ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	SMG1
Symbol Alias	LIP, KIAA0421, ATX
Approved Name	SMG1 phosphatidylinositol 3-kinase-related kinase
Previous Name	"smg-1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)"
Name Alias	"phosphatidylinositol 3-kinase-related kinase"
Location	16p12.3
Position	chr16:18816175-18937776, -1
External Links	HGNC: 30045 Entrez Gene: 23049 Ensembl: ENSG00000157106 UCSC: uc002dfm.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
16p12.3-12.2	chr16:16800000-24200000	1 (1/0/0)

Gene related GO terms (count: 18)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0018105	peptidyl-serine phosphorylation	biological process	IDA[15175154]; TAS[14636577]	13
GO:0005829	cytosol	cellular component	TAS	485
GO:0016071	mRNA metabolic process	biological process	TAS	41
GO:0006950	response to stress	biological process	IDA[15175154]	31
GO:0010467	gene expression	biological process	TAS	154
GO:0005634	nucleus	cellular component	IDA[14636577]	877
GO:0006281	DNA repair	biological process	IEA	70
GO:0006406	mRNA export from nucleus	biological process	TAS[16488880]	15
GO:0046777	protein autophosphorylation	biological process	IDA[11331269]	26
GO:0005515	protein binding	molecular function	IPI	1015
GO:0004672	protein kinase activity	molecular function	TAS[14636577]	31
GO:0046872	metal ion binding	molecular function	IEA	200
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	biological process	IDA[11544179]; NAS[11331269]; TAS	23
GO:0005524	ATP binding	molecular function	IEA	265
GO:0016070	RNA metabolic process	biological process	TAS	54
GO:0046854	phosphatidylinositol phosphorylation	biological process	IDA[11331269]	5
GO:0004674	protein serine/threonine kinase activity	molecular function	EXP; IDA[19417104]; NAS[11331269]	65
GO:0005737	cytoplasm	cellular component	IDA[14636577]	781

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with SMG1 (count: 105)

