ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PPARGC1B
Symbol Alias	PERC, PGC1B
Approved Name	peroxisome proliferator-activated receptor gamma, coactivator 1 beta
Previous Name	peroxisome proliferative activated receptor, gamma, coactivator 1, beta
Location	5q33.1
Position	chr5:149109815-149234585, +
External Links	HGNC: 30022 Entrez Gene: 133522 Ensembl: ENSG00000155846 UCSC: uc003lrc.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 26)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0035257	nuclear hormone receptor binding	Molecular Function		30

GO terms by database search (count: 25)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005739	mitochondrion	Cellular Component		183
GO:0006390	transcription from mitochondrial promoter	Biological Process		1
GO:0003723	RNA binding	Molecular Function	NAS[11854298]	104
GO:0005634	nucleus	Cellular Component	IDA[11854298]	770
GO:0001104	RNA polymerase II transcription cofactor activity	Molecular Function	IDA[11854298]	16
GO:0001503	ossification	Biological Process		9
GO:0000166	nucleotide binding	Molecular Function		73
GO:0030546	receptor activator activity	Molecular Function	IDA[11854298]	2
GO:0034614	cellular response to reactive oxygen species	Biological Process		5
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	Molecular Function	IDA[11854298]	19
GO:0030520	intracellular estrogen receptor signaling pathway	Biological Process	IDA[11854298]	4
GO:0016592	mediator complex	Cellular Component	IDA[11854298]	17
GO:0030331	estrogen receptor binding	Molecular Function	IDA[11854298]	10
GO:0007015	actin filament organization	Biological Process		12
GO:0010694	positive regulation of alkaline phosphatase activity	Biological Process		1
GO:0051384	response to glucocorticoid stimulus	Biological Process		17
GO:0050682	AF-2 domain binding	Molecular Function	IPI[11854298]	1
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA[11854298]	131
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process		64
GO:0045780	positive regulation of bone resorption	Biological Process		6
GO:0045672	positive regulation of osteoclast differentiation	Biological Process		3
GO:0042327	positive regulation of phosphorylation	Biological Process		5
GO:2000273	positive regulation of receptor activity	Biological Process	IDA[11854298]	3
GO:0060346	bone trabecula formation	Biological Process		1
GO:0051591	response to cAMP	Biological Process		11

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with PPARGC1B (count: 12)

Gene Symbol	Pathway Count	Pathway List
RBM14	8	RNA binding; nucleus; RNA polymerase II transcription cofactor activity; nucleotide binding; ligand-dependent nuclear receptor transcription coactivator activity; intracellular estrogen receptor signaling pathway; mediator complex; positive regulation of transcription from RNA polymerase II promoter;
MED1	8	nucleus; RNA polymerase II transcription cofactor activity; ligand-dependent nuclear receptor transcription coactivator activity; mediator complex; estrogen receptor binding; positive regulation of transcription from RNA polymerase II promoter; nuclear hormone receptor binding; positive regulation of receptor activity;
MED12	6	nucleus; RNA polymerase II transcription cofactor activity; ligand-dependent nuclear receptor transcription coactivator activity; mediator complex; positive regulation of transcription from RNA polymerase II promoter; nuclear hormone receptor binding;
MED13	6	nucleus; RNA polymerase II transcription cofactor activity; ligand-dependent nuclear receptor transcription coactivator activity; mediator complex; positive regulation of transcription from RNA polymerase II promoter; nuclear hormone receptor binding;
MED14	6	nucleus; RNA polymerase II transcription cofactor activity; ligand-dependent nuclear receptor transcription coactivator activity; mediator complex; positive regulation of transcription from RNA polymerase II promoter; nuclear hormone receptor binding;
MED17	6	nucleus; RNA polymerase II transcription cofactor activity; ligand-dependent nuclear receptor transcription coactivator activity; mediator complex; positive regulation of transcription from RNA polymerase II promoter; nuclear hormone receptor binding;
NCOA6	6	nucleus; ligand-dependent nuclear receptor transcription coactivator activity; intracellular estrogen receptor signaling pathway; estrogen receptor binding; positive regulation of transcription from RNA polymerase II promoter; nuclear hormone receptor binding;
THRAP3	6	nucleus; RNA polymerase II transcription cofactor activity; ligand-dependent nuclear receptor transcription coactivator activity; mediator complex; positive regulation of transcription from RNA polymerase II promoter; nuclear hormone receptor binding;
DDX54	5	RNA binding; nucleus; intracellular estrogen receptor signaling pathway; estrogen receptor binding; nuclear hormone receptor binding;
MED24	5	nucleus; RNA polymerase II transcription cofactor activity; ligand-dependent nuclear receptor transcription coactivator activity; mediator complex; nuclear hormone receptor binding;
MED30	5	nucleus; RNA polymerase II transcription cofactor activity; ligand-dependent nuclear receptor transcription coactivator activity; mediator complex; nuclear hormone receptor binding;
MED4	5	nucleus; RNA polymerase II transcription cofactor activity; ligand-dependent nuclear receptor transcription coactivator activity; mediator complex; nuclear hormone receptor binding;

Genes shared at least 2 KEGG pathways with PPARGC1B (count: 0)

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Region: chr5:149109815..149234585 View in gBrowse