ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	RPS3
Symbol Alias	FLJ26283, FLJ27450, MGC87870, S3
Approved Name	ribosomal protein S3
Name Alias	IMR-90 ribosomal protein S3, "40S ribosomal protein S3"
Location	11q13.3-q13.5
Position	chr11:75110530-75133324, +
External Links	HGNC: 10420 Entrez Gene: 6188 Ensembl: ENSG00000149273 UCSC: uc001owh.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 33)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 33)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	Biological Process		16
GO:0003684	damaged DNA binding	Molecular Function	IDA[16737853]	10
GO:0003729	mRNA binding	Molecular Function	IDA[18464793]	10
GO:0003735	structural constituent of ribosome	Molecular Function	IDA[15883184]; NAS[1712897]	24
GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity	Molecular Function	IDA[16737853]	2
GO:0004519	endonuclease activity	Molecular Function		7
GO:0005515	protein binding	Molecular Function		910
GO:0005634	nucleus	Cellular Component	IDA[18045535]	770
GO:0005737	cytoplasm	Cellular Component	IDA[14988002]	690
GO:0005829	cytosol	Cellular Component	IDA[16814409]	447
GO:0006412	translation	Biological Process	IC[8706699]; NAS[1712897]	42
GO:0006413	translational initiation	Biological Process	NAS[15883184]	14
GO:0006414	translational elongation	Biological Process		16
GO:0006415	translational termination	Biological Process		13
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	Biological Process		18
GO:0006917	induction of apoptosis	Biological Process	IDA[14988002]	31
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	Biological Process	IDA[14988002]	11
GO:0006974	response to DNA damage stimulus	Biological Process	IEP[17560175]	37
GO:0016032	viral reproduction	Biological Process		57
GO:0010467	gene expression	Biological Process		140
GO:0016071	mRNA metabolic process	Biological Process		34
GO:0016070	RNA metabolic process	Biological Process		46
GO:0019083	viral transcription	Biological Process		13
GO:0019058	viral infectious cycle	Biological Process		15
GO:0022627	cytosolic small ribosomal subunit	Cellular Component	IDA[8706699]	6
GO:0019901	protein kinase binding	Molecular Function	IPI[15950189]	51
GO:0032088	negative regulation of NF-kappaB transcription factor activity	Biological Process	IMP[18045535]	10
GO:0030529	ribonucleoprotein complex	Cellular Component	IDA[17289661]	23
GO:0044267	cellular protein metabolic process	Biological Process		64
GO:0032587	ruffle membrane	Cellular Component	IDA[16814409]	12
GO:0051059	NF-kappaB binding	Molecular Function	IPI[18045535]	7
GO:0045738	negative regulation of DNA repair	Biological Process	IMP[17049931]	1
GO:0051536	iron-sulfur cluster binding	Molecular Function	NAS[11911468]	1

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03010	Ribosome	14

Genes shared at least 5 GO terms with RPS3 (count: 79)

Gene Symbol	Pathway Count	Pathway List
RPS9	19	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; structural constituent of ribosome; protein binding; cytoplasm; cytosol; translation; translational initiation; translational elongation; translational termination; SRP-dependent cotranslational protein targeting to membrane; viral reproduction; gene expression; mRNA metabolic process; RNA metabolic process; viral transcription; viral infectious cycle; cytosolic small ribosomal subunit; ribonucleoprotein complex; cellular protein metabolic process;
RPL14	17	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; structural constituent of ribosome; protein binding; cytoplasm; cytosol; translation; translational initiation; translational elongation; translational termination; SRP-dependent cotranslational protein targeting to membrane; viral reproduction; gene expression; mRNA metabolic process; RNA metabolic process; viral transcription; viral infectious cycle; cellular protein metabolic process;