Gene Symbol	Pathway Count	Pathway List
PRKD1	9	peptidyl-serine phosphorylation; cytosol; nucleus; protein autophosphorylation; protein binding; metal ion binding; ATP binding; protein serine/threonine kinase activity; cytoplasm;
SMG7	9	cytosol; mRNA metabolic process; gene expression; nucleus; mRNA export from nucleus; protein binding; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; RNA metabolic process; cytoplasm;
PARN	9	cytosol; mRNA metabolic process; gene expression; nucleus; protein binding; metal ion binding; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; RNA metabolic process; cytoplasm;
RNPS1	9	cytosol; mRNA metabolic process; gene expression; nucleus; mRNA export from nucleus; protein binding; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; RNA metabolic process; cytoplasm;
MAPK1	8	peptidyl-serine phosphorylation; cytosol; response to stress; nucleus; protein binding; ATP binding; protein serine/threonine kinase activity; cytoplasm;
RPS3	8	cytosol; mRNA metabolic process; gene expression; nucleus; protein binding; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; RNA metabolic process; cytoplasm;
NCBP1	8	cytosol; mRNA metabolic process; gene expression; nucleus; mRNA export from nucleus; protein binding; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; RNA metabolic process;
PSMC3	8	cytosol; mRNA metabolic process; gene expression; nucleus; protein binding; ATP binding; RNA metabolic process; cytoplasm;
NEK6	7	peptidyl-serine phosphorylation; nucleus; protein autophosphorylation; protein binding; ATP binding; protein serine/threonine kinase activity; cytoplasm;
PLK1	7	peptidyl-serine phosphorylation; cytosol; nucleus; protein binding; protein kinase activity; ATP binding; protein serine/threonine kinase activity;
GSK3B	7	peptidyl-serine phosphorylation; cytosol; nucleus; protein binding; ATP binding; protein serine/threonine kinase activity; cytoplasm;
MAP2K5	7	cytosol; nucleus; protein binding; protein kinase activity; metal ion binding; ATP binding; protein serine/threonine kinase activity;
HSPA8	7	cytosol; mRNA metabolic process; gene expression; nucleus; protein binding; ATP binding; RNA metabolic process;
CSNK1E	7	cytosol; nucleus; DNA repair; protein binding; protein kinase activity; ATP binding; protein serine/threonine kinase activity;
STK11	7	cytosol; nucleus; protein autophosphorylation; protein binding; ATP binding; protein serine/threonine kinase activity; cytoplasm;
CNOT6	7	cytosol; mRNA metabolic process; gene expression; nucleus; protein binding; metal ion binding; RNA metabolic process;
PAK1	7	cytosol; protein autophosphorylation; protein binding; protein kinase activity; ATP binding; protein serine/threonine kinase activity; cytoplasm;
DCPS	7	cytosol; mRNA metabolic process; gene expression; nucleus; protein binding; RNA metabolic process; cytoplasm;
RPL14	7	cytosol; mRNA metabolic process; gene expression; protein binding; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; RNA metabolic process; cytoplasm;
RPS9	7	cytosol; mRNA metabolic process; gene expression; protein binding; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; RNA metabolic process; cytoplasm;
PRKAA1	7	cytosol; response to stress; nucleus; protein binding; protein kinase activity; metal ion binding; ATP binding;
TNNI3K	7	nucleus; protein binding; protein kinase activity; metal ion binding; ATP binding; protein serine/threonine kinase activity; cytoplasm;
ADRBK1	6	peptidyl-serine phosphorylation; cytosol; protein binding; protein kinase activity; ATP binding; cytoplasm;
ILK	6	peptidyl-serine phosphorylation; cytosol; protein binding; ATP binding; protein serine/threonine kinase activity; cytoplasm;
ATM	6	peptidyl-serine phosphorylation; DNA repair; protein autophosphorylation; protein binding; ATP binding; protein serine/threonine kinase activity;
TGFBR1	6	peptidyl-serine phosphorylation; protein binding; protein kinase activity; metal ion binding; ATP binding; protein serine/threonine kinase activity;
RPS15A	6	cytosol; mRNA metabolic process; gene expression; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; RNA metabolic process; cytoplasm;
RPL37	6	cytosol; mRNA metabolic process; gene expression; metal ion binding; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; RNA metabolic process;
UBC	6	cytosol; mRNA metabolic process; gene expression; DNA repair; protein binding; RNA metabolic process;
PAIP1	6	cytosol; mRNA metabolic process; gene expression; protein binding; RNA metabolic process; cytoplasm;
RPL35	6	cytosol; mRNA metabolic process; gene expression; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; RNA metabolic process; cytoplasm;
PIK3CG	6	cytosol; protein binding; protein kinase activity; ATP binding; protein serine/threonine kinase activity; cytoplasm;
LATS2	6	cytosol; nucleus; protein binding; metal ion binding; ATP binding; protein serine/threonine kinase activity;
GEMIN2	6	cytosol; gene expression; nucleus; protein binding; RNA metabolic process; cytoplasm;
IARS	6	cytosol; gene expression; nucleus; protein binding; ATP binding; cytoplasm;
DDX6	6	cytosol; mRNA metabolic process; gene expression; protein binding; ATP binding; RNA metabolic process;
ROCK2	6	cytosol; nucleus; protein binding; metal ion binding; ATP binding; protein serine/threonine kinase activity;
RQCD1	6	cytosol; mRNA metabolic process; gene expression; nucleus; protein binding; RNA metabolic process;
XPO1	6	cytosol; mRNA metabolic process; gene expression; protein binding; RNA metabolic process; cytoplasm;
DNAJA3	6	cytosol; nucleus; protein binding; metal ion binding; ATP binding; cytoplasm;
TNKS1BP1	6	cytosol; mRNA metabolic process; gene expression; nucleus; RNA metabolic process; cytoplasm;
RPL13	6	cytosol; mRNA metabolic process; gene expression; protein binding; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; RNA metabolic process;
MEN1	6	cytosol; gene expression; nucleus; DNA repair; protein binding; cytoplasm;
KARS	6	cytosol; gene expression; nucleus; metal ion binding; ATP binding; cytoplasm;
