ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	TNFAIP3
Symbol Alias	A20, OTUD7C
Approved Name	tumor necrosis factor, alpha-induced protein 3
Location	6q23-q25
Position	chr6:138188351-138204449, +
External Links	HGNC: 11896 Entrez Gene: 7128 Ensembl: ENSG00000118503 UCSC: uc003qhr.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
6q22-23	chr6:114600000-139000000	1 (1/0/0)

Gene related GO terms (count: 60)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 60)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006954	inflammatory response	Biological Process		51
GO:0006508	proteolysis	Biological Process		102
GO:0005829	cytosol	Cellular Component		447
GO:0005813	centrosome	Cellular Component		71
GO:0031397	negative regulation of protein ubiquitination	Biological Process		5
GO:0019900	kinase binding	Molecular Function		7
GO:0016579	protein deubiquitination	Biological Process		6
GO:0008270	zinc ion binding	Molecular Function		323
GO:0004843	ubiquitin-specific protease activity	Molecular Function	IDA[15258597]	9
GO:0004842	ubiquitin-protein ligase activity	Molecular Function	IDA[15258597]	52
GO:0004221	ubiquitin thiolesterase activity	Molecular Function	IMP[15258597]	12
GO:0003677	DNA binding	Molecular Function		220
GO:0005764	lysosome	Cellular Component		31
GO:0005737	cytoplasm	Cellular Component		690
GO:0005634	nucleus	Cellular Component	IDA[11463333]	770
GO:0005515	protein binding	Molecular Function		910
GO:0001922	B-1 B cell homeostasis	Biological Process		1
GO:0002634	regulation of germinal center formation	Biological Process		2
GO:0002677	negative regulation of chronic inflammatory response	Biological Process		1
GO:0002020	protease binding	Molecular Function	IPI[18223652]	13
GO:0002237	response to molecule of bacterial origin	Biological Process	IDA[19912257]	2
GO:0050869	negative regulation of B cell activation	Biological Process		1
GO:0050728	negative regulation of inflammatory response	Biological Process		11
GO:0061043	regulation of vascular wound healing	Biological Process	NAS[16816117]	1
GO:0051259	protein oligomerization	Biological Process	NAS[15474016]	8
GO:0070429	negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway	Biological Process		1
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway	Biological Process		3
GO:0070536	protein K63-linked deubiquitination	Biological Process	IDA[15258597]	1
GO:0070433	negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	Biological Process		1
GO:0043621	protein self-association	Molecular Function	IDA[8797804]	8
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	Biological Process	IDA[12167698]	9
GO:0045732	positive regulation of protein catabolic process	Biological Process		8
GO:0045087	innate immune response	Biological Process		54
GO:0045779	negative regulation of bone resorption	Biological Process		1
GO:0045736	negative regulation of cyclin-dependent protein kinase activity	Biological Process		6
GO:0050691	regulation of defense response to virus by host	Biological Process	NAS[15142865]	1
GO:0048662	negative regulation of smooth muscle cell proliferation	Biological Process	IDA[16816117]	7
GO:0034140	negative regulation of toll-like receptor 3 signaling pathway	Biological Process	IDA[15474016]	1
GO:0034144	negative regulation of toll-like receptor 4 signaling pathway	Biological Process	NAS[15142865]	1
GO:0034148	negative regulation of toll-like receptor 5 signaling pathway	Biological Process		1
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	Biological Process		8
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	Molecular Function	NAS[12167698]	6
GO:0043066	negative regulation of apoptotic process	Biological Process	IDA[12167698]	77
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB cascade	Biological Process		5
GO:0043130	ubiquitin binding	Molecular Function	IPI[19285159]	9
GO:0032088	negative regulation of NF-kappaB transcription factor activity	Biological Process	IDA[18223652]	10
GO:0032480	negative regulation of type I interferon production	Biological Process		10
GO:0032495	response to muramyl dipeptide	Biological Process		2
GO:0032691	negative regulation of interleukin-1 beta production	Biological Process		3
GO:0032703	negative regulation of interleukin-2 production	Biological Process	IMP[18223652]	2
GO:0032715	negative regulation of interleukin-6 production	Biological Process		4
GO:0032720	negative regulation of tumor necrosis factor production	Biological Process		6
GO:0034136	negative regulation of toll-like receptor 2 signaling pathway	Biological Process	NAS[15142865]	1
GO:2000352	negative regulation of endothelial cell apoptotic process	Biological Process	IDA[12885753]	1
GO:2000347	positive regulation of hepatocyte proliferation	Biological Process		2
GO:2000349	negative regulation of CD40 signaling pathway	Biological Process	IMP[12885753]	1
GO:0072573	tolerance induction to lipopolysaccharide	Biological Process		1
GO:0090291	negative regulation of osteoclast proliferation	Biological Process		2
GO:0070936	protein K48-linked ubiquitination	Biological Process	IDA[15258597]	5
GO:0071222	cellular response to lipopolysaccharide	Biological Process	IDA[19912257]	13

