ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	HNRNPA2B1
Previous Symbol	HNRPA2B1
Approved Name	heterogeneous nuclear ribonucleoprotein A2/B1
Location	7p15
Position	chr7:26229547-26241149, -
External Links	HGNC: 5033 Entrez Gene: 3181 Ensembl: ENSG00000122566 UCSC: uc003sxr.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV; Mapped by PBA pathway; Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Lesch[2011]_6	chr7:23010000-26070000 (NCBI Build 35 (hg17))	3060000	7p15.2-7p15.3	Duplication	Paternal (affected)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
7p15	chr7:20900000-28800000	2 (1/1/0)

Gene related GO terms (count: 18)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005681	spliceosomal complex	Cellular Component	IDA[9731529]	51

GO terms by database search (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0030529	ribonucleoprotein complex	Cellular Component	IDA[2557628]	23
GO:0010467	gene expression	Biological Process		140
GO:0048025	negative regulation of mRNA splicing, via spliceosome	Biological Process		2
GO:0043047	single-stranded telomeric DNA binding	Molecular Function	IDA[15659580]	1
GO:0071013	catalytic step 2 spliceosome	Cellular Component	IDA[11991638]	31
GO:0050658	RNA transport	Biological Process	IDA[17004321]	4
GO:0097157	pre-mRNA intronic binding	Molecular Function		2
GO:0005634	nucleus	Cellular Component		770
GO:0005515	protein binding	Molecular Function	IPI[15703215]	910
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005737	cytoplasm	Cellular Component		690
GO:0005730	nucleolus	Cellular Component		243
GO:0008380	RNA splicing	Biological Process		65
GO:0006397	mRNA processing	Biological Process	IDA[2557628]	50
GO:0000398	mRNA splicing, via spliceosome	Biological Process	IC[9731529]	54
GO:0003723	RNA binding	Molecular Function	IDA[15659580]	104
GO:0000166	nucleotide binding	Molecular Function		73

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with HNRNPA2B1 (count: 112)

Gene Symbol	Pathway Count	Pathway List
HNRNPA1	13	ribonucleoprotein complex; gene expression; catalytic step 2 spliceosome; nucleus; spliceosomal complex; nucleoplasm; cytoplasm; nucleolus; RNA splicing; mRNA processing; mRNA splicing, via spliceosome; RNA binding; nucleotide binding;
U2AF1	12	gene expression; catalytic step 2 spliceosome; nucleus; protein binding; spliceosomal complex; nucleoplasm; nucleolus; RNA splicing; mRNA processing; mRNA splicing, via spliceosome; RNA binding; nucleotide binding;
EFTUD2	11	gene expression; catalytic step 2 spliceosome; nucleus; protein binding; spliceosomal complex; nucleoplasm; cytoplasm; nucleolus; RNA splicing; mRNA processing; mRNA splicing, via spliceosome;
HNRNPH1	11	gene expression; catalytic step 2 spliceosome; nucleus; protein binding; nucleoplasm; cytoplasm; nucleolus; RNA splicing; mRNA splicing, via spliceosome; RNA binding; nucleotide binding;
SF3A1	11	gene expression; catalytic step 2 spliceosome; nucleus; protein binding; spliceosomal complex; nucleoplasm; nucleolus; RNA splicing; mRNA processing; mRNA splicing, via spliceosome; RNA binding;
FUS	10	gene expression; nucleus; protein binding; nucleoplasm; cytoplasm; nucleolus; RNA splicing; mRNA splicing, via spliceosome; RNA binding; nucleotide binding;
SF3A3	10	gene expression; catalytic step 2 spliceosome; nucleus; protein binding; spliceosomal complex; nucleoplasm; nucleolus; RNA splicing; mRNA processing; mRNA splicing, via spliceosome;
U2AF2	10	gene expression; negative regulation of mRNA splicing, via spliceosome; protein binding; spliceosomal complex; nucleoplasm; RNA splicing; mRNA processing; mRNA splicing, via spliceosome; RNA binding; nucleotide binding;
RBM4	10	pre-mRNA intronic binding; nucleus; protein binding; nucleoplasm; cytoplasm; nucleolus; RNA splicing; mRNA processing; RNA binding; nucleotide binding;
