ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	FOSL1
Symbol Alias	fra-1
Approved Name	FOS-like antigen 1
Location	11q13
Position	chr11:65659520-65668044, -1
External Links	HGNC: 13718 Entrez Gene: 8061 Ensembl: ENSG00000175592 UCSC: uc001ogg.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 31)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 31)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0009615	response to virus	biological process	TAS[8230424]	22
GO:0042734	presynaptic membrane	cellular component	IEA	16
GO:0009629	response to gravity	biological process	IEA	2
GO:0051591	response to cAMP	biological process	IEA	12
GO:0005634	nucleus	cellular component	IEA	877
GO:0007565	female pregnancy	biological process	IEA	15
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	IEA	148
GO:0042493	response to drug	biological process	IEA	73
GO:0006968	cellular defense response	biological process	TAS[10918580]	12
GO:0034097	response to cytokine stimulus	biological process	IEA	11
GO:0005515	protein binding	molecular function	IPI[19060904]	1015
GO:0005829	cytosol	cellular component	IEA	485
GO:0042542	response to hydrogen peroxide	biological process	IEA	7
GO:0051412	response to corticosterone stimulus	biological process	IEA	5
GO:0008284	positive regulation of cell proliferation	biological process	TAS[8230424]	75
GO:0032570	response to progesterone stimulus	biological process	IEA	7
GO:0007296	vitellogenesis	biological process	IEA	1
GO:0008285	negative regulation of cell proliferation	biological process	IEA	65
GO:0009612	response to mechanical stimulus	biological process	IEA	10
GO:0060674	placenta blood vessel development	biological process	IEA	2
GO:0006357	regulation of transcription from RNA polymerase II promoter	biological process	TAS[10918580]	46
GO:0006366	transcription from RNA polymerase II promoter	biological process	TAS[2107490]	63
GO:0043065	positive regulation of apoptotic process	biological process	IEA	38
GO:0001701	in utero embryonic development	biological process	IEA	39
GO:0007612	learning	biological process	IEA	13
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	biological process	IEA	12
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	molecular function	IEA	3
GO:0031668	cellular response to extracellular stimulus	biological process	IEA	2
GO:0043005	neuron projection	cellular component	IEA	38
GO:0045787	positive regulation of cell cycle	biological process	IEA	7
GO:0006935	chemotaxis	biological process	TAS[10918580]	18

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04310	Wnt signaling pathway	25

Genes shared at least 5 GO terms with FOSL1 (count: 26)

Gene Symbol	Pathway Count	Pathway List
RELA	11	response to cAMP; nucleus; sequence-specific DNA binding transcription factor activity; response to drug; cellular defense response; protein binding; cytosol; response to hydrogen peroxide; positive regulation of cell proliferation; response to progesterone stimulus; response to mechanical stimulus;
ETS1	8	nucleus; female pregnancy; sequence-specific DNA binding transcription factor activity; protein binding; positive regulation of cell proliferation; negative regulation of cell proliferation; response to mechanical stimulus; transcription from RNA polymerase II promoter;
SREBF1	7	response to cAMP; nucleus; sequence-specific DNA binding transcription factor activity; response to drug; protein binding; response to progesterone stimulus; regulation of transcription from RNA polymerase II promoter;
HMGA1	6	response to virus; nucleus; sequence-specific DNA binding transcription factor activity; protein binding; cytosol; negative regulation of cell proliferation;
GATA6	6	nucleus; sequence-specific DNA binding transcription factor activity; response to drug; protein binding; transcription from RNA polymerase II promoter; in utero embryonic development;
TH	6	nucleus; protein binding; cytosol; response to corticosterone stimulus; learning; neuron projection;
KDM1A	6	nucleus; sequence-specific DNA binding transcription factor activity; protein binding; regulation of transcription from RNA polymerase II promoter; in utero embryonic development; positive regulation of sequence-specific DNA binding transcription factor activity;
BAD	6	response to drug; protein binding; cytosol; response to hydrogen peroxide; response to progesterone stimulus; positive regulation of apoptotic process;
IRF7	5	response to virus; nucleus; protein binding; cytosol; transcription from RNA polymerase II promoter;
ADORA2A	5	presynaptic membrane; response to drug; cellular defense response; protein binding; negative regulation of cell proliferation;
PYCARD	5	nucleus; protein binding; cytosol; positive regulation of apoptotic process; positive regulation of sequence-specific DNA binding transcription factor activity;
CCND1	5	nucleus; response to drug; protein binding; cytosol; response to corticosterone stimulus;
DNAJA3	5	nucleus; protein binding; cytosol; negative regulation of cell proliferation; positive regulation of apoptotic process;
KLF11	5	nucleus; sequence-specific DNA binding transcription factor activity; negative regulation of cell proliferation; transcription from RNA polymerase II promoter; positive regulation of apoptotic process;
APC	5	nucleus; protein binding; cytosol; negative regulation of cell proliferation; positive regulation of apoptotic process;
PTTG1	5	nucleus; sequence-specific DNA binding transcription factor activity; protein binding; cytosol; transcription from RNA polymerase II promoter;
MEN1	5	nucleus; protein binding; cytosol; negative regulation of cell proliferation; positive regulation of apoptotic process;
TFAP2B	5	nucleus; sequence-specific DNA binding transcription factor activity; protein binding; positive regulation of cell proliferation; negative regulation of cell proliferation;
MAPK1	5	nucleus; protein binding; cytosol; positive regulation of cell proliferation; chemotaxis;
SMARCB1	5	nucleus; protein binding; negative regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; positive regulation of sequence-specific DNA binding transcription factor activity;
IRF9	5	nucleus; sequence-specific DNA binding transcription factor activity; protein binding; cytosol; transcription from RNA polymerase II promoter;
SLC6A4	5	response to drug; protein binding; cytosol; neuron projection; positive regulation of cell cycle;
MAPK9	5	response to drug; protein binding; cytosol; response to mechanical stimulus; positive regulation of apoptotic process;
IL6	5	response to drug; positive regulation of cell proliferation; negative regulation of cell proliferation; response to mechanical stimulus; positive regulation of sequence-specific DNA binding transcription factor activity;
NCF2	5	response to drug; cellular defense response; protein binding; cytosol; response to progesterone stimulus;
BCL2L11	5	protein binding; cytosol; positive regulation of apoptotic process; in utero embryonic development; positive regulation of cell cycle;

Genes shared at least 2 KEGG pathways with FOSL1 (count: 0)

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Region: chr11:65659520..65668044 View in gBrowse