ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	IRF7
Approved Name	interferon regulatory factor 7
Location	11p15.5
Position	chr11:612553-615999, -
External Links	HGNC: 6122 Entrez Gene: 3665 Ensembl: ENSG00000185507 UCSC: uc001lqh.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy

Gene related studies (count: 0)

Gene related SNPs (count: 2)

Literature-origin SNPs (count: 0)

LD-proxies (count: 2)

rs_ID	Location	Functional Annotation
rs7932167	Chr11:620599(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs12360820	Chr11:620927(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 42)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 42)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005515	protein binding	Molecular Function		910
GO:0003677	DNA binding	Molecular Function	IMP[12374802]	220
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005634	nucleus	Cellular Component	TAS[9786932]	770
GO:0000982	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity	Molecular Function	IDA[17404045]	3
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	Molecular Function	IDA[17404045]	6
GO:0002819	regulation of adaptive immune response	Biological Process	IDA[17404045]	2
GO:0002756	MyD88-independent toll-like receptor signaling pathway	Biological Process		9
GO:0006974	response to DNA damage stimulus	Biological Process	TAS[16979567]	37
GO:0006473	protein acetylation	Biological Process	IMP[12374802]	1
GO:0009615	response to virus	Biological Process		21
GO:0008063	Toll signaling pathway	Biological Process		11
GO:0005829	cytosol	Cellular Component		447
GO:0005737	cytoplasm	Cellular Component	TAS[9786932]	690
GO:0006468	protein phosphorylation	Biological Process	IDA[12374802]	53
GO:0006366	transcription from RNA polymerase II promoter	Biological Process	TAS[9315633]	62
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	TAS[9315633]	78
GO:0034124	regulation of MyD88-dependent toll-like receptor signaling pathway	Biological Process		1
GO:0032728	positive regulation of interferon-beta production	Biological Process	TAS[16979567]	3
GO:0034138	toll-like receptor 3 signaling pathway	Biological Process		11
GO:0034127	regulation of MyD88-independent toll-like receptor signaling pathway	Biological Process		1
GO:0035666	TRIF-dependent toll-like receptor signaling pathway	Biological Process		10
GO:0034142	toll-like receptor 4 signaling pathway	Biological Process		11
GO:0045087	innate immune response	Biological Process		54
GO:0039530	MDA-5 signaling pathway	Biological Process	TAS[16979567]	1
GO:0016064	immunoglobulin mediated immune response	Biological Process		1
GO:0010008	endosome membrane	Cellular Component		27
GO:0019221	cytokine-mediated signaling pathway	Biological Process		28
GO:0019043	establishment of viral latency	Biological Process		1
GO:0032607	interferon-alpha production	Biological Process		1
GO:0032479	regulation of type I interferon production	Biological Process		1
GO:0032727	positive regulation of interferon-alpha production	Biological Process	IDA[16127453]; TAS[16979567]	3
GO:0032608	interferon-beta production	Biological Process		1
GO:2000110	negative regulation of macrophage apoptotic process	Biological Process		1
GO:0045351	type I interferon biosynthetic process	Biological Process		2
GO:0045655	regulation of monocyte differentiation	Biological Process		1
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	IMP[12374802]	80
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA[16127453]	131
GO:0050776	regulation of immune response	Biological Process		9
GO:0060333	interferon-gamma-mediated signaling pathway	Biological Process		8
GO:0060337	type I interferon-mediated signaling pathway	Biological Process		5
GO:0060340	positive regulation of type I interferon-mediated signaling pathway	Biological Process		3

