ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MED30
Previous Symbol	THRAP6
Symbol Alias	TRAP25
Approved Name	mediator complex subunit 30
Previous Name	"thyroid hormone receptor associated protein 6"
Location	8q24.11
Position	chr8:118532952-118552501, 1
External Links	HGNC: 23032 Entrez Gene: 90390 Ensembl: ENSG00000164758 UCSC: uc003yoj.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 16)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0001104	RNA polymerase II transcription cofactor activity	molecular function	IDA[10198638]	18
GO:0005634	nucleus	cellular component	IDA[10235267]	877
GO:0005515	protein binding	molecular function	IPI	1015
GO:0006367	transcription initiation from RNA polymerase II promoter	biological process	IDA[12218053]; TAS	44
GO:0042809	vitamin D receptor binding	molecular function	NAS[10235266]	11
GO:0019827	stem cell maintenance	biological process	IEA	14
GO:0003712	transcription cofactor activity	molecular function	IDA[12218053]	18
GO:0016592	mediator complex	cellular component	IDA[10198638]	20
GO:0030518	intracellular steroid hormone receptor signaling pathway	biological process	IDA[11867769]	10
GO:0010467	gene expression	biological process	TAS	154
GO:0004872	receptor activity	molecular function	IDA[12218053]	38
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	molecular function	NAS[10235266]	18
GO:0005654	nucleoplasm	cellular component	TAS	210
GO:0045893	positive regulation of transcription, DNA-dependent	biological process	IDA[10198638]	89
GO:0030521	androgen receptor signaling pathway	biological process	IDA[12218053]	16
GO:0046966	thyroid hormone receptor binding	molecular function	IDA[10198638]	17

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with MED30 (count: 36)

