ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	IL12B
Previous Symbol	NKSF2
Symbol Alias	CLMF, IL-12B, NKSF, CLMF2
Approved Name	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
Name Alias	"natural killer cell stimulatory factor-2", "cytotoxic lymphocyte maturation factor 2, p40", "interleukin 12, p40", "natural killer cell stimulatory factor, 40 kD subunit", "interleukin-12 beta chain", "IL12, subunit p40"
Location	5q31.1-q33.1
Position	chr5:158741791-158757895, -1
External Links	HGNC: 5970 Entrez Gene: 3593 Ensembl: ENSG00000113302 UCSC: uc003lxr.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
5q33.3	chr5:155700000-159900000	1 (1/0/0)

Gene related GO terms (count: 66)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 66)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0032729	positive regulation of interferon-gamma production	biological process	IDA[11114383]	9
GO:0051135	positive regulation of NK T cell activation	biological process	IC; IDA[19088061]	1
GO:0042035	regulation of cytokine biosynthetic process	biological process	TAS[1673147]	4
GO:0042088	T-helper 1 type immune response	biological process	TAS[1673147]	5
GO:0042346	positive regulation of NF-kappaB import into nucleus	biological process	TAS	5
GO:0010535	positive regulation of activation of JAK2 kinase activity	biological process	IDA[12023369]	1
GO:0032735	positive regulation of interleukin-12 production	biological process	IDA	8
GO:0042803	protein homodimerization activity	molecular function	IEA	128
GO:0042802	identical protein binding	molecular function	IPI[7527811]	77
GO:0005125	cytokine activity	molecular function	IDA[1674604]	20
GO:0042104	positive regulation of activated T cell proliferation	biological process	IDA[11114383]	6
GO:2000330	positive regulation of T-helper 17 cell lineage commitment	biological process	ISS	1
GO:0032700	negative regulation of interleukin-17 production	biological process	IDA[16482511]	3
GO:0042510	regulation of tyrosine phosphorylation of Stat1 protein	biological process	IDA[12023369]	1
GO:0002862	negative regulation of inflammatory response to antigenic stimulus	biological process	IEA	1
GO:0034105	positive regulation of tissue remodeling	biological process	IC[16482511]	2
GO:0032740	positive regulation of interleukin-17 production	biological process	IDA[16482511]	2
GO:0043514	interleukin-12 complex	cellular component	IDA[11114383]	1
GO:0002860	positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	biological process	IDA[7903063]	2
GO:0045519	interleukin-23 receptor binding	molecular function	IDA[11114383]	1
GO:0019953	sexual reproduction	biological process	TAS[16772281]	3
GO:0071346	cellular response to interferon-gamma	biological process	IEA	4
GO:0007050	cell cycle arrest	biological process	IDA[16942485]	28
GO:0045672	positive regulation of osteoclast differentiation	biological process	IDA[17888176]	2
GO:0046982	protein heterodimerization activity	molecular function	IPI[1674604]	73
GO:0001916	positive regulation of T cell mediated cytotoxicity	biological process	ISS	1
GO:0005737	cytoplasm	cellular component	IEA	781
GO:0032693	negative regulation of interleukin-10 production	biological process	IMP[16751425]	1
GO:0045785	positive regulation of cell adhesion	biological process	IDA[7903063]	7
GO:0005515	protein binding	molecular function	IPI[11114383]	1015
GO:2000318	positive regulation of T-helper 17 type immune response	biological process	ISS	2
GO:0005143	interleukin-12 receptor binding	molecular function	TAS[1674604]; TAS[9603733]	1
GO:0004896	cytokine receptor activity	molecular function	IEA	2
GO:0050671	positive regulation of lymphocyte proliferation	biological process	IDA[1674604]	2
GO:0042164	interleukin-12 alpha subunit binding	molecular function	IEA	1
GO:0016477	cell migration	biological process	IDA[7903063]	25
GO:0051142	positive regulation of NK T cell proliferation	biological process	IDA[19088061]	2
GO:0034393	positive regulation of smooth muscle cell apoptotic process	biological process	IDA[16942485]	1
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein	biological process	IDA[12023369]	7
GO:0042832	defense response to protozoan	biological process	IEA	5
GO:0030101	natural killer cell activation	biological process	IDA[1673147]	1
GO:0002827	positive regulation of T-helper 1 type immune response	biological process	IDA[15114670]; ISS	3
GO:0044130	negative regulation of growth of symbiont in host	biological process	IEA	4
GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein	biological process	IDA[12023369]	2
GO:0008083	growth factor activity	molecular function	IDA[1674604]	28
GO:0043382	positive regulation of memory T cell differentiation	biological process	ISS	2
GO:0071222	cellular response to lipopolysaccharide	biological process	IEA	15
GO:0016020	membrane	cellular component	IEA	155
GO:0070743	interleukin-23 complex	cellular component	IDA[11114383]	1
GO:0050829	defense response to Gram-negative bacterium	biological process	IDA[15114670]	7
GO:0032819	positive regulation of natural killer cell proliferation	biological process	IDA[19088061]	2
GO:0032733	positive regulation of interleukin-10 production	biological process	IDA[15265908]; TAS[18675459]	5
GO:0042102	positive regulation of T cell proliferation	biological process	IDA[12023369]	13
GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production	biological process	IDA	3
GO:0045078	positive regulation of interferon-gamma biosynthetic process	biological process	TAS[1673147]	3
GO:0002230	positive regulation of defense response to virus by host	biological process	IDA[12421946]; ISS	3
GO:0042093	T-helper cell differentiation	biological process	IDA[1673147]	2
GO:0005615	extracellular space	cellular component	TAS[1673147]	133
GO:0048662	negative regulation of smooth muscle cell proliferation	biological process	IDA[16942485]	7
GO:0032760	positive regulation of tumor necrosis factor production	biological process	IMP[16751425]	10
GO:0050729	positive regulation of inflammatory response	biological process	IC[16482511]	9
GO:0010224	response to UV-B	biological process	IDA[8992506]	2
GO:0032816	positive regulation of natural killer cell activation	biological process	IC; IDA[1674604]	1
GO:0042520	positive regulation of tyrosine phosphorylation of Stat4 protein	biological process	IDA[19088061]	1
GO:0042095	interferon-gamma biosynthetic process	biological process	TAS[1673147]	2
GO:0051607	defense response to virus	biological process	IEA	16

