ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	SKP2
Symbol Alias	FBXL1, FBL1, p45
Approved Name	S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
Previous Name	"S-phase kinase-associated protein 2 (p45)"
Location	5p13
Position	chr5:36152091-36184421, 1
External Links	HGNC: 10901 Entrez Gene: 6502 Ensembl: ENSG00000145604 UCSC: uc003jkc.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (significant/non-significant/trend)
5p	chr5:0-48400000	1 (1/0/0)
5p13	chr5:28900000-42500000	3 (1/1/1)

Gene related GO terms (count: 18)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0071460	cellular response to cell-matrix adhesion	biological process	IEA	1
GO:0005515	protein binding	molecular function	IPI	1015
GO:0000084	S phase of mitotic cell cycle	biological process	TAS	19
GO:0048661	positive regulation of smooth muscle cell proliferation	biological process	IEA	5
GO:0019005	SCF ubiquitin ligase complex	cellular component	IDA[16880511]	6
GO:0000209	protein polyubiquitination	biological process	IEA	26
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	biological process	TAS	14
GO:0000086	G2/M transition of mitotic cell cycle	biological process	IEA	34
GO:0042802	identical protein binding	molecular function	IPI	77
GO:0005654	nucleoplasm	cellular component	TAS	210
GO:0051726	regulation of cell cycle	biological process	IEA	10
GO:0000082	G1/S transition of mitotic cell cycle	biological process	TAS	27
GO:0005829	cytosol	cellular component	TAS	485
GO:0000278	mitotic cell cycle	biological process	TAS	66
GO:0004842	ubiquitin-protein ligase activity	molecular function	IEA	60
GO:0000080	G1 phase of mitotic cell cycle	biological process	TAS	5
GO:0008283	cell proliferation	biological process	TAS[7553852]	66
GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway	biological process	IEA	3

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene
hsa05222	Small cell lung cancer	17
hsa04120	Ubiquitin mediated proteolysis	34
hsa04110	Cell cycle	19

Genes shared at least 5 GO terms with SKP2 (count: 22)

Gene Symbol	Pathway Count	Pathway List
UBC	9	protein binding; S phase of mitotic cell cycle; protein polyubiquitination; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; nucleoplasm; G1/S transition of mitotic cell cycle; cytosol; mitotic cell cycle; G1 phase of mitotic cell cycle;
UBB	9	protein binding; S phase of mitotic cell cycle; protein polyubiquitination; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; nucleoplasm; G1/S transition of mitotic cell cycle; cytosol; mitotic cell cycle; G1 phase of mitotic cell cycle;
PSMD7	8	protein binding; S phase of mitotic cell cycle; protein polyubiquitination; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; nucleoplasm; G1/S transition of mitotic cell cycle; cytosol; mitotic cell cycle;
PSMB7	8	protein binding; S phase of mitotic cell cycle; protein polyubiquitination; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; nucleoplasm; G1/S transition of mitotic cell cycle; cytosol; mitotic cell cycle;
PSMD5	8	protein binding; S phase of mitotic cell cycle; protein polyubiquitination; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; nucleoplasm; G1/S transition of mitotic cell cycle; cytosol; mitotic cell cycle;
PLK1	8	protein binding; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; G2/M transition of mitotic cell cycle; nucleoplasm; regulation of cell cycle; cytosol; mitotic cell cycle; cell proliferation;
PSMC3	8	protein binding; S phase of mitotic cell cycle; protein polyubiquitination; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; nucleoplasm; G1/S transition of mitotic cell cycle; cytosol; mitotic cell cycle;
CCND1	7	protein binding; S phase of mitotic cell cycle; nucleoplasm; G1/S transition of mitotic cell cycle; cytosol; mitotic cell cycle; G1 phase of mitotic cell cycle;
PSME1	7	S phase of mitotic cell cycle; protein polyubiquitination; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; nucleoplasm; G1/S transition of mitotic cell cycle; cytosol; mitotic cell cycle;
PSME2	7	S phase of mitotic cell cycle; protein polyubiquitination; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; nucleoplasm; G1/S transition of mitotic cell cycle; cytosol; mitotic cell cycle;
CDT1	6	protein binding; S phase of mitotic cell cycle; nucleoplasm; G1/S transition of mitotic cell cycle; cytosol; mitotic cell cycle;
PKMYT1	6	protein binding; G2/M transition of mitotic cell cycle; nucleoplasm; regulation of cell cycle; G1/S transition of mitotic cell cycle; mitotic cell cycle;
ANAPC4	6	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; G2/M transition of mitotic cell cycle; nucleoplasm; cytosol; mitotic cell cycle; ubiquitin-protein ligase activity;
CDC26	5	protein binding; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; nucleoplasm; cytosol; mitotic cell cycle;
BIRC2	5	protein binding; protein polyubiquitination; regulation of cell cycle; cytosol; ubiquitin-protein ligase activity;
MAPRE1	5	protein binding; G2/M transition of mitotic cell cycle; cytosol; mitotic cell cycle; cell proliferation;
RRM2	5	protein binding; nucleoplasm; G1/S transition of mitotic cell cycle; cytosol; mitotic cell cycle;
CEP72	5	protein binding; G2/M transition of mitotic cell cycle; identical protein binding; cytosol; mitotic cell cycle;
NUMA1	5	protein binding; G2/M transition of mitotic cell cycle; nucleoplasm; cytosol; mitotic cell cycle;
CDC45	5	protein binding; S phase of mitotic cell cycle; nucleoplasm; G1/S transition of mitotic cell cycle; mitotic cell cycle;
NDE1	5	protein binding; G2/M transition of mitotic cell cycle; identical protein binding; cytosol; mitotic cell cycle;
PSMA8	5	S phase of mitotic cell cycle; protein polyubiquitination; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cytosol; mitotic cell cycle;

Genes shared at least 2 KEGG pathways with SKP2 (count: 5)

Gene Symbol	Pathway Count	Pathway List
CCND1	2	Small cell lung cancer; Cell cycle;
BIRC3	2	Small cell lung cancer; Ubiquitin mediated proteolysis;
BIRC2	2	Small cell lung cancer; Ubiquitin mediated proteolysis;
CDC26	2	Ubiquitin mediated proteolysis; Cell cycle;
ANAPC4	2	Ubiquitin mediated proteolysis; Cell cycle;

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Region: chr5:36152091..36184421 View in gBrowse