ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	SMG1
Symbol Alias	LIP, KIAA0421, ATX
Approved Name	smg-1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
Name Alias	phosphatidylinositol 3-kinase-related kinase
Location	16p12.3
Position	chr16:18816175-18937776, -
External Links	HGNC: 30045 Entrez Gene: 23049 Ensembl: ENSG00000157106 UCSC: uc002dfm.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
16p12.3-12.2	chr16:16800000-24200000	1 (1/0/0)

Gene related GO terms (count: 18)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0046872	metal ion binding	Molecular Function		170
GO:0046854	phosphatidylinositol phosphorylation	Biological Process	IDA[11331269]	5
GO:0046777	protein autophosphorylation	Biological Process	IDA[11331269]	23
GO:0018105	peptidyl-serine phosphorylation	Biological Process	IDA[15175154]; TAS[14636577]	12
GO:0016071	mRNA metabolic process	Biological Process		34
GO:0016070	RNA metabolic process	Biological Process		46
GO:0010467	gene expression	Biological Process		140
GO:0006950	response to stress	Biological Process	IDA[15175154]	30
GO:0006281	DNA repair	Biological Process		62
GO:0006406	mRNA export from nucleus	Biological Process	TAS[16488880]	12
GO:0005737	cytoplasm	Cellular Component	IDA[14636577]	690
GO:0005829	cytosol	Cellular Component		447
GO:0005524	ATP binding	Molecular Function		228
GO:0005634	nucleus	Cellular Component	IDA[14636577]	770
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IDA[19417104]; NAS[11331269]	61
GO:0005515	protein binding	Molecular Function		910
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	Biological Process	IDA[11544179]; NAS[11331269]	16
GO:0004672	protein kinase activity	Molecular Function	TAS[14636577]	27

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03015	mRNA surveillance pathway	17	The mRNA surveillance pathway is a quality control mechanism...... The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins. More...

Genes shared at least 5 GO terms with SMG1 (count: 89)

