ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0000122
Name negative regulation of transcription from RNA polymerase II promoter
Type biological process
No. of Genes in ADHDgene  90
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 90)

Literature-origin genes (count: 16)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2p25 1(0/1/0) IEA
HES1 hes family bHLH transcription factor 1 3q28-q29 1(1/0/0) IDA[12535671]
XPO1 exportin 1 2p15 1(0/0/1) IEA
GFI1B growth factor independent 1B transcription repressor 9q34.13 1(0/1/0) TAS[9566867]
ISL1 ISL LIM homeobox 1 5q11.2 1(0/1/0) ISS
DACT1 dishevelled-binding antagonist of beta-catenin 1 14q22.3 1(0/1/0) IDA[18936100]
MAP2K5 mitogen-activated protein kinase kinase 5 15q22.31 1(1/0/0) ISS
TLE4 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) 9q21.32 1(1/0/0) IEA
NFIL3 nuclear factor, interleukin 3 regulated 9q22 2(1/1/0) IMP
VEGFA vascular endothelial growth factor A 6p12 1(0/1/0) IDA[18093989]
DRD3 dopamine receptor D3 3q13.3 8(1/7/0) IEA
MEIS2 Meis homeobox 2 15q14 1(0/0/1) TAS[10764806]
KANK2 KN motif and ankyrin repeat domains 2 19p13.2 1(0/1/0) IDA[17476305]
PER2 period circadian clock 2 2q37.3 1(1/0/0) ISS
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta) 6p12 1(1/0/0) IDA[7559606]
PER1 period circadian clock 1 17p13.1 1(0/1/0) ISS

Genes from other sources Help (count: 74)

Approved Symbol Approved Name Source Evidence[PMID]
UBC ubiquitin C Mapped by CNV TAS
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Mapped by significant region IEA
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 Mapped by significant region IDA[16293227]; IMP[11486045]
KLF4 Kruppel-like factor 4 (gut) Mapped by significant region IDA
JAZF1 JAZF zinc finger 1 Mapped by significant region IDA[15302918]
MTA2 metastasis associated 1 family, member 2 Mapped by significant region IEA
CREBBP CREB binding protein Mapped by significant region IDA
HOXA7 homeobox A7 Mapped by significant region IDA[11435435]
AHRR aryl-hydrocarbon receptor repressor Mapped by significant region IEA
PLK1 polo-like kinase 1 Mapped by significant region IMP[18174154]
HNF1B HNF1 homeobox B Mapped by CNV IEA
NIPBL Nipped-B homolog (Drosophila) Mapped by significant region IDA[18854353]
NSD1 nuclear receptor binding SET domain protein 1 Mapped by PBA pathway ISS
GLIS2 GLIS family zinc finger 2 Mapped by significant region ISS
HOXB3 homeobox B3 Mapped by LD-proxy IEA
TCF25 transcription factor 25 (basic helix-loop-helix) Mapped by significant region IDA[16574069]
BARX2 BARX homeobox 2 Mapped by significant region IEA
MYB v-myb avian myeloblastosis viral oncogene homolog Mapped by significant region IMP
UXT ubiquitously-expressed, prefoldin-like chaperone Mapped by PBA pathway IDA
RBBP8 retinoblastoma binding protein 8 Mapped by significant region IDA[16287852]
SNW1 SNW domain containing 1 Mapped by PBA pathway IDA[14985122]
SKOR1 SKI family transcriptional corepressor 1 Mapped by LD-proxy IBA
ZNF189 zinc finger protein 189 Mapped by significant region TAS[9653648]
USP2 ubiquitin specific peptidase 2 Mapped by significant region IMP[17290220]
KAT5 K(lysine) acetyltransferase 5 Mapped by significant region IMP[17360565]
CIITA class II, major histocompatibility complex, transactivator Mapped by significant region IMP[19041327]
E4F1 E4F transcription factor 1 Mapped by significant region IDA[14645522]
KLF11 Kruppel-like factor 11 Mapped by significant region IDA
RNF2 ring finger protein 2 Mapped by significant region IEA
UBE2I ubiquitin-conjugating enzyme E2I Mapped by significant region IMP[19955185]
RBPJ recombination signal binding protein for immunoglobulin kappa J region Mapped by CNV IMP[18663143]; ISS
IKZF1 IKAROS family zinc finger 1 (Ikaros) Mapped by LD-proxy IEA
TBX6 T-box 6 Mapped by CNV ISS
HBZ hemoglobin, zeta Mapped by significant region IEA
SREBF1 sterol regulatory element binding transcription factor 1 Mapped by significant region IEA
FOXC2 forkhead box C2 (MFH-1, mesenchyme forkhead 1) Mapped by significant region ISS
DAB2IP DAB2 interacting protein Mapped by significant region IDA[15310755]; IMP
PTCH1 patched 1 Mapped by significant region IMP[16229683]
NCOR2 nuclear receptor corepressor 2 Mapped by CNV IDA[10097068]; IMP[19955185]; TAS
SORBS3 sorbin and SH3 domain containing 3 Mapped by PBA pathway IEA
FOXE1 forkhead box E1 (thyroid transcription factor 2) Mapped by significant region ISS; NAS[9169137]
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase Mapped by significant region TAS
HSBP1 heat shock factor binding protein 1 Mapped by CNV; Mapped by significant region TAS[9649501]
IRF8 interferon regulatory factor 8 Mapped by significant region TAS[1460054]
PRDM1 PR domain containing 1, with ZNF domain Mapped by CNV IEA
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) Mapped by significant region IEA
FOXF1 forkhead box F1 Mapped by significant region IEA
NR6A1 nuclear receptor subfamily 6, group A, member 1 Mapped by significant region ISS
PDE2A phosphodiesterase 2A, cGMP-stimulated Mapped by significant region IDA[17329248]
NKX6-2 NK6 homeobox 2 Mapped by CNV IEA
TRIM29 tripartite motif containing 29 Mapped by significant region IEA
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 Mapped by significant region IDA
TCF21 transcription factor 21 Mapped by CNV; Mapped by significant region IDA[12493738]
ZNF174 zinc finger protein 174 Mapped by significant region IDA[7673192]
IRF7 interferon regulatory factor 7 Mapped by LD-proxy TAS[9315633]
CRYM crystallin, mu Mapped by significant region IMP[11897713]
E2F6 E2F transcription factor 6 Mapped by significant region TAS[9501179]
ZNF202 zinc finger protein 202 Mapped by significant region TAS[10748193]
KDM1A lysine (K)-specific demethylase 1A Mapped by LD-proxy IMP[17805299]; ISS
TXN thioredoxin Mapped by significant region IEA
FLCN folliculin Mapped by significant region IDA; IMP
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 Mapped by CNV IDA
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) Mapped by significant region IEA
MED1 mediator complex subunit 1 Mapped by LD-proxy; Mapped by PBA pathway ISS
UBB ubiquitin B Mapped by significant region TAS
HOXA2 homeobox A2 Mapped by significant region IEA
MEN1 multiple endocrine neoplasia I Mapped by significant region IDA[9989505]
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D Mapped by significant region IMP
SPI1 spleen focus forming virus (SFFV) proviral integration oncogene Mapped by LD-proxy TAS[10867017]
NRIP1 nuclear receptor interacting protein 1 Mapped by PBA pathway IDA[10364267]
LPIN1 lipin 1 Mapped by significant region IEA
STRN3 striatin, calmodulin binding protein 3 Mapped by significant region IDA[11570823]
GATA6 GATA binding protein 6 Mapped by significant region IDA[18177748]
ZNF205 zinc finger protein 205 Mapped by significant region IMP