ADHDgene Database

Gene Report

Basic Info

Approved Symbol	USP22
Previous Symbol	USP3L
Symbol Alias	KIAA1063
Approved Name	ubiquitin specific peptidase 22
Previous Name	ubiquitin specific protease 22, "ubiquitin specific peptidase 3-like"
Location	17p11.2
Position	chr17:20902906-20946369, -
External Links	HGNC: 12621 Entrez Gene: 23326 Ensembl: ENSG00000124422 UCSC: uc002gym.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
17p11	chr17:16000000-24000000	3 (2/0/1)

Gene related GO terms (count: 19)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	IMP[18206973]	80
GO:0043967	histone H4 acetylation	Biological Process	IDA[18206973]	2
GO:0070461	SAGA-type complex	Cellular Component	IDA[18838386]	1
GO:0045931	positive regulation of mitotic cell cycle	Biological Process	IMP[18206973]	5
GO:0016578	histone deubiquitination	Biological Process	IDA[18206972]	3
GO:0016574	histone ubiquitination	Biological Process	IDA[18469533]	1
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	Molecular Function	IMP[18206972]	19
GO:0016579	protein deubiquitination	Biological Process	IDA[16378762]	6
GO:0008270	zinc ion binding	Molecular Function		323
GO:0007049	cell cycle	Biological Process		31
GO:0010485	H4 histone acetyltransferase activity	Molecular Function	IDA[18206973]	1
GO:0009790	embryo development	Biological Process	NAS[16378762]	17
GO:0005515	protein binding	Molecular Function	IPI[18206972]	910
GO:0004843	ubiquitin-specific protease activity	Molecular Function	IDA[16378762]; IMP[18206973]	9
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process		25
GO:0006351	transcription, DNA-dependent	Biological Process		247
GO:0000124	SAGA complex	Cellular Component	IDA[18206973]	1
GO:0003713	transcription coactivator activity	Molecular Function	IDA[18206972]	52
GO:0004221	ubiquitin thiolesterase activity	Molecular Function		12

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with USP22 (count: 8)

Gene Symbol	Pathway Count	Pathway List
USP2	6	positive regulation of mitotic cell cycle; protein deubiquitination; cell cycle; protein binding; ubiquitin-dependent protein catabolic process; ubiquitin thiolesterase activity;
HINFP	5	positive regulation of transcription, DNA-dependent; zinc ion binding; protein binding; transcription, DNA-dependent; transcription coactivator activity;
RNF20	5	positive regulation of transcription, DNA-dependent; zinc ion binding; protein binding; ubiquitin-dependent protein catabolic process; transcription coactivator activity;
SMARCD3	5	positive regulation of transcription, DNA-dependent; ligand-dependent nuclear receptor transcription coactivator activity; protein binding; transcription, DNA-dependent; transcription coactivator activity;
TNFAIP3	5	protein deubiquitination; zinc ion binding; protein binding; ubiquitin-specific protease activity; ubiquitin thiolesterase activity;
USP10	5	protein deubiquitination; protein binding; ubiquitin-specific protease activity; ubiquitin-dependent protein catabolic process; ubiquitin thiolesterase activity;
USP28	5	protein deubiquitination; protein binding; ubiquitin-specific protease activity; ubiquitin-dependent protein catabolic process; ubiquitin thiolesterase activity;
USP46	5	protein deubiquitination; protein binding; ubiquitin-specific protease activity; ubiquitin-dependent protein catabolic process; ubiquitin thiolesterase activity;

Genes shared at least 2 KEGG pathways with USP22 (count: 0)

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Region: chr17:20902906..20946369 View in gBrowse