ADHDgene Database

Gene Report

Basic Info

Approved Symbol	CNTF
Symbol Alias	HCNTF
Approved Name	ciliary neurotrophic factor
Location	11q12
Position	chr11:58390146-58393198, 1
External Links	HGNC: 2169 Entrez Gene: 1270 Ensembl: ENSG00000242689 UCSC: uc001nna.4
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin; Mapped by Literature SNP; Mapped by significant region

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Ribases M, 2008	1 SNP showed significant association with both adulthood and childhood ADHD; 2 SNP showed significant association with childhood ADHD; 1 SNP showed significant association with adulthood ADHD	Significant

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs550942	chr11:58394154(Fwd)	downstream_gene_variant	1(1/0/0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005737	cytoplasm	cellular component	IEA	781
GO:0070120	ciliary neurotrophic factor-mediated signaling pathway	biological process	IDA[12643274]	3
GO:0040007	growth	biological process	IEA	4
GO:0097058	CRLF-CLCF1 complex	cellular component	IDA[10966616]	2
GO:0005138	interleukin-6 receptor binding	molecular function	IPI[12643274]	3
GO:0008083	growth factor activity	molecular function	IDA[12643274]	28
GO:0005127	ciliary neurotrophic factor receptor binding	molecular function	TAS[1714745]	3
GO:0043524	negative regulation of neuron apoptotic process	biological process	IDA[10966616]	18
GO:0043231	intracellular membrane-bounded organelle	cellular component	IDA	65
GO:0048644	muscle organ morphogenesis	biological process	IEA	2
GO:0008284	positive regulation of cell proliferation	biological process	IEA	75
GO:0007165	signal transduction	biological process	NAS[1840538]	189
GO:0046533	negative regulation of photoreceptor cell differentiation	biological process	IEA	2
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein	biological process	IDA[12643274]	7
GO:0005615	extracellular space	cellular component	IC[12643274]	133
GO:0046668	regulation of retinal cell programmed cell death	biological process	IEA	2
GO:0048666	neuron development	biological process	IEA	8

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04630	Jak-STAT signaling pathway	25
hsa04060	Cytokine-cytokine receptor interaction	39

Genes shared at least 5 GO terms with CNTF (count: 4)

Gene Symbol	Pathway Count	Pathway List
CLCF1	6	CRLF-CLCF1 complex; growth factor activity; ciliary neurotrophic factor receptor binding; negative regulation of neuron apoptotic process; positive regulation of cell proliferation; positive regulation of tyrosine phosphorylation of Stat3 protein;
FGF9	5	cytoplasm; growth factor activity; positive regulation of cell proliferation; signal transduction; extracellular space;
VEGFA	5	cytoplasm; growth; growth factor activity; positive regulation of cell proliferation; extracellular space;
IL6	5	interleukin-6 receptor binding; growth factor activity; positive regulation of cell proliferation; positive regulation of tyrosine phosphorylation of Stat3 protein; extracellular space;

Genes shared at least 2 KEGG pathways with CNTF (count: 16)

Gene Symbol	Pathway Count	Pathway List
IL5RA	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
OSMR	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
IL7R	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
IL12B	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
GHR	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
IFNGR1	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
LIFR	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
IL22RA2	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
IL10RA	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
IL11RA	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
CNTFR	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
CTF1	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
PRLR	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
IL6	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
CLCF1	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
IL20RA	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;

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Region: chr11:58390146..58393198 View in gBrowse