Gene Symbol	Pathway Count	Pathway List
MED14	15	RNA polymerase II transcription cofactor activity; nucleus; transcription initiation from RNA polymerase II promoter; vitamin D receptor binding; stem cell maintenance; transcription cofactor activity; mediator complex; intracellular steroid hormone receptor signaling pathway; gene expression; receptor activity; ligand-dependent nuclear receptor transcription coactivator activity; nucleoplasm; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; thyroid hormone receptor binding;
MED4	15	RNA polymerase II transcription cofactor activity; nucleus; protein binding; transcription initiation from RNA polymerase II promoter; vitamin D receptor binding; transcription cofactor activity; mediator complex; intracellular steroid hormone receptor signaling pathway; gene expression; receptor activity; ligand-dependent nuclear receptor transcription coactivator activity; nucleoplasm; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; thyroid hormone receptor binding;
MED24	15	RNA polymerase II transcription cofactor activity; nucleus; transcription initiation from RNA polymerase II promoter; vitamin D receptor binding; stem cell maintenance; transcription cofactor activity; mediator complex; intracellular steroid hormone receptor signaling pathway; gene expression; receptor activity; ligand-dependent nuclear receptor transcription coactivator activity; nucleoplasm; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; thyroid hormone receptor binding;
MED17	15	RNA polymerase II transcription cofactor activity; nucleus; transcription initiation from RNA polymerase II promoter; vitamin D receptor binding; stem cell maintenance; transcription cofactor activity; mediator complex; intracellular steroid hormone receptor signaling pathway; gene expression; receptor activity; ligand-dependent nuclear receptor transcription coactivator activity; nucleoplasm; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; thyroid hormone receptor binding;
MED1	15	RNA polymerase II transcription cofactor activity; nucleus; protein binding; transcription initiation from RNA polymerase II promoter; vitamin D receptor binding; transcription cofactor activity; mediator complex; intracellular steroid hormone receptor signaling pathway; gene expression; receptor activity; ligand-dependent nuclear receptor transcription coactivator activity; nucleoplasm; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; thyroid hormone receptor binding;
MED12	15	RNA polymerase II transcription cofactor activity; nucleus; transcription initiation from RNA polymerase II promoter; vitamin D receptor binding; stem cell maintenance; transcription cofactor activity; mediator complex; intracellular steroid hormone receptor signaling pathway; gene expression; receptor activity; ligand-dependent nuclear receptor transcription coactivator activity; nucleoplasm; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; thyroid hormone receptor binding;
MED13	14	RNA polymerase II transcription cofactor activity; nucleus; transcription initiation from RNA polymerase II promoter; vitamin D receptor binding; transcription cofactor activity; mediator complex; intracellular steroid hormone receptor signaling pathway; gene expression; receptor activity; ligand-dependent nuclear receptor transcription coactivator activity; nucleoplasm; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; thyroid hormone receptor binding;
THRAP3	13	RNA polymerase II transcription cofactor activity; nucleus; protein binding; transcription initiation from RNA polymerase II promoter; vitamin D receptor binding; transcription cofactor activity; mediator complex; intracellular steroid hormone receptor signaling pathway; receptor activity; ligand-dependent nuclear receptor transcription coactivator activity; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; thyroid hormone receptor binding;
MED16	12	nucleus; transcription initiation from RNA polymerase II promoter; vitamin D receptor binding; transcription cofactor activity; mediator complex; intracellular steroid hormone receptor signaling pathway; gene expression; receptor activity; nucleoplasm; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; thyroid hormone receptor binding;
MED15	8	RNA polymerase II transcription cofactor activity; nucleus; protein binding; transcription initiation from RNA polymerase II promoter; stem cell maintenance; mediator complex; gene expression; nucleoplasm;
MED7	7	RNA polymerase II transcription cofactor activity; protein binding; transcription initiation from RNA polymerase II promoter; stem cell maintenance; mediator complex; gene expression; nucleoplasm;
NCOA6	7	nucleus; protein binding; transcription initiation from RNA polymerase II promoter; ligand-dependent nuclear receptor transcription coactivator activity; nucleoplasm; positive regulation of transcription, DNA-dependent; thyroid hormone receptor binding;
MED10	6	RNA polymerase II transcription cofactor activity; transcription initiation from RNA polymerase II promoter; stem cell maintenance; mediator complex; gene expression; nucleoplasm;
MED20	6	RNA polymerase II transcription cofactor activity; protein binding; transcription initiation from RNA polymerase II promoter; mediator complex; gene expression; nucleoplasm;
SNW1	6	nucleus; protein binding; transcription initiation from RNA polymerase II promoter; vitamin D receptor binding; gene expression; nucleoplasm;
MED27	6	nucleus; transcription initiation from RNA polymerase II promoter; stem cell maintenance; mediator complex; gene expression; nucleoplasm;
CREBBP	6	nucleus; protein binding; transcription initiation from RNA polymerase II promoter; gene expression; nucleoplasm; positive regulation of transcription, DNA-dependent;
RBM14	5	RNA polymerase II transcription cofactor activity; nucleus; protein binding; mediator complex; ligand-dependent nuclear receptor transcription coactivator activity;
TP53BP1	5	RNA polymerase II transcription cofactor activity; nucleus; protein binding; nucleoplasm; positive regulation of transcription, DNA-dependent;
SMARCD3	5	nucleus; protein binding; ligand-dependent nuclear receptor transcription coactivator activity; nucleoplasm; positive regulation of transcription, DNA-dependent;
PGR	5	nucleus; protein binding; transcription initiation from RNA polymerase II promoter; gene expression; nucleoplasm;
TAF10	5	nucleus; protein binding; transcription initiation from RNA polymerase II promoter; gene expression; nucleoplasm;
HMGA1	5	nucleus; protein binding; ligand-dependent nuclear receptor transcription coactivator activity; nucleoplasm; positive regulation of transcription, DNA-dependent;
MAML1	5	nucleus; protein binding; transcription initiation from RNA polymerase II promoter; gene expression; nucleoplasm;
NEDD4L	5	nucleus; protein binding; transcription initiation from RNA polymerase II promoter; gene expression; nucleoplasm;
MEN1	5	nucleus; protein binding; transcription initiation from RNA polymerase II promoter; gene expression; nucleoplasm;
YAP1	5	nucleus; protein binding; transcription initiation from RNA polymerase II promoter; gene expression; nucleoplasm;
TAF13	5	nucleus; protein binding; transcription initiation from RNA polymerase II promoter; gene expression; nucleoplasm;
SMC1A	5	nucleus; protein binding; stem cell maintenance; gene expression; nucleoplasm;
NR4A2	5	nucleus; protein binding; transcription initiation from RNA polymerase II promoter; gene expression; nucleoplasm;
NR5A1	5	nucleus; protein binding; transcription initiation from RNA polymerase II promoter; gene expression; nucleoplasm;
ESRRA	5	nucleus; protein binding; transcription initiation from RNA polymerase II promoter; gene expression; nucleoplasm;
RBPJ	5	nucleus; protein binding; transcription initiation from RNA polymerase II promoter; gene expression; nucleoplasm;
NCOR2	5	nucleus; protein binding; transcription initiation from RNA polymerase II promoter; gene expression; nucleoplasm;
RAN	5	protein binding; gene expression; nucleoplasm; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway;
MED23	5	protein binding; transcription initiation from RNA polymerase II promoter; mediator complex; gene expression; nucleoplasm;

Genes shared at least 2 KEGG pathways with MED30 (count: 0)

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Region: chr8:118532952..118552501 View in gBrowse