ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0042802
Name	identical protein binding
Type	Molecular Function
No. of Genes in ADHDgene	70
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 70)

Literature-origin genes (count: 9)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
VEGFA	vascular endothelial growth factor A	6p12	1(0/1/0)
ASMT	acetylserotonin O-methyltransferase	Xp22.3 and Yp11.3	1(1/0/0)
ATXN1	ataxin 1	6p23	1(0/0/1)	IPI[16713569]
SYP	synaptophysin	Xp11.23-p11.22	3(3/0/0)
BAIAP2	BAI1-associated protein 2	17q25	1(1/0/0)	IPI[14752106]
PTPRG	protein tyrosine phosphatase, receptor type, G	3p21-p14	1(0/0/1)	IPI[19167335]
SYT1	synaptotagmin I	12cen-q21	4(2/2/0)
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	4q21.3-q22	1(0/1/0)	IPI[18614564]
DNM1	dynamin 1	9q34	1(0/0/1)

Genes from other sources (count: 61)

Approved Symbol	Approved Name	Source	Evidence[PMID]
APLP2	amyloid beta (A4) precursor-like protein 2	Mapped by significant region	IPI[16193067]
VIL1	villin 1	Mapped by significant region	IPI[17606613]
P2RX6	purinergic receptor P2X, ligand-gated ion channel, 6	Mapped by CNV	IPI[15313628]
ZBTB16	zinc finger and BTB domain containing 16	Mapped by significant region	IPI[9294197]
PRKAB2	protein kinase, AMP-activated, beta 2 non-catalytic subunit	Mapped by CNV
GRIN3A	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	Mapped by significant region	IPI[17997397]
STAC3	SH3 and cysteine rich domain 3	Mapped by CNV	IPI[16189514]
SQSTM1	sequestosome 1	Mapped by CNV
ALAD	aminolevulinate dehydratase	Mapped by significant region	IPI[11032836]
BNIP3	BCL2/adenovirus E1B 19kDa interacting protein 3	Mapped by CNV	IPI[16189514]
HOOK3	hook homolog 3 (Drosophila)	Mapped by PBA pathway	IPI[18799622]
MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	Mapped by significant region	IPI[11313484]
THG1L	tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)	Mapped by significant region
MAP1S	microtubule-associated protein 1S	Mapped by PBA pathway
PLN	phospholamban	Mapped by significant region
SYT9	synaptotagmin IX	Mapped by CNV
PYCRL	pyrroline-5-carboxylate reductase-like	Mapped by LD-proxy
RIPK3	receptor-interacting serine-threonine kinase 3	Mapped by significant region
PRKD1	protein kinase D1	Mapped by significant region	IPI[19135240]
NDE1	nudE nuclear distribution gene E homolog 1 (A. nidulans)	Mapped by CNV; Mapped by significant region
KCNRG	potassium channel regulator	Mapped by LD-proxy	IPI[19447967]
GPSM2	G-protein signaling modulator 2	Mapped by CNV	IPI[15537540]
SKP2	S-phase kinase-associated protein 2 (p45)	Mapped by significant region
CPT1A	carnitine palmitoyltransferase 1A (liver)	Mapped by CNV; Mapped by significant region
ATL3	atlastin GTPase 3	Mapped by significant region	IDA[18270207]
PRPF19	PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)	Mapped by significant region	IPI[16332694]
KCTD13	potassium channel tetramerisation domain containing 13	Mapped by CNV
PTS	6-pyruvoyltetrahydropterin synthase	Mapped by significant region	IPI[16189514]
RILPL2	Rab interacting lysosomal protein-like 2	Mapped by CNV	IPI[16189514]
TSSK2	testis-specific serine kinase 2	Mapped by CNV	IPI[15044604]
MAP3K11	mitogen-activated protein kinase kinase kinase 11	Mapped by significant region	IPI[9829970]
CLDN5	claudin 5	Mapped by CNV
CTSC	cathepsin C	Mapped by significant region
TNN	tenascin N	Mapped by significant region
CBX3	chromobox homolog 3	Mapped by CNV; Mapped by significant region
C1QTNF3	C1q and tumor necrosis factor related protein 3	Mapped by significant region
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	Mapped by significant region	IPI[7527811]
SSSCA1	Sjogren syndrome/scleroderma autoantigen 1	Mapped by significant region
ACY3	aspartoacylase (aminocyclase) 3	Mapped by significant region
USP2	ubiquitin specific peptidase 2	Mapped by significant region
GLUL	glutamate-ammonia ligase	Mapped by significant region
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	Mapped by LD-proxy
APOA1	apolipoprotein A-I	Mapped by significant region	IPI[8049247]
PON2	paraoxonase 2	Mapped by PBA pathway	IDA[15772423]
TRIM5	tripartite motif containing 5	Mapped by CNV
TPCN2	two pore segment channel 2	Mapped by CNV; Mapped by significant region
FADD	Fas (TNFRSF6)-associated via death domain	Mapped by significant region	IPI[8681376]
ALDOB	aldolase B, fructose-bisphosphate	Mapped by significant region	IPI[10625657]
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	Mapped by significant region
EED	embryonic ectoderm development	Mapped by significant region	IPI[11124122]
MAP3K5	mitogen-activated protein kinase kinase kinase 5	Mapped by LD-proxy; Mapped by significant region
AMOTL1	angiomotin like 1	Mapped by significant region	IDA[16019084]
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mapped by significant region	IDA[9437432]; IPI[10498867]
ALDOA	aldolase A, fructose-bisphosphate	Mapped by CNV	TAS[14766013]
TTK	TTK protein kinase	Mapped by PBA pathway
C1QTNF2	C1q and tumor necrosis factor related protein 2	Mapped by significant region
RYR2	ryanodine receptor 2 (cardiac)	Mapped by CNV; Mapped by PBA pathway	IPI[10830164]
SHMT2	serine hydroxymethyltransferase 2 (mitochondrial)	Mapped by CNV
TPD52L1	tumor protein D52-like 1	Mapped by significant region	IPI[9484778]
PRC1	protein regulator of cytokinesis 1	Mapped by PBA pathway
HNRNPC	heterogeneous nuclear ribonucleoprotein C (C1/C2)	Mapped by PBA pathway	IPI[16189514]