ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0007165
Name signal transduction
Type biological process
No. of Genes in ADHDgene  189
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 189)

Literature-origin genes (count: 34)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 9q21.32 1(1/0/0) TAS[8808280]
PRKG1 protein kinase, cGMP-dependent, type I 10q11.2 2(0/1/1) IEA
CLOCK clock circadian regulator 4q12 2(2/0/0) TAS[10198158]
CSNK1E casein kinase 1, epsilon 22q13.1 2(1/1/0) TAS[7797465]
CNTFR ciliary neurotrophic factor receptor 9p13 1(1/0/0) NAS[1648265]
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 20p13 1(0/1/0) IEA
FGF12 fibroblast growth factor 12 3q28 1(0/1/0) TAS[8790420]
ADRBK2 adrenergic, beta, receptor kinase 2 22q11 1(0/1/0) IEA
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 18p11.22-p11.21 1(1/0/0) TAS[8243272]
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 4q32.3 1(1/0/0) IEA
MAP2K3 mitogen-activated protein kinase kinase 3 17q11.2 1(0/1/0) TAS[7839144]
BRE brain and reproductive organ-expressed (TNFRSF1A modulator) 2p23 1(1/0/0) TAS[9737713]
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2) 12q23 2(2/0/0) TAS[7958835]
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) 15q13.3 2(0/1/1) IDA[8906617]
ADRA1A adrenoceptor alpha 1A 8p21.2 3(2/1/0) TAS[8396931]
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 10q21 2(0/2/0) IEA
NR4A2 nuclear receptor subfamily 4, group A, member 2 2q22-q23 2(0/2/0) NAS[7877627]
GDNF glial cell derived neurotrophic factor 5p13.1-p12 2(1/1/0) TAS[7830769]
TENM4 teneurin transmembrane protein 4 11q13 1(0/1/0) IEA
NET1 neuroepithelial cell transforming 1 10p15 1(1/0/0) TAS[8649828]
NTF3 neurotrophin 3 12p13 4(1/3/0) TAS[2236018]
ADRBK1 adrenergic, beta, receptor kinase 1 11q13 1(0/1/0) TAS
TSPAN8 tetraspanin 8 12q14.1-q21.1 1(0/1/0) TAS[2395876]
ADRA2A adrenoceptor alpha 2A 10q25.2 13(4/9/0) TAS[2823383]
NR3C2 nuclear receptor subfamily 3, group C, member 2 4q31 1(0/1/0) TAS[3037703]
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) 15q24 1(0/1/0) IDA[8906617]
UNC5B unc-5 homolog B (C. elegans) 10q22.2 1(0/0/1) IEA
PRKD1 protein kinase D1 14q11 1(0/1/0) TAS[8119958]
CNTF ciliary neurotrophic factor 11q12 1(1/0/0) NAS[1840538]
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B 17q12 1(0/1/0) TAS[10604473]
MAP2K5 mitogen-activated protein kinase kinase 5 15q22.31 1(1/0/0) TAS[7759517]
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 3p24.3 1(0/0/1) TAS[9571151]
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 20q13.33 7(4/3/0) IDA[8906617]
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma 4p16.1 1(1/0/0) NAS

Genes from other sources Help (count: 155)

Approved Symbol Approved Name Source Evidence[PMID]
TRHDE thyrotropin-releasing hormone degrading enzyme Mapped by LD-proxy TAS[10491199]
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) Mapped by LD-proxy IDA[8906617]
SIPA1 signal-induced proliferation-associated 1 Mapped by significant region TAS[9346962]
PDE4D phosphodiesterase 4D, cAMP-specific Mapped by CNV IEA
RASD1 RAS, dexamethasone-induced 1 Mapped by significant region TAS[10673050]
MAPK7 mitogen-activated protein kinase 7 Mapped by significant region TAS[7646528]
IQGAP2 IQ motif containing GTPase activating protein 2 Mapped by CNV TAS[8756646]
STMN1 stathmin 1 Mapped by PBA pathway NAS[8003023]
PPP1R12B protein phosphatase 1, regulatory subunit 12B Mapped by Literature SNP TAS[9570949]
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta Mapped by CNV TAS
TRPM1 transient receptor potential cation channel, subfamily M, member 1 Mapped by CNV; Mapped by significant region; Mapped by PBA pathway IEA
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit Mapped by significant region TAS[8557660]