Gene related KEGG pathways (count: 5)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa05160	Hepatitis C	17	Hepatitis C virus (HCV) is a major cause of chronic liver di...... Hepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the cytoplasm of the host cell and forms membrane-associated replication complexes along with non-structural proteins. Viral RNA can trigger the RIG-I pathway and interferon production during this process. Translated HCV protein products regulate immune response to inhibit the action of interferon. HCV core and NS5A proteins appear to be the most important molecules with regulatory functions that modulate transcription, cellular proliferation, and apoptosis. More...
hsa04622	RIG-I-like receptor signaling pathway	10	Specific families of pattern recognition receptors are respo...... Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses. More...
hsa04623	Cytosolic DNA-sensing pathway	9	Specific families of pattern recognition receptors are respo...... Specific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified sensor of cytosolic DNA which activates the IRF and NF-{kappa}B transcription factors, leading to production of type I interferon and other cytokines. The second type of cytoplasmic DNA sensor is AIM2. Upon sensing DNA, AIM2 triggers the assembly of the inflammasome, culminating in interleukin maturation. In addition to these receptors, there is a mechanism to sense foreign DNA, with the host RNA polymerase III converting the DNA into RNA for recognition by the RNA sensor RIG-I. These pathways provide various means to alert the cell. More...
hsa04620	Toll-like receptor signaling pathway	13	Specific families of pattern recognition receptors are respo...... Specific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors identified as homologs of Toll in Drosophila. Mammalian TLRs are expressed on innate immune cells, such as macrophages and dendritic cells, and respond to the membrane components of Gram-positive or Gram-negative bacteria. Pathogen recognition by TLRs provokes rapid activation of innate immunity by inducing production of proinflammatory cytokines and upregulation of costimulatory molecules. TLR signaling pathways are separated into two groups: a MyD88-dependent pathway that leads to the production of proinflammatory cytokines with quick activation of NF-{kappa}B and MAPK, and a MyD88-independent pathway associated with the induction of IFN-beta and IFN-inducible genes, and maturation of dendritic cells with slow activation of NF-{kappa}B and MAPK. More...
hsa05162	Measles	20	Measles virus (MV) is highly contagious virus that leads inf...... Measles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacterial infections. Several MV proteins have been suggested to disturb host immunity. After infection of host lymphoid cells via SLAM, MV inhibits cytokine response by direct interference with host signaling systems. Three proteins (P, V, and C) associate with Jak/STAT proteins in interferon-triggered pathway and other important proteins related to apoptosis. Interaction between MV and host brings about the shift towards a Th2 response by decreasing IL-12 production and induces lymphopenia by suppressing cell proliferation. More...

Genes shared at least 5 GO terms with IRF7 (count: 117)

