ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	KLF11
Previous Symbol	TIEG2
Symbol Alias	Tieg3, MODY7
Approved Name	Kruppel-like factor 11
Previous Name	TGFB inducible early growth response 2
Location	2p25
Position	chr2:10182976-10194963, +
External Links	HGNC: 11811 Entrez Gene: 8462 Ensembl: ENSG00000172059 UCSC: uc002raf.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
2p25.1	chr2:7100000-12200000	2 (1/0/1)

Gene related GO terms (count: 11)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0008285	negative regulation of cell proliferation	Biological Process		59
GO:0043065	positive regulation of apoptotic process	Biological Process		34
GO:0006915	apoptotic process	Biological Process		111
GO:0008270	zinc ion binding	Molecular Function		323
GO:0044212	transcription regulatory region DNA binding	Molecular Function		23
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process		78
GO:0000115	regulation of transcription involved in S phase of mitotic cell cycle	Biological Process		1
GO:0003700	sequence-specific DNA binding transcription factor activity	Molecular Function	TAS[9748269]	132
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	Molecular Function		6
GO:0006366	transcription from RNA polymerase II promoter	Biological Process	TAS[9748269]	62
GO:0005634	nucleus	Cellular Component		770

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with KLF11 (count: 10)

Gene Symbol	Pathway Count	Pathway List
GATA6	8	apoptotic process; zinc ion binding; transcription regulatory region DNA binding; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding RNA polymerase II transcription factor activity; transcription from RNA polymerase II promoter; nucleus;
KLF4	6	negative regulation of cell proliferation; zinc ion binding; transcription regulatory region DNA binding; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter;
TFAP2A	6	negative regulation of cell proliferation; transcription regulatory region DNA binding; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding RNA polymerase II transcription factor activity; transcription from RNA polymerase II promoter; nucleus;
MLL	6	apoptotic process; zinc ion binding; transcription regulatory region DNA binding; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter; nucleus;
FOSL1	5	negative regulation of cell proliferation; positive regulation of apoptotic process; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter; nucleus;
MEN1	5	negative regulation of cell proliferation; positive regulation of apoptotic process; transcription regulatory region DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleus;
ZBTB16	5	negative regulation of cell proliferation; positive regulation of apoptotic process; apoptotic process; zinc ion binding; nucleus;
MTA2	5	zinc ion binding; transcription regulatory region DNA binding; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; nucleus;
ZNF202	5	zinc ion binding; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter; nucleus;
NCOR1	5	transcription regulatory region DNA binding; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter; nucleus;

Genes shared at least 2 KEGG pathways with KLF11 (count: 0)

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Region: chr2:10182976..10194963 View in gBrowse