DTNA dystrobrevin, alpha Mapped by significant region TAS[10767327]
MAPRE2 microtubule-associated protein, RP/EB family, member 2 Mapped by significant region TAS[9233623]
CHRM1 cholinergic receptor, muscarinic 1 Mapped by significant region; Mapped by PBA pathway TAS[9614217]
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal Mapped by CNV; Mapped by PBA pathway TAS[7670466]
IL11RA interleukin 11 receptor, alpha Mapped by LD-proxy TAS[8786120]
GJA1 gap junction protein, alpha 1, 43kDa Mapped by Literature SNP; Mapped by significant region IMP[12761501]
MAPK1 mitogen-activated protein kinase 1 Mapped by LD-proxy TAS[1540184]
LPXN leupaxin Mapped by significant region TAS[9565592]
RAN RAN, member RAS oncogene family Mapped by PBA pathway TAS[7603572]
INHA inhibin, alpha Mapped by significant region TAS[3267209]
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated) Mapped by significant region TAS[9789079]
FAM126A family with sequence similarity 126, member A Mapped by significant region NAS[10910037]
PYCARD PYD and CARD domain containing Mapped by CNV NAS[12019269]
TAAR5 trace amine associated receptor 5 Mapped by significant region TAS[9464258]
DGKG diacylglycerol kinase, gamma 90kDa Mapped by Literature SNP TAS[8034597]
NCK2 NCK adaptor protein 2 Mapped by PBA pathway TAS[9737977]
CTNND2 catenin (cadherin-associated protein), delta 2 Mapped by CNV; Mapped by significant region TAS[9223106]
ULK2 unc-51 like autophagy activating kinase 2 Mapped by significant region IEA
SMC3 structural maintenance of chromosomes 3 Mapped by PBA pathway IDA[12651860]
OR1F1 olfactory receptor, family 1, subfamily F, member 1 Mapped by significant region NAS[9500546]
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 Mapped by Literature SNP TAS
RHBDL1 rhomboid, veinlet-like 1 (Drosophila) Mapped by significant region TAS[9662444]
ADCY9 adenylate cyclase 9 Mapped by significant region TAS
IGFBP2 insulin-like growth factor binding protein 2, 36kDa Mapped by significant region IEA
GAPVD1 GTPase activating protein and VPS9 domains 1 Mapped by significant region IEA
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 Mapped by CNV NAS[8648241]; TAS
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) Mapped by CNV TAS[2142460]
CREBBP CREB binding protein Mapped by significant region NAS[15261140]
PDIA3 protein disulfide isomerase family A, member 3 Mapped by PBA pathway TAS[3398923]
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein Mapped by significant region TAS[9751059]
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) Mapped by Literature SNP IMP[12761501]
PPP2R2D protein phosphatase 2, regulatory subunit B, delta Mapped by CNV IEA
GRP gastrin-releasing peptide Mapped by significant region NAS[3027901]
IL7R interleukin 7 receptor Mapped by significant region TAS[2317865]
APOL3 apolipoprotein L, 3 Mapped by CNV IMP[12761501]
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 Mapped by significant region TAS[7796809]
IFNGR1 interferon gamma receptor 1 Mapped by significant region TAS[2971451]
CHL1 cell adhesion molecule L1-like Mapped by CNV TAS[9799093]
CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase) Mapped by CNV TAS[9000130]
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) Mapped by CNV NAS[8894693]
CHRM3 cholinergic receptor, muscarinic 3 Mapped by CNV; Mapped by PBA pathway TAS[10940357]
KCNIP1 Kv channel interacting protein 1 Mapped by Literature SNP TAS[10676964]
CLCN6 chloride channel, voltage-sensitive 6 Mapped by LD-proxy NAS[9224655]
ROPN1L rhophilin associated tail protein 1-like Mapped by significant region IEA
NRGN neurogranin (protein kinase C substrate, RC3) Mapped by significant region TAS[10075657]
HBS1L HBS1-like (S. cerevisiae) Mapped by significant region TAS[9872408]