RPL35	17	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; mRNA binding; structural constituent of ribosome; cytoplasm; cytosol; translation; translational initiation; translational elongation; translational termination; SRP-dependent cotranslational protein targeting to membrane; viral reproduction; gene expression; mRNA metabolic process; RNA metabolic process; viral transcription; viral infectious cycle; cellular protein metabolic process;
RPS15A	17	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; structural constituent of ribosome; cytoplasm; cytosol; translation; translational initiation; translational elongation; translational termination; SRP-dependent cotranslational protein targeting to membrane; viral reproduction; gene expression; mRNA metabolic process; RNA metabolic process; viral transcription; viral infectious cycle; cytosolic small ribosomal subunit; cellular protein metabolic process;
RPS25	17	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; structural constituent of ribosome; cytoplasm; cytosol; translation; translational initiation; translational elongation; translational termination; SRP-dependent cotranslational protein targeting to membrane; viral reproduction; gene expression; mRNA metabolic process; RNA metabolic process; viral transcription; viral infectious cycle; cytosolic small ribosomal subunit; cellular protein metabolic process;
FAU	16	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; structural constituent of ribosome; cytosol; translation; translational initiation; translational elongation; translational termination; SRP-dependent cotranslational protein targeting to membrane; viral reproduction; gene expression; mRNA metabolic process; RNA metabolic process; viral transcription; viral infectious cycle; cytosolic small ribosomal subunit; cellular protein metabolic process;
RPL13	16	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; structural constituent of ribosome; protein binding; cytosol; translation; translational initiation; translational elongation; translational termination; SRP-dependent cotranslational protein targeting to membrane; viral reproduction; gene expression; mRNA metabolic process; RNA metabolic process; viral transcription; viral infectious cycle; cellular protein metabolic process;
RPS12	16	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; structural constituent of ribosome; cytosol; translation; translational initiation; translational elongation; translational termination; SRP-dependent cotranslational protein targeting to membrane; viral reproduction; gene expression; mRNA metabolic process; RNA metabolic process; viral transcription; viral infectious cycle; cytosolic small ribosomal subunit; cellular protein metabolic process;
RPL12	15	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; structural constituent of ribosome; cytosol; translation; translational initiation; translational elongation; translational termination; SRP-dependent cotranslational protein targeting to membrane; viral reproduction; gene expression; mRNA metabolic process; RNA metabolic process; viral transcription; viral infectious cycle; cellular protein metabolic process;
RPL37	15	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; structural constituent of ribosome; cytosol; translation; translational initiation; translational elongation; translational termination; SRP-dependent cotranslational protein targeting to membrane; viral reproduction; gene expression; mRNA metabolic process; RNA metabolic process; viral transcription; viral infectious cycle; cellular protein metabolic process;
RPL37A	15	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; structural constituent of ribosome; cytosol; translation; translational initiation; translational elongation; translational termination; SRP-dependent cotranslational protein targeting to membrane; viral reproduction; gene expression; mRNA metabolic process; RNA metabolic process; viral transcription; viral infectious cycle; cellular protein metabolic process;