DHX9	9	ribonucleoprotein complex; gene expression; nucleus; protein binding; nucleoplasm; cytoplasm; nucleolus; RNA splicing; mRNA splicing, via spliceosome;
NCBP1	9	ribonucleoprotein complex; gene expression; nucleus; protein binding; nucleoplasm; RNA splicing; mRNA processing; mRNA splicing, via spliceosome; RNA binding;
CPSF7	9	gene expression; nucleus; protein binding; nucleoplasm; RNA splicing; mRNA processing; mRNA splicing, via spliceosome; RNA binding; nucleotide binding;
DDX23	9	gene expression; catalytic step 2 spliceosome; nucleus; protein binding; spliceosomal complex; nucleoplasm; nucleolus; RNA splicing; mRNA splicing, via spliceosome;
HNRNPC	9	gene expression; catalytic step 2 spliceosome; protein binding; spliceosomal complex; nucleoplasm; RNA splicing; mRNA splicing, via spliceosome; RNA binding; nucleotide binding;
PRPF6	9	gene expression; catalytic step 2 spliceosome; nucleus; protein binding; spliceosomal complex; nucleoplasm; RNA splicing; mRNA splicing, via spliceosome; RNA binding;
PRPF8	9	gene expression; catalytic step 2 spliceosome; protein binding; spliceosomal complex; nucleoplasm; RNA splicing; mRNA processing; mRNA splicing, via spliceosome; RNA binding;
SF3B2	9	gene expression; catalytic step 2 spliceosome; nucleus; spliceosomal complex; nucleoplasm; nucleolus; RNA splicing; mRNA processing; mRNA splicing, via spliceosome;
SF3B4	9	gene expression; protein binding; spliceosomal complex; nucleoplasm; RNA splicing; mRNA processing; mRNA splicing, via spliceosome; RNA binding; nucleotide binding;
SNRNP200	9	gene expression; catalytic step 2 spliceosome; nucleus; protein binding; spliceosomal complex; nucleoplasm; nucleolus; RNA splicing; mRNA splicing, via spliceosome;
SNRPB2	9	gene expression; catalytic step 2 spliceosome; protein binding; spliceosomal complex; nucleoplasm; RNA splicing; mRNA processing; mRNA splicing, via spliceosome; nucleotide binding;
SNRPG	9	gene expression; catalytic step 2 spliceosome; protein binding; spliceosomal complex; nucleoplasm; RNA splicing; mRNA processing; mRNA splicing, via spliceosome; RNA binding;
CPSF3	8	ribonucleoprotein complex; gene expression; protein binding; nucleoplasm; RNA splicing; mRNA processing; mRNA splicing, via spliceosome; RNA binding;
HSPA8	8	ribonucleoprotein complex; gene expression; nucleus; protein binding; spliceosomal complex; nucleolus; RNA splicing; mRNA processing;
PRPF4	8	gene expression; nucleus; protein binding; spliceosomal complex; nucleoplasm; nucleolus; RNA splicing; mRNA splicing, via spliceosome;
SMC1A	8	gene expression; nucleus; protein binding; nucleoplasm; cytoplasm; nucleolus; RNA splicing; mRNA splicing, via spliceosome;
SNRPA	8	gene expression; protein binding; spliceosomal complex; nucleoplasm; RNA splicing; mRNA splicing, via spliceosome; RNA binding; nucleotide binding;
SNRPA1	8	gene expression; catalytic step 2 spliceosome; protein binding; spliceosomal complex; nucleoplasm; RNA splicing; mRNA splicing, via spliceosome; RNA binding;
SNRPB	8	gene expression; catalytic step 2 spliceosome; protein binding; spliceosomal complex; nucleoplasm; RNA splicing; mRNA processing; mRNA splicing, via spliceosome;
SNRPD1	8	gene expression; catalytic step 2 spliceosome; nucleus; protein binding; nucleoplasm; RNA splicing; mRNA splicing, via spliceosome; RNA binding;
SNRPD3	8	gene expression; catalytic step 2 spliceosome; protein binding; spliceosomal complex; nucleoplasm; RNA splicing; mRNA processing; mRNA splicing, via spliceosome;
SNRPF	8	gene expression; catalytic step 2 spliceosome; spliceosomal complex; nucleoplasm; RNA splicing; mRNA processing; mRNA splicing, via spliceosome; RNA binding;
SNW1	8	gene expression; catalytic step 2 spliceosome; nucleus; protein binding; spliceosomal complex; nucleoplasm; nucleolus; mRNA splicing, via spliceosome;
