembly; ncRNA metabolic process; RNA metabolic process; gene expression; RNA splicing;
PCF11	9	mRNA cleavage; mRNA processing; termination of RNA polymerase II transcription; transcription from RNA polymerase II promoter; nucleoplasm; mRNA splicing, via spliceosome; mRNA 3'-end processing; gene expression; RNA splicing;
HNRNPA2B1	9	mRNA processing; nucleus; nucleoplasm; RNA binding; protein binding; mRNA splicing, via spliceosome; ribonucleoprotein complex; gene expression; RNA splicing;
HSPA8	9	mRNA processing; cytosol; nucleus; protein binding; ribonucleoprotein complex; mRNA metabolic process; RNA metabolic process; gene expression; RNA splicing;
SSRP1	9	transcription from RNA polymerase II promoter; transcription elongation from RNA polymerase II promoter; nucleus; nucleoplasm; protein binding; DNA binding; positive regulation of viral transcription; viral reproduction; gene expression;
RPS3	9	cytosol; nucleus; protein binding; ribonucleoprotein complex; mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
SNRPD2	9	cytosol; nucleoplasm; protein binding; mRNA splicing, via spliceosome; spliceosomal snRNP assembly; ncRNA metabolic process; RNA metabolic process; gene expression; RNA splicing;
XPO1	9	cytosol; nucleoplasm; RNA binding; protein binding; ribonucleoprotein complex; mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression;
CLP1	8	mRNA processing; termination of RNA polymerase II transcription; transcription from RNA polymerase II promoter; nucleoplasm; mRNA splicing, via spliceosome; mRNA 3'-end processing; gene expression; RNA splicing;
HNRNPA1	8	mRNA processing; nucleus; nucleoplasm; RNA binding; mRNA splicing, via spliceosome; ribonucleoprotein complex; gene expression; RNA splicing;
LSM11	8	mRNA processing; termination of RNA polymerase II transcription; transcription from RNA polymerase II promoter; nucleus; nucleoplasm; protein binding; gene expression; histone mRNA metabolic process;
LSM4	8	mRNA processing; cytosol; RNA binding; protein binding; mRNA metabolic process; RNA metabolic process; gene expression; RNA splicing;
SF3A1	8	mRNA processing; nucleus; nucleoplasm; RNA binding; protein binding; mRNA splicing, via spliceosome; gene expression; RNA splicing;
CDC40	8	termination of RNA polymerase II transcription; transcription from RNA polymerase II promoter; nucleoplasm; mRNA splicing, via spliceosome; mRNA 3'-end processing; gene expression; RNA splicing; mRNA export from nucleus;
TAF13	8	transcription from RNA polymerase II promoter; transcription elongation from RNA polymerase II promoter; nucleus; nucleoplasm; protein binding; DNA binding; viral reproduction; gene expression;
TCEB1	8	transcription from RNA polymerase II promoter; transcription elongation from RNA polymerase II promoter; cytosol; nucleoplasm; protein binding; positive regulation of viral transcription; viral reproduction; gene expression;
PSMC3	8	cytosol; nucleus; nucleoplasm; protein binding; mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression;
RPL13	8	cytosol; RNA binding; protein binding; mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
RPL14	8	cytosol; RNA binding; protein binding; mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
RPS9	8	cytosol; protein binding; ribonucleoprotein complex; mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
SMG1	8	cytosol; nucleus; protein binding; mRNA metabolic process; RNA metabolic process; gene expression; mRNA export from nucleus; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
SMG7	8	cytosol; nucleus; protein binding; mRNA metabolic process; RNA metabolic process; gene expression; mRNA export from nucleus; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
DHX9	8	nucleus; nucleoplasm; protein binding; mRNA splicing, via spliceosome; DNA binding; ribonucleoprotein complex; gene expression; RNA splicing;
FUS	8	nucleus; nucleoplasm; RNA binding; protein binding; mRNA splicing, via spliceosome; DNA binding; gene expression; RNA splicing;
EFTUD2	7	mRNA processing; nucleus; nucleoplasm; protein binding; mRNA splicing, via spliceosome; gene expression; RNA splicing;
