ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	FOSL1
Symbol Alias	fra-1
Approved Name	FOS-like antigen 1
Location	11q13
Position	chr11:65659490-65668044, -
External Links	HGNC: 13718 Entrez Gene: 8061 Ensembl: ENSG00000175592 UCSC: uc001ogg.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 31)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 31)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	Molecular Function		3
GO:0005515	protein binding	Molecular Function	IPI[19060904]	910
GO:0005634	nucleus	Cellular Component		770
GO:0001701	in utero embryonic development	Biological Process		32
GO:0003700	sequence-specific DNA binding transcription factor activity	Molecular Function		132
GO:0006366	transcription from RNA polymerase II promoter	Biological Process	TAS[2107490]	62
GO:0006935	chemotaxis	Biological Process	TAS[10918580]	15
GO:0005829	cytosol	Cellular Component		447
GO:0006357	regulation of transcription from RNA polymerase II promoter	Biological Process	TAS[10918580]	42
GO:0007612	learning	Biological Process		13
GO:0007565	female pregnancy	Biological Process		14
GO:0007296	vitellogenesis	Biological Process		1
GO:0006968	cellular defense response	Biological Process	TAS[10918580]	12
GO:0009615	response to virus	Biological Process	TAS[8230424]	21
GO:0009612	response to mechanical stimulus	Biological Process		9
GO:0008285	negative regulation of cell proliferation	Biological Process		59
GO:0008284	positive regulation of cell proliferation	Biological Process	TAS[8230424]	69
GO:0034097	response to cytokine stimulus	Biological Process		9
GO:0032570	response to progesterone stimulus	Biological Process		7
GO:0031668	cellular response to extracellular stimulus	Biological Process		2
GO:0009629	response to gravity	Biological Process		2
GO:0043005	neuron projection	Cellular Component		35
GO:0042734	presynaptic membrane	Cellular Component		15
GO:0042542	response to hydrogen peroxide	Biological Process		6
GO:0042493	response to drug	Biological Process		68
GO:0060674	placenta blood vessel development	Biological Process		1
GO:0051591	response to cAMP	Biological Process		11
GO:0045787	positive regulation of cell cycle	Biological Process		7
GO:0043065	positive regulation of apoptotic process	Biological Process		34
GO:0051412	response to corticosterone stimulus	Biological Process		5
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	Biological Process		11

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04380	Osteoclast differentiation	25	The osteoclasts, multinucleared cells originating from the h...... The osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways activated by RANK and immune receptors, whose ligands are expressed on the surface of osteoblasts. Signaling from RANK changes gene expression patterns through transcription factors like NFATc1 and characterizes the active osteoclast. More...
hsa04310	Wnt signaling pathway	22	Wnt proteins are secreted morphogens that are required for b...... Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin. More...

Genes shared at least 5 GO terms with FOSL1 (count: 23)

Gene Symbol	Pathway Count	Pathway List
RELA	11	protein binding; nucleus; sequence-specific DNA binding transcription factor activity; cytosol; cellular defense response; response to mechanical stimulus; positive regulation of cell proliferation; response to progesterone stimulus; response to hydrogen peroxide; response to drug; response to cAMP;
ETS1	8	protein binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter; female pregnancy; response to mechanical stimulus; negative regulation of cell proliferation; positive regulation of cell proliferation;
SREBF1	7	protein binding; nucleus; sequence-specific DNA binding transcription factor activity; regulation of transcription from RNA polymerase II promoter; response to progesterone stimulus; response to drug; response to cAMP;
BAD	6	protein binding; cytosol; response to progesterone stimulus; response to hydrogen peroxide; response to drug; positive regulation of apoptotic process;
GATA6	6	protein binding; nucleus; in utero embryonic development; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter; response to drug;
HMGA1	6	protein binding; nucleus; sequence-specific DNA binding transcription factor activity; cytosol; response to virus; negative regulation of cell proliferation;
KDM1A	6	protein binding; nucleus; in utero embryonic development; sequence-specific DNA binding transcription factor activity; regulation of transcription from RNA polymerase II promoter; positive regulation of sequence-specific DNA binding transcription factor activity;
TH	6	protein binding; nucleus; cytosol; learning; neuron projection; response to corticosterone stimulus;
ADORA2A	5	protein binding; cellular defense response; negative regulation of cell proliferation; presynaptic membrane; response to drug;
APC	5	protein binding; nucleus; cytosol; negative regulation of cell proliferation; positive regulation of apoptotic process;
CCND1	5	protein binding; nucleus; cytosol; response to drug; response to corticosterone stimulus;
IRF7	5	protein binding; nucleus; transcription from RNA polymerase II promoter; cytosol; response to virus;
IRF9	5	protein binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter; cytosol;
MAPK1	5	protein binding; nucleus; chemotaxis; cytosol; positive regulation of cell proliferation;
MAPK9	5	protein binding; cytosol; response to mechanical stimulus; response to drug; positive regulation of apoptotic process;
MEN1	5	protein binding; nucleus; cytosol; negative regulation of cell proliferation; positive regulation of apoptotic process;
NCF2	5	protein binding; cytosol; cellular defense response; response to progesterone stimulus; response to drug;
PTTG1	5	protein binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter; cytosol;
PYCARD	5	protein binding; nucleus; cytosol; positive regulation of apoptotic process; positive regulation of sequence-specific DNA binding transcription factor activity;
SLC6A4	5	protein binding; cytosol; neuron projection; response to drug; positive regulation of cell cycle;
SMARCB1	5	protein binding; nucleus; regulation of transcription from RNA polymerase II promoter; negative regulation of cell proliferation; positive regulation of sequence-specific DNA binding transcription factor activity;
KLF11	5	nucleus; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter; negative regulation of cell proliferation; positive regulation of apoptotic process;
IL6	5	response to mechanical stimulus; negative regulation of cell proliferation; positive regulation of cell proliferation; response to drug; positive regulation of sequence-specific DNA binding transcription factor activity;

Genes shared at least 2 KEGG pathways with FOSL1 (count: 1)

Gene Symbol	Pathway Count	Pathway List
MAPK9	2	Osteoclast differentiation; Wnt signaling pathway;

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Region: chr11:65659490..65668044 View in gBrowse