Gene Symbol	Pathway Count	Pathway List
RELA	15	protein binding; DNA binding; nucleoplasm; nucleus; MyD88-independent toll-like receptor signaling pathway; Toll signaling pathway; cytosol; cytoplasm; toll-like receptor 3 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; toll-like receptor 4 signaling pathway; innate immune response; cytokine-mediated signaling pathway; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
MAPK1	14	protein binding; DNA binding; nucleoplasm; nucleus; MyD88-independent toll-like receptor signaling pathway; response to DNA damage stimulus; Toll signaling pathway; cytosol; cytoplasm; toll-like receptor 3 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; toll-like receptor 4 signaling pathway; innate immune response; positive regulation of transcription, DNA-dependent;
MAPK3	14	protein binding; nucleoplasm; nucleus; MyD88-independent toll-like receptor signaling pathway; response to DNA damage stimulus; Toll signaling pathway; cytosol; protein phosphorylation; toll-like receptor 3 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; toll-like receptor 4 signaling pathway; innate immune response; cytokine-mediated signaling pathway; positive regulation of transcription from RNA polymerase II promoter;
UBB	13	protein binding; nucleoplasm; MyD88-independent toll-like receptor signaling pathway; Toll signaling pathway; cytosol; negative regulation of transcription from RNA polymerase II promoter; toll-like receptor 3 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; toll-like receptor 4 signaling pathway; innate immune response; endosome membrane; cytokine-mediated signaling pathway; positive regulation of transcription from RNA polymerase II promoter;
UBC	13	protein binding; nucleoplasm; MyD88-independent toll-like receptor signaling pathway; Toll signaling pathway; cytosol; negative regulation of transcription from RNA polymerase II promoter; toll-like receptor 3 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; toll-like receptor 4 signaling pathway; innate immune response; endosome membrane; cytokine-mediated signaling pathway; positive regulation of transcription from RNA polymerase II promoter;
MAPK7	11	protein binding; nucleoplasm; nucleus; MyD88-independent toll-like receptor signaling pathway; Toll signaling pathway; cytosol; toll-like receptor 3 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; toll-like receptor 4 signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter;
TLR4	11	protein binding; Toll signaling pathway; cytoplasm; positive regulation of interferon-beta production; toll-like receptor 3 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; toll-like receptor 4 signaling pathway; innate immune response; endosome membrane; positive regulation of interferon-alpha production; positive regulation of transcription from RNA polymerase II promoter;
IRF9	10	protein binding; nucleoplasm; nucleus; cytosol; cytoplasm; transcription from RNA polymerase II promoter; cytokine-mediated signaling pathway; type I interferon biosynthetic process; interferon-gamma-mediated signaling pathway; type I interferon-mediated signaling pathway;
MAP2K3	10	protein binding; nucleoplasm; MyD88-independent toll-like receptor signaling pathway; Toll signaling pathway; cytosol; toll-like receptor 3 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; toll-like receptor 4 signaling pathway; innate immune response; positive regulation of transcription, DNA-dependent;
MAPK9	10	protein binding; nucleoplasm; MyD88-independent toll-like receptor signaling pathway; Toll signaling pathway; cytosol; toll-like receptor 3 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; toll-like receptor 4 signaling pathway; innate immune response; positive regulation of transcription, DNA-dependent;
TFAP2A	9	protein binding; nucleus; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity; RNA polymerase II core promoter sequence-specific DNA binding; cytoplasm; transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
IRF8	8	protein binding; nucleus; cytosol; negative regulation of transcription from RNA polymerase II promoter; cytokine-mediated signaling pathway; positive regulation of transcription, DNA-dependent; interferon-gamma-mediated signaling pathway; type I interferon-mediated signaling pathway;
MEN1	8	protein binding; nucleoplasm; nucleus; response to DNA damage stimulus; cytosol; cytoplasm; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
GATA6	7	protein binding; nucleoplasm; nucleus; RNA polymerase II core promoter sequence-specific DNA binding; transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
HMGA1	7	protein binding; DNA binding; nucleoplasm; nucleus; response to virus; cytosol; positive regulation of transcription, DNA-dependent;
RBPJ	7	protein binding; DNA binding; nucleoplasm; nucleus; cytoplasm; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
TP53BP1	7	protein binding; nucleoplasm; nucleus; response to DNA damage stimulus; cytoplasm; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
YAP1	7	protein binding; nucleoplasm; nucleus; response to DNA damage stimulus; cytosol; cytoplasm; positive regulation of transcription from RNA polymerase II promoter;
OASL	7	DNA binding; response to virus; cytosol; cytoplasm; cytokine-mediated signaling pathway; interferon-gamma-mediated signaling pathway; type I interferon-mediated signaling pathway;
ARRB1	6	protein binding; nucleus; cytosol; cytoplasm; transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
ATXN1	6	protein binding; DNA binding; nucleoplasm; nucleus; cytoplasm; positive regulation of transcription from RNA polymerase II promoter;
