ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CHEK1
Symbol Alias	CHK1
Approved Name	CHK1 checkpoint homolog (S. pombe)
Previous Name	CHK1 (checkpoint, S.pombe) homolog
Location	11q24.2
Position	chr11:125495036-125546150, +
External Links	HGNC: 1925 Entrez Gene: 1111 Ensembl: ENSG00000149554 UCSC: uc001qcg.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 33)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 33)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0090399	replicative senescence	Biological Process	NAS[15149599]	2
GO:2000615	regulation of histone H3-K9 acetylation	Biological Process		1
GO:0071260	cellular response to mechanical stimulus	Biological Process	IEP[19593445]	14
GO:0071313	cellular response to caffeine	Biological Process		4
GO:0048096	chromatin-mediated maintenance of transcription	Biological Process		1
GO:0046602	regulation of mitotic centrosome separation	Biological Process	IDA[15311285]	1
GO:0045839	negative regulation of mitosis	Biological Process	IDA[15311285]	1
GO:0042127	regulation of cell proliferation	Biological Process		20
GO:0035407	histone H3-T11 phosphorylation	Biological Process	IDA[18243098]	1
GO:0035402	histone kinase activity (H3-T11 specific)	Molecular Function	IDA[18243098]	1
GO:0033261	regulation of S phase	Biological Process		1
GO:0031572	G2/M transition DNA damage checkpoint	Biological Process		7
GO:0018107	peptidyl-threonine phosphorylation	Biological Process	IDA[15665856]	3
GO:0010767	regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage	Biological Process		1
GO:0010569	regulation of double-strand break repair via homologous recombination	Biological Process	IDA[15665856]	3
GO:0006975	DNA damage induced protein phosphorylation	Biological Process	IDA[16963448]	2
GO:0006974	response to DNA damage stimulus	Biological Process		37
GO:0006281	DNA repair	Biological Process	IMP[19716789]	62
GO:0006260	DNA replication	Biological Process		27
GO:0005829	cytosol	Cellular Component		447
GO:0000075	cell cycle checkpoint	Biological Process		21
GO:0000785	chromatin	Cellular Component		13
GO:0000781	chromosome, telomeric region	Cellular Component	IDA[15149599]	9
GO:0000086	G2/M transition of mitotic cell cycle	Biological Process		29
GO:0000077	DNA damage checkpoint	Biological Process	IDA[16963448]; IMP[19716789]	7
GO:0005524	ATP binding	Molecular Function		228
GO:0005515	protein binding	Molecular Function		910
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IDA[16963448]	61
GO:0000794	condensed nuclear chromosome	Cellular Component	IDA[9382850]	6
GO:0005813	centrosome	Cellular Component	IDA[15311285]	71
GO:0005657	replication fork	Cellular Component		3
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005634	nucleus	Cellular Component		770

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04110	Cell cycle	19	Mitotic cell cycle progression is accomplished through a rep...... Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated. More...
hsa04115	p53 signaling pathway	14	p53 activation is induced by a number of stress signals, inc...... p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways. More...

Genes shared at least 5 GO terms with CHEK1 (count: 62)

