ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	FADD
Symbol Alias	MORT1, GIG3
Approved Name	Fas (TNFRSF6)-associated via death domain
Name Alias	Fas-associating protein with death domain, "Fas-associating death domain-containing protein", "mediator of receptor-induced toxicity", "growth-inhibiting gene 3 protein"
Location	11q13.3
Position	chr11:70049269-70053508, +
External Links	HGNC: 3573 Entrez Gene: 8772 Ensembl: ENSG00000168040 UCSC: uc001opm.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 30)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 30)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	Biological Process		2
GO:0097191	extrinsic apoptotic signaling pathway	Biological Process	IMP[16611992]; TAS[18309324]	2
GO:0097190	apoptotic signaling pathway	Biological Process	IDA[11101870]	6
GO:0032757	positive regulation of interleukin-8 production	Biological Process	IDA[16127453]	5
GO:0032760	positive regulation of tumor necrosis factor production	Biological Process	IDA[16127453]	9
GO:0032813	tumor necrosis factor receptor superfamily binding	Molecular Function		3
GO:0042802	identical protein binding	Molecular Function	IPI[8681376]	70
GO:0043005	neuron projection	Cellular Component		35
GO:0043065	positive regulation of apoptotic process	Biological Process		34
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	Biological Process	IEP[12761501]	27
GO:0044297	cell body	Cellular Component		3
GO:0045087	innate immune response	Biological Process		54
GO:0045121	membrane raft	Cellular Component		22
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA[16127453]	131
GO:0051291	protein heterooligomerization	Biological Process		10
GO:0051607	defense response to virus	Biological Process		15
GO:0060340	positive regulation of type I interferon-mediated signaling pathway	Biological Process		3
GO:0070265	necrotic cell death	Biological Process	IMP[11101870]	1
GO:0071260	cellular response to mechanical stimulus	Biological Process	IEP[19593445]	14
GO:0002020	protease binding	Molecular Function	IPI[9208847]	13
GO:0005164	tumor necrosis factor receptor binding	Molecular Function		5
GO:0005123	death receptor binding	Molecular Function	TAS[7538907]	3
GO:0005829	cytosol	Cellular Component		447
GO:0005515	protein binding	Molecular Function	IPI[16127453]	910
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	Biological Process		11
GO:0006915	apoptotic process	Biological Process		111
GO:0019048	virus-host interaction	Biological Process		54
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	Biological Process	TAS[7538907]	2
GO:0031265	CD95 death-inducing signaling complex	Cellular Component		1
GO:0031264	death-inducing signaling complex	Cellular Component	IDA[11101870]	1

