ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	SMARCD3
Symbol Alias	BAF60C, Rsc6p, CRACD3
Approved Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
Name Alias	mammalian chromatin remodeling complex BRG1-associated factor 60C, "Swp73-like protein", "SWI/SNF complex 60 kDa subunit C", "60kDa BRG-1/Brm associated factor subunit c"
Location	7q35-q36
Position	chr7:150935850-150974982, -
External Links	HGNC: 11108 Entrez Gene: 6604 Ensembl: ENSG00000082014 UCSC: uc003wjs.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 27)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0035257	nuclear hormone receptor binding	Molecular Function	IPI[14701856]	30

GO terms by database search (count: 26)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0071565	nBAF complex	Cellular Component		2
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	Molecular Function	IMP[17363140]	19
GO:0042692	muscle cell differentiation	Biological Process		8
GO:0043393	regulation of protein binding	Biological Process		4
GO:0044255	cellular lipid metabolic process	Biological Process		30
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	IDA[14701856]	80
GO:0071564	npBAF complex	Cellular Component	IDA[18816825]	2
GO:0005634	nucleus	Cellular Component	IDA[18816825]	770
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005102	receptor binding	Molecular Function	IPI[14701856]	61
GO:0005515	protein binding	Molecular Function	IPI[14701856]	910
GO:0003407	neural retina development	Biological Process	IEP[18816825]	1
GO:0003713	transcription coactivator activity	Molecular Function	NAS[8804307]	52
GO:0003139	secondary heart field specification	Biological Process		2
GO:0003219	cardiac right ventricle formation	Biological Process		1
GO:0016514	SWI/SNF complex	Cellular Component	IDA[8804307]; NAS[14701856]	2
GO:0016922	ligand-dependent nuclear receptor binding	Molecular Function	IPI[17363140]	4
GO:0006357	regulation of transcription from RNA polymerase II promoter	Biological Process	IMP[17363140]; NAS[8804307]	42
GO:0008134	transcription factor binding	Molecular Function	IPI[14701856]	38
GO:0006338	chromatin remodeling	Biological Process	IC[18816825]; IDA[11726552]	10
GO:0006351	transcription, DNA-dependent	Biological Process	IDA[14701856]	247
GO:0005737	cytoplasm	Cellular Component	IDA[17363140]	690
GO:0006337	nucleosome disassembly	Biological Process	IDA[8895581]	4
GO:0002052	positive regulation of neuroblast proliferation	Biological Process	IDA[18816825]	4
GO:0000790	nuclear chromatin	Cellular Component	IDA[17363140]	11

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with SMARCD3 (count: 64)