EGLN3	6	protein binding; nucleoplasm; nucleus; response to DNA damage stimulus; cytosol; cytoplasm;
ETS1	6	protein binding; DNA binding; nucleus; transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
GSK3B	6	protein binding; nucleus; cytosol; cytoplasm; protein phosphorylation; positive regulation of transcription from RNA polymerase II promoter;
HERC5	6	protein binding; nucleus; cytosol; cytoplasm; innate immune response; cytokine-mediated signaling pathway;
HES1	6	protein binding; DNA binding; nucleus; cytoplasm; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
HNF1B	6	protein binding; DNA binding; nucleus; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
ID2	6	protein binding; nucleus; cytosol; cytoplasm; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent;
KAT5	6	protein binding; nucleus; cytosol; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
MAVS	6	protein binding; positive regulation of interferon-beta production; innate immune response; positive regulation of interferon-alpha production; positive regulation of transcription from RNA polymerase II promoter; positive regulation of type I interferon-mediated signaling pathway;
MED1	6	protein binding; nucleoplasm; nucleus; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
NCBP1	6	protein binding; DNA binding; nucleoplasm; nucleus; cytosol; transcription from RNA polymerase II promoter;
NCOA6	6	protein binding; nucleoplasm; nucleus; response to DNA damage stimulus; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
NCOR1	6	protein binding; nucleoplasm; nucleus; cytoplasm; transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter;
NEDD4L	6	protein binding; nucleoplasm; nucleus; cytosol; cytoplasm; negative regulation of transcription from RNA polymerase II promoter;
PLK1	6	protein binding; nucleoplasm; nucleus; cytosol; protein phosphorylation; negative regulation of transcription from RNA polymerase II promoter;
PRKD1	6	protein binding; nucleus; cytosol; cytoplasm; innate immune response; positive regulation of transcription from RNA polymerase II promoter;
SSRP1	6	protein binding; DNA binding; nucleoplasm; nucleus; cytoplasm; transcription from RNA polymerase II promoter;
STRN3	6	protein binding; nucleoplasm; nucleus; cytoplasm; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
TNFAIP3	6	protein binding; DNA binding; nucleus; cytosol; cytoplasm; innate immune response;
AATF	5	protein binding; nucleus; response to DNA damage stimulus; cytoplasm; positive regulation of transcription from RNA polymerase II promoter;
ALKBH8	5	protein binding; nucleus; response to DNA damage stimulus; cytosol; cytoplasm;
APBB1	5	protein binding; nucleus; response to DNA damage stimulus; cytoplasm; positive regulation of transcription, DNA-dependent;
APC	5	protein binding; nucleus; response to DNA damage stimulus; cytosol; cytoplasm;
ARRB2	5	protein binding; nucleus; cytosol; cytoplasm; transcription from RNA polymerase II promoter;
BANF1	5	protein binding; DNA binding; nucleoplasm; response to virus; cytosol;
CCND1	5	protein binding; nucleoplasm; nucleus; response to DNA damage stimulus; cytosol;
CDT1	5	protein binding; DNA binding; nucleoplasm; nucleus; cytosol;
CFL1	5	protein binding; nucleus; response to virus; cytoplasm; protein phosphorylation;
CHD1L	5	protein binding; DNA binding; nucleus; response to DNA damage stimulus; cytoplasm;
CHEK1	5	protein binding; nucleoplasm; nucleus; response to DNA damage stimulus; cytosol;
DDB1	5	protein binding; DNA binding; nucleoplasm; nucleus; cytoplasm;
DEAF1	5	protein binding; DNA binding; nucleus; cytoplasm; transcription from RNA polymerase II promoter;
DHX9	5	protein binding; DNA binding; nucleoplasm; nucleus; cytoplasm;
E2F5	5	protein binding; DNA binding; nucleoplasm; cytoplasm; positive regulation of transcription from RNA polymerase II promoter;
ESRRA	5	protein binding; DNA binding; nucleoplasm; nucleus; positive regulation of transcription from RNA polymerase II promoter;
FADD	5	protein binding; cytosol; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of type I interferon-mediated signaling pathway;
FANCC	5	protein binding; nucleoplasm; nucleus; cytosol; cytoplasm;
FLCN	5	protein binding; nucleus; cytoplasm; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
FOSL1	5	protein binding; nucleus; response to virus; cytosol; transcription from RNA polymerase II promoter;
FUS	5	protein binding; DNA binding; nucleoplasm; nucleus; cytoplasm;
GFI1B	5	protein binding; DNA binding; nucleus; transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter;
H2AFX	5	protein binding; DNA binding; nucleoplasm; nucleus; response to DNA damage stimulus;
HEY2	5	protein binding; nucleus; cytoplasm; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
HINFP	5	protein binding; DNA binding; nucleoplasm; nucleus; positive regulation of transcription, DNA-dependent;
ILK	5	protein binding; cytosol; cytoplasm; protein phosphorylation; positive regulation of transcription, DNA-dependent;
KDM1A	5	protein binding; nucleoplasm; nucleus; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
KLF13	5	protein binding; DNA binding; nucleus; transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
MALT1	5	protein binding; nucleus; cytosol; cytoplasm; innate immune response;
MAML1	5	protein binding; nucleoplasm; nucleus; protein phosphorylation; positive regulation of transcription from RNA polymerase II promoter;
MED4	5	protein binding; nucleoplasm; nucleus; transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent;
MEIS2	5	protein binding; nucleus; transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
MLL	5	protein binding; nucleus; transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