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04621	NOD-like receptor signaling pathway	16	Specific families of pattern recognition receptors are respo...... Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. These NLRs include NALP1, NALP3 and Ipaf. The inflammasomes are critical for generating mature proinflammatory cytokines in concert with Toll-like receptor signaling pathway. More...
hsa05162	Measles	20	Measles virus (MV) is highly contagious virus that leads inf...... Measles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacterial infections. Several MV proteins have been suggested to disturb host immunity. After infection of host lymphoid cells via SLAM, MV inhibits cytokine response by direct interference with host signaling systems. Three proteins (P, V, and C) associate with Jak/STAT proteins in interferon-triggered pathway and other important proteins related to apoptosis. Interaction between MV and host brings about the shift towards a Th2 response by decreasing IL-12 production and induces lymphopenia by suppressing cell proliferation. More...

Genes shared at least 5 GO terms with TNFAIP3 (count: 78)

Gene Symbol	Pathway Count	Pathway List
MALT1	12	proteolysis; cytosol; ubiquitin-protein ligase activity; cytoplasm; nucleus; protein binding; protease binding; response to molecule of bacterial origin; protein oligomerization; protein self-association; innate immune response; negative regulation of apoptotic process;
PYCARD	11	inflammatory response; proteolysis; cytosol; cytoplasm; nucleus; protein binding; innate immune response; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of NF-kappaB transcription factor activity; cellular response to lipopolysaccharide;
RELA	10	inflammatory response; cytosol; DNA binding; cytoplasm; nucleus; protein binding; innate immune response; negative regulation of apoptotic process; response to muramyl dipeptide; cellular response to lipopolysaccharide;
TRIM32	10	zinc ion binding; ubiquitin-protein ligase activity; cytoplasm; nucleus; protein binding; protein self-association; positive regulation of protein catabolic process; innate immune response; negative regulation of apoptotic process; ubiquitin binding;
ARRB2	9	cytosol; negative regulation of protein ubiquitination; cytoplasm; nucleus; protein binding; negative regulation of NF-kappaB transcription factor activity; negative regulation of interleukin-1 beta production; negative regulation of interleukin-6 production; negative regulation of tumor necrosis factor production;
GSTP1	9	cytosol; cytoplasm; nucleus; protein binding; negative regulation of apoptotic process; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of interleukin-1 beta production; negative regulation of tumor necrosis factor production; cellular response to lipopolysaccharide;
APC	8	cytosol; centrosome; cytoplasm; nucleus; protein binding; positive regulation of protein catabolic process; negative regulation of cyclin-dependent protein kinase activity; negative regulation of apoptotic process;
ARRB1	8	cytosol; negative regulation of protein ubiquitination; cytoplasm; nucleus; protein binding; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; negative regulation of NF-kappaB transcription factor activity; negative regulation of interleukin-6 production;
PARK2	8	cytosol; kinase binding; zinc ion binding; ubiquitin-protein ligase activity; cytoplasm; nucleus; protein binding; protein K48-linked ubiquitination;
SNCA	8	cytosol; zinc ion binding; cytoplasm; nucleus; protein binding; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; negative regulation of apoptotic process;
TAX1BP1	8	cytosol; kinase binding; zinc ion binding; protein binding; innate immune response; negative regulation of apoptotic process; negative regulation of NF-kappaB transcription factor activity; negative regulation of type I interferon production;
BARD1	8	kinase binding; zinc ion binding; ubiquitin-protein ligase activity; cytoplasm; nucleus; protein binding; positive regulation of protein catabolic process; negative regulation of apoptotic process;