Gene Symbol	Pathway Count	Pathway List
SMARCB1	11	nBAF complex; npBAF complex; nucleus; nucleoplasm; protein binding; transcription coactivator activity; SWI/SNF complex; regulation of transcription from RNA polymerase II promoter; chromatin remodeling; transcription, DNA-dependent; nucleosome disassembly;
MED1	11	ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; cellular lipid metabolic process; small molecule metabolic process; positive regulation of transcription, DNA-dependent; nucleus; nucleoplasm; protein binding; transcription coactivator activity; ligand-dependent nuclear receptor binding; transcription factor binding;
HMGA1	9	ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; positive regulation of transcription, DNA-dependent; nucleus; nucleoplasm; protein binding; transcription factor binding; transcription, DNA-dependent; nucleosome disassembly;
NCOA6	9	ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; cellular lipid metabolic process; small molecule metabolic process; positive regulation of transcription, DNA-dependent; nucleus; nucleoplasm; protein binding; transcription coactivator activity;
KDM1A	8	ligand-dependent nuclear receptor transcription coactivator activity; nucleus; nucleoplasm; protein binding; regulation of transcription from RNA polymerase II promoter; transcription factor binding; transcription, DNA-dependent; nuclear chromatin;
NCOR1	8	cellular lipid metabolic process; small molecule metabolic process; nucleus; nucleoplasm; protein binding; transcription, DNA-dependent; cytoplasm; nuclear chromatin;
MED14	7	ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; positive regulation of transcription, DNA-dependent; nucleus; nucleoplasm; transcription coactivator activity; regulation of transcription from RNA polymerase II promoter;
MED17	7	ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; positive regulation of transcription, DNA-dependent; nucleus; nucleoplasm; transcription coactivator activity; regulation of transcription from RNA polymerase II promoter;
MMS19	7	nuclear hormone receptor binding; positive regulation of transcription, DNA-dependent; nucleus; protein binding; transcription coactivator activity; transcription, DNA-dependent; cytoplasm;
MAPK1	7	positive regulation of transcription, DNA-dependent; nucleus; nucleoplasm; protein binding; transcription factor binding; transcription, DNA-dependent; cytoplasm;
MED12	6	ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; positive regulation of transcription, DNA-dependent; nucleus; nucleoplasm; transcription coactivator activity;
MED13	6	ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; positive regulation of transcription, DNA-dependent; nucleus; nucleoplasm; transcription coactivator activity;
MED30	6	ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; positive regulation of transcription, DNA-dependent; nucleus; nucleoplasm; protein binding;
MED4	6	ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; positive regulation of transcription, DNA-dependent; nucleus; nucleoplasm; protein binding;
PRKCB	6	ligand-dependent nuclear receptor transcription coactivator activity; nucleus; protein binding; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; cytoplasm;
THRAP3	6	ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; positive regulation of transcription, DNA-dependent; nucleus; protein binding; transcription coactivator activity;
DAXX	6	nuclear hormone receptor binding; nucleus; protein binding; transcription factor binding; transcription, DNA-dependent; cytoplasm;
MED16	6	nuclear hormone receptor binding; positive regulation of transcription, DNA-dependent; nucleus; nucleoplasm; transcription coactivator activity; regulation of transcription from RNA polymerase II promoter;
NRIP1	6	nuclear hormone receptor binding; positive regulation of transcription, DNA-dependent; nucleus; protein binding; transcription coactivator activity; transcription, DNA-dependent;
NUP62	6	nuclear hormone receptor binding; small molecule metabolic process; positive regulation of transcription, DNA-dependent; protein binding; transcription, DNA-dependent; cytoplasm;
SNW1	6	nuclear hormone receptor binding; nucleus; nucleoplasm; protein binding; transcription coactivator activity; regulation of transcription from RNA polymerase II promoter;
HIRA	6	muscle cell differentiation; nucleus; protein binding; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; nuclear chromatin;
GRHL1	6	cellular lipid metabolic process; small molecule metabolic process; nucleus; nucleoplasm; transcription, DNA-dependent; cytoplasm;
LPIN1	6	cellular lipid metabolic process; small molecule metabolic process; nucleus; transcription coactivator activity; transcription, DNA-dependent; cytoplasm;
NCOR2	6	cellular lipid metabolic process; small molecule metabolic process; nucleus; nucleoplasm; protein binding; transcription, DNA-dependent;