Gene related KEGG pathways (count: 7)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa05152	Tuberculosis	30	Tuberculosis, or TB, is an infectious disease caused by Myco...... Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent infections, and about 10% of latent infections develop active diseases when their immune system is impaired due to the age, other diseases such as AIDS or exposure to immunosuppressive drugs. TB is transmitted through the air and primarily attacks the lungs, then it can spread by the circulatory system to other parts of body. Once TB bacilli have entered the host by the respiratory route and infected macrophages in the lungs, they interfere with phagosomal maturation, antigen presentation, apoptosis and host immune system to establish persistent or latent infection. More...
hsa05010	Alzheimer's disease	40	Alzheimer's disease (AD) is a chronic disorder that slowly d...... Alzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. The extracellular Abeta oligomers may activate caspases through activation of cell surface death receptors. Alternatively, intracellular Abeta may contribute to pathology by facilitating tau hyper-phosphorylation, disrupting mitochondria function, and triggering calcium dysfunction. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress. More...
hsa04622	RIG-I-like receptor signaling pathway	10	Specific families of pattern recognition receptors are respo...... Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses. More...
hsa04210	Apoptosis	13	Apoptosis is a genetically controlled mechanisms of cell dea...... Apoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily members and ligands) and the intrinsic (mitochondria-associated) pathways, both of which are found in the cytoplasm. The extrinsic pathway is triggered by death receptor engagement, which initiates a signaling cascade mediated by caspase-8 activation. Caspase-8 both feeds directly into caspase-3 activation and stimulates the release of cytochrome c by the mitochondria. Caspase-3 activation leads to the degradation of cellular proteins necessary to maintain cell survival and integrity. The intrinsic pathway occurs when various apoptotic stimuli trigger the release of cytochrome c from the mitochondria (independently of caspase-8 activation). Cytochrome c interacts with Apaf-1 and caspase-9 to promote the activation of caspase-3. Recent studies point to the ER as a third subcellular compartment implicated in apoptotic execution. Alterations in Ca2+ homeostasis and accumulation of misfolded proteins in the ER cause ER stress. Prolonged ER stress can result in the activation of BAD and/or caspase-12, and execute apoptosis. More...
hsa05142	Chagas disease (American trypanosomiasis)	23	Trypanosoma cruzi is an intracellular protozoan parasite tha...... Trypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they invade diverse host cells including cardiomyocytes. Establishment of infection depends on various parasite molecules such as cruzipain, oligopeptidase B, and trans-sialidase that activate Ca2+ signaling. Internalized parasites escape from the parasitophorous vacuole using secreted pore-forming TcTOX molecule and replicate in the cytosol. Multiplied parasites eventually lyse infected host cells and are released in the circulation. During these events, the parasites manipulate host innate immunity and elicit cardiomyocyte hypertrophy. T lymphocyte responses are also disturbed. More...
hsa04620	Toll-like receptor signaling pathway	13	Specific families of pattern recognition receptors are respo...... Specific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors identified as homologs of Toll in Drosophila. Mammalian TLRs are expressed on innate immune cells, such as macrophages and dendritic cells, and respond to the membrane components of Gram-positive or Gram-negative bacteria. Pathogen recognition by TLRs provokes rapid activation of innate immunity by inducing production of proinflammatory cytokines and upregulation of costimulatory molecules. TLR signaling pathways are separated into two groups: a MyD88-dependent pathway that leads to the production of proinflammatory cytokines with quick activation of NF-{kappa}B and MAPK, and a MyD88-independent pathway associated with the induction of IFN-beta and IFN-inducible genes, and maturation of dendritic cells with slow activation of NF-{kappa}B and MAPK. More...
hsa05200	Pathways in cancer	52

Genes shared at least 5 GO terms with FADD (count: 24)

Gene Symbol	Pathway Count	Pathway List
MAVS	9	positive regulation of interleukin-8 production; positive regulation of tumor necrosis factor production; positive regulation of I-kappaB kinase/NF-kappaB cascade; innate immune response; positive regulation of transcription from RNA polymerase II promoter; defense response to virus; positive regulation of type I interferon-mediated signaling pathway; protein binding; virus-host interaction;
PYCARD	8	positive regulation of extrinsic apoptotic signaling pathway; positive regulation of tumor necrosis factor production; positive regulation of apoptotic process; innate immune response; defense response to virus; cytosol; protein binding; activation of cysteine-type endopeptidase activity involved in apoptotic process;
RELA	8	identical protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; innate immune response; positive regulation of transcription from RNA polymerase II promoter; defense response to virus; cytosol; protein binding; virus-host interaction;
BAD	7	extrinsic apoptotic signaling pathway; positive regulation of apoptotic process; cellular response to mechanical stimulus; cytosol; protein binding; activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic process;
MAP3K5	7	apoptotic signaling pathway; identical protein binding; positive regulation of apoptotic process; innate immune response; protein binding; activation of cysteine-type endopeptidase activity involved in apoptotic process; virus-host interaction;
TLR4	7	positive regulation of interleukin-8 production; positive regulation of tumor necrosis factor production; positive regulation of I-kappaB kinase/NF-kappaB cascade; innate immune response; positive regulation of transcription from RNA polymerase II promoter; cellular response to mechanical stimulus; protein binding;
PRKD1	7	identical protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; innate immune response; positive regulation of transcription from RNA polymerase II promoter; cytosol; protein binding; apoptotic process;
CASP1	7	positive regulation of I-kappaB kinase/NF-kappaB cascade; innate immune response; cellular response to mechanical stimulus; cytosol; protein binding; activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic process;
UBC	7	positive regulation of I-kappaB kinase/NF-kappaB cascade; innate immune response; positive regulation of transcription from RNA polymerase II promoter; protease binding; cytosol; protein binding; apoptotic process;
MAPK3	7	innate immune response; positive regulation of transcription from RNA polymerase II promoter; cellular response to mechanical stimulus; cytosol; protein binding; apoptotic process; virus-host interaction;
RIPK3	6	apoptotic signaling pathway; identical protein binding; innate immune response; protein heterooligomerization; cytosol; protein binding;
BNIP3	6	identical protein binding; defense response to virus; cellular response to mechanical stimulus; protein binding; apoptotic process; virus-host interaction;
SQSTM1	6	identical protein binding; positive regulation of transcription from RNA polymerase II promoter; protein heterooligomerization; cytosol; protein binding; apoptotic process;
TRIM5	6	identical protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; innate immune response; defense response to virus; protein binding; virus-host interaction;
UBB	6	positive regulation of I-kappaB kinase/NF-kappaB cascade; innate immune response; positive regulation of transcription from RNA polymerase II promoter; cytosol; protein binding; apoptotic process;
TIRAP	5	positive regulation of interleukin-8 production; positive regulation of tumor necrosis factor production; positive regulation of I-kappaB kinase/NF-kappaB cascade; innate immune response; protein binding;
PIK3R1	5	positive regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter; cytosol; protein binding; virus-host interaction;
PMAIP1	5	positive regulation of apoptotic process; cytosol; protein binding; activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic process;
WWOX	5	positive regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter; cytosol; protein binding; apoptotic process;
MALT1	5	positive regulation of I-kappaB kinase/NF-kappaB cascade; innate immune response; protease binding; cytosol; protein binding;
IRF7	5	innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of type I interferon-mediated signaling pathway; cytosol; protein binding;
MAPK1	5	innate immune response; cytosol; protein binding; apoptotic process; virus-host interaction;
MAPK7	5	innate immune response; positive regulation of transcription from RNA polymerase II promoter; cytosol; protein binding; apoptotic process;
DAXX	5	cytosol; protein binding; apoptotic process; virus-host interaction; extrinsic apoptotic signaling pathway via death domain receptors;

