ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ZBTB16
Previous Symbol	ZNF145
Symbol Alias	PLZF
Approved Name	zinc finger and BTB domain containing 16
Previous Name	"zinc finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia)"
Name Alias	"promyelocytic leukaemia zinc finger"
Location	11q23
Position	chr11:113930315-114121398, 1
External Links	HGNC: 12930 Entrez Gene: 7704 Ensembl: ENSG00000109906 UCSC: uc001poq.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 32)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 32)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0045893	positive regulation of transcription, DNA-dependent	biological process	IDA	89
GO:0001823	mesonephros development	biological process	ISS[8541544]	2
GO:0048133	male germ-line stem cell division	biological process	IEA	2
GO:0006351	transcription, DNA-dependent	biological process	IEA	281
GO:0005634	nucleus	cellular component	IDA[11929873]	877
GO:0035116	embryonic hindlimb morphogenesis	biological process	IEA	3
GO:0045778	positive regulation of ossification	biological process	IDA	2
GO:0061036	positive regulation of cartilage development	biological process	IDA	1
GO:0003677	DNA binding	molecular function	IDA[12802276]; NAS[9294197]	257
GO:0051216	cartilage development	biological process	IDA	12
GO:0007417	central nervous system development	biological process	ISS[8541544]	22
GO:0045892	negative regulation of transcription, DNA-dependent	biological process	IDA[12802276]; NAS[9294197]	77
GO:0016605	PML body	cellular component	IDA[9294197]	14
GO:0009952	anterior/posterior pattern specification	biological process	IEA	26
GO:0045600	positive regulation of fat cell differentiation	biological process	IMP	5
GO:0017053	transcriptional repressor complex	cellular component	IDA[12802276]	8
GO:0042802	identical protein binding	molecular function	IPI[9294197]	77
GO:0008285	negative regulation of cell proliferation	biological process	IEA	65
GO:0030099	myeloid cell differentiation	biological process	TAS[9294197]	6
GO:0045638	negative regulation of myeloid cell differentiation	biological process	ISS[8541544]	3
GO:0016604	nuclear body	cellular component	IDA[19648967]	5
GO:0035136	forelimb morphogenesis	biological process	IEA	5
GO:0043065	positive regulation of apoptotic process	biological process	IEA	38
GO:0009880	embryonic pattern specification	biological process	IEA	4
GO:0016607	nuclear speck	cellular component	IDA[8541544]	40
GO:0030097	hemopoiesis	biological process	IDA[8541544]; TAS[9294197]	10
GO:0006915	apoptotic process	biological process	NAS[9294197]	127
GO:0005515	protein binding	molecular function	IPI	1015
GO:0032332	positive regulation of chondrocyte differentiation	biological process	IMP	3
GO:0042803	protein homodimerization activity	molecular function	IDA[8622986]	128
GO:0008270	zinc ion binding	molecular function	IEA	367
GO:0016567	protein ubiquitination	biological process	IEA	48

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa05221	Acute myeloid leukemia	10

Genes shared at least 5 GO terms with ZBTB16 (count: 68)

