ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MEN1
Approved Name	multiple endocrine neoplasia I
Name Alias	"menin"
Location	11q13
Position	chr11:64570982-64578766, -1
External Links	HGNC: 7010 Entrez Gene: 4221 Ensembl: ENSG00000133895 UCSC: uc001obn.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 61)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 61)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0035097	histone methyltransferase complex	cellular component	IDA[17500065]; IPI[14992727]	6
GO:0008285	negative regulation of cell proliferation	biological process	IDA[15331604]	65
GO:0051781	positive regulation of cell division	biological process	IEA	12
GO:0043065	positive regulation of apoptotic process	biological process	IEA	38
GO:0044212	transcription regulatory region DNA binding	molecular function	IDA	28
GO:0045668	negative regulation of osteoblast differentiation	biological process	IGI[15563473]	6
GO:0010467	gene expression	biological process	TAS	154
GO:0045892	negative regulation of transcription, DNA-dependent	biological process	IDA[12226747]	77
GO:0005829	cytosol	cellular component	IDA[14508515]	485
GO:0000400	four-way junction DNA binding	molecular function	IDA[15331604]	1
GO:0010332	response to gamma radiation	biological process	IDA[12874027]	3
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	biological process	IMP[11274402]	8
GO:0007179	transforming growth factor beta receptor signaling pathway	biological process	TAS	13
GO:0003690	double-stranded DNA binding	molecular function	IDA[15331604]	17
GO:0032925	regulation of activin receptor signaling pathway	biological process	IEA	2
GO:0005654	nucleoplasm	cellular component	TAS	210
GO:0000403	Y-form DNA binding	molecular function	IDA[15331604]	1
GO:0001933	negative regulation of protein phosphorylation	biological process	IDA[12226747]	5
GO:0045669	positive regulation of osteoblast differentiation	biological process	IEA	7
GO:0070412	R-SMAD binding	molecular function	IPI[11274402]	2
GO:0005515	protein binding	molecular function	IPI[14508515]	1015
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	TAS	141
GO:0016363	nuclear matrix	cellular component	IDA[12874027]	16
GO:0001776	leukocyte homeostasis	biological process	IEA	1
GO:0005634	nucleus	cellular component	IDA	877
GO:0034968	histone lysine methylation	biological process	IDA[14992727]	1
GO:0018024	histone-lysine N-methyltransferase activity	molecular function	IDA[14992727]	4
GO:0006281	DNA repair	biological process	NAS[12874027]	70
GO:0032092	positive regulation of protein binding	biological process	IDA	5
GO:0002051	osteoblast fate commitment	biological process	IEA	1
GO:0005730	nucleolus	cellular component	IDA	271
GO:0006351	transcription, DNA-dependent	biological process	TAS	281
GO:0031062	positive regulation of histone methylation	biological process	IEA	2
GO:0043234	protein complex	cellular component	IDA[15199122]	47
GO:0003682	chromatin binding	molecular function	IEA	50
GO:0006367	transcription initiation from RNA polymerase II promoter	biological process	TAS	44
GO:0046621	negative regulation of organ growth	biological process	IEA	2
GO:0030674	protein binding, bridging	molecular function	IDA	13
GO:0045736	negative regulation of cyclin-dependent protein kinase activity	biological process	IMP[15640349]	7
GO:0009411	response to UV	biological process	IDA[16690369]	8
GO:0032154	cleavage furrow	cellular component	IDA[14508515]	10
GO:0000785	chromatin	cellular component	IDA[12874027]	16
GO:0007420	brain development	biological process	IEA	36
GO:0005737	cytoplasm	cellular component	IDA	781
GO:0060135	maternal process involved in female pregnancy	biological process	IEA	5
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	biological process	IEA	7
GO:0043565	sequence-specific DNA binding	molecular function	IEA	80
GO:0060021	palate development	biological process	IEA	4
GO:0000165	MAPK cascade	biological process	IDA[12226747]	10
GO:0045786	negative regulation of cell cycle	biological process	IDA[15331604]	9
GO:0030097	hemopoiesis	biological process	IEA	10
GO:0006338	chromatin remodeling	biological process	IEA	11
GO:0046329	negative regulation of JNK cascade	biological process	IDA[12226747]	5
GO:0048704	embryonic skeletal system morphogenesis	biological process	IEA	9
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IDA[9989505]	90
GO:0007050	cell cycle arrest	biological process	IEA	28
GO:0006974	response to DNA damage stimulus	biological process	IDA[16690369]	41
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	biological process	IDA[12226747]	7
GO:0047485	protein N-terminus binding	molecular function	IPI[11526476]	27
GO:0051974	negative regulation of telomerase activity	biological process	IMP[12837246]	1
GO:0002076	osteoblast development	biological process	IGI[15563473]	4

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with MEN1 (count: 272)

Gene Symbol	Pathway Count	Pathway List
SNW1	12	gene expression; negative regulation of transcription, DNA-dependent; positive regulation of transforming growth factor beta receptor signaling pathway; nucleoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; nuclear matrix; nucleus; nucleolus; transcription initiation from RNA polymerase II promoter; chromatin; negative regulation of transcription from RNA polymerase II promoter;
