ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	SF3A2
Symbol Alias	SF3a66, SAP62, PRPF11, Prp11
Approved Name	splicing factor 3a, subunit 2, 66kDa
Previous Name	splicing factor 3a, subunit 2, 66kD
Location	19p13.3-p13.2
Position	chr19:2236816-2248678, +
External Links	HGNC: 10766 Entrez Gene: 8175 Ensembl: ENSG00000104897 UCSC: uc002lvg.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 11)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005681	spliceosomal complex	Cellular Component	IDA[9731529]	51

GO terms by database search (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000389	mRNA 3'-splice site recognition	Biological Process	TAS[15647371]	5
GO:0003676	nucleic acid binding	Molecular Function		41
GO:0000398	mRNA splicing, via spliceosome	Biological Process	IC[9731529]	54
GO:0006397	mRNA processing	Biological Process	IMP[15647371]	50
GO:0008270	zinc ion binding	Molecular Function		323
GO:0005654	nucleoplasm	Cellular Component		183
GO:0030532	small nuclear ribonucleoprotein complex	Cellular Component	TAS[8211113]	12
GO:0071013	catalytic step 2 spliceosome	Cellular Component	IDA[11991638]	31
GO:0008380	RNA splicing	Biological Process		65
GO:0010467	gene expression	Biological Process		140

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03040	Spliceosome	47	After transcription, eukaryotic mRNA precursors contain prot...... After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified. More...

Genes shared at least 5 GO terms with SF3A2 (count: 41)

