ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ZBTB16
Previous Symbol	ZNF145
Symbol Alias	PLZF
Approved Name	zinc finger and BTB domain containing 16
Previous Name	zinc finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia)
Location	11q23
Position	chr11:113930315-114121398, +
External Links	HGNC: 12930 Entrez Gene: 7704 Ensembl: ENSG00000109906 UCSC: uc001poq.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 32)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 32)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0016567	protein ubiquitination	Biological Process		41
GO:0009952	anterior/posterior pattern specification	Biological Process		26
GO:0016605	PML body	Cellular Component	IDA[9294197]	10
GO:0016604	nuclear body	Cellular Component	IDA[19648967]	4
GO:0008270	zinc ion binding	Molecular Function		323
GO:0007417	central nervous system development	Biological Process	ISS[8541544]	22
GO:0009880	embryonic pattern specification	Biological Process		5
GO:0008285	negative regulation of cell proliferation	Biological Process		59
GO:0035116	embryonic hindlimb morphogenesis	Biological Process		3
GO:0032332	positive regulation of chondrocyte differentiation	Biological Process		3
GO:0042802	identical protein binding	Molecular Function	IPI[9294197]	70
GO:0035136	forelimb morphogenesis	Biological Process		4
GO:0017053	transcriptional repressor complex	Cellular Component	IDA[12802276]	8
GO:0016607	nuclear speck	Cellular Component	IDA[8541544]	34
GO:0030099	myeloid cell differentiation	Biological Process	TAS[9294197]	5
GO:0030097	hemopoiesis	Biological Process	IDA[8541544]; TAS[9294197]	8
GO:0045778	positive regulation of ossification	Biological Process		2
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process	IDA[12802276]; NAS[9294197]	64
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process		80
GO:0048133	male germ-line stem cell division	Biological Process		1
GO:0042803	protein homodimerization activity	Molecular Function	IDA[8622986]	113
GO:0043065	positive regulation of apoptotic process	Biological Process		34
GO:0045600	positive regulation of fat cell differentiation	Biological Process		4
GO:0045638	negative regulation of myeloid cell differentiation	Biological Process	ISS[8541544]	3
GO:0051216	cartilage development	Biological Process		11
GO:0061036	positive regulation of cartilage development	Biological Process		1
GO:0006351	transcription, DNA-dependent	Biological Process		247
GO:0006915	apoptotic process	Biological Process	NAS[9294197]	111
GO:0005515	protein binding	Molecular Function		910
GO:0005634	nucleus	Cellular Component	IDA[11929873]	770
GO:0001823	mesonephros development	Biological Process	ISS[8541544]	2
GO:0003677	DNA binding	Molecular Function	IDA[12802276]; NAS[9294197]	220

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa05221	Acute myeloid leukemia	10	Acute myeloid leukemia (AML) is a disease that is characteri...... Acute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation program. AML accounts for approximately 80% of all adult leukemias and remains the most common cause of leukemia death. Two major types of genetic events have been described that are crucial for leukemic transformation. A proposed necessary first event is disordered cell growth and upregulation of cell survival genes. The most common of these activating events were observed in the RTK Flt3, in N-Ras and K-Ras, in Kit, and sporadically in other RTKs. Alterations in myeloid transcription factors governing hematopoietic differentiation provide second necessary event for leukemogenesis. Transcription factor fusion proteins such as AML-ETO, PML-RARalpha or PLZF-RARalpha block myeloid cell differentiation by repressing target genes. In other cases, the transcription factors themselves are mutated. More...
hsa05200	Pathways in cancer	52

Genes shared at least 5 GO terms with ZBTB16 (count: 59)