Genes shared at least 2 KEGG pathways with FADD (count: 22)

Gene Symbol	Pathway Count	Pathway List
RELA	6	Tuberculosis; RIG-I-like receptor signaling pathway; Apoptosis; Chagas disease (American trypanosomiasis); Toll-like receptor signaling pathway; Pathways in cancer;
MAPK1	5	Tuberculosis; Alzheimer's disease; Chagas disease (American trypanosomiasis); Toll-like receptor signaling pathway; Pathways in cancer;
MAPK3	5	Tuberculosis; Alzheimer's disease; Chagas disease (American trypanosomiasis); Toll-like receptor signaling pathway; Pathways in cancer;
MAPK9	5	Tuberculosis; RIG-I-like receptor signaling pathway; Chagas disease (American trypanosomiasis); Toll-like receptor signaling pathway; Pathways in cancer;
BAD	4	Tuberculosis; Alzheimer's disease; Apoptosis; Pathways in cancer;
CYCS	4	Tuberculosis; Alzheimer's disease; Apoptosis; Pathways in cancer;
IL12B	4	Tuberculosis; RIG-I-like receptor signaling pathway; Chagas disease (American trypanosomiasis); Toll-like receptor signaling pathway;
IL6	4	Tuberculosis; Chagas disease (American trypanosomiasis); Toll-like receptor signaling pathway; Pathways in cancer;
PIK3CG	4	Apoptosis; Chagas disease (American trypanosomiasis); Toll-like receptor signaling pathway; Pathways in cancer;
PIK3R1	4	Apoptosis; Chagas disease (American trypanosomiasis); Toll-like receptor signaling pathway; Pathways in cancer;
PPP3R2	3	Tuberculosis; Alzheimer's disease; Apoptosis;
TLR4	3	Tuberculosis; Chagas disease (American trypanosomiasis); Toll-like receptor signaling pathway;
IFNGR1	2	Tuberculosis; Chagas disease (American trypanosomiasis);
TIRAP	2	Tuberculosis; Toll-like receptor signaling pathway;
CAPN1	2	Alzheimer's disease; Apoptosis;
GSK3B	2	Alzheimer's disease; Pathways in cancer;
PLCB2	2	Alzheimer's disease; Chagas disease (American trypanosomiasis);
PLCB3	2	Alzheimer's disease; Chagas disease (American trypanosomiasis);
IRF7	2	RIG-I-like receptor signaling pathway; Toll-like receptor signaling pathway;
BIRC2	2	Apoptosis; Pathways in cancer;
BIRC3	2	Apoptosis; Pathways in cancer;
TGFBR1	2	Chagas disease (American trypanosomiasis); Pathways in cancer;

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Region: chr11:70049269..70053508 View in gBrowse