Gene Symbol	Pathway Count	Pathway List
PRKD1	9	metal ion binding; protein autophosphorylation; peptidyl-serine phosphorylation; cytoplasm; cytosol; ATP binding; nucleus; protein serine/threonine kinase activity; protein binding;
SMG7	9	mRNA metabolic process; RNA metabolic process; gene expression; mRNA export from nucleus; cytoplasm; cytosol; nucleus; protein binding; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
MAPK1	8	peptidyl-serine phosphorylation; response to stress; cytoplasm; cytosol; ATP binding; nucleus; protein serine/threonine kinase activity; protein binding;
NCBP1	8	mRNA metabolic process; RNA metabolic process; gene expression; mRNA export from nucleus; cytosol; nucleus; protein binding; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
PSMC3	8	mRNA metabolic process; RNA metabolic process; gene expression; cytoplasm; cytosol; ATP binding; nucleus; protein binding;
RPS3	8	mRNA metabolic process; RNA metabolic process; gene expression; cytoplasm; cytosol; nucleus; protein binding; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
CNOT6	7	metal ion binding; mRNA metabolic process; RNA metabolic process; gene expression; cytosol; nucleus; protein binding;
PRKAA1	7	metal ion binding; response to stress; cytosol; ATP binding; nucleus; protein binding; protein kinase activity;
NEK6	7	protein autophosphorylation; peptidyl-serine phosphorylation; cytoplasm; ATP binding; nucleus; protein serine/threonine kinase activity; protein binding;
PAK1	7	protein autophosphorylation; cytoplasm; cytosol; ATP binding; protein serine/threonine kinase activity; protein binding; protein kinase activity;
GSK3B	7	peptidyl-serine phosphorylation; cytoplasm; cytosol; ATP binding; nucleus; protein serine/threonine kinase activity; protein binding;
PLK1	7	peptidyl-serine phosphorylation; cytosol; ATP binding; nucleus; protein serine/threonine kinase activity; protein binding; protein kinase activity;
DCPS	7	mRNA metabolic process; RNA metabolic process; gene expression; cytoplasm; cytosol; nucleus; protein binding;
HSPA8	7	mRNA metabolic process; RNA metabolic process; gene expression; cytosol; ATP binding; nucleus; protein binding;
RPL14	7	mRNA metabolic process; RNA metabolic process; gene expression; cytoplasm; cytosol; protein binding; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
RPS9	7	mRNA metabolic process; RNA metabolic process; gene expression; cytoplasm; cytosol; protein binding; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
CSNK1E	7	DNA repair; cytosol; ATP binding; nucleus; protein serine/threonine kinase activity; protein binding; protein kinase activity;
KARS	6	metal ion binding; gene expression; cytoplasm; cytosol; ATP binding; nucleus;
LATS2	6	metal ion binding; cytosol; ATP binding; nucleus; protein serine/threonine kinase activity; protein binding;
ROCK2	6	metal ion binding; cytosol; ATP binding; nucleus; protein serine/threonine kinase activity; protein binding;
RPL37	6	metal ion binding; mRNA metabolic process; RNA metabolic process; gene expression; cytosol; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
RPL37A	6	metal ion binding; mRNA metabolic process; RNA metabolic process; gene expression; cytosol; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
TGFBR1	6	metal ion binding; peptidyl-serine phosphorylation; ATP binding; protein serine/threonine kinase activity; protein binding; protein kinase activity;
ATM	6	protein autophosphorylation; peptidyl-serine phosphorylation; DNA repair; ATP binding; protein serine/threonine kinase activity; protein binding;
MAP3K11	6	protein autophosphorylation; cytoplasm; ATP binding; protein serine/threonine kinase activity; protein binding; protein kinase activity;
SIK2	6	protein autophosphorylation; cytoplasm; ATP binding; nucleus; protein serine/threonine kinase activity; protein binding;
ADRBK1	6	peptidyl-serine phosphorylation; cytoplasm; cytosol; ATP binding; protein binding; protein kinase activity;
ILK	6	peptidyl-serine phosphorylation; cytoplasm; cytosol; ATP binding; protein serine/threonine kinase activity; protein binding;
DDX6	6	mRNA metabolic process; RNA metabolic process; gene expression; cytosol; ATP binding; protein binding;
RPL13	6	mRNA metabolic process; RNA metabolic process; gene expression; cytosol; protein binding; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
RPL35	6	mRNA metabolic process; RNA metabolic process; gene expression; cytoplasm; cytosol; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
RPS15A	6	mRNA metabolic process; RNA metabolic process; gene expression; cytoplasm; cytosol; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
RPS25	6	mRNA metabolic process; RNA metabolic process; gene expression; cytoplasm; cytosol; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
RQCD1	6	mRNA metabolic process; RNA metabolic process; gene expression; cytosol; nucleus; protein binding;
TNKS1BP1	6	mRNA metabolic process; RNA metabolic process; gene expression; cytoplasm; cytosol; nucleus;
UBB	6	mRNA metabolic process; RNA metabolic process; gene expression; DNA repair; cytosol; protein binding;