RPL38	15	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; structural constituent of ribosome; cytosol; translation; translational initiation; translational elongation; translational termination; SRP-dependent cotranslational protein targeting to membrane; viral reproduction; gene expression; mRNA metabolic process; RNA metabolic process; viral transcription; viral infectious cycle; cellular protein metabolic process;
NCBP1	9	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; protein binding; nucleus; cytosol; viral reproduction; gene expression; mRNA metabolic process; RNA metabolic process; ribonucleoprotein complex;
XPO1	9	protein binding; cytoplasm; cytosol; viral reproduction; gene expression; mRNA metabolic process; RNA metabolic process; viral infectious cycle; ribonucleoprotein complex;
SMG1	8	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; protein binding; nucleus; cytoplasm; cytosol; gene expression; mRNA metabolic process; RNA metabolic process;
SMG7	8	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; protein binding; nucleus; cytoplasm; cytosol; gene expression; mRNA metabolic process; RNA metabolic process;
PSMC3	8	protein binding; nucleus; cytoplasm; cytosol; viral reproduction; gene expression; mRNA metabolic process; RNA metabolic process;
APC	7	protein binding; nucleus; cytoplasm; cytosol; response to DNA damage stimulus; protein kinase binding; ruffle membrane;
DCPS	7	protein binding; nucleus; cytoplasm; cytosol; gene expression; mRNA metabolic process; RNA metabolic process;
EEF1D	7	protein binding; nucleus; cytosol; translation; translational elongation; gene expression; cellular protein metabolic process;
EIF2B1	7	protein binding; cytoplasm; cytosol; translation; translational initiation; gene expression; cellular protein metabolic process;
GSK3B	7	protein binding; nucleus; cytoplasm; cytosol; protein kinase binding; ribonucleoprotein complex; NF-kappaB binding;
HSPA8	7	protein binding; nucleus; cytosol; gene expression; mRNA metabolic process; RNA metabolic process; ribonucleoprotein complex;
PYCARD	7	protein binding; nucleus; cytoplasm; cytosol; induction of apoptosis; activation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of NF-kappaB transcription factor activity;
SRP19	7	nucleus; cytoplasm; cytosol; translation; SRP-dependent cotranslational protein targeting to membrane; gene expression; cellular protein metabolic process;
CNOT6	6	protein binding; nucleus; cytosol; gene expression; mRNA metabolic process; RNA metabolic process;
EEF1G	6	protein binding; cytosol; translation; translational elongation; gene expression; cellular protein metabolic process;
EGLN3	6	protein binding; nucleus; cytoplasm; cytosol; activation of cysteine-type endopeptidase activity involved in apoptotic process; response to DNA damage stimulus;
MAPK1	6	protein binding; nucleus; cytoplasm; cytosol; induction of apoptosis; response to DNA damage stimulus;
MEN1	6	protein binding; nucleus; cytoplasm; cytosol; response to DNA damage stimulus; gene expression;
PMAIP1	6	protein binding; nucleus; cytosol; induction of apoptosis; activation of cysteine-type endopeptidase activity involved in apoptotic process; response to DNA damage stimulus;
PSMB7	6	protein binding; cytosol; viral reproduction; gene expression; mRNA metabolic process; RNA metabolic process;
PSMD5	6	protein binding; cytosol; viral reproduction; gene expression; mRNA metabolic process; RNA metabolic process;
PSMD7	6	protein binding; cytosol; viral reproduction; gene expression; mRNA metabolic process; RNA metabolic process;
RAN	6	protein binding; cytoplasm; cytosol; viral reproduction; gene expression; viral infectious cycle;
RELA	6	protein binding; nucleus; cytoplasm; cytosol; protein kinase binding; NF-kappaB binding;
RQCD1	6	protein binding; nucleus; cytosol; gene expression; mRNA metabolic process; RNA metabolic process;
UBB	6	protein binding; cytosol; viral reproduction; gene expression; mRNA metabolic process; RNA metabolic process;
UBC	6	protein binding; cytosol; viral reproduction; gene expression; mRNA metabolic process; RNA metabolic process;