NCOA6	11	histone methyltransferase complex; nucleoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; DNA repair; nucleolus; chromatin binding; transcription initiation from RNA polymerase II promoter; brain development; response to DNA damage stimulus;
YAP1	11	transcription regulatory region DNA binding; gene expression; cytosol; nucleoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; chromatin binding; transcription initiation from RNA polymerase II promoter; cytoplasm; response to DNA damage stimulus;
RELA	11	transcription regulatory region DNA binding; negative regulation of transcription, DNA-dependent; cytosol; nucleoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; chromatin binding; cytoplasm; sequence-specific DNA binding; protein N-terminus binding;
ID2	11	negative regulation of osteoblast differentiation; negative regulation of transcription, DNA-dependent; cytosol; protein binding; nucleus; nucleolus; protein complex; chromatin; cytoplasm; negative regulation of transcription from RNA polymerase II promoter; negative regulation of sequence-specific DNA binding transcription factor activity;
NCOR2	11	gene expression; transforming growth factor beta receptor signaling pathway; nucleoplasm; protein binding; nucleus; nucleolus; transcription, DNA-dependent; chromatin binding; transcription initiation from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; protein N-terminus binding;
APC	10	negative regulation of cell proliferation; positive regulation of cell division; positive regulation of apoptotic process; cytosol; protein binding; nucleus; negative regulation of cyclin-dependent protein kinase activity; cytoplasm; cell cycle arrest; response to DNA damage stimulus;
KDM1A	10	transcription regulatory region DNA binding; negative regulation of transcription, DNA-dependent; nucleoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent; chromatin binding; negative regulation of transcription from RNA polymerase II promoter; negative regulation of sequence-specific DNA binding transcription factor activity;
XRCC5	10	transcription regulatory region DNA binding; negative regulation of transcription, DNA-dependent; double-stranded DNA binding; nucleoplasm; protein binding; nucleus; DNA repair; nucleolus; transcription, DNA-dependent; cytoplasm;
MED1	10	gene expression; nucleoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; nucleolus; chromatin binding; transcription initiation from RNA polymerase II promoter; brain development; negative regulation of transcription from RNA polymerase II promoter;
UBB	10	gene expression; cytosol; transforming growth factor beta receptor signaling pathway; nucleoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; DNA repair; transcription, DNA-dependent; transcription initiation from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter;
NEDD4L	10	gene expression; cytosol; transforming growth factor beta receptor signaling pathway; nucleoplasm; protein binding; nucleus; transcription, DNA-dependent; transcription initiation from RNA polymerase II promoter; cytoplasm; negative regulation of transcription from RNA polymerase II promoter;
RBPJ	10	gene expression; negative regulation of transcription, DNA-dependent; nucleoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; nucleolus; transcription initiation from RNA polymerase II promoter; cytoplasm; negative regulation of transcription from RNA polymerase II promoter;
UBC	10	gene expression; cytosol; transforming growth factor beta receptor signaling pathway; nucleoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; DNA repair; transcription, DNA-dependent; transcription initiation from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter;
MAPK1	10	cytosol; nucleoplasm; protein binding; nucleus; nucleolus; transcription, DNA-dependent; protein complex; cytoplasm; MAPK cascade; response to DNA damage stimulus;
STK11	9	negative regulation of cell proliferation; cytosol; positive regulation of transforming growth factor beta receptor signaling pathway; protein binding; nucleus; protein complex; cytoplasm; cell cycle arrest; response to DNA damage stimulus;
HINFP	9	transcription regulatory region DNA binding; negative regulation of transcription, DNA-dependent; nucleoplasm; protein binding; nucleus; DNA repair; nucleolus; transcription, DNA-dependent; chromatin binding;
NR4A2	9	gene expression; nucleoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent; transcription initiation from RNA polymerase II promoter; cytoplasm; sequence-specific DNA binding;
MAPK3	9	gene expression; cytosol; nucleoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; nucleolus; MAPK cascade; response to DNA damage stimulus;
NR5A1	9	gene expression; double-stranded DNA binding; nucleoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; chromatin binding; transcription initiation from RNA polymerase II promoter; sequence-specific DNA binding;
KAT5	9	negative regulation of transcription, DNA-dependent; cytosol; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; nucleolus; transcription, DNA-dependent; chromatin; negative regulation of transcription from RNA polymerase II promoter;
ATXN1	9	negative regulation of transcription, DNA-dependent; nucleoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; nuclear matrix; nucleus; nucleolus; transcription, DNA-dependent; cytoplasm;