RASA1 RAS p21 protein activator (GTPase activating protein) 1 Mapped by PBA pathway IDA[1756860]
STAP1 signal transducing adaptor family member 1 Mapped by significant region TAS[10518561]
PDE7B phosphodiesterase 7B Mapped by significant region IEA
EDARADD EDAR-associated death domain Mapped by CNV IEA
TRIM13 tripartite motif containing 13 Mapped by LD-proxy IMP[12761501]
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 Mapped by CNV; Mapped by significant region TAS[1664410]
SPN sialophorin Mapped by CNV TAS[2023632]
FGF3 fibroblast growth factor 3 Mapped by significant region TAS[2470007]
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 Mapped by CNV; Mapped by significant region TAS[1321750]
GUCY1A2 guanylate cyclase 1, soluble, alpha 2 Mapped by significant region TAS[1683630]
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated Mapped by significant region IEA
ANGPTL5 angiopoietin-like 5 Mapped by significant region IEA
FGF4 fibroblast growth factor 4 Mapped by significant region TAS[2959959]
CNTNAP2 contactin associated protein-like 2 Mapped by CNV IEA
IL5RA interleukin 5 receptor, alpha Mapped by CNV TAS[1732409]
TNC tenascin C Mapped by significant region IEA
TXN thioredoxin Mapped by significant region TAS[10947064]
LITAF lipopolysaccharide-induced TNF factor Mapped by significant region IMP[12761501]
GPR123 G protein-coupled receptor 123 Mapped by CNV NAS[17212699]
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha Mapped by CNV NAS[7961848]
PPP1R1C protein phosphatase 1, regulatory (inhibitor) subunit 1C Mapped by Literature SNP IEA
PLA2G1B phospholipase A2, group IB (pancreas) Mapped by PBA pathway TAS[9886417]
ATF6 activating transcription factor 6 Mapped by CNV TAS[9271374]
TNFRSF17 tumor necrosis factor receptor superfamily, member 17 Mapped by significant region TAS[10908663]
IGFBP5 insulin-like growth factor binding protein 5 Mapped by significant region NAS[7525452]
RIT2 Ras-like without CAAX 2 Mapped by significant region TAS[8918462]
COPS3 COP9 signalosome subunit 3 Mapped by significant region TAS[9535219]
ANGPTL2 angiopoietin-like 2 Mapped by significant region IEA
TRAF1 TNF receptor-associated factor 1 Mapped by significant region IEA
P2RX6 purinergic receptor P2X, ligand-gated ion channel, 6 Mapped by CNV TAS[9242461]
OMP olfactory marker protein Mapped by significant region TAS[8790421]
CHKA choline kinase alpha Mapped by significant region TAS[10363580]
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) Mapped by significant region NAS[10587371]
PRKRIR protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) Mapped by significant region TAS[9447982]
GNG10 guanine nucleotide binding protein (G protein), gamma 10 Mapped by significant region TAS[7665596]
ADCY2 adenylate cyclase 2 (brain) Mapped by significant region TAS
OPTN optineurin Mapped by PBA pathway TAS[9488477]
ADCY4 adenylate cyclase 4 Mapped by significant region TAS
ADCY3 adenylate cyclase 3 Mapped by LD-proxy TAS
RIPK3 receptor-interacting serine-threonine kinase 3 Mapped by significant region TAS[10339433]
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 Mapped by significant region TAS[9804755]
CASKIN1 CASK interacting protein 1 Mapped by significant region ISS[12040031]
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 Mapped by significant region NAS[9872942]
CABP2 calcium binding protein 2 Mapped by significant region TAS[10625670]
CXCL12 chemokine (C-X-C motif) ligand 12 Mapped by PBA pathway TAS[10491003]
PGR progesterone receptor Mapped by significant region TAS[1557371]
AIP aryl hydrocarbon receptor interacting protein Mapped by significant region TAS[9111057]
OR6A2 olfactory receptor, family 6, subfamily A, member 2 Mapped by CNV NAS[9787077]
CLTCL1 clathrin, heavy chain-like 1 Mapped by CNV TAS[8844170]