UBE3A	7	proteolysis; cytosol; ubiquitin-protein ligase activity; cytoplasm; nucleus; protein binding; protein K48-linked ubiquitination;
CBL	7	cytosol; zinc ion binding; ubiquitin-protein ligase activity; cytoplasm; nucleus; protein binding; negative regulation of apoptotic process;
GSK3B	7	cytosol; centrosome; cytoplasm; nucleus; protein binding; positive regulation of protein catabolic process; negative regulation of apoptotic process;
HERC5	7	cytosol; ubiquitin-protein ligase activity; cytoplasm; nucleus; protein binding; innate immune response; negative regulation of type I interferon production;
UBC	7	cytosol; protein binding; protease binding; nucleotide-binding oligomerization domain containing signaling pathway; innate immune response; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway; negative regulation of type I interferon production;
ADAM8	6	inflammatory response; proteolysis; zinc ion binding; cytoplasm; protein binding; protein self-association;
PIK3CG	6	inflammatory response; cytosol; cytoplasm; protein binding; innate immune response; negative regulation of apoptotic process;
PRDX5	6	inflammatory response; cytoplasm; nucleus; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; negative regulation of apoptotic process;
PRKD1	6	inflammatory response; cytosol; cytoplasm; nucleus; protein binding; innate immune response;
DPEP1	6	proteolysis; zinc ion binding; protein binding; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; negative regulation of apoptotic process;
PYDC1	6	proteolysis; cytosol; nucleus; protein binding; innate immune response; negative regulation of NF-kappaB transcription factor activity;
BIRC2	6	cytosol; zinc ion binding; ubiquitin-protein ligase activity; nucleus; protein binding; negative regulation of apoptotic process;
CRYAB	6	cytosol; cytoplasm; nucleus; protein binding; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of apoptotic process;
IRF7	6	cytosol; DNA binding; cytoplasm; nucleus; protein binding; innate immune response;
MAPK1	6	cytosol; DNA binding; cytoplasm; nucleus; protein binding; innate immune response;
MAPK7	6	cytosol; nucleus; protein binding; negative regulation of inflammatory response; innate immune response; negative regulation of apoptotic process;
PLK1	6	cytosol; centrosome; nucleus; protein binding; negative regulation of cyclin-dependent protein kinase activity; negative regulation of apoptotic process;
RFWD2	6	cytosol; centrosome; zinc ion binding; cytoplasm; nucleus; protein binding;
RNF146	6	cytosol; zinc ion binding; ubiquitin-protein ligase activity; nucleus; protein binding; protein K48-linked ubiquitination;
UBB	6	cytosol; protein binding; nucleotide-binding oligomerization domain containing signaling pathway; innate immune response; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway; negative regulation of type I interferon production;
ATG5	6	negative regulation of protein ubiquitination; cytoplasm; protein binding; innate immune response; negative regulation of apoptotic process; negative regulation of type I interferon production;
USP10	6	protein deubiquitination; ubiquitin-specific protease activity; ubiquitin thiolesterase activity; cytoplasm; nucleus; protein binding;
BIRC3	6	zinc ion binding; ubiquitin-protein ligase activity; cytoplasm; nucleus; protein binding; negative regulation of apoptotic process;
TRIM5	6	zinc ion binding; ubiquitin-protein ligase activity; cytoplasm; nucleus; protein binding; innate immune response;
TLR4	6	cytoplasm; protein binding; innate immune response; negative regulation of interleukin-6 production; negative regulation of tumor necrosis factor production; cellular response to lipopolysaccharide;
MIF	5	inflammatory response; cytoplasm; protein binding; innate immune response; negative regulation of apoptotic process;
NFRKB	5	inflammatory response; DNA binding; nucleus; protein binding; protease binding;
BLMH	5	proteolysis; cytosol; cytoplasm; nucleus; protein binding;