SMARCB1	8	negative regulation of cell proliferation; nucleoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; nucleolus; transcription, DNA-dependent; chromatin remodeling;
TFAP4	8	negative regulation of cell proliferation; positive regulation of apoptotic process; transcription regulatory region DNA binding; negative regulation of transcription, DNA-dependent; protein binding; nucleus; negative regulation of cyclin-dependent protein kinase activity; sequence-specific DNA binding;
RAD9A	8	positive regulation of apoptotic process; nucleoplasm; protein binding; nucleus; DNA repair; nucleolus; cytoplasm; response to DNA damage stimulus;
FLCN	8	positive regulation of apoptotic process; positive regulation of transforming growth factor beta receptor signaling pathway; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; cytoplasm; hemopoiesis; negative regulation of transcription from RNA polymerase II promoter;
ATM	8	positive regulation of apoptotic process; nucleoplasm; protein binding; DNA repair; brain development; cell cycle arrest; response to DNA damage stimulus; protein N-terminus binding;
APBB1	8	positive regulation of apoptotic process; protein binding; nucleus; transcription, DNA-dependent; chromatin binding; cytoplasm; cell cycle arrest; response to DNA damage stimulus;
ARRB1	8	transcription regulatory region DNA binding; cytosol; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of protein binding; chromatin; cytoplasm;
GATA6	8	transcription regulatory region DNA binding; negative regulation of transcription, DNA-dependent; nucleoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; chromatin binding; negative regulation of transcription from RNA polymerase II promoter;
MTA2	8	transcription regulatory region DNA binding; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; nucleolus; chromatin binding; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter;
CREBBP	8	gene expression; nucleoplasm; protein binding; nucleus; chromatin binding; transcription initiation from RNA polymerase II promoter; cytoplasm; negative regulation of transcription from RNA polymerase II promoter;
RAN	8	gene expression; cytosol; nucleoplasm; protein binding; positive regulation of protein binding; chromatin binding; chromatin; cytoplasm;
PGR	8	gene expression; nucleoplasm; protein binding; nucleus; nucleolus; transcription initiation from RNA polymerase II promoter; cytoplasm; sequence-specific DNA binding;
XPO1	8	gene expression; cytosol; transforming growth factor beta receptor signaling pathway; nucleoplasm; protein binding; nucleolus; cytoplasm; negative regulation of transcription from RNA polymerase II promoter;
SMC1A	8	gene expression; nucleoplasm; protein binding; nucleus; DNA repair; nucleolus; chromatin binding; cytoplasm;
SSRP1	8	gene expression; nucleoplasm; protein binding; nucleus; DNA repair; nucleolus; chromatin binding; cytoplasm;
MYB	8	negative regulation of transcription, DNA-dependent; protein binding; positive regulation of transcription from RNA polymerase II promoter; nuclear matrix; transcription, DNA-dependent; chromatin binding; chromatin remodeling; negative regulation of transcription from RNA polymerase II promoter;
DAXX	8	negative regulation of transcription, DNA-dependent; cytosol; protein binding; nucleus; nucleolus; transcription, DNA-dependent; cytoplasm; protein N-terminus binding;
STRN3	8	negative regulation of transcription, DNA-dependent; nucleoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; protein complex; cytoplasm; negative regulation of transcription from RNA polymerase II promoter;
NIPBL	8	negative regulation of transcription, DNA-dependent; protein binding; nucleus; chromatin binding; brain development; negative regulation of transcription from RNA polymerase II promoter; response to DNA damage stimulus; protein N-terminus binding;
GSK3B	8	negative regulation of transcription, DNA-dependent; cytosol; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of protein binding; nucleolus; cytoplasm;
FOXP1	8	negative regulation of transcription, DNA-dependent; double-stranded DNA binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; nucleolus; chromatin binding; cytoplasm; sequence-specific DNA binding;
IRF7	8	cytosol; nucleoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; cytoplasm; negative regulation of transcription from RNA polymerase II promoter; response to DNA damage stimulus;
ERCC8	8	nucleoplasm; protein binding; nuclear matrix; nucleus; DNA repair; protein complex; response to UV; response to DNA damage stimulus;
SMC3	8	nucleoplasm; protein binding; nuclear matrix; nucleus; DNA repair; chromatin binding; chromatin; cytoplasm;
SREBF1	8	protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent; protein complex; chromatin binding; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter;
ZBTB16	7	negative regulation of cell proliferation; positive regulation of apoptotic process; negative regulation of transcription, DNA-dependent; protein binding; nucleus; transcription, DNA-dependent; hemopoiesis;
TSC1	7	negative regulation of cell proliferation; cytosol; protein binding; protein complex; cytoplasm; cell cycle arrest; protein N-terminus binding;
HMGA1	7	negative regulation of cell proliferation; negative regulation of transcription, DNA-dependent; cytosol; nucleoplasm; protein binding; nucleus; transcription, DNA-dependent;