Gene Symbol	Pathway Count	Pathway List
DAXX	7	PML body; negative regulation of transcription, DNA-dependent; protein homodimerization activity; transcription, DNA-dependent; apoptotic process; protein binding; nucleus;
RREB1	7	nuclear body; zinc ion binding; nuclear speck; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; nucleus; DNA binding;
HINFP	7	zinc ion binding; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent; protein binding; nucleus; DNA binding;
MLL	7	zinc ion binding; identical protein binding; positive regulation of transcription, DNA-dependent; protein homodimerization activity; apoptotic process; protein binding; nucleus;
ZNF423	7	zinc ion binding; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent; protein binding; nucleus; DNA binding;
TFAP2A	7	embryonic pattern specification; negative regulation of cell proliferation; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; protein homodimerization activity; protein binding; nucleus;
HMGA1	7	negative regulation of cell proliferation; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent; protein binding; nucleus; DNA binding;
MEN1	7	negative regulation of cell proliferation; hemopoiesis; negative regulation of transcription, DNA-dependent; positive regulation of apoptotic process; transcription, DNA-dependent; protein binding; nucleus;
RELA	7	positive regulation of chondrocyte differentiation; identical protein binding; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; protein binding; nucleus; DNA binding;
APBB1	7	nuclear speck; positive regulation of transcription, DNA-dependent; positive regulation of apoptotic process; transcription, DNA-dependent; apoptotic process; protein binding; nucleus;
BARD1	6	protein ubiquitination; zinc ion binding; protein homodimerization activity; positive regulation of apoptotic process; protein binding; nucleus;
RCHY1	6	protein ubiquitination; zinc ion binding; nuclear speck; protein homodimerization activity; protein binding; nucleus;
APC	6	anterior/posterior pattern specification; negative regulation of cell proliferation; positive regulation of apoptotic process; apoptotic process; protein binding; nucleus;
HNF1B	6	anterior/posterior pattern specification; positive regulation of transcription, DNA-dependent; protein homodimerization activity; protein binding; nucleus; DNA binding;
HOXA5	6	anterior/posterior pattern specification; positive regulation of apoptotic process; transcription, DNA-dependent; protein binding; nucleus; DNA binding;
LHX1	6	anterior/posterior pattern specification; zinc ion binding; embryonic pattern specification; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; nucleus;
TBX1	6	anterior/posterior pattern specification; positive regulation of transcription, DNA-dependent; protein homodimerization activity; transcription, DNA-dependent; nucleus; DNA binding;
NCOR2	6	nuclear body; transcriptional repressor complex; transcription, DNA-dependent; protein binding; nucleus; DNA binding;
ZNF24	6	zinc ion binding; negative regulation of transcription, DNA-dependent; transcription, DNA-dependent; protein binding; nucleus; DNA binding;
ETS1	6	negative regulation of cell proliferation; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent; protein binding; nucleus; DNA binding;
ATXN1	6	identical protein binding; negative regulation of transcription, DNA-dependent; transcription, DNA-dependent; protein binding; nucleus; DNA binding;
DAB2	6	myeloid cell differentiation; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; apoptotic process; protein binding; nucleus;
BCLAF1	6	negative regulation of transcription, DNA-dependent; positive regulation of apoptotic process; transcription, DNA-dependent; protein binding; nucleus; DNA binding;
MAPK1	6	positive regulation of transcription, DNA-dependent; transcription, DNA-dependent; apoptotic process; protein binding; nucleus; DNA binding;
RFWD2	5	protein ubiquitination; zinc ion binding; nuclear speck; protein binding; nucleus;
TRIM22	5	protein ubiquitination; zinc ion binding; nuclear speck; transcription, DNA-dependent; nucleus;
WWP1	5	protein ubiquitination; central nervous system development; negative regulation of transcription, DNA-dependent; protein binding; nucleus;
HOXA9	5	anterior/posterior pattern specification; negative regulation of myeloid cell differentiation; transcription, DNA-dependent; protein binding; nucleus;
