ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	DHX15
Previous Symbol	DDX15
Symbol Alias	HRH2, DBP1, PRP43, PrPp43p, PRPF43
Approved Name	DEAH (Asp-Glu-Ala-His) box polypeptide 15
Previous Name	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 15
Location	4p15.3
Position	chr4:24519064-24586184, -
External Links	HGNC: 2738 Entrez Gene: 1665 Ensembl: ENSG00000109606 UCSC: uc003gqx.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV; Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_18	chr4:23596065-27014659 (NCBI Build 36.1 (hg18))	3365040	4p15.2	Gain

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 10)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005681	spliceosomal complex	Cellular Component		51

GO terms by database search (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005634	nucleus	Cellular Component		770
GO:0003724	RNA helicase activity	Molecular Function	TAS[7935475]	4
GO:0005524	ATP binding	Molecular Function		228
GO:0003676	nucleic acid binding	Molecular Function		41
GO:0008380	RNA splicing	Biological Process	IC[15146077]	65
GO:0005730	nucleolus	Cellular Component		243
GO:0005689	U12-type spliceosomal complex	Cellular Component	IDA[15146077]	16
GO:0008026	ATP-dependent helicase activity	Molecular Function		9
GO:0006397	mRNA processing	Biological Process		50

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03040	Spliceosome	47	After transcription, eukaryotic mRNA precursors contain prot...... After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified. More...

Genes shared at least 5 GO terms with DHX15 (count: 17)

Gene Symbol	Pathway Count	Pathway List
DDX23	7	nucleus; spliceosomal complex; ATP binding; nucleic acid binding; RNA splicing; nucleolus; ATP-dependent helicase activity;
SF3B2	7	nucleus; spliceosomal complex; nucleic acid binding; RNA splicing; nucleolus; U12-type spliceosomal complex; mRNA processing;
SNRNP200	7	nucleus; spliceosomal complex; ATP binding; nucleic acid binding; RNA splicing; nucleolus; ATP-dependent helicase activity;
ZMAT5	7	nucleus; spliceosomal complex; nucleic acid binding; RNA splicing; nucleolus; U12-type spliceosomal complex; mRNA processing;
HSPA8	6	nucleus; spliceosomal complex; ATP binding; RNA splicing; nucleolus; mRNA processing;
SF3A3	6	nucleus; spliceosomal complex; nucleic acid binding; RNA splicing; nucleolus; mRNA processing;
CDK12	5	nucleus; ATP binding; RNA splicing; nucleolus; mRNA processing;
DHX8	5	nucleus; spliceosomal complex; ATP binding; RNA splicing; nucleolus;
DHX9	5	nucleus; RNA helicase activity; ATP binding; RNA splicing; nucleolus;
EFTUD2	5	nucleus; spliceosomal complex; RNA splicing; nucleolus; mRNA processing;
HNRNPA1	5	nucleus; spliceosomal complex; RNA splicing; nucleolus; mRNA processing;
HNRNPA2B1	5	nucleus; spliceosomal complex; RNA splicing; nucleolus; mRNA processing;
SCAF8	5	nucleus; spliceosomal complex; RNA splicing; nucleolus; mRNA processing;
SF3A1	5	nucleus; spliceosomal complex; RNA splicing; nucleolus; mRNA processing;
THRAP3	5	nucleus; ATP binding; RNA splicing; nucleolus; mRNA processing;
U2AF1	5	nucleus; spliceosomal complex; RNA splicing; nucleolus; mRNA processing;
SF3B3	5	spliceosomal complex; nucleic acid binding; RNA splicing; U12-type spliceosomal complex; mRNA processing;

Genes shared at least 2 KEGG pathways with DHX15 (count: 0)

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Region: chr4:24519064..24586184 View in gBrowse