ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PSMA8
Symbol Alias	MGC26605, PSMA7L
Approved Name	proteasome (prosome, macropain) subunit, alpha type, 8
Location	18q11.2
Position	chr18:23713816-23773319, +
External Links	HGNC: 22985 Entrez Gene: 143471 Ensembl: ENSG00000154611 UCSC: uc002kvp.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
18q11.2-12.3	chr18:19000000-43500000	1 (1/0/0)

Gene related GO terms (count: 25)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 25)

ID	Name	Type	No. of Genes in ADHDgene
GO:0005634	nucleus	Cellular Component	770
GO:0005829	cytosol	Cellular Component	447
GO:0006521	regulation of cellular amino acid metabolic process	Biological Process	9
GO:0006915	apoptotic process	Biological Process	111
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	Biological Process	11
GO:0010467	gene expression	Biological Process	140
GO:0016032	viral reproduction	Biological Process	57
GO:0016070	RNA metabolic process	Biological Process	46
GO:0000075	cell cycle checkpoint	Biological Process	21
GO:0000084	S phase of mitotic cell cycle	Biological Process	20
GO:0000209	protein polyubiquitination	Biological Process	23
GO:0000216	M/G1 transition of mitotic cell cycle	Biological Process	13
GO:0000278	mitotic cell cycle	Biological Process	63
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	Biological Process	17
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	Biological Process	14
GO:0004298	threonine-type endopeptidase activity	Molecular Function	3
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	Biological Process	12
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	Biological Process	12
GO:0044281	small molecule metabolic process	Biological Process	248
GO:0042981	regulation of apoptotic process	Biological Process	32
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	Biological Process	14
GO:0034641	cellular nitrogen compound metabolic process	Biological Process	30
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	14
GO:0019773	proteasome core complex, alpha-subunit complex	Cellular Component	1
GO:0016071	mRNA metabolic process	Biological Process	34

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03050	Proteasome	7	The proteasome is a protein-destroying apparatus involved in...... The proteasome is a protein-destroying apparatus involved in many essential cellular functions, such as regulation of cell cycle, cell differentiation, signal transduction pathways, antigen processing for appropriate immune responses, stress signaling, inflammatory responses, and apoptosis. It is capable of degrading a variety of cellular proteins in a rapid and timely fashion and most substrate proteins are modified by ubiquitin before their degradation by the proteasome. The proteasome is a large protein complex consisting of a proteolytic core called the 20S particle and ancillary factors that regulate its activity in various ways. The most common form is the 26S proteasome containing one 20S core particle and two 19S regulatory particles that enable the proteasome to degrade ubiquitinated proteins by an ATP-dependent mechanism. Another form is the immunoproteasome containing two 11S regulatory particles, PA28 alpha and PA28 beta, which are induced by interferon gamma under the conditions of intensified immune response. Other regulatory particles include PA28 gamma and PA200. Although PA28 gamma also belongs to a family of activators of the 20S proteasome, it is localized within the nucleus and forms a homoheptamer. PA28 gamma has been implicated in the regulation of cell cycle progression and apoptosis. PA200 has been identified as a large nuclear protein that stimulates proteasomal hydrolysis of peptides. More...

Genes shared at least 5 GO terms with PSMA8 (count: 36)