ETS1	7	negative regulation of cell proliferation; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent; sequence-specific DNA binding; negative regulation of cell cycle;
DNAJA3	7	negative regulation of cell proliferation; positive regulation of apoptotic process; cytosol; protein binding; nucleus; cytoplasm; negative regulation of transcription from RNA polymerase II promoter;
TFAP2B	7	negative regulation of cell proliferation; negative regulation of transcription, DNA-dependent; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter;
PMAIP1	7	positive regulation of apoptotic process; cytosol; protein binding; nucleus; response to UV; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; response to DNA damage stimulus;
BCLAF1	7	positive regulation of apoptotic process; negative regulation of transcription, DNA-dependent; protein binding; nucleus; nucleolus; transcription, DNA-dependent; cytoplasm;
HOXA5	7	positive regulation of apoptotic process; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent; sequence-specific DNA binding; embryonic skeletal system morphogenesis;
BARD1	7	positive regulation of apoptotic process; protein binding; nucleus; DNA repair; cytoplasm; cell cycle arrest; response to DNA damage stimulus;
CIITA	7	transcription regulatory region DNA binding; negative regulation of transcription, DNA-dependent; nucleoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter;
GLIS2	7	transcription regulatory region DNA binding; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; nucleus; cytoplasm; negative regulation of transcription from RNA polymerase II promoter; negative regulation of sequence-specific DNA binding transcription factor activity;
HNF1B	7	transcription regulatory region DNA binding; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; nucleolus; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter;
ZNF174	7	transcription regulatory region DNA binding; negative regulation of transcription, DNA-dependent; nucleus; nucleolus; transcription, DNA-dependent; cytoplasm; negative regulation of transcription from RNA polymerase II promoter;
RNPS1	7	gene expression; cytosol; nucleoplasm; protein binding; nucleus; transcription, DNA-dependent; cytoplasm;
HSPA8	7	gene expression; negative regulation of transcription, DNA-dependent; cytosol; protein binding; nucleus; nucleolus; transcription, DNA-dependent;
MAML1	7	gene expression; nucleoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; nucleolus; transcription initiation from RNA polymerase II promoter;
ESRRA	7	gene expression; nucleoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; transcription initiation from RNA polymerase II promoter; sequence-specific DNA binding;
HES1	7	negative regulation of transcription, DNA-dependent; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; cytoplasm; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter;
FOXG1	7	negative regulation of transcription, DNA-dependent; double-stranded DNA binding; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; brain development; sequence-specific DNA binding;
GATAD2A	7	negative regulation of transcription, DNA-dependent; protein binding; nucleus; nucleolus; transcription, DNA-dependent; protein binding, bridging; sequence-specific DNA binding;
HOXA7	7	negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent; sequence-specific DNA binding; embryonic skeletal system morphogenesis; negative regulation of transcription from RNA polymerase II promoter;
PDCD4	7	negative regulation of transcription, DNA-dependent; cytosol; protein binding; nucleus; nucleolus; cytoplasm; negative regulation of cell cycle;
HEY2	7	negative regulation of transcription, DNA-dependent; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; cytoplasm; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter;
NUMA1	7	cytosol; nucleoplasm; protein binding; nuclear matrix; nucleus; nucleolus; cytoplasm;
SART1	7	cytosol; nucleoplasm; protein binding; nucleus; nucleolus; cytoplasm; cell cycle arrest;
CHEK1	7	cytosol; nucleoplasm; protein binding; nucleus; DNA repair; chromatin; response to DNA damage stimulus;
MRE11A	7	double-stranded DNA binding; nucleoplasm; protein binding; nucleus; DNA repair; nucleolus; response to DNA damage stimulus;
TP53BP1	7	nucleoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; DNA repair; cytoplasm; response to DNA damage stimulus;
USP28	7	nucleoplasm; protein binding; nucleus; DNA repair; nucleolus; protein complex; response to DNA damage stimulus;
MMS19	7	protein binding; nucleus; DNA repair; transcription, DNA-dependent; protein binding, bridging; cytoplasm; response to DNA damage stimulus;
POU2F3	7	protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; nucleolus; transcription, DNA-dependent; cytoplasm; sequence-specific DNA binding;
CHD1L	7	protein binding; nucleus; DNA repair; nucleolus; cytoplasm; chromatin remodeling; response to DNA damage stimulus;
HOXB1	7	positive regulation of transcription from RNA polymerase II promoter; nucleus; nucleolus; transcription, DNA-dependent; cytoplasm; sequence-specific DNA binding; embryonic skeletal system morphogenesis;
HOXA2	7	positive regulation of transcription from RNA polymerase II promoter; nucleus; nucleolus; transcription, DNA-dependent; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; osteoblast development;