YAP1	6	protein binding; nucleus; cytoplasm; cytosol; response to DNA damage stimulus; gene expression;
PSMA8	6	nucleus; cytosol; viral reproduction; gene expression; mRNA metabolic process; RNA metabolic process;
TNKS1BP1	6	nucleus; cytoplasm; cytosol; gene expression; mRNA metabolic process; RNA metabolic process;
PSME1	6	cytoplasm; cytosol; viral reproduction; gene expression; mRNA metabolic process; RNA metabolic process;
TP53BP1	5	damaged DNA binding; protein binding; nucleus; cytoplasm; response to DNA damage stimulus;
CELF1	5	mRNA binding; protein binding; nucleus; cytoplasm; ribonucleoprotein complex;
HMGA1	5	DNA-(apurinic or apyrimidinic site) lyase activity; protein binding; nucleus; cytosol; viral reproduction;
AKAP7	5	protein binding; nucleus; cytosol; RNA metabolic process; protein kinase binding;
ALKBH8	5	protein binding; nucleus; cytoplasm; cytosol; response to DNA damage stimulus;
ARRB1	5	protein binding; nucleus; cytoplasm; cytosol; negative regulation of NF-kappaB transcription factor activity;
ARRB2	5	protein binding; nucleus; cytoplasm; cytosol; negative regulation of NF-kappaB transcription factor activity;
ATXN2	5	protein binding; nucleus; cytoplasm; RNA metabolic process; ribonucleoprotein complex;
BAD	5	protein binding; cytosol; induction of apoptosis; activation of cysteine-type endopeptidase activity involved in apoptotic process; protein kinase binding;
BRMS1	5	protein binding; nucleus; cytoplasm; negative regulation of NF-kappaB transcription factor activity; NF-kappaB binding;
CCND1	5	protein binding; nucleus; cytosol; response to DNA damage stimulus; protein kinase binding;
CLNS1A	5	protein binding; nucleus; cytosol; gene expression; RNA metabolic process;
DAXX	5	protein binding; nucleus; cytoplasm; cytosol; induction of apoptosis;
DDX6	5	protein binding; cytosol; gene expression; mRNA metabolic process; RNA metabolic process;
DHX9	5	protein binding; nucleus; cytoplasm; gene expression; ribonucleoprotein complex;
HNRNPA2B1	5	protein binding; nucleus; cytoplasm; gene expression; ribonucleoprotein complex;
IARS	5	protein binding; nucleus; cytoplasm; cytosol; gene expression;
IGF2BP3	5	protein binding; nucleus; cytoplasm; cytosol; translation;
IGHMBP2	5	protein binding; nucleus; cytoplasm; translation; ribonucleoprotein complex;
IRF7	5	protein binding; nucleus; cytoplasm; cytosol; response to DNA damage stimulus;
LSM4	5	protein binding; cytosol; gene expression; mRNA metabolic process; RNA metabolic process;
MAPK3	5	protein binding; nucleus; cytosol; response to DNA damage stimulus; gene expression;
NEDD4L	5	protein binding; nucleus; cytoplasm; cytosol; gene expression;
PARK2	5	protein binding; nucleus; cytoplasm; cytosol; protein kinase binding;
PATL1	5	protein binding; cytosol; gene expression; mRNA metabolic process; RNA metabolic process;
PDCD4	5	protein binding; nucleus; cytoplasm; cytosol; RNA metabolic process;
RAD9A	5	protein binding; nucleus; cytoplasm; response to DNA damage stimulus; protein kinase binding;
SEC61B	5	protein binding; translation; SRP-dependent cotranslational protein targeting to membrane; gene expression; cellular protein metabolic process;
SNCA	5	protein binding; nucleus; cytoplasm; cytosol; activation of cysteine-type endopeptidase activity involved in apoptotic process;
SNRPD1	5	protein binding; nucleus; cytosol; gene expression; RNA metabolic process;
SSRP1	5	protein binding; nucleus; cytoplasm; viral reproduction; gene expression;
TAF10	5	protein binding; nucleus; cytoplasm; viral reproduction; gene expression;
TNFAIP3	5	protein binding; nucleus; cytoplasm; cytosol; negative regulation of NF-kappaB transcription factor activity;
WWOX	5	protein binding; nucleus; cytoplasm; cytosol; induction of apoptosis;
TAF4B	5	nucleus; cytoplasm; viral reproduction; gene expression; NF-kappaB binding;
PSME2	5	cytosol; viral reproduction; gene expression; mRNA metabolic process; RNA metabolic process;

Genes shared at least 2 KEGG pathways with RPS3 (count: 0)

View in gBrowse

Region: chr11:75110530..75133324 View in gBrowse