CASP1	5	proteolysis; cytosol; protein binding; innate immune response; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway;
OTUB1	5	proteolysis; ubiquitin-specific protease activity; cytoplasm; protein binding; ubiquitin binding;
OTUD7A	5	proteolysis; zinc ion binding; DNA binding; cytoplasm; nucleus;
CCS	5	cytosol; zinc ion binding; cytoplasm; nucleus; protein binding;
CEP164	5	cytosol; centrosome; cytoplasm; nucleus; protein binding;
CEP57	5	cytosol; centrosome; cytoplasm; nucleus; protein binding;
MEN1	5	cytosol; cytoplasm; nucleus; protein binding; negative regulation of cyclin-dependent protein kinase activity;
NEDD4L	5	cytosol; ubiquitin-protein ligase activity; cytoplasm; nucleus; protein binding;
PAFAH1B1	5	cytosol; centrosome; cytoplasm; nucleus; protein binding;
PRKAA1	5	cytosol; kinase binding; nucleus; protein binding; negative regulation of apoptotic process;
PRKCB	5	cytosol; zinc ion binding; cytoplasm; nucleus; protein binding;
RPS3	5	cytosol; cytoplasm; nucleus; protein binding; negative regulation of NF-kappaB transcription factor activity;
SQSTM1	5	cytosol; zinc ion binding; lysosome; protein binding; ubiquitin binding;
UBE2L6	5	cytosol; ubiquitin-protein ligase activity; protein binding; innate immune response; negative regulation of type I interferon production;
WWP1	5	cytosol; ubiquitin-protein ligase activity; cytoplasm; nucleus; protein binding;
YAP1	5	cytosol; cytoplasm; nucleus; protein binding; negative regulation of apoptotic process;
AATF	5	centrosome; cytoplasm; nucleus; protein binding; negative regulation of apoptotic process;
DHX9	5	centrosome; DNA binding; cytoplasm; nucleus; protein binding;
TFAP2A	5	centrosome; cytoplasm; nucleus; protein binding; negative regulation of apoptotic process;
USP2	5	centrosome; protein deubiquitination; ubiquitin thiolesterase activity; nucleus; protein binding;
UBXN1	5	negative regulation of protein ubiquitination; cytoplasm; nucleus; protein binding; ubiquitin binding;
USP22	5	protein deubiquitination; zinc ion binding; ubiquitin-specific protease activity; ubiquitin thiolesterase activity; protein binding;
USP28	5	protein deubiquitination; ubiquitin-specific protease activity; ubiquitin thiolesterase activity; nucleus; protein binding;
DEAF1	5	zinc ion binding; DNA binding; cytoplasm; nucleus; protein binding;
FUS	5	zinc ion binding; DNA binding; cytoplasm; nucleus; protein binding;
HERC2	5	zinc ion binding; ubiquitin-protein ligase activity; cytoplasm; nucleus; protein binding;
IGHMBP2	5	zinc ion binding; DNA binding; cytoplasm; nucleus; protein binding;
KLF4	5	zinc ion binding; negative regulation of inflammatory response; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of smooth muscle cell proliferation; negative regulation of NF-kappaB transcription factor activity;
PGR	5	zinc ion binding; DNA binding; cytoplasm; nucleus; protein binding;
RCHY1	5	zinc ion binding; ubiquitin-protein ligase activity; cytoplasm; nucleus; protein binding;
RNF31	5	zinc ion binding; ubiquitin-protein ligase activity; cytoplasm; protein binding; ubiquitin binding;
RNF40	5	zinc ion binding; ubiquitin-protein ligase activity; cytoplasm; nucleus; protein binding;
ZFR	5	zinc ion binding; DNA binding; cytoplasm; nucleus; protein binding;
ZNRF1	5	zinc ion binding; ubiquitin-protein ligase activity; lysosome; protein binding; protein K48-linked ubiquitination;
KLHL20	5	ubiquitin-protein ligase activity; cytoplasm; nucleus; protein binding; negative regulation of apoptotic process;
PRPF19	5	ubiquitin-protein ligase activity; DNA binding; cytoplasm; nucleus; protein binding;
ATXN1	5	DNA binding; cytoplasm; nucleus; protein binding; protein self-association;
XRCC5	5	DNA binding; cytoplasm; nucleus; protein binding; negative regulation of apoptotic process;

Genes shared at least 2 KEGG pathways with TNFAIP3 (count: 2)

Gene Symbol	Pathway Count	Pathway List
IL6	2	NOD-like receptor signaling pathway; Measles;
RELA	2	NOD-like receptor signaling pathway; Measles;

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Region: chr6:138188351..138204449 View in gBrowse