NF2	6	negative regulation of cell proliferation; protein binding; nucleus; nucleolus; cleavage furrow; cytoplasm;
TSC2	6	negative regulation of cell proliferation; cytosol; protein binding; nucleus; cytoplasm; cell cycle arrest;
KLF4	6	negative regulation of cell proliferation; transcription regulatory region DNA binding; negative regulation of transcription, DNA-dependent; double-stranded DNA binding; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter;
PYCARD	6	positive regulation of apoptotic process; cytosol; protein binding; nucleus; cytoplasm; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;
WWOX	6	positive regulation of apoptotic process; cytosol; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; cytoplasm;
HOXA13	6	positive regulation of apoptotic process; transcription regulatory region DNA binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent; sequence-specific DNA binding;
FOXF1	6	transcription regulatory region DNA binding; double-stranded DNA binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter;
FOXC2	6	transcription regulatory region DNA binding; double-stranded DNA binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter;
DHX9	6	gene expression; nucleoplasm; protein binding; nucleus; nucleolus; cytoplasm;
TAF10	6	gene expression; nucleoplasm; protein binding; nucleus; transcription initiation from RNA polymerase II promoter; cytoplasm;
TAF4B	6	gene expression; nucleoplasm; nucleus; nucleolus; transcription initiation from RNA polymerase II promoter; cytoplasm;
DGCR8	6	gene expression; nucleoplasm; protein binding; nucleus; nucleolus; cytoplasm;
DCPS	6	gene expression; cytosol; protein binding; nucleus; nucleolus; cytoplasm;
RORA	6	gene expression; nucleoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; sequence-specific DNA binding;
HNRNPH1	6	gene expression; nucleoplasm; protein binding; nucleus; nucleolus; cytoplasm;
HNRNPA2B1	6	gene expression; nucleoplasm; protein binding; nucleus; nucleolus; cytoplasm;
TAF13	6	gene expression; nucleoplasm; protein binding; nucleus; nucleolus; transcription initiation from RNA polymerase II promoter;
MED4	6	gene expression; nucleoplasm; protein binding; nucleus; nucleolus; transcription initiation from RNA polymerase II promoter;
GEMIN2	6	gene expression; cytosol; nucleoplasm; protein binding; nucleus; cytoplasm;
SMG1	6	gene expression; cytosol; protein binding; nucleus; DNA repair; cytoplasm;
MED27	6	gene expression; nucleoplasm; nucleus; nucleolus; transcription initiation from RNA polymerase II promoter; cytoplasm;
MED12	6	gene expression; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter; nucleus; chromatin binding; transcription initiation from RNA polymerase II promoter;
PARN	6	gene expression; cytosol; protein binding; nucleus; nucleolus; cytoplasm;
FUS	6	gene expression; nucleoplasm; protein binding; nucleus; nucleolus; cytoplasm;
EFTUD2	6	gene expression; nucleoplasm; protein binding; nucleus; nucleolus; cytoplasm;
PSMC3	6	gene expression; cytosol; nucleoplasm; protein binding; nucleus; cytoplasm;
IARS	6	gene expression; cytosol; protein binding; nucleus; nucleolus; cytoplasm;
RPS3	6	gene expression; cytosol; protein binding; nucleus; cytoplasm; response to DNA damage stimulus;
TLE1	6	negative regulation of transcription, DNA-dependent; cytosol; nucleoplasm; protein binding; nucleus; chromatin binding;
FOXE1	6	negative regulation of transcription, DNA-dependent; double-stranded DNA binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter;
CBX3	6	negative regulation of transcription, DNA-dependent; protein binding; nucleus; transcription, DNA-dependent; chromatin; chromatin remodeling;
FANCC	6	cytosol; nucleoplasm; protein binding; nucleus; DNA repair; cytoplasm;
PAFAH1B1	6	cytosol; protein binding; nucleus; nucleolus; cytoplasm; negative regulation of JNK cascade;
AXIN1	6	cytosol; positive regulation of transforming growth factor beta receptor signaling pathway; R-SMAD binding; protein binding; nucleus; cytoplasm;
MALT1	6	cytosol; protein binding; nucleus; nucleolus; protein complex; cytoplasm;
LPIN1	6	cytosol; positive regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent; cytoplasm; negative regulation of transcription from RNA polymerase II promoter;
ILK	6	cytosol; positive regulation of osteoblast differentiation; protein binding; protein complex; cytoplasm; cell cycle arrest;
PRKAA1	6	cytosol; protein binding; nucleus; transcription, DNA-dependent; chromatin binding; cell cycle arrest;
PPP1CA	6	cytosol; transforming growth factor beta receptor signaling pathway; protein binding; nucleus; nucleolus; cytoplasm;
SNCA	6	cytosol; negative regulation of protein phosphorylation; protein binding; nucleus; cytoplasm; protein N-terminus binding;
ALKBH8	6	cytosol; protein binding; nucleus; nucleolus; cytoplasm; response to DNA damage stimulus;
ARRB2	6	cytosol; transforming growth factor beta receptor signaling pathway; protein binding; nucleus; brain development; cytoplasm;
UBE3A	6	cytosol; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; brain development; cytoplasm;
EGLN3	6	cytosol; nucleoplasm; protein binding; nucleus; cytoplasm; response to DNA damage stimulus;
STUB1	6	cytosol; transforming growth factor beta receptor signaling pathway; protein binding; DNA repair; protein binding, bridging; cytoplasm;
CEP164	6	cytosol; protein binding; nucleus; DNA repair; nucleolus; cytoplasm;