Gene Symbol	Pathway Count	Pathway List
SF3A3	10	mRNA 3'-splice site recognition; nucleic acid binding; mRNA splicing, via spliceosome; mRNA processing; zinc ion binding; nucleoplasm; spliceosomal complex; catalytic step 2 spliceosome; RNA splicing; gene expression;
SF3B3	9	nucleic acid binding; mRNA splicing, via spliceosome; mRNA processing; nucleoplasm; spliceosomal complex; small nuclear ribonucleoprotein complex; catalytic step 2 spliceosome; RNA splicing; gene expression;
SF3A1	8	mRNA 3'-splice site recognition; mRNA splicing, via spliceosome; mRNA processing; nucleoplasm; spliceosomal complex; catalytic step 2 spliceosome; RNA splicing; gene expression;
SF3B2	8	nucleic acid binding; mRNA splicing, via spliceosome; mRNA processing; nucleoplasm; spliceosomal complex; catalytic step 2 spliceosome; RNA splicing; gene expression;
SNRPB	8	mRNA splicing, via spliceosome; mRNA processing; nucleoplasm; spliceosomal complex; small nuclear ribonucleoprotein complex; catalytic step 2 spliceosome; RNA splicing; gene expression;
SNRPD3	8	mRNA splicing, via spliceosome; mRNA processing; nucleoplasm; spliceosomal complex; small nuclear ribonucleoprotein complex; catalytic step 2 spliceosome; RNA splicing; gene expression;
SNRPF	8	mRNA splicing, via spliceosome; mRNA processing; nucleoplasm; spliceosomal complex; small nuclear ribonucleoprotein complex; catalytic step 2 spliceosome; RNA splicing; gene expression;
SNRPG	8	mRNA splicing, via spliceosome; mRNA processing; nucleoplasm; spliceosomal complex; small nuclear ribonucleoprotein complex; catalytic step 2 spliceosome; RNA splicing; gene expression;
U2AF1	8	mRNA splicing, via spliceosome; mRNA processing; zinc ion binding; nucleoplasm; spliceosomal complex; catalytic step 2 spliceosome; RNA splicing; gene expression;
DDX23	7	nucleic acid binding; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; catalytic step 2 spliceosome; RNA splicing; gene expression;
SNRNP200	7	nucleic acid binding; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; catalytic step 2 spliceosome; RNA splicing; gene expression;
EFTUD2	7	mRNA splicing, via spliceosome; mRNA processing; nucleoplasm; spliceosomal complex; catalytic step 2 spliceosome; RNA splicing; gene expression;
HNRNPA1	7	mRNA splicing, via spliceosome; mRNA processing; nucleoplasm; spliceosomal complex; catalytic step 2 spliceosome; RNA splicing; gene expression;
HNRNPA2B1	7	mRNA splicing, via spliceosome; mRNA processing; nucleoplasm; spliceosomal complex; catalytic step 2 spliceosome; RNA splicing; gene expression;
PRPF8	7	mRNA splicing, via spliceosome; mRNA processing; nucleoplasm; spliceosomal complex; catalytic step 2 spliceosome; RNA splicing; gene expression;
SNRPA1	7	mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; small nuclear ribonucleoprotein complex; catalytic step 2 spliceosome; RNA splicing; gene expression;
SNRPB2	7	mRNA splicing, via spliceosome; mRNA processing; nucleoplasm; spliceosomal complex; catalytic step 2 spliceosome; RNA splicing; gene expression;
SNRPD2	7	mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; small nuclear ribonucleoprotein complex; catalytic step 2 spliceosome; RNA splicing; gene expression;
SLU7	6	mRNA 3'-splice site recognition; mRNA splicing, via spliceosome; zinc ion binding; spliceosomal complex; small nuclear ribonucleoprotein complex; catalytic step 2 spliceosome;
CDC40	6	mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; catalytic step 2 spliceosome; RNA splicing; gene expression;
HNRNPC	6	mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; catalytic step 2 spliceosome; RNA splicing; gene expression;
PRPF6	6	mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; catalytic step 2 spliceosome; RNA splicing; gene expression;
SF3B4	6	mRNA splicing, via spliceosome; mRNA processing; nucleoplasm; spliceosomal complex; RNA splicing; gene expression;
SNRPD1	6	mRNA splicing, via spliceosome; nucleoplasm; small nuclear ribonucleoprotein complex; catalytic step 2 spliceosome; RNA splicing; gene expression;
U2AF2	6	mRNA splicing, via spliceosome; mRNA processing; nucleoplasm; spliceosomal complex; RNA splicing; gene expression;
SF1	5	mRNA 3'-splice site recognition; nucleic acid binding; mRNA splicing, via spliceosome; zinc ion binding; spliceosomal complex;
ZMAT5	5	nucleic acid binding; mRNA processing; zinc ion binding; spliceosomal complex; RNA splicing;
CLP1	5	mRNA splicing, via spliceosome; mRNA processing; nucleoplasm; RNA splicing; gene expression;
CPSF3	5	mRNA splicing, via spliceosome; mRNA processing; nucleoplasm; RNA splicing; gene expression;
CPSF7	5	mRNA splicing, via spliceosome; mRNA processing; nucleoplasm; RNA splicing; gene expression;
FUS	5	mRNA splicing, via spliceosome; zinc ion binding; nucleoplasm; RNA splicing; gene expression;
HNRNPH1	5	mRNA splicing, via spliceosome; nucleoplasm; catalytic step 2 spliceosome; RNA splicing; gene expression;
NCBP1	5	mRNA splicing, via spliceosome; mRNA processing; nucleoplasm; RNA splicing; gene expression;
PCF11	5	mRNA splicing, via spliceosome; mRNA processing; nucleoplasm; RNA splicing; gene expression;
PHF5A	5	mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; RNA splicing; gene expression;
PRPF4	5	mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; RNA splicing; gene expression;
SNRPA	5	mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; RNA splicing; gene expression;
SNW1	5	mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; catalytic step 2 spliceosome; gene expression;
TXNL4A	5	mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; RNA splicing; gene expression;
LSM4	5	mRNA processing; spliceosomal complex; small nuclear ribonucleoprotein complex; RNA splicing; gene expression;
ZCRB1	5	mRNA processing; zinc ion binding; nucleoplasm; spliceosomal complex; RNA splicing;

Genes shared at least 2 KEGG pathways with SF3A2 (count: 0)

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Region: chr19:2236816..2248678 View in gBrowse