DHX8	8	catalytic step 2 spliceosome; nucleus; protein binding; spliceosomal complex; nucleolus; RNA splicing; mRNA splicing, via spliceosome; RNA binding;
RBFOX1	8	RNA transport; nucleus; protein binding; cytoplasm; RNA splicing; mRNA processing; RNA binding; nucleotide binding;
ATXN2	7	ribonucleoprotein complex; RNA transport; nucleus; protein binding; cytoplasm; nucleolus; RNA binding;
CELF1	7	ribonucleoprotein complex; nucleus; protein binding; cytoplasm; mRNA processing; RNA binding; nucleotide binding;
XPO1	7	ribonucleoprotein complex; gene expression; protein binding; nucleoplasm; cytoplasm; nucleolus; RNA binding;
CD2BP2	7	gene expression; nucleus; protein binding; nucleoplasm; cytoplasm; RNA splicing; mRNA splicing, via spliceosome;
SF3A2	7	gene expression; catalytic step 2 spliceosome; spliceosomal complex; nucleoplasm; RNA splicing; mRNA processing; mRNA splicing, via spliceosome;
SF3B3	7	gene expression; catalytic step 2 spliceosome; spliceosomal complex; nucleoplasm; RNA splicing; mRNA processing; mRNA splicing, via spliceosome;
SNRPD2	7	gene expression; catalytic step 2 spliceosome; protein binding; spliceosomal complex; nucleoplasm; RNA splicing; mRNA splicing, via spliceosome;
SART1	7	catalytic step 2 spliceosome; nucleus; protein binding; nucleoplasm; cytoplasm; nucleolus; mRNA splicing, via spliceosome;
SCAF8	7	nucleus; spliceosomal complex; nucleolus; RNA splicing; mRNA processing; RNA binding; nucleotide binding;
SMNDC1	7	nucleus; protein binding; spliceosomal complex; cytoplasm; RNA splicing; mRNA processing; RNA binding;
TARDBP	7	nucleus; protein binding; nucleolus; RNA splicing; mRNA processing; RNA binding; nucleotide binding;
LARP7	6	ribonucleoprotein complex; nucleus; nucleoplasm; cytoplasm; RNA binding; nucleotide binding;
RBM14	6	ribonucleoprotein complex; nucleus; protein binding; nucleolus; RNA binding; nucleotide binding;
CDC40	6	gene expression; catalytic step 2 spliceosome; spliceosomal complex; nucleoplasm; RNA splicing; mRNA splicing, via spliceosome;
DGCR8	6	gene expression; nucleus; protein binding; nucleoplasm; cytoplasm; nucleolus;
LSM4	6	gene expression; protein binding; spliceosomal complex; RNA splicing; mRNA processing; RNA binding;
MEN1	6	gene expression; nucleus; protein binding; nucleoplasm; cytoplasm; nucleolus;
PGR	6	gene expression; nucleus; protein binding; nucleoplasm; cytoplasm; nucleolus;
POLR2G	6	gene expression; nucleus; nucleoplasm; RNA splicing; mRNA splicing, via spliceosome; RNA binding;
RBPJ	6	gene expression; nucleus; protein binding; nucleoplasm; cytoplasm; nucleolus;
SSRP1	6	gene expression; nucleus; protein binding; nucleoplasm; cytoplasm; nucleolus;
TXNL4A	6	gene expression; protein binding; spliceosomal complex; nucleoplasm; RNA splicing; mRNA splicing, via spliceosome;
CWC15	6	catalytic step 2 spliceosome; nucleus; protein binding; spliceosomal complex; mRNA splicing, via spliceosome; RNA binding;
SLU7	6	catalytic step 2 spliceosome; nucleus; spliceosomal complex; cytoplasm; nucleolus; mRNA splicing, via spliceosome;
NOL8	6	nucleus; protein binding; cytoplasm; nucleolus; RNA binding; nucleotide binding;
PSPC1	6	nucleus; protein binding; cytoplasm; nucleolus; RNA binding; nucleotide binding;
ZMAT5	6	nucleus; spliceosomal complex; cytoplasm; nucleolus; RNA splicing; mRNA processing;
ZCRB1	6	spliceosomal complex; nucleoplasm; RNA splicing; mRNA processing; RNA binding; nucleotide binding;
GSK3B	5	ribonucleoprotein complex; nucleus; protein binding; cytoplasm; nucleolus;
IGHMBP2	5	ribonucleoprotein complex; nucleus; protein binding; cytoplasm; RNA binding;
NSRP1	5	ribonucleoprotein complex; nucleus; protein binding; RNA splicing; mRNA processing;
RBMXL2	5	ribonucleoprotein complex; nucleus; nucleolus; RNA binding; nucleotide binding;