PLK1	6	cytosol; nucleoplasm; protein binding; nucleus; negative regulation of cyclin-dependent protein kinase activity; negative regulation of transcription from RNA polymerase II promoter;
PRKD1	6	cytosol; positive regulation of osteoblast differentiation; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; cytoplasm;
FEN1	6	double-stranded DNA binding; nucleoplasm; protein binding; nucleus; DNA repair; nucleolus;
RAD1	6	nucleoplasm; protein binding; nucleus; DNA repair; nucleolus; response to DNA damage stimulus;
TRIP12	6	nucleoplasm; protein binding; nucleus; DNA repair; cytoplasm; response to DNA damage stimulus;
CBFA2T3	6	nucleoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleolus; transcription, DNA-dependent; chromatin binding;
SMARCD3	6	nucleoplasm; protein binding; nucleus; transcription, DNA-dependent; cytoplasm; chromatin remodeling;
ERCC4	6	nucleoplasm; protein binding; nucleus; DNA repair; response to UV; protein N-terminus binding;
RAD23B	6	nucleoplasm; protein binding; nucleus; DNA repair; nucleolus; cytoplasm;
RCC1	6	nucleoplasm; protein binding; nucleus; nucleolus; chromatin binding; cytoplasm;
AATF	6	protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; nucleolus; cytoplasm; response to DNA damage stimulus;
PSPC1	6	protein binding; nuclear matrix; nucleus; nucleolus; transcription, DNA-dependent; cytoplasm;
TCF25	6	protein binding; nucleus; nucleolus; transcription, DNA-dependent; cytoplasm; negative regulation of transcription from RNA polymerase II promoter;
PKD1	6	protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of protein binding; cytoplasm; cell cycle arrest;
RBM14	6	protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; DNA repair; nucleolus; protein binding, bridging;
RNF2	6	protein binding; nucleus; nucleolus; transcription, DNA-dependent; chromatin binding; negative regulation of transcription from RNA polymerase II promoter;
IKZF1	6	positive regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent; cytoplasm; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter;
MAF	6	positive regulation of transcription from RNA polymerase II promoter; nucleus; chromatin; cytoplasm; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter;
KMT2A	5	histone methyltransferase complex; transcription regulatory region DNA binding; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus;
SETD1A	5	histone methyltransferase complex; protein binding; nucleus; nucleolus; transcription, DNA-dependent;
INPPL1	5	negative regulation of cell proliferation; cytosol; protein binding; brain development; cytoplasm;
PTPN14	5	negative regulation of cell proliferation; protein binding; nucleus; transcription, DNA-dependent; cytoplasm;
CUL5	5	negative regulation of cell proliferation; cytosol; protein binding; nucleus; cell cycle arrest;
KANK2	5	negative regulation of cell proliferation; protein binding; transcription, DNA-dependent; cytoplasm; negative regulation of transcription from RNA polymerase II promoter;
PBRM1	5	negative regulation of cell proliferation; protein binding; transcription, DNA-dependent; chromatin binding; chromatin remodeling;
PTPRK	5	negative regulation of cell proliferation; negative regulation of transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; protein binding; negative regulation of cell cycle;
KLF11	5	negative regulation of cell proliferation; positive regulation of apoptotic process; transcription regulatory region DNA binding; nucleus; negative regulation of transcription from RNA polymerase II promoter;
TGFB1I1	5	negative regulation of cell proliferation; positive regulation of transforming growth factor beta receptor signaling pathway; protein binding; nuclear matrix; cytoplasm;
NUP62	5	negative regulation of cell proliferation; protein binding; transcription, DNA-dependent; chromatin binding; cytoplasm;
NCK2	5	negative regulation of cell proliferation; cytosol; protein binding; positive regulation of transcription from RNA polymerase II promoter; cytoplasm;
FOSL1	5	negative regulation of cell proliferation; positive regulation of apoptotic process; cytosol; protein binding; nucleus;
VEGFA	5	positive regulation of cell division; protein binding; positive regulation of transcription from RNA polymerase II promoter; cytoplasm; negative regulation of transcription from RNA polymerase II promoter;
WNT11	5	positive regulation of apoptotic process; transcription regulatory region DNA binding; negative regulation of transcription, DNA-dependent; cytoplasm; palate development;
CDK5RAP2	5	transcription regulatory region DNA binding; cytosol; protein binding; brain development; cytoplasm;
TFEB	5	transcription regulatory region DNA binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent; cytoplasm;
BASP1	5	transcription regulatory region DNA binding; negative regulation of transcription, DNA-dependent; protein binding; nucleus; cytoplasm;
PTCH1	5	negative regulation of osteoblast differentiation; protein binding; brain development; negative regulation of transcription from RNA polymerase II promoter; negative regulation of sequence-specific DNA binding transcription factor activity;
MED30	5	gene expression; nucleoplasm; protein binding; nucleus; transcription initiation from RNA polymerase II promoter;
RPS9	5	gene expression; cytosol; protein binding; nucleolus; cytoplasm;
RQCD1	5	gene expression; cytosol; protein binding; nucleus; transcription, DNA-dependent;