PRPF8	7	mRNA processing; nucleoplasm; RNA binding; protein binding; mRNA splicing, via spliceosome; gene expression; RNA splicing;
SF3A3	7	mRNA processing; nucleus; nucleoplasm; protein binding; mRNA splicing, via spliceosome; gene expression; RNA splicing;
SF3B4	7	mRNA processing; nucleoplasm; RNA binding; protein binding; mRNA splicing, via spliceosome; gene expression; RNA splicing;
GTF2H3	7	7-methylguanosine mRNA capping; transcription from RNA polymerase II promoter; transcription elongation from RNA polymerase II promoter; nucleoplasm; positive regulation of viral transcription; viral reproduction; gene expression;
TAF10	7	transcription from RNA polymerase II promoter; transcription elongation from RNA polymerase II promoter; nucleus; nucleoplasm; protein binding; viral reproduction; gene expression;
TAF4B	7	transcription from RNA polymerase II promoter; transcription elongation from RNA polymerase II promoter; nucleus; nucleoplasm; DNA binding; viral reproduction; gene expression;
CLNS1A	7	cytosol; nucleus; protein binding; spliceosomal snRNP assembly; ncRNA metabolic process; RNA metabolic process; gene expression;
CNOT6	7	cytosol; nucleus; RNA binding; protein binding; mRNA metabolic process; RNA metabolic process; gene expression;
FAU	7	cytosol; RNA binding; mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
PSMB7	7	cytosol; nucleoplasm; protein binding; mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression;
PSMD5	7	cytosol; nucleoplasm; protein binding; mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression;
PSMD7	7	cytosol; nucleoplasm; protein binding; mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression;
RPL12	7	cytosol; RNA binding; mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
RPL37	7	cytosol; RNA binding; mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
RPL38	7	cytosol; RNA binding; mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
RPS15A	7	cytosol; RNA binding; mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
RPS25	7	cytosol; RNA binding; mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
UBB	7	cytosol; nucleoplasm; protein binding; mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression;
UBC	7	cytosol; nucleoplasm; protein binding; mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression;
HNRNPH1	7	nucleus; nucleoplasm; RNA binding; protein binding; mRNA splicing, via spliceosome; gene expression; RNA splicing;
PRPF6	7	nucleus; nucleoplasm; RNA binding; protein binding; mRNA splicing, via spliceosome; gene expression; RNA splicing;
RBM4	6	mRNA processing; nucleus; nucleoplasm; RNA binding; protein binding; RNA splicing;
SF3B2	6	mRNA processing; nucleus; nucleoplasm; mRNA splicing, via spliceosome; gene expression; RNA splicing;
SNRPB2	6	mRNA processing; nucleoplasm; protein binding; mRNA splicing, via spliceosome; gene expression; RNA splicing;
TARDBP	6	mRNA processing; transcription from RNA polymerase II promoter; nucleus; RNA binding; protein binding; RNA splicing;
IRF7	6	transcription from RNA polymerase II promoter; cytosol; nucleus; nucleoplasm; protein binding; DNA binding;
DCPS	6	cytosol; nucleus; protein binding; mRNA metabolic process; RNA metabolic process; gene expression;
DDX6	6	cytosol; RNA binding; protein binding; mRNA metabolic process; RNA metabolic process; gene expression;
HMGA1	6	cytosol; nucleus; nucleoplasm; protein binding; DNA binding; viral reproduction;
PATL1	6	cytosol; RNA binding; protein binding; mRNA metabolic process; RNA metabolic process; gene expression;
PSMA8	6	cytosol; nucleus; mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression;
PSME1	6	cytosol; nucleoplasm; mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression;
PSME2	6	cytosol; nucleoplasm; mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression;
RPL35	6	cytosol; mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
RPL37A	6	cytosol; mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
RPS12	6	cytosol; mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
RQCD1	6	cytosol; nucleus; protein binding; mRNA metabolic process; RNA metabolic process; gene expression;