RPL37A	6	cytosol; mRNA metabolic process; gene expression; metal ion binding; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; RNA metabolic process;
UBB	6	cytosol; mRNA metabolic process; gene expression; DNA repair; protein binding; RNA metabolic process;
RPL27A	6	cytosol; mRNA metabolic process; gene expression; protein binding; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; RNA metabolic process;
RPS2	6	cytosol; mRNA metabolic process; gene expression; protein binding; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; RNA metabolic process;
RPS10	6	cytosol; mRNA metabolic process; gene expression; protein binding; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; RNA metabolic process;
CHEK1	6	cytosol; nucleus; DNA repair; protein binding; ATP binding; protein serine/threonine kinase activity;
RPS25	6	cytosol; mRNA metabolic process; gene expression; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; RNA metabolic process; cytoplasm;
PDPK1	6	cytosol; protein autophosphorylation; protein binding; ATP binding; protein serine/threonine kinase activity; cytoplasm;
SMC1A	6	gene expression; nucleus; DNA repair; protein binding; ATP binding; cytoplasm;
SIK2	6	nucleus; protein autophosphorylation; protein binding; ATP binding; protein serine/threonine kinase activity; cytoplasm;
MAP3K11	6	protein autophosphorylation; protein binding; protein kinase activity; ATP binding; protein serine/threonine kinase activity; cytoplasm;
MAPK7	5	peptidyl-serine phosphorylation; cytosol; nucleus; protein binding; ATP binding;
FANCC	5	cytosol; nucleus; DNA repair; protein binding; cytoplasm;
PDCD4	5	cytosol; nucleus; protein binding; RNA metabolic process; cytoplasm;
CRYAB	5	cytosol; nucleus; protein binding; metal ion binding; cytoplasm;
MAPK3	5	cytosol; gene expression; nucleus; protein binding; ATP binding;
RPL12	5	cytosol; mRNA metabolic process; gene expression; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; RNA metabolic process;
RPL38	5	cytosol; mRNA metabolic process; gene expression; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; RNA metabolic process;
PSME1	5	cytosol; mRNA metabolic process; gene expression; RNA metabolic process; cytoplasm;
PSMD5	5	cytosol; mRNA metabolic process; gene expression; protein binding; RNA metabolic process;
RPS12	5	cytosol; mRNA metabolic process; gene expression; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; RNA metabolic process;
RPL3L	5	cytosol; mRNA metabolic process; gene expression; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; RNA metabolic process;
CLNS1A	5	cytosol; gene expression; nucleus; protein binding; RNA metabolic process;
NEDD4L	5	cytosol; gene expression; nucleus; protein binding; cytoplasm;
PSMD7	5	cytosol; mRNA metabolic process; gene expression; protein binding; RNA metabolic process;
KIF22	5	cytosol; nucleus; DNA repair; ATP binding; cytoplasm;
LSM4	5	cytosol; mRNA metabolic process; gene expression; protein binding; RNA metabolic process;
PPP1CA	5	cytosol; nucleus; protein binding; metal ion binding; cytoplasm;
NUBP1	5	cytosol; protein binding; metal ion binding; ATP binding; cytoplasm;
ALKBH8	5	cytosol; nucleus; protein binding; metal ion binding; cytoplasm;
PDE2A	5	cytosol; nucleus; protein binding; metal ion binding; cytoplasm;
RIPK3	5	cytosol; protein binding; protein kinase activity; ATP binding; protein serine/threonine kinase activity;
PATL1	5	cytosol; mRNA metabolic process; gene expression; protein binding; RNA metabolic process;
SNRPD1	5	cytosol; gene expression; nucleus; protein binding; RNA metabolic process;
FAU	5	cytosol; mRNA metabolic process; gene expression; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; RNA metabolic process;
PTTG1	5	cytosol; nucleus; DNA repair; protein binding; cytoplasm;
CEP164	5	cytosol; nucleus; DNA repair; protein binding; cytoplasm;
PSMA8	5	cytosol; mRNA metabolic process; gene expression; nucleus; RNA metabolic process;
SYK	5	cytosol; protein autophosphorylation; protein binding; protein kinase activity; ATP binding;
PSMB7	5	cytosol; mRNA metabolic process; gene expression; protein binding; RNA metabolic process;
EEF2K	5	cytosol; protein autophosphorylation; protein kinase activity; ATP binding; cytoplasm;
YAP1	5	cytosol; gene expression; nucleus; protein binding; cytoplasm;
TAOK2	5	response to stress; nucleus; ATP binding; protein serine/threonine kinase activity; cytoplasm;
DHX9	5	gene expression; nucleus; protein binding; ATP binding; cytoplasm;
DGCR8	5	gene expression; nucleus; protein binding; metal ion binding; cytoplasm;
SSRP1	5	gene expression; nucleus; DNA repair; protein binding; cytoplasm;
NUBP2	5	nucleus; protein binding; metal ion binding; ATP binding; cytoplasm;
SMC2	5	nucleus; DNA repair; protein binding; ATP binding; cytoplasm;
MARK2	5	nucleus; protein autophosphorylation; protein binding; ATP binding; protein serine/threonine kinase activity;
CDK12	5	nucleus; protein autophosphorylation; protein binding; protein kinase activity; ATP binding;
XRCC5	5	nucleus; DNA repair; protein binding; ATP binding; cytoplasm;
AURKC	5	nucleus; protein kinase activity; ATP binding; protein serine/threonine kinase activity; cytoplasm;
CHD1L	5	nucleus; DNA repair; protein binding; ATP binding; cytoplasm;
STK36	5	nucleus; protein binding; ATP binding; protein serine/threonine kinase activity; cytoplasm;
IGHMBP2	5	nucleus; DNA repair; protein binding; ATP binding; cytoplasm;
STK33	5	nucleus; protein autophosphorylation; ATP binding; protein serine/threonine kinase activity; cytoplasm;
SMC3	5	nucleus; DNA repair; protein binding; ATP binding; cytoplasm;
RPS6KA4	5	nucleus; protein binding; ATP binding; protein serine/threonine kinase activity; cytoplasm;
FLT4	5	nucleus; protein autophosphorylation; protein binding; ATP binding; cytoplasm;
TSSK2	5	protein autophosphorylation; protein binding; ATP binding; protein serine/threonine kinase activity; cytoplasm;
PKMYT1	5	protein binding; protein kinase activity; metal ion binding; ATP binding; protein serine/threonine kinase activity;

Genes shared at least 2 KEGG pathways with SMG1 (count: 0)

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Region: chr16:18816175..18937776 View in gBrowse