SRP19	5	gene expression; cytosol; nucleus; nucleolus; cytoplasm;
NCBP1	5	gene expression; cytosol; nucleoplasm; protein binding; nucleus;
MED17	5	gene expression; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter; nucleus; transcription initiation from RNA polymerase II promoter;
GTF2H3	5	gene expression; nucleoplasm; DNA repair; transcription initiation from RNA polymerase II promoter; protein N-terminus binding;
SF3A3	5	gene expression; nucleoplasm; protein binding; nucleus; nucleolus;
MAML2	5	gene expression; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter; nucleus; transcription initiation from RNA polymerase II promoter;
SNRPD1	5	gene expression; cytosol; nucleoplasm; protein binding; nucleus;
POLR2G	5	gene expression; nucleoplasm; nucleus; DNA repair; transcription initiation from RNA polymerase II promoter;
RPS2	5	gene expression; cytosol; nucleoplasm; protein binding; nucleolus;
SF3A1	5	gene expression; nucleoplasm; protein binding; nucleus; nucleolus;
MED15	5	gene expression; nucleoplasm; protein binding; nucleus; transcription initiation from RNA polymerase II promoter;
MED14	5	gene expression; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter; nucleus; transcription initiation from RNA polymerase II promoter;
PRPF4	5	gene expression; nucleoplasm; protein binding; nucleus; nucleolus;
EEF1D	5	gene expression; cytosol; protein binding; nucleus; transcription, DNA-dependent;
CD2BP2	5	gene expression; nucleoplasm; protein binding; nucleus; cytoplasm;
NR6A1	5	gene expression; nucleoplasm; transcription initiation from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter;
SMG7	5	gene expression; cytosol; protein binding; nucleus; cytoplasm;
SNRNP200	5	gene expression; nucleoplasm; protein binding; nucleus; nucleolus;
MED13	5	gene expression; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter; nucleus; transcription initiation from RNA polymerase II promoter;
PRPF6	5	gene expression; nucleoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus;
MED20	5	gene expression; nucleoplasm; protein binding; transcription, DNA-dependent; transcription initiation from RNA polymerase II promoter;
NR3C2	5	gene expression; nucleoplasm; protein binding; transcription initiation from RNA polymerase II promoter; sequence-specific DNA binding;
HNRNPA1	5	gene expression; nucleoplasm; nucleus; nucleolus; cytoplasm;
CNOT6	5	gene expression; cytosol; protein binding; nucleus; transcription, DNA-dependent;
U2AF1	5	gene expression; nucleoplasm; protein binding; nucleus; nucleolus;
DDX23	5	gene expression; nucleoplasm; protein binding; nucleus; nucleolus;
CCDC85B	5	negative regulation of transcription, DNA-dependent; protein binding; nucleus; transcription, DNA-dependent; cytoplasm;
ZNF24	5	negative regulation of transcription, DNA-dependent; protein binding; nucleus; transcription, DNA-dependent; sequence-specific DNA binding;
MPHOSPH8	5	negative regulation of transcription, DNA-dependent; nucleus; nucleolus; transcription, DNA-dependent; cytoplasm;
PPM1F	5	negative regulation of transcription, DNA-dependent; cytosol; protein binding; protein complex; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;
ZNF263	5	negative regulation of transcription, DNA-dependent; nucleus; nucleolus; transcription, DNA-dependent; cytoplasm;
UBE2I	5	negative regulation of transcription, DNA-dependent; protein binding; nucleus; cytoplasm; negative regulation of transcription from RNA polymerase II promoter;
RSF1	5	negative regulation of transcription, DNA-dependent; nucleoplasm; protein binding; nucleus; chromatin remodeling;
FOXP2	5	negative regulation of transcription, DNA-dependent; double-stranded DNA binding; chromatin binding; cytoplasm; sequence-specific DNA binding;
CREBZF	5	negative regulation of transcription, DNA-dependent; protein binding; nucleus; transcription, DNA-dependent; sequence-specific DNA binding;
PER1	5	negative regulation of transcription, DNA-dependent; nucleus; transcription, DNA-dependent; cytoplasm; negative regulation of transcription from RNA polymerase II promoter;
EED	5	negative regulation of transcription, DNA-dependent; protein binding; nucleus; transcription, DNA-dependent; chromatin binding;
BRMS1	5	negative regulation of transcription, DNA-dependent; protein binding; nucleus; transcription, DNA-dependent; cytoplasm;
SOX8	5	negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent; cytoplasm;
ELK3	5	negative regulation of transcription, DNA-dependent; protein binding; nucleus; nucleolus; transcription, DNA-dependent;
MAP2K5	5	cytosol; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; negative regulation of transcription from RNA polymerase II promoter;
AIP	5	cytosol; protein binding; nucleus; nucleolus; cytoplasm;
CTNND1	5	cytosol; protein binding; nucleus; transcription, DNA-dependent; cytoplasm;
STXBP3	5	cytosol; protein binding; nucleus; nucleolus; cytoplasm;
HABP4	5	cytosol; protein binding; nucleus; transcription, DNA-dependent; cytoplasm;
PAK1	5	cytosol; protein binding; protein complex; cytoplasm; MAPK cascade;
TXN	5	cytosol; nucleoplasm; protein binding; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter;
TNFAIP3	5	cytosol; protein binding; nucleus; negative regulation of cyclin-dependent protein kinase activity; cytoplasm;
IRF9	5	cytosol; nucleoplasm; protein binding; nucleus; cytoplasm;
