ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PMAIP1
Symbol Alias	APR, NOXA
Approved Name	phorbol-12-myristate-13-acetate-induced protein 1
Location	18q21.32
Position	chr18:57567180-57571538, 1
External Links	HGNC: 9108 Entrez Gene: 5366 Ensembl: ENSG00000141682 UCSC: uc002lic.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
18q21.31-21.32	chr18:53800000-59000000	1 (1/0/0)

Gene related GO terms (count: 33)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 33)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006926	virus-infected cell apoptotic process	biological process	IDA[15705586]	2
GO:0048147	negative regulation of fibroblast proliferation	biological process	IEA	5
GO:0005741	mitochondrial outer membrane	cellular component	TAS	22
GO:0010917	negative regulation of mitochondrial membrane potential	biological process	ISS[14699081]	1
GO:0072593	reactive oxygen species metabolic process	biological process	IDA[14699081]	8
GO:0006974	response to DNA damage stimulus	biological process	IEA	41
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	biological process	IEA	1
GO:0046902	regulation of mitochondrial membrane permeability	biological process	IDA[14500711]	3
GO:0042149	cellular response to glucose starvation	biological process	IMP	4
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	biological process	IMP[15102863]	4
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	biological process	IDA	3
GO:0010907	positive regulation of glucose metabolic process	biological process	IDA	1
GO:0005739	mitochondrion	cellular component	IDA[15705586]	221
GO:0005515	protein binding	molecular function	IPI	1015
GO:0001836	release of cytochrome c from mitochondria	biological process	IEA	2
GO:0010498	proteasomal protein catabolic process	biological process	IDA[15901672]	1
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	biological process	IDA[14699081]	7
GO:0090200	positive regulation of release of cytochrome c from mitochondria	biological process	IDA[14699081]; IMP[17289999]	6
GO:0006921	cellular component disassembly involved in execution phase of apoptosis	biological process	IDA[15705586]	9
GO:0032461	positive regulation of protein oligomerization	biological process	IDA[17024184]	1
GO:0043029	T cell homeostasis	biological process	ISS	3
GO:0043331	response to dsRNA	biological process	IDA[15705586]	1
GO:0043525	positive regulation of neuron apoptotic process	biological process	IEA	10
GO:0009411	response to UV	biological process	IEA	8
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	biological process	IDA[15705586]	15
GO:0043065	positive regulation of apoptotic process	biological process	IDA; IMP	38
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	biological process	IMP[15102863]	2
GO:0006915	apoptotic process	biological process	IMP[17599062]; TAS	127
GO:0010165	response to X-ray	biological process	IEA	4
GO:0071456	cellular response to hypoxia	biological process	IEP	14
GO:0006917	induction of apoptosis	biological process	IDA[15705586]	35
GO:0005829	cytosol	cellular component	IDA; TAS	485
GO:0005634	nucleus	cellular component	IDA[12879012]	877

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04115	p53 signaling pathway	14

Genes shared at least 5 GO terms with PMAIP1 (count: 28)

Gene Symbol	Pathway Count	Pathway List
BAD	12	mitochondrial outer membrane; regulation of mitochondrial membrane permeability; mitochondrion; protein binding; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of release of cytochrome c from mitochondria; activation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of apoptotic process; apoptotic process; cellular response to hypoxia; induction of apoptosis; cytosol;
BCL2L11	11	mitochondrial outer membrane; positive regulation of intrinsic apoptotic signaling pathway; protein binding; positive regulation of release of cytochrome c from mitochondria; T cell homeostasis; positive regulation of neuron apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of apoptotic process; apoptotic process; induction of apoptosis; cytosol;
BNIP3	10	mitochondrial outer membrane; reactive oxygen species metabolic process; regulation of mitochondrial membrane permeability; mitochondrion; protein binding; positive regulation of release of cytochrome c from mitochondria; apoptotic process; cellular response to hypoxia; induction of apoptosis; nucleus;
PYCARD	10	intrinsic apoptotic signaling pathway by p53 class mediator; mitochondrion; protein binding; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of release of cytochrome c from mitochondria; activation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of apoptotic process; induction of apoptosis; cytosol; nucleus;
MEN1	7	response to DNA damage stimulus; protein binding; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; response to UV; positive regulation of apoptotic process; cytosol; nucleus;
EGLN3	7	response to DNA damage stimulus; protein binding; activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic process; cellular response to hypoxia; cytosol; nucleus;
APC	7	response to DNA damage stimulus; protein binding; cellular component disassembly involved in execution phase of apoptosis; positive regulation of apoptotic process; apoptotic process; cytosol; nucleus;
MAPK1	7	response to DNA damage stimulus; mitochondrion; protein binding; apoptotic process; induction of apoptosis; cytosol; nucleus;
WWOX	7	mitochondrion; protein binding; positive regulation of apoptotic process; apoptotic process; induction of apoptosis; cytosol; nucleus;
MAPK3	6	response to DNA damage stimulus; mitochondrion; protein binding; apoptotic process; cytosol; nucleus;
RPS3	6	response to DNA damage stimulus; protein binding; activation of cysteine-type endopeptidase activity involved in apoptotic process; induction of apoptosis; cytosol; nucleus;
STK11	6	response to DNA damage stimulus; intrinsic apoptotic signaling pathway by p53 class mediator; mitochondrion; protein binding; cytosol; nucleus;
GSTP1	5	negative regulation of fibroblast proliferation; mitochondrion; protein binding; cytosol; nucleus;
HK1	5	mitochondrial outer membrane; mitochondrion; protein binding; cytosol; nucleus;
APBB1	5	response to DNA damage stimulus; protein binding; positive regulation of apoptotic process; apoptotic process; nucleus;
ATM	5	response to DNA damage stimulus; protein binding; positive regulation of neuron apoptotic process; positive regulation of apoptotic process; positive regulation of DNA damage response, signal transduction by p53 class mediator;
CCND1	5	response to DNA damage stimulus; protein binding; response to X-ray; cytosol; nucleus;
ERCC8	5	response to DNA damage stimulus; protein binding; response to UV; response to X-ray; nucleus;
PRKAA1	5	cellular response to glucose starvation; protein binding; cellular response to hypoxia; cytosol; nucleus;
BCLAF1	5	positive regulation of intrinsic apoptotic signaling pathway; protein binding; positive regulation of apoptotic process; induction of apoptosis; nucleus;
SNCA	5	mitochondrion; protein binding; activation of cysteine-type endopeptidase activity involved in apoptotic process; cytosol; nucleus;
MAPK9	5	mitochondrion; protein binding; release of cytochrome c from mitochondria; positive regulation of apoptotic process; cytosol;
FADD	5	protein binding; activation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of apoptotic process; apoptotic process; cytosol;
BIRC2	5	protein binding; cellular component disassembly involved in execution phase of apoptosis; apoptotic process; cytosol; nucleus;
DNAJA3	5	protein binding; activation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of apoptotic process; cytosol; nucleus;
CASP1	5	protein binding; activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic process; induction of apoptosis; cytosol;
DAXX	5	protein binding; apoptotic process; induction of apoptosis; cytosol; nucleus;
TJP1	5	protein binding; cellular component disassembly involved in execution phase of apoptosis; apoptotic process; cytosol; nucleus;

Genes shared at least 2 KEGG pathways with PMAIP1 (count: 0)

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Region: chr18:57567180..57571538 View in gBrowse