PSMC3	6	small molecule metabolic process; nucleus; nucleoplasm; protein binding; transcription coactivator activity; cytoplasm;
APBB1	6	positive regulation of transcription, DNA-dependent; nucleus; protein binding; transcription factor binding; transcription, DNA-dependent; cytoplasm;
HINFP	6	positive regulation of transcription, DNA-dependent; nucleus; nucleoplasm; protein binding; transcription coactivator activity; transcription, DNA-dependent;
RELA	6	positive regulation of transcription, DNA-dependent; nucleus; nucleoplasm; protein binding; transcription factor binding; cytoplasm;
ATF6	6	nucleus; nucleoplasm; protein binding; transcription coactivator activity; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent;
MEN1	6	nucleus; nucleoplasm; protein binding; chromatin remodeling; transcription, DNA-dependent; cytoplasm;
MED24	5	ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; positive regulation of transcription, DNA-dependent; nucleus; nucleoplasm;
NCOA7	5	ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; nucleus; protein binding; transcription, DNA-dependent;
USP22	5	ligand-dependent nuclear receptor transcription coactivator activity; positive regulation of transcription, DNA-dependent; protein binding; transcription coactivator activity; transcription, DNA-dependent;
NSD1	5	nuclear hormone receptor binding; positive regulation of transcription, DNA-dependent; nucleus; ligand-dependent nuclear receptor binding; transcription, DNA-dependent;
PRPF6	5	nuclear hormone receptor binding; nucleus; nucleoplasm; protein binding; transcription coactivator activity;
TGFB1I1	5	nuclear hormone receptor binding; positive regulation of transcription, DNA-dependent; protein binding; transcription coactivator activity; cytoplasm;
TRIP12	5	nuclear hormone receptor binding; nucleus; nucleoplasm; protein binding; cytoplasm;
ETS1	5	positive regulation of transcription, DNA-dependent; nucleus; protein binding; transcription factor binding; transcription, DNA-dependent;
IRF7	5	positive regulation of transcription, DNA-dependent; nucleus; nucleoplasm; protein binding; cytoplasm;
KAT5	5	positive regulation of transcription, DNA-dependent; nucleus; protein binding; transcription coactivator activity; transcription, DNA-dependent;
NPAT	5	positive regulation of transcription, DNA-dependent; nucleus; protein binding; transcription coactivator activity; transcription, DNA-dependent;
RAN	5	positive regulation of transcription, DNA-dependent; nucleoplasm; protein binding; transcription coactivator activity; cytoplasm;
RSF1	5	positive regulation of transcription, DNA-dependent; nucleus; nucleoplasm; protein binding; chromatin remodeling;
TFAP2A	5	positive regulation of transcription, DNA-dependent; nucleus; protein binding; transcription coactivator activity; cytoplasm;
TP53BP1	5	positive regulation of transcription, DNA-dependent; nucleus; nucleoplasm; protein binding; cytoplasm;
AIP	5	nucleus; protein binding; transcription coactivator activity; transcription factor binding; cytoplasm;
ATXN1	5	nucleus; nucleoplasm; protein binding; transcription, DNA-dependent; cytoplasm;
BNIP3	5	nucleus; nucleoplasm; protein binding; chromatin remodeling; cytoplasm;
CTNND1	5	nucleus; receptor binding; protein binding; transcription, DNA-dependent; cytoplasm;
IGHMBP2	5	nucleus; protein binding; transcription factor binding; transcription, DNA-dependent; cytoplasm;
NEDD4L	5	nucleus; nucleoplasm; protein binding; transcription, DNA-dependent; cytoplasm;
NR4A2	5	nucleus; nucleoplasm; protein binding; transcription, DNA-dependent; cytoplasm;
PGR	5	nucleus; nucleoplasm; receptor binding; protein binding; cytoplasm;
POU2F3	5	nucleus; protein binding; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; cytoplasm;
RCC1	5	nucleus; nucleoplasm; protein binding; cytoplasm; nuclear chromatin;
SAP18	5	nucleus; protein binding; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; cytoplasm;
SUB1	5	nucleus; protein binding; transcription coactivator activity; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent;
TAF10	5	nucleus; nucleoplasm; protein binding; transcription coactivator activity; cytoplasm;
TERF2IP	5	nucleus; nucleoplasm; protein binding; transcription, DNA-dependent; cytoplasm;
UTF1	5	nucleus; protein binding; transcription coactivator activity; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent;
XRCC5	5	nucleus; nucleoplasm; protein binding; transcription, DNA-dependent; cytoplasm;
YAP1	5	nucleus; nucleoplasm; protein binding; transcription coactivator activity; cytoplasm;
E2F5	5	nucleoplasm; protein binding; transcription factor binding; transcription, DNA-dependent; cytoplasm;

Genes shared at least 2 KEGG pathways with SMARCD3 (count: 0)

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Region: chr7:150935850..150974982 View in gBrowse