RPS3	5	ribonucleoprotein complex; gene expression; nucleus; protein binding; cytoplasm;
RPS9	5	ribonucleoprotein complex; gene expression; protein binding; cytoplasm; nucleolus;
CLP1	5	gene expression; nucleoplasm; RNA splicing; mRNA processing; mRNA splicing, via spliceosome;
DCPS	5	gene expression; nucleus; protein binding; cytoplasm; nucleolus;
IARS	5	gene expression; nucleus; protein binding; cytoplasm; nucleolus;
LSM11	5	gene expression; nucleus; protein binding; nucleoplasm; mRNA processing;
MAML1	5	gene expression; nucleus; protein binding; nucleoplasm; nucleolus;
MAPK3	5	gene expression; nucleus; protein binding; nucleoplasm; nucleolus;
MED1	5	gene expression; nucleus; protein binding; nucleoplasm; nucleolus;
MED4	5	gene expression; nucleus; protein binding; nucleoplasm; nucleolus;
NCOR1	5	gene expression; nucleus; protein binding; nucleoplasm; cytoplasm;
NCOR2	5	gene expression; nucleus; protein binding; nucleoplasm; nucleolus;
NEDD4L	5	gene expression; nucleus; protein binding; nucleoplasm; cytoplasm;
NR4A2	5	gene expression; nucleus; protein binding; nucleoplasm; cytoplasm;
PCF11	5	gene expression; nucleoplasm; RNA splicing; mRNA processing; mRNA splicing, via spliceosome;
PHF5A	5	gene expression; spliceosomal complex; nucleoplasm; RNA splicing; mRNA splicing, via spliceosome;
PSMC3	5	gene expression; nucleus; protein binding; nucleoplasm; cytoplasm;
TAF10	5	gene expression; nucleus; protein binding; nucleoplasm; cytoplasm;
TAF13	5	gene expression; nucleus; protein binding; nucleoplasm; nucleolus;
TAF4B	5	gene expression; nucleus; nucleoplasm; cytoplasm; nucleolus;
YAP1	5	gene expression; nucleus; protein binding; nucleoplasm; cytoplasm;
PRPF19	5	catalytic step 2 spliceosome; nucleus; protein binding; cytoplasm; mRNA splicing, via spliceosome;
ALKBH8	5	nucleus; protein binding; cytoplasm; nucleolus; RNA binding;
ATXN1	5	nucleus; protein binding; nucleoplasm; cytoplasm; nucleolus;
CDK12	5	nucleus; protein binding; nucleolus; RNA splicing; mRNA processing;
CHD1L	5	nucleus; protein binding; cytoplasm; nucleolus; nucleotide binding;
DHX15	5	nucleus; spliceosomal complex; nucleolus; RNA splicing; mRNA processing;
IGF2BP3	5	nucleus; protein binding; cytoplasm; RNA binding; nucleotide binding;
MAPK1	5	nucleus; protein binding; nucleoplasm; cytoplasm; nucleolus;
MPHOSPH6	5	nucleus; protein binding; cytoplasm; nucleolus; RNA binding;
NUMA1	5	nucleus; protein binding; nucleoplasm; cytoplasm; nucleolus;
PDCD4	5	nucleus; protein binding; cytoplasm; nucleolus; RNA binding;
RAD23B	5	nucleus; protein binding; nucleoplasm; cytoplasm; nucleolus;
RAD9A	5	nucleus; protein binding; nucleoplasm; cytoplasm; nucleolus;
RCC1	5	nucleus; protein binding; nucleoplasm; cytoplasm; nucleolus;
RFWD2	5	nucleus; protein binding; nucleoplasm; cytoplasm; nucleolus;
SETD1A	5	nucleus; protein binding; nucleolus; RNA binding; nucleotide binding;
SF1	5	nucleus; spliceosomal complex; nucleolus; mRNA splicing, via spliceosome; RNA binding;
SNRNP35	5	nucleus; RNA splicing; mRNA processing; RNA binding; nucleotide binding;
SRSF8	5	nucleus; RNA splicing; mRNA processing; RNA binding; nucleotide binding;
THRAP3	5	nucleus; protein binding; nucleolus; RNA splicing; mRNA processing;
XRCC5	5	nucleus; protein binding; nucleoplasm; cytoplasm; nucleolus;
ZFR	5	nucleus; protein binding; cytoplasm; nucleolus; RNA binding;
BCAS2	5	protein binding; spliceosomal complex; nucleolus; RNA splicing; mRNA processing;
ZRSR2	5	protein binding; spliceosomal complex; RNA splicing; mRNA splicing, via spliceosome; nucleotide binding;
RBM4B	5	nucleolus; RNA splicing; mRNA processing; RNA binding; nucleotide binding;

Genes shared at least 2 KEGG pathways with HNRNPA2B1 (count: 0)

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Region: chr7:26229547..26241149 View in gBrowse