ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ANAPC4
Symbol Alias	APC4
Approved Name	anaphase promoting complex subunit 4
Location	4p15.31
Position	chr4:25378835-25420120, 1
External Links	HGNC: 19990 Entrez Gene: 29945 Ensembl: ENSG00000053900 UCSC: uc003gro.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_18	chr4:23596065-27014659 (NCBI Build 36.1 (hg18))	3365040	4p15.2	Gain

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 19)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 19)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005829	cytosol	cellular component	TAS	485
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	biological process	TAS	14
GO:0019903	protein phosphatase binding	molecular function	IPI	12
GO:0051301	cell division	biological process	IEA	68
GO:0070979	protein K11-linked ubiquitination	biological process	IDA[18485873]	3
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	biological process	TAS	10
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	biological process	TAS	12
GO:0006511	ubiquitin-dependent protein catabolic process	biological process	TAS[9469815]	31
GO:0004842	ubiquitin-protein ligase activity	molecular function	TAS[6180011]	60
GO:0005680	anaphase-promoting complex	cellular component	IDA	3
GO:0000086	G2/M transition of mitotic cell cycle	biological process	TAS[9469815]	34
GO:0007067	mitosis	biological process	TAS[9469815]	45
GO:0005654	nucleoplasm	cellular component	TAS	210
GO:0000278	mitotic cell cycle	biological process	TAS	66
GO:0000090	mitotic anaphase	biological process	TAS[9469815]	4
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	biological process	TAS	12
GO:0000075	cell cycle checkpoint	biological process	TAS	21
GO:0007094	mitotic cell cycle spindle assembly checkpoint	biological process	TAS	7
GO:0005634	nucleus	cellular component	IDA	877

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04120	Ubiquitin mediated proteolysis	34
hsa04110	Cell cycle	19

Genes shared at least 5 GO terms with ANAPC4 (count: 24)

Gene Symbol	Pathway Count	Pathway List
CDC26	13	cytosol; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; protein K11-linked ubiquitination; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; anaphase-promoting complex; mitosis; nucleoplasm; mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; cell cycle checkpoint; mitotic cell cycle spindle assembly checkpoint;
PSMC3	9	cytosol; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleoplasm; mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; cell cycle checkpoint; nucleus;
PLK1	9	cytosol; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; G2/M transition of mitotic cell cycle; mitosis; nucleoplasm; mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleus;
UBC	8	cytosol; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleoplasm; mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; cell cycle checkpoint;
PSME1	8	cytosol; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleoplasm; mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; cell cycle checkpoint;
PSMD5	8	cytosol; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleoplasm; mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; cell cycle checkpoint;
PSME2	8	cytosol; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleoplasm; mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; cell cycle checkpoint;
PSMD7	8	cytosol; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleoplasm; mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; cell cycle checkpoint;
UBB	8	cytosol; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleoplasm; mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; cell cycle checkpoint;
PSMB7	8	cytosol; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleoplasm; mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; cell cycle checkpoint;
NUMA1	7	cytosol; cell division; G2/M transition of mitotic cell cycle; nucleoplasm; mitotic cell cycle; mitotic anaphase; nucleus;
MAD1L1	7	cytosol; cell division; mitotic cell cycle; mitotic anaphase; cell cycle checkpoint; mitotic cell cycle spindle assembly checkpoint; nucleus;
PSMA8	7	cytosol; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; cell cycle checkpoint; nucleus;
CDC25B	6	cytosol; cell division; G2/M transition of mitotic cell cycle; mitosis; nucleoplasm; mitotic cell cycle;
SKP2	6	cytosol; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; G2/M transition of mitotic cell cycle; nucleoplasm; mitotic cell cycle;
PTTG1	6	cytosol; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; mitosis; mitotic cell cycle; nucleus;
CEP164	6	cytosol; cell division; G2/M transition of mitotic cell cycle; mitosis; mitotic cell cycle; nucleus;
CCND1	5	cytosol; cell division; nucleoplasm; mitotic cell cycle; nucleus;
CHEK1	5	cytosol; G2/M transition of mitotic cell cycle; nucleoplasm; cell cycle checkpoint; nucleus;
KIF2C	5	cytosol; cell division; mitosis; mitotic cell cycle; nucleus;
UBE2I	5	cell division; ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; mitosis; nucleus;
SMC3	5	cell division; mitosis; nucleoplasm; mitotic cell cycle; nucleus;
FBXL7	5	cell division; ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; G2/M transition of mitotic cell cycle; mitosis;
SMC1A	5	cell division; nucleoplasm; mitotic cell cycle; cell cycle checkpoint; nucleus;

Genes shared at least 2 KEGG pathways with ANAPC4 (count: 2)

Gene Symbol	Pathway Count	Pathway List
CDC26	2	Ubiquitin mediated proteolysis; Cell cycle;
SKP2	2	Ubiquitin mediated proteolysis; Cell cycle;

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Region: chr4:25378835..25420120 View in gBrowse