ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	RORA
Symbol Alias	RZRA, ROR1, ROR2, ROR3, NR1F1
Approved Name	RAR-related orphan receptor A
Location	15q21-q22
Position	chr15:60780483-61521518, -
External Links	HGNC: 10258 Entrez Gene: 6095 Ensembl: ENSG00000069667 UCSC: uc002agv.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 0)

Gene related SNPs (count: 2)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs922781	Chr15:61070344(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant	2(0/2/0)

LD-proxies (count: 1)

rs_ID	Location	Functional Annotation
rs922782	Chr15:61070183(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 16)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0030522	intracellular receptor mediated signaling pathway	Biological Process	TAS[7926749]	6
GO:0021702	cerebellar Purkinje cell differentiation	Biological Process		3
GO:0010467	gene expression	Biological Process		140
GO:0008270	zinc ion binding	Molecular Function		323
GO:0046068	cGMP metabolic process	Biological Process		1
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA[17545671]	131
GO:0043565	sequence-specific DNA binding	Molecular Function		72
GO:0043030	regulation of macrophage activation	Biological Process		4
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	Molecular Function		6
GO:0005515	protein binding	Molecular Function	IPI[16713569]	910
GO:0003700	sequence-specific DNA binding transcription factor activity	Molecular Function	IDA[17545671]	132
GO:0003707	steroid hormone receptor activity	Molecular Function		9
GO:0006809	nitric oxide biosynthetic process	Biological Process		2
GO:0007165	signal transduction	Biological Process	NAS[7926749]	171
GO:0005654	nucleoplasm	Cellular Component		183
GO:0006367	transcription initiation from RNA polymerase II promoter	Biological Process		42

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04710	Circadian rhythm - mammal	6

Genes shared at least 5 GO terms with RORA (count: 24)

Gene Symbol	Pathway Count	Pathway List
NR4A2	11	intracellular receptor mediated signaling pathway; gene expression; zinc ion binding; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; protein binding; steroid hormone receptor activity; signal transduction; nucleoplasm; transcription initiation from RNA polymerase II promoter;
ESRRA	10	intracellular receptor mediated signaling pathway; gene expression; zinc ion binding; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; protein binding; steroid hormone receptor activity; nucleoplasm; transcription initiation from RNA polymerase II promoter;
NR5A1	10	intracellular receptor mediated signaling pathway; gene expression; zinc ion binding; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; protein binding; steroid hormone receptor activity; nucleoplasm; transcription initiation from RNA polymerase II promoter;
NR3C2	9	gene expression; zinc ion binding; sequence-specific DNA binding; protein binding; sequence-specific DNA binding transcription factor activity; steroid hormone receptor activity; signal transduction; nucleoplasm; transcription initiation from RNA polymerase II promoter;
PGR	9	gene expression; zinc ion binding; sequence-specific DNA binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; protein binding; steroid hormone receptor activity; signal transduction; nucleoplasm; transcription initiation from RNA polymerase II promoter;
NR6A1	8	intracellular receptor mediated signaling pathway; gene expression; zinc ion binding; sequence-specific DNA binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; steroid hormone receptor activity; nucleoplasm; transcription initiation from RNA polymerase II promoter;
E2F5	6	gene expression; positive regulation of transcription from RNA polymerase II promoter; protein binding; sequence-specific DNA binding transcription factor activity; nucleoplasm; transcription initiation from RNA polymerase II promoter;
MEN1	6	gene expression; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; protein binding; nucleoplasm; transcription initiation from RNA polymerase II promoter;
NCOR1	6	gene expression; sequence-specific DNA binding; protein binding; sequence-specific DNA binding transcription factor activity; nucleoplasm; transcription initiation from RNA polymerase II promoter;
NR4A3	6	gene expression; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity; nucleoplasm; transcription initiation from RNA polymerase II promoter;
RBPJ	6	gene expression; positive regulation of transcription from RNA polymerase II promoter; protein binding; sequence-specific DNA binding transcription factor activity; nucleoplasm; transcription initiation from RNA polymerase II promoter;
MAML1	5	gene expression; positive regulation of transcription from RNA polymerase II promoter; protein binding; nucleoplasm; transcription initiation from RNA polymerase II promoter;
MED1	5	gene expression; positive regulation of transcription from RNA polymerase II promoter; protein binding; nucleoplasm; transcription initiation from RNA polymerase II promoter;
SNW1	5	gene expression; positive regulation of transcription from RNA polymerase II promoter; protein binding; nucleoplasm; transcription initiation from RNA polymerase II promoter;
TAF10	5	gene expression; protein binding; sequence-specific DNA binding transcription factor activity; nucleoplasm; transcription initiation from RNA polymerase II promoter;
TAF13	5	gene expression; protein binding; sequence-specific DNA binding transcription factor activity; nucleoplasm; transcription initiation from RNA polymerase II promoter;
UBB	5	gene expression; positive regulation of transcription from RNA polymerase II promoter; protein binding; nucleoplasm; transcription initiation from RNA polymerase II promoter;
UBC	5	gene expression; positive regulation of transcription from RNA polymerase II promoter; protein binding; nucleoplasm; transcription initiation from RNA polymerase II promoter;
YAP1	5	gene expression; positive regulation of transcription from RNA polymerase II promoter; protein binding; nucleoplasm; transcription initiation from RNA polymerase II promoter;
CBFA2T3	5	zinc ion binding; positive regulation of transcription from RNA polymerase II promoter; protein binding; sequence-specific DNA binding transcription factor activity; nucleoplasm;
GATA6	5	zinc ion binding; positive regulation of transcription from RNA polymerase II promoter; protein binding; sequence-specific DNA binding transcription factor activity; nucleoplasm;
MTA2	5	zinc ion binding; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; protein binding; sequence-specific DNA binding transcription factor activity;
RELA	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; protein binding; sequence-specific DNA binding transcription factor activity; nucleoplasm;
ATF6	5	sequence-specific DNA binding; protein binding; sequence-specific DNA binding transcription factor activity; signal transduction; nucleoplasm;

Genes shared at least 2 KEGG pathways with RORA (count: 0)

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Region: chr15:60780483..61521518 View in gBrowse