KIF22	5	cytosol; nucleus; DNA repair; chromatin; cytoplasm;
MAPK7	5	cytosol; nucleoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus;
BIRC2	5	cytosol; protein binding; nucleus; transcription, DNA-dependent; protein N-terminus binding;
PDE2A	5	cytosol; protein binding; nucleus; cytoplasm; negative regulation of transcription from RNA polymerase II promoter;
HMGCS1	5	cytosol; nucleus; nucleolus; brain development; cytoplasm;
CCND1	5	cytosol; nucleoplasm; protein binding; nucleus; response to DNA damage stimulus;
BAIAP2	5	cytosol; protein binding; nucleus; nucleolus; cytoplasm;
PTTG1	5	cytosol; protein binding; nucleus; DNA repair; cytoplasm;
CEP57	5	cytosol; protein binding; nucleus; nucleolus; cytoplasm;
PDPK1	5	cytosol; nucleoplasm; protein binding; transcription, DNA-dependent; cytoplasm;
PARK2	5	cytosol; negative regulation of protein phosphorylation; protein binding; nucleus; cytoplasm;
NCK1	5	cytosol; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; cytoplasm;
FOXD4	5	double-stranded DNA binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; nucleolus; sequence-specific DNA binding;
NTHL1	5	double-stranded DNA binding; nucleoplasm; protein binding; nucleus; DNA repair;
RBM4	5	nucleoplasm; protein binding; nucleus; nucleolus; cytoplasm;
POLD3	5	nucleoplasm; protein binding; nucleus; DNA repair; nucleolus;
FANCA	5	nucleoplasm; protein binding; nucleus; DNA repair; cytoplasm;
DDB1	5	nucleoplasm; protein binding; nucleus; DNA repair; cytoplasm;
XPA	5	nucleoplasm; protein binding; nucleus; DNA repair; response to UV;
MAU2	5	nucleoplasm; protein binding; nucleus; chromatin; protein N-terminus binding;
BNIP3	5	nucleoplasm; protein binding; nucleus; cytoplasm; chromatin remodeling;
E4F1	5	nucleoplasm; protein binding; transcription, DNA-dependent; cytoplasm; negative regulation of transcription from RNA polymerase II promoter;
ATF6	5	nucleoplasm; protein binding; nucleus; transcription, DNA-dependent; sequence-specific DNA binding;
TERF2IP	5	nucleoplasm; protein binding; nucleus; transcription, DNA-dependent; cytoplasm;
CIRBP	5	nucleoplasm; protein binding; nucleus; response to UV; cytoplasm;
H2AFX	5	nucleoplasm; protein binding; nucleus; DNA repair; response to DNA damage stimulus;
THRAP3	5	protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; nucleolus; transcription initiation from RNA polymerase II promoter;
INO80E	5	protein binding; nucleus; DNA repair; nucleolus; transcription, DNA-dependent;
FLII	5	protein binding; nucleus; nucleolus; transcription, DNA-dependent; cytoplasm;
CDCA5	5	protein binding; nucleus; nucleolus; chromatin binding; cytoplasm;
STAP1	5	protein binding; nucleus; nucleolus; protein complex; cytoplasm;
DACT1	5	protein binding; nucleus; cytoplasm; negative regulation of JNK cascade; negative regulation of transcription from RNA polymerase II promoter;
MKL2	5	protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent; cytoplasm;
MEIS2	5	protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter;
RRP8	5	protein binding; nucleus; nucleolus; transcription, DNA-dependent; cytoplasm;
INIP	5	protein binding; nucleus; DNA repair; nucleolus; response to DNA damage stimulus;
SAP18	5	protein binding; nucleus; nucleolus; transcription, DNA-dependent; cytoplasm;
HOXA1	5	protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent; sequence-specific DNA binding;
NRIP1	5	protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter;
HOXA9	5	protein binding; nucleus; transcription, DNA-dependent; cytoplasm; sequence-specific DNA binding;
HERC2	5	protein binding; nucleus; DNA repair; cytoplasm; response to DNA damage stimulus;
RNF20	5	protein binding; nucleus; nucleolus; positive regulation of histone methylation; chromatin binding;
RPS6KA4	5	protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; nucleolus; cytoplasm;
IGHMBP2	5	protein binding; nucleus; DNA repair; transcription, DNA-dependent; cytoplasm;
ASF1A	5	protein binding; nucleus; DNA repair; transcription, DNA-dependent; chromatin binding;
UXT	5	protein binding; nucleus; chromatin binding; cytoplasm; negative regulation of transcription from RNA polymerase II promoter;
ISL1	5	positive regulation of transcription from RNA polymerase II promoter; nucleus; chromatin binding; cytoplasm; negative regulation of transcription from RNA polymerase II promoter;
BSX	5	positive regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent; cytoplasm; sequence-specific DNA binding;
ARID3C	5	positive regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent; chromatin binding; cytoplasm;
BCL11A	5	positive regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent; cytoplasm; hemopoiesis;
ZEB2	5	nucleus; nucleolus; transcription, DNA-dependent; cytoplasm; sequence-specific DNA binding;
MTA3	5	nucleus; nucleolus; chromatin binding; cytoplasm; sequence-specific DNA binding;
HOXA3	5	nucleus; nucleolus; transcription, DNA-dependent; sequence-specific DNA binding; embryonic skeletal system morphogenesis;
PRDM1	5	nucleus; transcription, DNA-dependent; cytoplasm; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter;
HOXA11	5	nucleolus; transcription, DNA-dependent; protein complex; cytoplasm; sequence-specific DNA binding;

Genes shared at least 2 KEGG pathways with MEN1 (count: 0)

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Region: chr11:64570982..64578766 View in gBrowse