ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	DGCR8
Previous Symbol	C22orf12
Symbol Alias	DGCRK6, Gy1, pasha
Approved Name	DiGeorge syndrome critical region gene 8
Previous Name	chromosome 22 open reading frame 12
Location	22q11.2
Position	chr22:20067755-20099400, +
External Links	HGNC: 2847 Entrez Gene: 54487 Ensembl: ENSG00000128191 UCSC: uc002zri.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 2)

ID	Location	Size	Band	Type	Inheritance
CNV_Jarick[2012]_41	chr22:17616020-19792353 (NCBI36 / hg18)	2176334	22q11.21	dup
CNV_Jarick[2012]_40	chr22:17257787-19792353 (NCBI36 / hg18)	2534567	22q11.21	dup

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 10)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0046872	metal ion binding	Molecular Function		170
GO:0015630	microtubule cytoskeleton	Cellular Component		34
GO:0031053	primary miRNA processing	Biological Process	IDA[15574589]	1
GO:0005515	protein binding	Molecular Function	IPI[15574589]	910
GO:0005634	nucleus	Cellular Component		770
GO:0003725	double-stranded RNA binding	Molecular Function	IDA[17704815]	6
GO:0005737	cytoplasm	Cellular Component		690
GO:0010467	gene expression	Biological Process		140
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005730	nucleolus	Cellular Component		243

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with DGCR8 (count: 53)

Gene Symbol	Pathway Count	Pathway List
DHX9	7	protein binding; nucleus; double-stranded RNA binding; cytoplasm; gene expression; nucleoplasm; nucleolus;
ALKBH8	6	metal ion binding; microtubule cytoskeleton; protein binding; nucleus; cytoplasm; nucleolus;
DROSHA	6	metal ion binding; protein binding; double-stranded RNA binding; gene expression; nucleoplasm; nucleolus;
MAPK1	6	microtubule cytoskeleton; protein binding; nucleus; cytoplasm; nucleoplasm; nucleolus;
MAPK3	6	microtubule cytoskeleton; protein binding; nucleus; gene expression; nucleoplasm; nucleolus;
EFTUD2	6	protein binding; nucleus; cytoplasm; gene expression; nucleoplasm; nucleolus;
FUS	6	protein binding; nucleus; cytoplasm; gene expression; nucleoplasm; nucleolus;
HNRNPA2B1	6	protein binding; nucleus; cytoplasm; gene expression; nucleoplasm; nucleolus;
HNRNPH1	6	protein binding; nucleus; cytoplasm; gene expression; nucleoplasm; nucleolus;
MEN1	6	protein binding; nucleus; cytoplasm; gene expression; nucleoplasm; nucleolus;
PGR	6	protein binding; nucleus; cytoplasm; gene expression; nucleoplasm; nucleolus;
RBPJ	6	protein binding; nucleus; cytoplasm; gene expression; nucleoplasm; nucleolus;
SMC1A	6	protein binding; nucleus; cytoplasm; gene expression; nucleoplasm; nucleolus;
SSRP1	6	protein binding; nucleus; cytoplasm; gene expression; nucleoplasm; nucleolus;
CRYAB	5	metal ion binding; microtubule cytoskeleton; protein binding; nucleus; cytoplasm;
KARS	5	metal ion binding; microtubule cytoskeleton; nucleus; cytoplasm; gene expression;
PPP1CA	5	metal ion binding; protein binding; nucleus; cytoplasm; nucleolus;
SMG1	5	metal ion binding; protein binding; nucleus; cytoplasm; gene expression;
CEP57	5	microtubule cytoskeleton; protein binding; nucleus; cytoplasm; nucleolus;
PRC1	5	microtubule cytoskeleton; protein binding; nucleus; cytoplasm; nucleolus;
ATXN1	5	protein binding; nucleus; cytoplasm; nucleoplasm; nucleolus;
CD2BP2	5	protein binding; nucleus; cytoplasm; gene expression; nucleoplasm;
DCPS	5	protein binding; nucleus; cytoplasm; gene expression; nucleolus;
DDX23	5	protein binding; nucleus; gene expression; nucleoplasm; nucleolus;
IARS	5	protein binding; nucleus; cytoplasm; gene expression; nucleolus;
MAML1	5	protein binding; nucleus; gene expression; nucleoplasm; nucleolus;
MED1	5	protein binding; nucleus; gene expression; nucleoplasm; nucleolus;
MED4	5	protein binding; nucleus; gene expression; nucleoplasm; nucleolus;
NCOR1	5	protein binding; nucleus; cytoplasm; gene expression; nucleoplasm;
NCOR2	5	protein binding; nucleus; gene expression; nucleoplasm; nucleolus;
NEDD4L	5	protein binding; nucleus; cytoplasm; gene expression; nucleoplasm;
NR4A2	5	protein binding; nucleus; cytoplasm; gene expression; nucleoplasm;
NUMA1	5	protein binding; nucleus; cytoplasm; nucleoplasm; nucleolus;
PRPF4	5	protein binding; nucleus; gene expression; nucleoplasm; nucleolus;
PSMC3	5	protein binding; nucleus; cytoplasm; gene expression; nucleoplasm;
RAD23B	5	protein binding; nucleus; cytoplasm; nucleoplasm; nucleolus;
RAD9A	5	protein binding; nucleus; cytoplasm; nucleoplasm; nucleolus;
RBM4	5	protein binding; nucleus; cytoplasm; nucleoplasm; nucleolus;
RCC1	5	protein binding; nucleus; cytoplasm; nucleoplasm; nucleolus;
RFWD2	5	protein binding; nucleus; cytoplasm; nucleoplasm; nucleolus;
SART1	5	protein binding; nucleus; cytoplasm; nucleoplasm; nucleolus;
SF3A1	5	protein binding; nucleus; gene expression; nucleoplasm; nucleolus;
SF3A3	5	protein binding; nucleus; gene expression; nucleoplasm; nucleolus;
SNRNP200	5	protein binding; nucleus; gene expression; nucleoplasm; nucleolus;
SNW1	5	protein binding; nucleus; gene expression; nucleoplasm; nucleolus;
TAF10	5	protein binding; nucleus; cytoplasm; gene expression; nucleoplasm;
TAF13	5	protein binding; nucleus; gene expression; nucleoplasm; nucleolus;
U2AF1	5	protein binding; nucleus; gene expression; nucleoplasm; nucleolus;
XPO1	5	protein binding; cytoplasm; gene expression; nucleoplasm; nucleolus;
XRCC5	5	protein binding; nucleus; cytoplasm; nucleoplasm; nucleolus;
YAP1	5	protein binding; nucleus; cytoplasm; gene expression; nucleoplasm;
HNRNPA1	5	nucleus; cytoplasm; gene expression; nucleoplasm; nucleolus;
TAF4B	5	nucleus; cytoplasm; gene expression; nucleoplasm; nucleolus;

Genes shared at least 2 KEGG pathways with DGCR8 (count: 0)

View in gBrowse

Region: chr22:20067755..20099400 View in gBrowse