Gene Symbol	Pathway Count	Pathway List
PSMC3	23	nucleus; cytosol; regulation of cellular amino acid metabolic process; apoptotic process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; gene expression; viral reproduction; RNA metabolic process; cell cycle checkpoint; S phase of mitotic cell cycle; protein polyubiquitination; M/G1 transition of mitotic cell cycle; mitotic cell cycle; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; small molecule metabolic process; regulation of apoptotic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; cellular nitrogen compound metabolic process; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mRNA metabolic process;
PSMB7	23	cytosol; regulation of cellular amino acid metabolic process; apoptotic process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; gene expression; viral reproduction; RNA metabolic process; cell cycle checkpoint; S phase of mitotic cell cycle; protein polyubiquitination; M/G1 transition of mitotic cell cycle; mitotic cell cycle; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; threonine-type endopeptidase activity; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; small molecule metabolic process; regulation of apoptotic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; cellular nitrogen compound metabolic process; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mRNA metabolic process;
PSMD5	22	cytosol; regulation of cellular amino acid metabolic process; apoptotic process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; gene expression; viral reproduction; RNA metabolic process; cell cycle checkpoint; S phase of mitotic cell cycle; protein polyubiquitination; M/G1 transition of mitotic cell cycle; mitotic cell cycle; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; small molecule metabolic process; regulation of apoptotic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; cellular nitrogen compound metabolic process; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mRNA metabolic process;
PSMD7	22	cytosol; regulation of cellular amino acid metabolic process; apoptotic process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; gene expression; viral reproduction; RNA metabolic process; cell cycle checkpoint; S phase of mitotic cell cycle; protein polyubiquitination; M/G1 transition of mitotic cell cycle; mitotic cell cycle; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; small molecule metabolic process; regulation of apoptotic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; cellular nitrogen compound metabolic process; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mRNA metabolic process;
PSME1	22	cytosol; regulation of cellular amino acid metabolic process; apoptotic process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; gene expression; viral reproduction; RNA metabolic process; cell cycle checkpoint; S phase of mitotic cell cycle; protein polyubiquitination; M/G1 transition of mitotic cell cycle; mitotic cell cycle; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; small molecule metabolic process; regulation of apoptotic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; cellular nitrogen compound metabolic process; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mRNA metabolic process;
PSME2	22	cytosol; regulation of cellular amino acid metabolic process; apoptotic process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; gene expression; viral reproduction; RNA metabolic process; cell cycle checkpoint; S phase of mitotic cell cycle; protein polyubiquitination; M/G1 transition of mitotic cell cycle; mitotic cell cycle; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; small molecule metabolic process; regulation of apoptotic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; cellular nitrogen compound metabolic process; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mRNA metabolic process;
UBB	19	cytosol; apoptotic process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; gene expression; viral reproduction; RNA metabolic process; cell cycle checkpoint; S phase of mitotic cell cycle; protein polyubiquitination; M/G1 transition of mitotic cell cycle; mitotic cell cycle; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; regulation of apoptotic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mRNA metabolic process;
UBC	19	cytosol; apoptotic process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; gene expression; viral reproduction; RNA metabolic process; cell cycle checkpoint; S phase of mitotic cell cycle; protein polyubiquitination; M/G1 transition of mitotic cell cycle; mitotic cell cycle; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; regulation of apoptotic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mRNA metabolic process;
ANAPC4	7	nucleus; cytosol; cell cycle checkpoint; mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;
NCBP1	6	nucleus; cytosol; gene expression; viral reproduction; RNA metabolic process; mRNA metabolic process;
PLK1	6	nucleus; cytosol; mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;
RPS3	6	nucleus; cytosol; gene expression; viral reproduction; RNA metabolic process; mRNA metabolic process;
CDC26	6	cytosol; cell cycle checkpoint; mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;
XPO1	6	cytosol; gene expression; viral reproduction; RNA metabolic process; mitotic cell cycle; mRNA metabolic process;
CDC45	5	nucleus; cell cycle checkpoint; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle; mitotic cell cycle;
CDT1	5	nucleus; cytosol; S phase of mitotic cell cycle; M/G1 transition of mitotic cell cycle; mitotic cell cycle;
CNOT6	5	nucleus; cytosol; gene expression; RNA metabolic process; mRNA metabolic process;
DCPS	5	nucleus; cytosol; gene expression; RNA metabolic process; mRNA metabolic process;
HSPA8	5	nucleus; cytosol; gene expression; RNA metabolic process; mRNA metabolic process;
RQCD1	5	nucleus; cytosol; gene expression; RNA metabolic process; mRNA metabolic process;
SMG1	5	nucleus; cytosol; gene expression; RNA metabolic process; mRNA metabolic process;
SMG7	5	nucleus; cytosol; gene expression; RNA metabolic process; mRNA metabolic process;
TNKS1BP1	5	nucleus; cytosol; gene expression; RNA metabolic process; mRNA metabolic process;
FAU	5	cytosol; gene expression; viral reproduction; RNA metabolic process; mRNA metabolic process;
RPL12	5	cytosol; gene expression; viral reproduction; RNA metabolic process; mRNA metabolic process;
RPL13	5	cytosol; gene expression; viral reproduction; RNA metabolic process; mRNA metabolic process;
RPL14	5	cytosol; gene expression; viral reproduction; RNA metabolic process; mRNA metabolic process;
RPL35	5	cytosol; gene expression; viral reproduction; RNA metabolic process; mRNA metabolic process;
RPL37	5	cytosol; gene expression; viral reproduction; RNA metabolic process; mRNA metabolic process;
RPL37A	5	cytosol; gene expression; viral reproduction; RNA metabolic process; mRNA metabolic process;
RPL38	5	cytosol; gene expression; viral reproduction; RNA metabolic process; mRNA metabolic process;
RPS12	5	cytosol; gene expression; viral reproduction; RNA metabolic process; mRNA metabolic process;
RPS15A	5	cytosol; gene expression; viral reproduction; RNA metabolic process; mRNA metabolic process;
RPS25	5	cytosol; gene expression; viral reproduction; RNA metabolic process; mRNA metabolic process;
RPS9	5	cytosol; gene expression; viral reproduction; RNA metabolic process; mRNA metabolic process;
SKP2	5	cytosol; S phase of mitotic cell cycle; protein polyubiquitination; mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;

Genes shared at least 2 KEGG pathways with PSMA8 (count: 0)

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Region: chr18:23713816..23773319 View in gBrowse