ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ESRRA
Previous Symbol	ESRL1
Symbol Alias	ERR1, ERRalpha, NR3B1, ERRa
Approved Name	estrogen-related receptor alpha
Location	11q12
Position	chr11:64073044-64084215, +
External Links	HGNC: 3471 Entrez Gene: 2101 Ensembl: ENSG00000173153 UCSC: uc001nzq.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 18)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0045670	regulation of osteoclast differentiation	Biological Process		2
GO:0045667	regulation of osteoblast differentiation	Biological Process		3
GO:0051216	cartilage development	Biological Process		11
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process		131
GO:0030522	intracellular receptor mediated signaling pathway	Biological Process	TAS[9286700]	6
GO:0019904	protein domain specific binding	Molecular Function	IPI[11984006]	40
GO:0043565	sequence-specific DNA binding	Molecular Function		72
GO:0042127	regulation of cell proliferation	Biological Process		20
GO:0006367	transcription initiation from RNA polymerase II promoter	Biological Process		42
GO:0005654	nucleoplasm	Cellular Component		183
GO:0010467	gene expression	Biological Process		140
GO:0008270	zinc ion binding	Molecular Function		323
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	Molecular Function	TAS[9286700]	6
GO:0005496	steroid binding	Molecular Function		7
GO:0005515	protein binding	Molecular Function	IPI[16260778]	910
GO:0005634	nucleus	Cellular Component	TAS[9286700]	770
GO:0003677	DNA binding	Molecular Function	TAS[9286700]	220
GO:0003707	steroid hormone receptor activity	Molecular Function		9

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with ESRRA (count: 57)

Gene Symbol	Pathway Count	Pathway List
NR5A1	12	positive regulation of transcription from RNA polymerase II promoter; intracellular receptor mediated signaling pathway; sequence-specific DNA binding; transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; zinc ion binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; protein binding; nucleus; DNA binding; steroid hormone receptor activity;
NR4A2	11	positive regulation of transcription from RNA polymerase II promoter; intracellular receptor mediated signaling pathway; sequence-specific DNA binding; transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; zinc ion binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; protein binding; nucleus; steroid hormone receptor activity;
PGR	11	sequence-specific DNA binding; transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; zinc ion binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; steroid binding; protein binding; nucleus; DNA binding; steroid hormone receptor activity;
RORA	10	positive regulation of transcription from RNA polymerase II promoter; intracellular receptor mediated signaling pathway; sequence-specific DNA binding; transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; zinc ion binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; protein binding; steroid hormone receptor activity;
NR6A1	9	intracellular receptor mediated signaling pathway; sequence-specific DNA binding; transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; zinc ion binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; DNA binding; steroid hormone receptor activity;
NR3C2	8	sequence-specific DNA binding; transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; zinc ion binding; steroid binding; protein binding; steroid hormone receptor activity;
NR4A3	8	sequence-specific DNA binding; transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; zinc ion binding; nucleus; DNA binding; steroid hormone receptor activity;
MEN1	7	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; protein binding; nucleus;
RBPJ	7	positive regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; protein binding; nucleus; DNA binding;
MAPK3	6	cartilage development; positive regulation of transcription from RNA polymerase II promoter; nucleoplasm; gene expression; protein binding; nucleus;
E2F5	6	positive regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; protein binding; DNA binding;
MAML1	6	positive regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; protein binding; nucleus;
MED1	6	positive regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; protein binding; nucleus;
MED12	6	positive regulation of transcription from RNA polymerase II promoter; protein domain specific binding; transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; nucleus;
RELA	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; nucleoplasm; protein binding; nucleus; DNA binding;
SNW1	6	positive regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; protein binding; nucleus;
YAP1	6	positive regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; protein binding; nucleus;
NCOR1	6	sequence-specific DNA binding; transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; protein binding; nucleus;
NCOR2	6	transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; protein binding; nucleus; DNA binding;
TAF13	6	transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; protein binding; nucleus; DNA binding;
FUS	6	nucleoplasm; gene expression; zinc ion binding; protein binding; nucleus; DNA binding;
ZBTB16	5	cartilage development; zinc ion binding; protein binding; nucleus; DNA binding;
ATXN1	5	positive regulation of transcription from RNA polymerase II promoter; nucleoplasm; protein binding; nucleus; DNA binding;
ETS1	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; protein binding; nucleus; DNA binding;
FOXG1	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; protein binding; nucleus; DNA binding;
GATA6	5	positive regulation of transcription from RNA polymerase II promoter; nucleoplasm; zinc ion binding; protein binding; nucleus;
HES1	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; protein binding; nucleus; DNA binding;
HNF1B	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; protein binding; nucleus; DNA binding;
HOXA5	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; protein binding; nucleus; DNA binding;
HOXB1	5	positive regulation of transcription from RNA polymerase II promoter; protein domain specific binding; sequence-specific DNA binding; nucleus; DNA binding;
IKZF1	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; zinc ion binding; nucleus; DNA binding;
IRF7	5	positive regulation of transcription from RNA polymerase II promoter; nucleoplasm; protein binding; nucleus; DNA binding;
KLF13	5	positive regulation of transcription from RNA polymerase II promoter; zinc ion binding; protein binding; nucleus; DNA binding;
MAML2	5	positive regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; nucleus;
MED13	5	positive regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; nucleus;
MED14	5	positive regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; nucleus;
MED17	5	positive regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; nucleus;
MTA2	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; zinc ion binding; protein binding; nucleus;
NCOA6	5	positive regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; nucleoplasm; protein binding; nucleus;
PRPF6	5	positive regulation of transcription from RNA polymerase II promoter; nucleoplasm; gene expression; protein binding; nucleus;
SREBF1	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; protein binding; nucleus; DNA binding;
UBB	5	positive regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; protein binding;
UBC	5	positive regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; protein binding;
ZNF24	5	sequence-specific DNA binding; zinc ion binding; protein binding; nucleus; DNA binding;
MED15	5	transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; protein binding; nucleus;
MED30	5	transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; protein binding; nucleus;
MED4	5	transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; protein binding; nucleus;
NEDD4L	5	transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; protein binding; nucleus;
TAF10	5	transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; protein binding; nucleus;
TAF4B	5	transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; nucleus; DNA binding;
DHX9	5	nucleoplasm; gene expression; protein binding; nucleus; DNA binding;
HINFP	5	nucleoplasm; zinc ion binding; protein binding; nucleus; DNA binding;
NCBP1	5	nucleoplasm; gene expression; protein binding; nucleus; DNA binding;
POLR1A	5	nucleoplasm; gene expression; zinc ion binding; protein binding; DNA binding;
SF3A3	5	nucleoplasm; gene expression; zinc ion binding; protein binding; nucleus;
SSRP1	5	nucleoplasm; gene expression; protein binding; nucleus; DNA binding;
U2AF1	5	nucleoplasm; gene expression; zinc ion binding; protein binding; nucleus;

Genes shared at least 2 KEGG pathways with ESRRA (count: 0)

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Region: chr11:64073044..64084215 View in gBrowse