Gene Symbol	Pathway Count	Pathway List
ATM	11	replicative senescence; G2/M transition DNA damage checkpoint; DNA damage induced protein phosphorylation; response to DNA damage stimulus; DNA repair; cell cycle checkpoint; chromosome, telomeric region; ATP binding; protein binding; protein serine/threonine kinase activity; nucleoplasm;
PLK1	9	G2/M transition DNA damage checkpoint; cytosol; G2/M transition of mitotic cell cycle; ATP binding; protein binding; protein serine/threonine kinase activity; centrosome; nucleoplasm; nucleus;
H2AFX	9	response to DNA damage stimulus; DNA repair; chromosome, telomeric region; DNA damage checkpoint; protein binding; condensed nuclear chromosome; replication fork; nucleoplasm; nucleus;
RAD1	8	response to DNA damage stimulus; DNA repair; DNA replication; cell cycle checkpoint; DNA damage checkpoint; protein binding; nucleoplasm; nucleus;
RAD9A	8	response to DNA damage stimulus; DNA repair; DNA replication; cell cycle checkpoint; DNA damage checkpoint; protein binding; nucleoplasm; nucleus;
MAPK3	7	cellular response to mechanical stimulus; response to DNA damage stimulus; cytosol; ATP binding; protein binding; nucleoplasm; nucleus;
MAPK1	7	response to DNA damage stimulus; cytosol; ATP binding; protein binding; protein serine/threonine kinase activity; nucleoplasm; nucleus;
MEN1	7	response to DNA damage stimulus; DNA repair; cytosol; chromatin; protein binding; nucleoplasm; nucleus;
MRE11A	7	response to DNA damage stimulus; DNA repair; cell cycle checkpoint; chromosome, telomeric region; protein binding; nucleoplasm; nucleus;
TP53BP1	7	response to DNA damage stimulus; DNA repair; chromosome, telomeric region; protein binding; replication fork; nucleoplasm; nucleus;
CSNK1E	7	DNA repair; cytosol; G2/M transition of mitotic cell cycle; ATP binding; protein binding; protein serine/threonine kinase activity; nucleus;
SMC1A	7	DNA repair; cell cycle checkpoint; ATP binding; protein binding; condensed nuclear chromosome; nucleoplasm; nucleus;
EGLN3	6	regulation of cell proliferation; response to DNA damage stimulus; cytosol; protein binding; nucleoplasm; nucleus;
NCOA6	6	response to DNA damage stimulus; DNA repair; DNA replication; protein binding; nucleoplasm; nucleus;
USP28	6	response to DNA damage stimulus; DNA repair; DNA damage checkpoint; protein binding; nucleoplasm; nucleus;
CEP164	6	DNA repair; cytosol; G2/M transition of mitotic cell cycle; protein binding; centrosome; nucleus;
SMC3	6	DNA repair; chromatin; ATP binding; protein binding; nucleoplasm; nucleus;
SMG1	6	DNA repair; cytosol; ATP binding; protein binding; protein serine/threonine kinase activity; nucleus;
CDC45	6	DNA replication; cell cycle checkpoint; protein binding; centrosome; nucleoplasm; nucleus;
GSK3B	6	cytosol; ATP binding; protein binding; protein serine/threonine kinase activity; centrosome; nucleus;
KIF23	6	cytosol; ATP binding; protein binding; centrosome; nucleoplasm; nucleus;
PSMC3	6	cytosol; cell cycle checkpoint; ATP binding; protein binding; nucleoplasm; nucleus;
RFWD2	6	cytosol; cell cycle checkpoint; protein binding; centrosome; nucleoplasm; nucleus;
ROCK2	6	cytosol; ATP binding; protein binding; protein serine/threonine kinase activity; centrosome; nucleus;
FANCA	5	regulation of cell proliferation; DNA repair; protein binding; nucleoplasm; nucleus;
SGK1	5	regulation of cell proliferation; response to DNA damage stimulus; ATP binding; protein serine/threonine kinase activity; nucleus;
NEK6	5	G2/M transition DNA damage checkpoint; ATP binding; protein binding; protein serine/threonine kinase activity; nucleus;
RBBP8	5	G2/M transition DNA damage checkpoint; DNA repair; cell cycle checkpoint; protein binding; nucleus;
TAOK2	5	G2/M transition DNA damage checkpoint; response to DNA damage stimulus; ATP binding; protein serine/threonine kinase activity; nucleus;
TERF2IP	5	regulation of double-strand break repair via homologous recombination; chromosome, telomeric region; protein binding; nucleoplasm; nucleus;
APC	5	response to DNA damage stimulus; cytosol; protein binding; centrosome; nucleus;
CCND1	5	response to DNA damage stimulus; cytosol; protein binding; nucleoplasm; nucleus;
CHD1L	5	response to DNA damage stimulus; DNA repair; ATP binding; protein binding; nucleus;
ERCC8	5	response to DNA damage stimulus; DNA repair; protein binding; nucleoplasm; nucleus;
IRF7	5	response to DNA damage stimulus; cytosol; protein binding; nucleoplasm; nucleus;
TRIP12	5	response to DNA damage stimulus; DNA repair; protein binding; nucleoplasm; nucleus;
YAP1	5	response to DNA damage stimulus; cytosol; protein binding; nucleoplasm; nucleus;
DDB1	5	DNA repair; cell cycle checkpoint; protein binding; nucleoplasm; nucleus;
FANCC	5	DNA repair; cytosol; protein binding; nucleoplasm; nucleus;
FEN1	5	DNA repair; DNA replication; protein binding; nucleoplasm; nucleus;
HINFP	5	DNA repair; DNA damage checkpoint; protein binding; nucleoplasm; nucleus;
IGHMBP2	5	DNA repair; DNA replication; ATP binding; protein binding; nucleus;
KIF22	5	DNA repair; cytosol; chromatin; ATP binding; nucleus;
POLD4	5	DNA repair; DNA replication; protein binding; nucleoplasm; nucleus;
SSRP1	5	DNA repair; DNA replication; protein binding; nucleoplasm; nucleus;
UBB	5	DNA repair; cytosol; cell cycle checkpoint; protein binding; nucleoplasm;
UBC	5	DNA repair; cytosol; cell cycle checkpoint; protein binding; nucleoplasm;
XRCC5	5	DNA repair; ATP binding; protein binding; nucleoplasm; nucleus;
CDT1	5	DNA replication; cytosol; protein binding; nucleoplasm; nucleus;
ANAPC4	5	cytosol; cell cycle checkpoint; G2/M transition of mitotic cell cycle; nucleoplasm; nucleus;
CEP57	5	cytosol; G2/M transition of mitotic cell cycle; protein binding; centrosome; nucleus;
LATS1	5	cytosol; G2/M transition of mitotic cell cycle; ATP binding; protein binding; protein serine/threonine kinase activity;
LATS2	5	cytosol; ATP binding; protein binding; protein serine/threonine kinase activity; nucleus;
MAP2K3	5	cytosol; ATP binding; protein binding; protein serine/threonine kinase activity; nucleoplasm;
MAPK7	5	cytosol; ATP binding; protein binding; nucleoplasm; nucleus;
NUMA1	5	cytosol; G2/M transition of mitotic cell cycle; protein binding; nucleoplasm; nucleus;
PAFAH1B1	5	cytosol; G2/M transition of mitotic cell cycle; protein binding; centrosome; nucleus;
PRKCB	5	cytosol; ATP binding; protein binding; protein serine/threonine kinase activity; nucleus;
PRKD1	5	cytosol; ATP binding; protein binding; protein serine/threonine kinase activity; nucleus;
TUBG1	5	cytosol; G2/M transition of mitotic cell cycle; protein binding; condensed nuclear chromosome; centrosome;
TUBGCP2	5	cytosol; G2/M transition of mitotic cell cycle; protein binding; centrosome; nucleus;
DHX9	5	ATP binding; protein binding; centrosome; nucleoplasm; nucleus;

Genes shared at least 2 KEGG pathways with CHEK1 (count: 3)

Gene Symbol	Pathway Count	Pathway List
ATM	2	Cell cycle; p53 signaling pathway;
CCND1	2	Cell cycle; p53 signaling pathway;
GADD45G	2	Cell cycle; p53 signaling pathway;

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Region: chr11:125495036..125546150 View in gBrowse