Gene related KEGG pathways (count: 5)

ID	Name	No. of Genes in ADHDgene
hsa04620	Toll-like receptor signaling pathway	14
hsa04630	Jak-STAT signaling pathway	25
hsa04940	Type I diabetes mellitus	9
hsa04060	Cytokine-cytokine receptor interaction	39
hsa05330	Allograft rejection	6

Genes shared at least 5 GO terms with IL12B (count: 25)

Gene Symbol	Pathway Count	Pathway List
IL18	14	positive regulation of interferon-gamma production; T-helper 1 type immune response; cytokine activity; positive regulation of activated T cell proliferation; positive regulation of tissue remodeling; positive regulation of interleukin-17 production; cellular response to interferon-gamma; positive regulation of NK T cell proliferation; positive regulation of natural killer cell proliferation; positive regulation of granulocyte macrophage colony-stimulating factor production; extracellular space; positive regulation of tumor necrosis factor production; positive regulation of inflammatory response; interferon-gamma biosynthetic process;
TLR4	12	positive regulation of interferon-gamma production; T-helper 1 type immune response; positive regulation of NF-kappaB import into nucleus; positive regulation of interleukin-12 production; negative regulation of interleukin-17 production; cytoplasm; protein binding; cellular response to lipopolysaccharide; defense response to Gram-negative bacterium; positive regulation of interleukin-10 production; positive regulation of tumor necrosis factor production; positive regulation of inflammatory response;
TNFSF4	10	positive regulation of interferon-gamma production; positive regulation of interleukin-12 production; cytokine activity; positive regulation of activated T cell proliferation; negative regulation of interleukin-17 production; positive regulation of memory T cell differentiation; cellular response to lipopolysaccharide; positive regulation of interleukin-10 production; extracellular space; positive regulation of inflammatory response;
PYCARD	10	positive regulation of interferon-gamma production; protein homodimerization activity; positive regulation of activated T cell proliferation; cytoplasm; protein binding; cellular response to lipopolysaccharide; defense response to Gram-negative bacterium; positive regulation of defense response to virus by host; positive regulation of tumor necrosis factor production; defense response to virus;
VEGFA	10	protein homodimerization activity; identical protein binding; cytokine activity; protein heterodimerization activity; cytoplasm; positive regulation of cell adhesion; protein binding; growth factor activity; membrane; extracellular space;
IL6	8	cytokine activity; positive regulation of tyrosine phosphorylation of Stat3 protein; defense response to protozoan; growth factor activity; defense response to Gram-negative bacterium; positive regulation of T cell proliferation; extracellular space; defense response to virus;
TLR9	7	positive regulation of NF-kappaB import into nucleus; positive regulation of interleukin-12 production; cytoplasm; positive regulation of interleukin-10 production; positive regulation of interferon-gamma biosynthetic process; positive regulation of tumor necrosis factor production; positive regulation of inflammatory response;
IRF8	6	positive regulation of interferon-gamma production; positive regulation of interleukin-12 production; protein binding; defense response to protozoan; negative regulation of growth of symbiont in host; cellular response to lipopolysaccharide;
ISL1	6	positive regulation of interferon-gamma production; positive regulation of interleukin-12 production; cytoplasm; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of tumor necrosis factor production;
TIRAP	6	positive regulation of interleukin-12 production; protein homodimerization activity; protein heterodimerization activity; protein binding; negative regulation of growth of symbiont in host; positive regulation of tumor necrosis factor production;
