ADHDgene Database

Gene Report

Basic Info

Approved Symbol	USP10
Symbol Alias	UBPO, KIAA0190
Approved Name	ubiquitin specific peptidase 10
Previous Name	ubiquitin specific protease 10
Location	16q
Position	chr16:84733555-84813528, +
External Links	HGNC: 12608 Entrez Gene: 9100 Ensembl: ENSG00000103194 UCSC: uc002fii.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV; Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Jarick[2012]_37	chr16:82878275-83630163 (NCBI36 / hg18)	751889	16q24.1	dup

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
16q23.1-24.3	chr16:74100000-90354753	1 (1/0/0)

Gene related GO terms (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0045111	intermediate filament cytoskeleton	Cellular Component		5
GO:0006914	autophagy	Biological Process		13
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process		25
GO:0006281	DNA repair	Biological Process		62
GO:0005769	early endosome	Cellular Component	IDA[19398555]	25
GO:0044325	ion channel binding	Molecular Function	IDA[19398555]	15
GO:0030330	DNA damage response, signal transduction by p53 class mediator	Biological Process		2
GO:0016579	protein deubiquitination	Biological Process	IMP[19398555]	6
GO:0010506	regulation of autophagy	Biological Process		4
GO:0004197	cysteine-type endopeptidase activity	Molecular Function		17
GO:0004221	ubiquitin thiolesterase activity	Molecular Function		12
GO:0002039	p53 binding	Molecular Function		11
GO:0005634	nucleus	Cellular Component		770
GO:0005737	cytoplasm	Cellular Component		690
GO:0004843	ubiquitin-specific protease activity	Molecular Function	IMP[19398555]	9
GO:0005515	protein binding	Molecular Function		910

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with USP10 (count: 9)

Gene Symbol	Pathway Count	Pathway List
USP28	7	ubiquitin-dependent protein catabolic process; DNA repair; protein deubiquitination; ubiquitin thiolesterase activity; nucleus; ubiquitin-specific protease activity; protein binding;
USP2	6	ubiquitin-dependent protein catabolic process; protein deubiquitination; cysteine-type endopeptidase activity; ubiquitin thiolesterase activity; nucleus; protein binding;
USP37	6	ubiquitin-dependent protein catabolic process; cysteine-type endopeptidase activity; ubiquitin thiolesterase activity; nucleus; ubiquitin-specific protease activity; protein binding;
TNFAIP3	6	protein deubiquitination; ubiquitin thiolesterase activity; nucleus; cytoplasm; ubiquitin-specific protease activity; protein binding;
PARK2	5	ubiquitin-dependent protein catabolic process; regulation of autophagy; nucleus; cytoplasm; protein binding;
USP22	5	ubiquitin-dependent protein catabolic process; protein deubiquitination; ubiquitin thiolesterase activity; ubiquitin-specific protease activity; protein binding;
USP34	5	ubiquitin-dependent protein catabolic process; cysteine-type endopeptidase activity; ubiquitin thiolesterase activity; ubiquitin-specific protease activity; protein binding;
USP46	5	ubiquitin-dependent protein catabolic process; protein deubiquitination; ubiquitin thiolesterase activity; ubiquitin-specific protease activity; protein binding;
TP53BP1	5	DNA repair; p53 binding; nucleus; cytoplasm; protein binding;

Genes shared at least 2 KEGG pathways with USP10 (count: 0)

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Region: chr16:84733555..84813528 View in gBrowse