ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0000122
Name	negative regulation of transcription from RNA polymerase II promoter
Type	Biological Process
No. of Genes in ADHDgene	78
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 78)

Literature-origin genes (count: 13)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
MEIS2	Meis homeobox 2	15q14	1(0/0/1)	TAS[10764806]
DACT1	dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)	14q22.3	1(0/1/0)	IDA[18936100]
PER2	period homolog 2 (Drosophila)	2q37.3	1(1/0/0)
PER1	period homolog 1 (Drosophila)	17p13.1	1(0/1/0)
NFIL3	nuclear factor, interleukin 3 regulated	9q22	2(1/1/0)
VEGFA	vascular endothelial growth factor A	6p12	1(0/1/0)	IDA[18093989]
GFI1B	growth factor independent 1B transcription repressor	9q34.13	1(0/1/0)	TAS[9566867]
DRD3	dopamine receptor D3	3q13.3	8(1/7/0)
ISL1	ISL LIM homeobox 1	5q11.2	1(0/1/0)
ID2	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	2p25	1(0/1/0)
HES1	hairy and enhancer of split 1, (Drosophila)	3q28-q29	1(1/0/0)	IDA[12535671]
XPO1	exportin 1 (CRM1 homolog, yeast)	2p15	1(0/0/1)
KANK2	KN motif and ankyrin repeat domains 2	19p13.2	1(0/1/0)	IDA[17476305]

Genes from other sources (count: 65)

Approved Symbol	Approved Name	Source	Evidence[PMID]
STRN3	striatin, calmodulin binding protein 3	Mapped by significant region	IDA[11570823]
TBX6	T-box 6	Mapped by CNV
NCOR2	nuclear receptor corepressor 2	Mapped by CNV	IDA[10097068]; IMP[19955185]
SORBS3	sorbin and SH3 domain containing 3	Mapped by PBA pathway
BARX2	BARX homeobox 2	Mapped by significant region
SNW1	SNW domain containing 1	Mapped by PBA pathway	IDA[14985122]
TXN	thioredoxin	Mapped by significant region
IKZF1	IKAROS family zinc finger 1 (Ikaros)	Mapped by LD-proxy
HNF1B	HNF1 homeobox B	Mapped by CNV
HEY2	hairy/enhancer-of-split related with YRPW motif 2	Mapped by significant region	IDA[16293227]; IMP[11486045]
MTA2	metastasis associated 1 family, member 2	Mapped by significant region
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	Mapped by significant region
CHCHD3	coiled-coil-helix-coiled-coil-helix domain containing 3	Mapped by CNV
FOXF1	forkhead box F1	Mapped by significant region
KAT5	K(lysine) acetyltransferase 5	Mapped by significant region	IMP[17360565]
TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	Mapped by CNV	IDA[8321221]
USP2	ubiquitin specific peptidase 2	Mapped by significant region	IMP[17290220]
TRIM29	tripartite motif containing 29	Mapped by significant region
HSBP1	heat shock factor binding protein 1	Mapped by CNV; Mapped by significant region	TAS[9649501]
RNF2	ring finger protein 2	Mapped by significant region
IRF8	interferon regulatory factor 8	Mapped by significant region	TAS[1460054]
SREBF1	sterol regulatory element binding transcription factor 1	Mapped by significant region
LPIN1	lipin 1	Mapped by significant region
UBB	ubiquitin B	Mapped by significant region
FOXE1	forkhead box E1 (thyroid transcription factor 2)	Mapped by significant region	NAS[9169137]
UXT	ubiquitously-expressed transcript	Mapped by PBA pathway
MEN1	multiple endocrine neoplasia I	Mapped by significant region	IDA[9989505]
TCF25	transcription factor 25 (basic helix-loop-helix)	Mapped by significant region	IDA[16574069]
CRYM	crystallin, mu	Mapped by significant region	IMP[11897713]
MYB	v-myb myeloblastosis viral oncogene homolog (avian)	Mapped by significant region
PDE2A	phosphodiesterase 2A, cGMP-stimulated	Mapped by significant region	IDA[17329248]
DRAP1	DR1-associated protein 1 (negative cofactor 2 alpha)	Mapped by significant region
NSD1	nuclear receptor binding SET domain protein 1	Mapped by PBA pathway
KDM1A	lysine (K)-specific demethylase 1A	Mapped by LD-proxy	IMP[17805299]
RBBP8	retinoblastoma binding protein 8	Mapped by significant region	IDA[16287852]
UBC	ubiquitin C	Mapped by CNV
GATA6	GATA binding protein 6	Mapped by significant region	IDA[18177748]
SPI1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	Mapped by LD-proxy	TAS[10867017]
NCOR1	nuclear receptor corepressor 1	Mapped by significant region	IMP[19955185]
HOXA7	homeobox A7	Mapped by significant region	IDA[11435435]
NRIP1	nuclear receptor interacting protein 1	Mapped by PBA pathway	IDA[10364267]
NKX6-2	NK6 homeobox 2	Mapped by CNV
E2F6	E2F transcription factor 6	Mapped by significant region	TAS[9501179]
KLF11	Kruppel-like factor 11	Mapped by significant region
IRF7	interferon regulatory factor 7	Mapped by LD-proxy	TAS[9315633]
SCGB1A1	secretoglobin, family 1A, member 1 (uteroglobin)	Mapped by significant region
PTCH1	patched 1	Mapped by significant region	IMP[16229683]
TCF21	transcription factor 21	Mapped by CNV; Mapped by significant region	IDA[12493738]
JAZF1	JAZF zinc finger 1	Mapped by significant region	IDA[15302918]
MAF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)	Mapped by significant region
FLCN	folliculin	Mapped by significant region
PLK1	polo-like kinase 1	Mapped by significant region	IMP[18174154]
HOXB3	homeobox B3	Mapped by LD-proxy
NIPBL	Nipped-B homolog (Drosophila)	Mapped by significant region	IDA[18854353]
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	Mapped by CNV	IMP[18663143]
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	Mapped by significant region
KLF4	Kruppel-like factor 4 (gut)	Mapped by significant region
ZNF202	zinc finger protein 202	Mapped by significant region	TAS[10748193]
PRDM1	PR domain containing 1, with ZNF domain	Mapped by CNV
DAB2IP	DAB2 interacting protein	Mapped by significant region	IDA[15310755]
MED1	mediator complex subunit 1	Mapped by LD-proxy; Mapped by PBA pathway
NR6A1	nuclear receptor subfamily 6, group A, member 1	Mapped by significant region
ZNF189	zinc finger protein 189	Mapped by significant region	TAS[9653648]
SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	Mapped by significant region
HOXA2	homeobox A2	Mapped by significant region