SART1	6	cytosol; nucleus; nucleoplasm; protein binding; mRNA splicing, via spliceosome; spliceosomal snRNP assembly;
CD2BP2	6	nucleus; nucleoplasm; protein binding; mRNA splicing, via spliceosome; gene expression; RNA splicing;
DDX23	6	nucleus; nucleoplasm; protein binding; mRNA splicing, via spliceosome; gene expression; RNA splicing;
PRPF4	6	nucleus; nucleoplasm; protein binding; mRNA splicing, via spliceosome; gene expression; RNA splicing;
SMC1A	6	nucleus; nucleoplasm; protein binding; mRNA splicing, via spliceosome; gene expression; RNA splicing;
SNRNP200	6	nucleus; nucleoplasm; protein binding; mRNA splicing, via spliceosome; gene expression; RNA splicing;
HNRNPC	6	nucleoplasm; RNA binding; protein binding; mRNA splicing, via spliceosome; gene expression; RNA splicing;
SNRPA	6	nucleoplasm; RNA binding; protein binding; mRNA splicing, via spliceosome; gene expression; RNA splicing;
SNRPA1	6	nucleoplasm; RNA binding; protein binding; mRNA splicing, via spliceosome; gene expression; RNA splicing;
CELF1	5	mRNA processing; nucleus; RNA binding; protein binding; ribonucleoprotein complex;
NSRP1	5	mRNA processing; nucleus; protein binding; ribonucleoprotein complex; RNA splicing;
RBFOX1	5	mRNA processing; nucleus; RNA binding; protein binding; RNA splicing;
SF3A2	5	mRNA processing; nucleoplasm; mRNA splicing, via spliceosome; gene expression; RNA splicing;
SF3B3	5	mRNA processing; nucleoplasm; mRNA splicing, via spliceosome; gene expression; RNA splicing;
SMNDC1	5	mRNA processing; nucleus; RNA binding; protein binding; RNA splicing;
IRF9	5	transcription from RNA polymerase II promoter; cytosol; nucleus; nucleoplasm; protein binding;
MED4	5	transcription from RNA polymerase II promoter; nucleus; nucleoplasm; protein binding; gene expression;
NCOR1	5	transcription from RNA polymerase II promoter; nucleus; nucleoplasm; protein binding; gene expression;
BANF1	5	cytosol; nucleoplasm; protein binding; DNA binding; viral reproduction;
CDT1	5	cytosol; nucleus; nucleoplasm; protein binding; DNA binding;
EEF1D	5	cytosol; nucleus; protein binding; DNA binding; gene expression;
MAPK1	5	cytosol; nucleus; nucleoplasm; protein binding; DNA binding;
MAPK3	5	cytosol; nucleus; nucleoplasm; protein binding; gene expression;
MEN1	5	cytosol; nucleus; nucleoplasm; protein binding; gene expression;
NEDD4L	5	cytosol; nucleus; nucleoplasm; protein binding; gene expression;
NXF1	5	cytosol; nucleoplasm; protein binding; gene expression; mRNA export from nucleus;
PDCD4	5	cytosol; nucleus; RNA binding; protein binding; RNA metabolic process;
RAN	5	cytosol; nucleoplasm; protein binding; viral reproduction; gene expression;
RELA	5	cytosol; nucleus; nucleoplasm; protein binding; DNA binding;
TNKS1BP1	5	cytosol; nucleus; mRNA metabolic process; RNA metabolic process; gene expression;
YAP1	5	cytosol; nucleus; nucleoplasm; protein binding; gene expression;
ATXN2	5	nucleus; RNA binding; protein binding; ribonucleoprotein complex; RNA metabolic process;
DHX8	5	nucleus; RNA binding; protein binding; mRNA splicing, via spliceosome; RNA splicing;
ESRRA	5	nucleus; nucleoplasm; protein binding; DNA binding; gene expression;
IGHMBP2	5	nucleus; RNA binding; protein binding; DNA binding; ribonucleoprotein complex;
NCOR2	5	nucleus; nucleoplasm; protein binding; DNA binding; gene expression;
NR5A1	5	nucleus; nucleoplasm; protein binding; DNA binding; gene expression;
PGR	5	nucleus; nucleoplasm; protein binding; DNA binding; gene expression;
RBPJ	5	nucleus; nucleoplasm; protein binding; DNA binding; gene expression;
SNW1	5	nucleus; nucleoplasm; protein binding; mRNA splicing, via spliceosome; gene expression;
XRCC5	5	nucleus; nucleoplasm; protein binding; DNA binding; viral reproduction;
PHF5A	5	nucleoplasm; mRNA splicing, via spliceosome; DNA binding; gene expression; RNA splicing;
TXNL4A	5	nucleoplasm; protein binding; mRNA splicing, via spliceosome; gene expression; RNA splicing;

Genes shared at least 2 KEGG pathways with NCBP1 (count: 2)

Gene Symbol	Pathway Count	Pathway List
NXF1	2	mRNA surveillance pathway; RNA transport;
SAP18	2	mRNA surveillance pathway; RNA transport;

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Region: chr9:100395705..100436030 View in gBrowse