BNIP3	6	protein homodimerization activity; identical protein binding; protein heterodimerization activity; cytoplasm; protein binding; defense response to virus;
HES1	6	protein homodimerization activity; cytoplasm; protein binding; cell migration; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of T cell proliferation;
TSC2	6	protein homodimerization activity; cell cycle arrest; protein heterodimerization activity; cytoplasm; protein binding; membrane;
VEGFB	6	protein homodimerization activity; protein heterodimerization activity; protein binding; growth factor activity; membrane; extracellular space;
RELA	6	identical protein binding; cytoplasm; protein binding; cellular response to lipopolysaccharide; response to UV-B; defense response to virus;
SLC11A1	5	positive regulation of interferon-gamma production; protein homodimerization activity; defense response to protozoan; positive regulation of T-helper 1 type immune response; defense response to Gram-negative bacterium;
CCL19	5	positive regulation of NF-kappaB import into nucleus; positive regulation of interleukin-12 production; positive regulation of T cell proliferation; extracellular space; positive regulation of tumor necrosis factor production;
GHR	5	protein homodimerization activity; protein binding; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of tyrosine phosphorylation of Stat5 protein; extracellular space;
TRIM5	5	protein homodimerization activity; identical protein binding; cytoplasm; protein binding; defense response to virus;
BARD1	5	protein homodimerization activity; cell cycle arrest; protein heterodimerization activity; cytoplasm; protein binding;
TPD52L1	5	protein homodimerization activity; identical protein binding; protein heterodimerization activity; cytoplasm; protein binding;
STK11	5	identical protein binding; cell cycle arrest; cytoplasm; protein binding; membrane;
CLCF1	5	cytokine activity; protein heterodimerization activity; protein binding; positive regulation of tyrosine phosphorylation of Stat3 protein; growth factor activity;
INHA	5	cytokine activity; cell cycle arrest; protein heterodimerization activity; protein binding; growth factor activity;
APC	5	cell cycle arrest; cytoplasm; positive regulation of cell adhesion; protein binding; cell migration;

Genes shared at least 2 KEGG pathways with IL12B (count: 23)

Gene Symbol	Pathway Count	Pathway List
IL6	3	Toll-like receptor signaling pathway; Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
PIK3R1	2	Toll-like receptor signaling pathway; Jak-STAT signaling pathway;
PIK3CG	2	Toll-like receptor signaling pathway; Jak-STAT signaling pathway;
IL5RA	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
OSMR	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
IL7R	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
CNTF	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
GHR	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
IFNGR1	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
LIFR	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
IL22RA2	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
IL10RA	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
IL11RA	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
CNTFR	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
CTF1	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
PRLR	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
CLCF1	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
IL20RA	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
HLA-DPA1	2	Type I diabetes mellitus; Allograft rejection;
GZMB	2	Type I diabetes mellitus; Allograft rejection;
HLA-DRB1	2	Type I diabetes mellitus; Allograft rejection;
HLA-DOA	2	Type I diabetes mellitus; Allograft rejection;
HLA-DPB1	2	Type I diabetes mellitus; Allograft rejection;

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Region: chr5:158741791..158757895 View in gBrowse