MMS19	5	protein binding; nucleus; response to DNA damage stimulus; cytoplasm; positive regulation of transcription, DNA-dependent;
MRE11A	5	protein binding; DNA binding; nucleoplasm; nucleus; response to DNA damage stimulus;
MYB	5	protein binding; DNA binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
NCK1	5	protein binding; nucleus; cytosol; cytoplasm; positive regulation of transcription from RNA polymerase II promoter;
NCOR2	5	protein binding; DNA binding; nucleoplasm; nucleus; negative regulation of transcription from RNA polymerase II promoter;
NR4A2	5	protein binding; nucleoplasm; nucleus; cytoplasm; positive regulation of transcription from RNA polymerase II promoter;
NR5A1	5	protein binding; DNA binding; nucleoplasm; nucleus; positive regulation of transcription from RNA polymerase II promoter;
NRIP1	5	protein binding; nucleus; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
NUMA1	5	protein binding; nucleoplasm; nucleus; cytosol; cytoplasm;
PDE2A	5	protein binding; nucleus; cytosol; cytoplasm; negative regulation of transcription from RNA polymerase II promoter;
PGR	5	protein binding; DNA binding; nucleoplasm; nucleus; cytoplasm;
PRKCB	5	protein binding; nucleus; cytosol; cytoplasm; protein phosphorylation;
PSMC3	5	protein binding; nucleoplasm; nucleus; cytosol; cytoplasm;
PTTG1	5	protein binding; nucleus; cytosol; cytoplasm; transcription from RNA polymerase II promoter;
PYCARD	5	protein binding; nucleus; cytosol; cytoplasm; innate immune response;
RAD9A	5	protein binding; nucleoplasm; nucleus; response to DNA damage stimulus; cytoplasm;
RAN	5	protein binding; nucleoplasm; cytosol; cytoplasm; positive regulation of transcription, DNA-dependent;
RFWD2	5	protein binding; nucleoplasm; nucleus; cytosol; cytoplasm;
RPS3	5	protein binding; nucleus; response to DNA damage stimulus; cytosol; cytoplasm;
RPS6KA4	5	protein binding; nucleus; cytoplasm; protein phosphorylation; positive regulation of transcription from RNA polymerase II promoter;
SART1	5	protein binding; nucleoplasm; nucleus; cytosol; cytoplasm;
SMARCD3	5	protein binding; nucleoplasm; nucleus; cytoplasm; positive regulation of transcription, DNA-dependent;
SNW1	5	protein binding; nucleoplasm; nucleus; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
SREBF1	5	protein binding; DNA binding; nucleus; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
TAF10	5	protein binding; nucleoplasm; nucleus; cytoplasm; transcription from RNA polymerase II promoter;
TAF13	5	protein binding; DNA binding; nucleoplasm; nucleus; transcription from RNA polymerase II promoter;
TCF25	5	protein binding; DNA binding; nucleus; cytoplasm; negative regulation of transcription from RNA polymerase II promoter;
TRIP12	5	protein binding; nucleoplasm; nucleus; response to DNA damage stimulus; cytoplasm;
TXN	5	protein binding; nucleoplasm; cytosol; negative regulation of transcription from RNA polymerase II promoter; innate immune response;
UBE3A	5	protein binding; nucleus; cytosol; cytoplasm; positive regulation of transcription from RNA polymerase II promoter;
WWOX	5	protein binding; nucleus; cytosol; cytoplasm; positive regulation of transcription from RNA polymerase II promoter;
XPO1	5	protein binding; nucleoplasm; cytosol; cytoplasm; negative regulation of transcription from RNA polymerase II promoter;
XRCC5	5	protein binding; DNA binding; nucleoplasm; nucleus; cytoplasm;
FOXE1	5	DNA binding; nucleus; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
FOXF1	5	DNA binding; nucleus; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
IKZF1	5	DNA binding; nucleus; cytoplasm; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
NFATC4	5	DNA binding; cytosol; cytoplasm; transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
NFIL3	5	DNA binding; nucleus; RNA polymerase II core promoter sequence-specific DNA binding; transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter;
RREB1	5	DNA binding; nucleus; cytoplasm; transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent;
TAF4B	5	DNA binding; nucleoplasm; nucleus; cytoplasm; transcription from RNA polymerase II promoter;
CAMK2D	5	nucleoplasm; cytosol; protein phosphorylation; cytokine-mediated signaling pathway; interferon-gamma-mediated signaling pathway;
LPIN1	5	nucleus; cytosol; cytoplasm; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
MAF	5	nucleus; cytoplasm; transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
RNASEL	5	cytosol; protein phosphorylation; cytokine-mediated signaling pathway; positive regulation of transcription from RNA polymerase II promoter; type I interferon-mediated signaling pathway;

Genes shared at least 2 KEGG pathways with IRF7 (count: 13)

Gene Symbol	Pathway Count	Pathway List
RELA	5	Hepatitis C; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; Toll-like receptor signaling pathway; Measles;
MAVS	4	Hepatitis C; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; Measles;
MAPK9	3	Hepatitis C; RIG-I-like receptor signaling pathway; Toll-like receptor signaling pathway;
PIK3CG	3	Hepatitis C; Toll-like receptor signaling pathway; Measles;
PIK3R1	3	Hepatitis C; Toll-like receptor signaling pathway; Measles;
IL12B	3	RIG-I-like receptor signaling pathway; Toll-like receptor signaling pathway; Measles;
IL6	3	Cytosolic DNA-sensing pathway; Toll-like receptor signaling pathway; Measles;
GSK3B	2	Hepatitis C; Measles;
IRF9	2	Hepatitis C; Measles;
MAPK1	2	Hepatitis C; Toll-like receptor signaling pathway;
MAPK3	2	Hepatitis C; Toll-like receptor signaling pathway;
FADD	2	RIG-I-like receptor signaling pathway; Toll-like receptor signaling pathway;
TLR4	2	Toll-like receptor signaling pathway; Measles;

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Region: chr11:612553..615999 View in gBrowse