MFAP4 microfibrillar-associated protein 4 Mapped by significant region IEA
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator Mapped by CNV TAS[9367155]
TNR tenascin R Mapped by significant region IEA
CASP1 caspase 1, apoptosis-related cysteine peptidase Mapped by significant region TAS[1373520]
CXCR2 chemokine (C-X-C motif) receptor 2 Mapped by significant region IDA[10820279]
MAVS mitochondrial antiviral signaling protein Mapped by CNV IMP
EDNRA endothelin receptor type A Mapped by PBA pathway TAS[1326535]
TGFBR1 transforming growth factor, beta receptor 1 Mapped by significant region IDA[14633705]
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit Mapped by CNV TAS[9575201]
FGF9 fibroblast growth factor 9 Mapped by significant region TAS[8575785]
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) Mapped by LD-proxy NAS[9009220]
DRG2 developmentally regulated GTP binding protein 2 Mapped by significant region TAS[7929244]
RIN1 Ras and Rab interactor 1 Mapped by significant region IEA
RANBP1 RAN binding protein 1 Mapped by CNV TAS[16130169]
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 Mapped by significant region TAS[8391931]
SKAP2 src kinase associated phosphoprotein 2 Mapped by significant region TAS[9837776]
SPA17 sperm autoantigenic protein 17 Mapped by significant region IEA
CAPN5 calpain 5 Mapped by significant region TAS[9339374]
ARHGAP42 Rho GTPase activating protein 42 Mapped by significant region IEA
IL10RA interleukin 10 receptor, alpha Mapped by significant region TAS[8407942]
OR5I1 olfactory receptor, family 5, subfamily I, member 1 Mapped by CNV; Mapped by significant region NAS[9787077]
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 Mapped by significant region TAS[7913952]
NEK6 NIMA-related kinase 6 Mapped by significant region IMP[12761501]
ROR2 receptor tyrosine kinase-like orphan receptor 2 Mapped by significant region TAS[1334494]
CABP4 calcium binding protein 4 Mapped by significant region NAS[10625670]
AKAP10 A kinase (PRKA) anchor protein 10 Mapped by significant region TAS[9326583]
TNN tenascin N Mapped by significant region IEA
NMU neuromedin U Mapped by LD-proxy TAS[7619205]
P2RX3 purinergic receptor P2X, ligand-gated ion channel, 3 Mapped by significant region TAS[9221902]
RORA RAR-related orphan receptor A Mapped by Literature SNP NAS[7926749]
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) Mapped by CNV NAS[8103515]
IGFALS insulin-like growth factor binding protein, acid labile subunit Mapped by significant region TAS[1384485]
RTKN2 rhotekin 2 Mapped by CNV IEA
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7 Mapped by CNV TAS
ANKDD1B ankyrin repeat and death domain containing 1B Mapped by LD-proxy IEA
FYB FYN binding protein Mapped by significant region TAS[9207119]
ATM ataxia telangiectasia mutated Mapped by CNV; Mapped by significant region TAS[7792600]
SOX8 SRY (sex determining region Y)-box 8 Mapped by significant region ISS
ERBB2 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 Mapped by LD-proxy IDA[10572067]
PTPRK protein tyrosine phosphatase, receptor type, K Mapped by CNV; Mapped by significant region IDA[16849327]
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18 Mapped by significant region TAS[10074428]
PDCL phosducin-like Mapped by significant region NAS[10524200]
CCND3 cyclin D3 Mapped by CNV IEA
CNTNAP4 contactin associated protein-like 4 Mapped by significant region IEA
COL15A1 collagen, type XV, alpha 1 Mapped by significant region NAS[10891348]
SERGEF secretion regulating guanine nucleotide exchange factor Mapped by LD-proxy TAS[10571079]
ITK IL2-inducible T-cell kinase Mapped by significant region TAS[8364206]
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit Mapped by CNV TAS[10454147]