UBC	6	mRNA metabolic process; RNA metabolic process; gene expression; DNA repair; cytosol; protein binding;
XPO1	6	mRNA metabolic process; RNA metabolic process; gene expression; cytoplasm; cytosol; protein binding;
IARS	6	gene expression; cytoplasm; cytosol; ATP binding; nucleus; protein binding;
MEN1	6	gene expression; DNA repair; cytoplasm; cytosol; nucleus; protein binding;
SMC1A	6	gene expression; DNA repair; cytoplasm; ATP binding; nucleus; protein binding;
CHEK1	6	DNA repair; cytosol; ATP binding; nucleus; protein serine/threonine kinase activity; protein binding;
PIK3CG	6	cytoplasm; cytosol; ATP binding; protein serine/threonine kinase activity; protein binding; protein kinase activity;
PRKCB	6	cytoplasm; cytosol; ATP binding; nucleus; protein serine/threonine kinase activity; protein binding;
ALKBH8	5	metal ion binding; cytoplasm; cytosol; nucleus; protein binding;
CRYAB	5	metal ion binding; cytoplasm; cytosol; nucleus; protein binding;
DGCR8	5	metal ion binding; gene expression; cytoplasm; nucleus; protein binding;
PDE2A	5	metal ion binding; cytoplasm; cytosol; nucleus; protein binding;
PPP1CA	5	metal ion binding; cytoplasm; cytosol; nucleus; protein binding;
CDK12	5	protein autophosphorylation; ATP binding; nucleus; protein binding; protein kinase activity;
EEF2K	5	protein autophosphorylation; cytoplasm; cytosol; ATP binding; protein kinase activity;
FLT4	5	protein autophosphorylation; cytoplasm; ATP binding; nucleus; protein binding;
MARK2	5	protein autophosphorylation; ATP binding; nucleus; protein serine/threonine kinase activity; protein binding;
SYK	5	protein autophosphorylation; cytosol; ATP binding; protein binding; protein kinase activity;
TSSK2	5	protein autophosphorylation; cytoplasm; ATP binding; protein serine/threonine kinase activity; protein binding;
MAPK7	5	peptidyl-serine phosphorylation; cytosol; ATP binding; nucleus; protein binding;
FAU	5	mRNA metabolic process; RNA metabolic process; gene expression; cytosol; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
LSM4	5	mRNA metabolic process; RNA metabolic process; gene expression; cytosol; protein binding;
PATL1	5	mRNA metabolic process; RNA metabolic process; gene expression; cytosol; protein binding;
PSMA8	5	mRNA metabolic process; RNA metabolic process; gene expression; cytosol; nucleus;
PSMB7	5	mRNA metabolic process; RNA metabolic process; gene expression; cytosol; protein binding;
PSMD5	5	mRNA metabolic process; RNA metabolic process; gene expression; cytosol; protein binding;
PSMD7	5	mRNA metabolic process; RNA metabolic process; gene expression; cytosol; protein binding;
PSME1	5	mRNA metabolic process; RNA metabolic process; gene expression; cytoplasm; cytosol;
RPL12	5	mRNA metabolic process; RNA metabolic process; gene expression; cytosol; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
RPL38	5	mRNA metabolic process; RNA metabolic process; gene expression; cytosol; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
RPS12	5	mRNA metabolic process; RNA metabolic process; gene expression; cytosol; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
CLNS1A	5	RNA metabolic process; gene expression; cytosol; nucleus; protein binding;
PDCD4	5	RNA metabolic process; cytoplasm; cytosol; nucleus; protein binding;
SNRPD1	5	RNA metabolic process; gene expression; cytosol; nucleus; protein binding;
DHX9	5	gene expression; cytoplasm; ATP binding; nucleus; protein binding;
MAPK3	5	gene expression; cytosol; ATP binding; nucleus; protein binding;
NEDD4L	5	gene expression; cytoplasm; cytosol; nucleus; protein binding;
SSRP1	5	gene expression; DNA repair; cytoplasm; nucleus; protein binding;
YAP1	5	gene expression; cytoplasm; cytosol; nucleus; protein binding;
TAOK2	5	response to stress; cytoplasm; ATP binding; nucleus; protein serine/threonine kinase activity;
CEP164	5	DNA repair; cytoplasm; cytosol; nucleus; protein binding;
CHD1L	5	DNA repair; cytoplasm; ATP binding; nucleus; protein binding;
FANCC	5	DNA repair; cytoplasm; cytosol; nucleus; protein binding;
IGHMBP2	5	DNA repair; cytoplasm; ATP binding; nucleus; protein binding;
KIF22	5	DNA repair; cytoplasm; cytosol; ATP binding; nucleus;
PTTG1	5	DNA repair; cytoplasm; cytosol; nucleus; protein binding;
SMC2	5	DNA repair; cytoplasm; ATP binding; nucleus; protein binding;
SMC3	5	DNA repair; cytoplasm; ATP binding; nucleus; protein binding;
XRCC5	5	DNA repair; cytoplasm; ATP binding; nucleus; protein binding;
AURKC	5	cytoplasm; ATP binding; nucleus; protein serine/threonine kinase activity; protein kinase activity;
RPS6KA4	5	cytoplasm; ATP binding; nucleus; protein serine/threonine kinase activity; protein binding;
STK36	5	cytoplasm; ATP binding; nucleus; protein serine/threonine kinase activity; protein binding;
RIPK3	5	cytosol; ATP binding; protein serine/threonine kinase activity; protein binding; protein kinase activity;

Genes shared at least 2 KEGG pathways with SMG1 (count: 0)

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Region: chr16:18816175..18937776 View in gBrowse