TOP3A	5	PML body; zinc ion binding; protein binding; nucleus; DNA binding;
RNF2	5	nuclear body; zinc ion binding; transcription, DNA-dependent; protein binding; nucleus;
BCL11A	5	zinc ion binding; hemopoiesis; protein homodimerization activity; transcription, DNA-dependent; nucleus;
BIRC2	5	zinc ion binding; transcription, DNA-dependent; apoptotic process; protein binding; nucleus;
ESRRA	5	zinc ion binding; cartilage development; protein binding; nucleus; DNA binding;
GATA6	5	zinc ion binding; negative regulation of transcription, DNA-dependent; apoptotic process; protein binding; nucleus;
IGHMBP2	5	zinc ion binding; transcription, DNA-dependent; protein binding; nucleus; DNA binding;
KLF11	5	zinc ion binding; negative regulation of cell proliferation; positive regulation of apoptotic process; apoptotic process; nucleus;
KLF13	5	zinc ion binding; negative regulation of cell proliferation; protein binding; nucleus; DNA binding;
PRKCB	5	zinc ion binding; transcription, DNA-dependent; apoptotic process; protein binding; nucleus;
RSF1	5	zinc ion binding; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; protein binding; nucleus;
SQSTM1	5	zinc ion binding; identical protein binding; protein homodimerization activity; apoptotic process; protein binding;
TRIM5	5	zinc ion binding; identical protein binding; protein homodimerization activity; protein binding; nucleus;
ZNF263	5	zinc ion binding; negative regulation of transcription, DNA-dependent; transcription, DNA-dependent; nucleus; DNA binding;
ZNF287	5	zinc ion binding; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent; nucleus; DNA binding;
ZNF646	5	zinc ion binding; transcription, DNA-dependent; protein binding; nucleus; DNA binding;
NDN	5	central nervous system development; negative regulation of cell proliferation; transcription, DNA-dependent; nucleus; DNA binding;
FGF10	5	embryonic pattern specification; negative regulation of cell proliferation; positive regulation of transcription, DNA-dependent; nucleus; mesonephros development;
BNIP3	5	identical protein binding; protein homodimerization activity; apoptotic process; protein binding; nucleus;
CBX3	5	identical protein binding; negative regulation of transcription, DNA-dependent; transcription, DNA-dependent; protein binding; nucleus;
EED	5	identical protein binding; negative regulation of transcription, DNA-dependent; transcription, DNA-dependent; protein binding; nucleus;
MAP1S	5	identical protein binding; apoptotic process; protein binding; nucleus; DNA binding;
PRPF19	5	identical protein binding; nuclear speck; protein binding; nucleus; DNA binding;
NIPBL	5	forelimb morphogenesis; positive regulation of ossification; negative regulation of transcription, DNA-dependent; protein binding; nucleus;
BRMS1	5	negative regulation of transcription, DNA-dependent; transcription, DNA-dependent; apoptotic process; protein binding; nucleus;
CREBZF	5	negative regulation of transcription, DNA-dependent; transcription, DNA-dependent; protein binding; nucleus; DNA binding;
HES1	5	negative regulation of transcription, DNA-dependent; protein homodimerization activity; protein binding; nucleus; DNA binding;
ID2	5	negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; positive regulation of fat cell differentiation; protein binding; nucleus;
KAT5	5	negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent; protein binding; nucleus;
MYB	5	negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent; protein binding; DNA binding;
XRCC5	5	negative regulation of transcription, DNA-dependent; transcription, DNA-dependent; protein binding; nucleus; DNA binding;

Genes shared at least 2 KEGG pathways with ZBTB16 (count: 8)

Gene Symbol	Pathway Count	Pathway List
BAD	2	Acute myeloid leukemia; Pathways in cancer;
CCND1	2	Acute myeloid leukemia; Pathways in cancer;
MAPK1	2	Acute myeloid leukemia; Pathways in cancer;
MAPK3	2	Acute myeloid leukemia; Pathways in cancer;
PIK3CG	2	Acute myeloid leukemia; Pathways in cancer;
PIK3R1	2	Acute myeloid leukemia; Pathways in cancer;
RELA	2	Acute myeloid leukemia; Pathways in cancer;
SPI1	2	Acute myeloid leukemia; Pathways in cancer;

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Region: chr11:113930315..114121398 View in gBrowse