ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	SF3B3
Symbol Alias	SAP130, SF3b130, RSE1, KIAA0017
Approved Name	splicing factor 3b, subunit 3, 130kDa
Previous Name	splicing factor 3b, subunit 3, 130kD
Location	16q22
Position	chr16:70557691-70611571, +
External Links	HGNC: 10770 Entrez Gene: 23450 Ensembl: ENSG00000189091 UCSC: uc002ezf.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 12)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005681	spliceosomal complex	Cellular Component	TAS[10490618]	51

GO terms by database search (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0010467	gene expression	Biological Process		140
GO:0030532	small nuclear ribonucleoprotein complex	Cellular Component	TAS[10490618]	12
GO:0071013	catalytic step 2 spliceosome	Cellular Component	IDA[11991638]	31
GO:0005689	U12-type spliceosomal complex	Cellular Component	IDA[15146077]	16
GO:0006397	mRNA processing	Biological Process	TAS[10490618]	50
GO:0006461	protein complex assembly	Biological Process	TAS[10490618]	28
GO:0008380	RNA splicing	Biological Process		65
GO:0000398	mRNA splicing, via spliceosome	Biological Process	IC[11991638]	54
GO:0003676	nucleic acid binding	Molecular Function		41
GO:0005654	nucleoplasm	Cellular Component		183
GO:0000375	RNA splicing, via transesterification reactions	Biological Process	TAS[10490618]	11

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03040	Spliceosome	47	After transcription, eukaryotic mRNA precursors contain prot...... After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified. More...

Genes shared at least 5 GO terms with SF3B3 (count: 40)

Gene Symbol	Pathway Count	Pathway List
SF3A2	9	gene expression; small nuclear ribonucleoprotein complex; catalytic step 2 spliceosome; mRNA processing; RNA splicing; mRNA splicing, via spliceosome; nucleic acid binding; nucleoplasm; spliceosomal complex;
SF3A3	9	gene expression; catalytic step 2 spliceosome; mRNA processing; RNA splicing; mRNA splicing, via spliceosome; nucleic acid binding; nucleoplasm; spliceosomal complex; RNA splicing, via transesterification reactions;
SF3B2	9	gene expression; catalytic step 2 spliceosome; U12-type spliceosomal complex; mRNA processing; RNA splicing; mRNA splicing, via spliceosome; nucleic acid binding; nucleoplasm; spliceosomal complex;
SNRPB	9	gene expression; small nuclear ribonucleoprotein complex; catalytic step 2 spliceosome; U12-type spliceosomal complex; mRNA processing; RNA splicing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex;
SNRPD3	9	gene expression; small nuclear ribonucleoprotein complex; catalytic step 2 spliceosome; U12-type spliceosomal complex; mRNA processing; RNA splicing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex;
SNRPF	9	gene expression; small nuclear ribonucleoprotein complex; catalytic step 2 spliceosome; U12-type spliceosomal complex; mRNA processing; RNA splicing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex;
SNRPG	9	gene expression; small nuclear ribonucleoprotein complex; catalytic step 2 spliceosome; U12-type spliceosomal complex; mRNA processing; RNA splicing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex;
DDX23	8	gene expression; catalytic step 2 spliceosome; RNA splicing; mRNA splicing, via spliceosome; nucleic acid binding; nucleoplasm; spliceosomal complex; RNA splicing, via transesterification reactions;
PRPF8	8	gene expression; catalytic step 2 spliceosome; mRNA processing; RNA splicing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; RNA splicing, via transesterification reactions;
SF3B4	8	gene expression; U12-type spliceosomal complex; mRNA processing; RNA splicing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; RNA splicing, via transesterification reactions;
SNRPD2	8	gene expression; small nuclear ribonucleoprotein complex; catalytic step 2 spliceosome; U12-type spliceosomal complex; RNA splicing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex;
EFTUD2	7	gene expression; catalytic step 2 spliceosome; mRNA processing; RNA splicing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex;
HNRNPA1	7	gene expression; catalytic step 2 spliceosome; mRNA processing; RNA splicing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex;
HNRNPA2B1	7	gene expression; catalytic step 2 spliceosome; mRNA processing; RNA splicing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex;
PRPF6	7	gene expression; catalytic step 2 spliceosome; RNA splicing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; RNA splicing, via transesterification reactions;
SF3A1	7	gene expression; catalytic step 2 spliceosome; mRNA processing; RNA splicing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex;
SNRNP200	7	gene expression; catalytic step 2 spliceosome; RNA splicing; mRNA splicing, via spliceosome; nucleic acid binding; nucleoplasm; spliceosomal complex;
SNRPA1	7	gene expression; small nuclear ribonucleoprotein complex; catalytic step 2 spliceosome; RNA splicing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex;
SNRPB2	7	gene expression; catalytic step 2 spliceosome; mRNA processing; RNA splicing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex;
SNRPD1	7	gene expression; small nuclear ribonucleoprotein complex; catalytic step 2 spliceosome; U12-type spliceosomal complex; RNA splicing; mRNA splicing, via spliceosome; nucleoplasm;
U2AF1	7	gene expression; catalytic step 2 spliceosome; mRNA processing; RNA splicing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex;
CDC40	6	gene expression; catalytic step 2 spliceosome; RNA splicing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex;
HNRNPC	6	gene expression; catalytic step 2 spliceosome; RNA splicing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex;
PHF5A	6	gene expression; U12-type spliceosomal complex; RNA splicing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex;
PRPF4	6	gene expression; RNA splicing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; RNA splicing, via transesterification reactions;
TXNL4A	6	gene expression; RNA splicing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; RNA splicing, via transesterification reactions;
U2AF2	6	gene expression; mRNA processing; RNA splicing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex;
CLP1	5	gene expression; mRNA processing; RNA splicing; mRNA splicing, via spliceosome; nucleoplasm;
CPSF3	5	gene expression; mRNA processing; RNA splicing; mRNA splicing, via spliceosome; nucleoplasm;
CPSF7	5	gene expression; mRNA processing; RNA splicing; mRNA splicing, via spliceosome; nucleoplasm;
HNRNPH1	5	gene expression; catalytic step 2 spliceosome; RNA splicing; mRNA splicing, via spliceosome; nucleoplasm;
LSM4	5	gene expression; small nuclear ribonucleoprotein complex; mRNA processing; RNA splicing; spliceosomal complex;
NCBP1	5	gene expression; mRNA processing; RNA splicing; mRNA splicing, via spliceosome; nucleoplasm;
PCF11	5	gene expression; mRNA processing; RNA splicing; mRNA splicing, via spliceosome; nucleoplasm;
SNRPA	5	gene expression; RNA splicing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex;
SNW1	5	gene expression; catalytic step 2 spliceosome; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex;
SLU7	5	small nuclear ribonucleoprotein complex; catalytic step 2 spliceosome; mRNA splicing, via spliceosome; spliceosomal complex; RNA splicing, via transesterification reactions;
DHX15	5	U12-type spliceosomal complex; mRNA processing; RNA splicing; nucleic acid binding; spliceosomal complex;
ZCRB1	5	U12-type spliceosomal complex; mRNA processing; RNA splicing; nucleoplasm; spliceosomal complex;
ZMAT5	5	U12-type spliceosomal complex; mRNA processing; RNA splicing; nucleic acid binding; spliceosomal complex;

Genes shared at least 2 KEGG pathways with SF3B3 (count: 0)

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Region: chr16:70557691..70611571 View in gBrowse