Gene Symbol	Pathway Count	Pathway List
TFAP4	9	positive regulation of transcription, DNA-dependent; nucleus; DNA binding; negative regulation of transcription, DNA-dependent; transcriptional repressor complex; negative regulation of cell proliferation; positive regulation of apoptotic process; protein binding; protein homodimerization activity;
TFAP2B	8	positive regulation of transcription, DNA-dependent; nucleus; DNA binding; negative regulation of transcription, DNA-dependent; negative regulation of cell proliferation; forelimb morphogenesis; protein binding; protein homodimerization activity;
RREB1	7	positive regulation of transcription, DNA-dependent; nucleus; DNA binding; negative regulation of transcription, DNA-dependent; nuclear body; nuclear speck; zinc ion binding;
HMGA1	7	positive regulation of transcription, DNA-dependent; transcription, DNA-dependent; nucleus; DNA binding; negative regulation of transcription, DNA-dependent; negative regulation of cell proliferation; protein binding;
KMT2A	7	positive regulation of transcription, DNA-dependent; nucleus; identical protein binding; apoptotic process; protein binding; protein homodimerization activity; zinc ion binding;
HINFP	7	positive regulation of transcription, DNA-dependent; transcription, DNA-dependent; nucleus; DNA binding; negative regulation of transcription, DNA-dependent; protein binding; zinc ion binding;
APBB1	7	positive regulation of transcription, DNA-dependent; transcription, DNA-dependent; nucleus; positive regulation of apoptotic process; nuclear speck; apoptotic process; protein binding;
RELA	7	positive regulation of transcription, DNA-dependent; nucleus; DNA binding; negative regulation of transcription, DNA-dependent; identical protein binding; protein binding; positive regulation of chondrocyte differentiation;
ZNF423	7	positive regulation of transcription, DNA-dependent; transcription, DNA-dependent; nucleus; DNA binding; negative regulation of transcription, DNA-dependent; protein binding; zinc ion binding;
MEN1	7	transcription, DNA-dependent; nucleus; negative regulation of transcription, DNA-dependent; negative regulation of cell proliferation; positive regulation of apoptotic process; hemopoiesis; protein binding;
DAXX	7	transcription, DNA-dependent; nucleus; negative regulation of transcription, DNA-dependent; PML body; apoptotic process; protein binding; protein homodimerization activity;
AXIN1	6	positive regulation of transcription, DNA-dependent; nucleus; identical protein binding; apoptotic process; protein binding; protein homodimerization activity;
HNF1B	6	positive regulation of transcription, DNA-dependent; nucleus; DNA binding; anterior/posterior pattern specification; protein binding; protein homodimerization activity;
MAPK1	6	positive regulation of transcription, DNA-dependent; transcription, DNA-dependent; nucleus; DNA binding; apoptotic process; protein binding;
LHX1	6	positive regulation of transcription, DNA-dependent; nucleus; negative regulation of transcription, DNA-dependent; anterior/posterior pattern specification; embryonic pattern specification; zinc ion binding;
ETS1	6	positive regulation of transcription, DNA-dependent; transcription, DNA-dependent; nucleus; DNA binding; negative regulation of cell proliferation; protein binding;
KAT8	6	positive regulation of transcription, DNA-dependent; transcription, DNA-dependent; nucleus; negative regulation of transcription, DNA-dependent; myeloid cell differentiation; protein binding;
TBX1	6	positive regulation of transcription, DNA-dependent; transcription, DNA-dependent; nucleus; DNA binding; anterior/posterior pattern specification; protein homodimerization activity;
DAB2	6	positive regulation of transcription, DNA-dependent; nucleus; negative regulation of transcription, DNA-dependent; myeloid cell differentiation; apoptotic process; protein binding;
ATXN1	6	transcription, DNA-dependent; nucleus; DNA binding; negative regulation of transcription, DNA-dependent; identical protein binding; protein binding;
GATAD2A	6	transcription, DNA-dependent; nucleus; negative regulation of transcription, DNA-dependent; nuclear speck; protein binding; zinc ion binding;
BCLAF1	6	transcription, DNA-dependent; nucleus; DNA binding; negative regulation of transcription, DNA-dependent; positive regulation of apoptotic process; protein binding;
HOXA5	6	transcription, DNA-dependent; nucleus; DNA binding; anterior/posterior pattern specification; positive regulation of apoptotic process; protein binding;
ZNF24	6	transcription, DNA-dependent; nucleus; DNA binding; negative regulation of transcription, DNA-dependent; protein binding; zinc ion binding;
NCOR2	6	transcription, DNA-dependent; nucleus; DNA binding; transcriptional repressor complex; nuclear body; protein binding;
APC	6	nucleus; anterior/posterior pattern specification; negative regulation of cell proliferation; positive regulation of apoptotic process; apoptotic process; protein binding;
BARD1	6	nucleus; positive regulation of apoptotic process; protein binding; protein homodimerization activity; zinc ion binding; protein ubiquitination;
RCHY1	6	nucleus; nuclear speck; protein binding; protein homodimerization activity; zinc ion binding; protein ubiquitination;
ZNF287	5	positive regulation of transcription, DNA-dependent; transcription, DNA-dependent; nucleus; DNA binding; zinc ion binding;
SOX8	5	positive regulation of transcription, DNA-dependent; transcription, DNA-dependent; nucleus; DNA binding; negative regulation of transcription, DNA-dependent;
ID2	5	positive regulation of transcription, DNA-dependent; nucleus; negative regulation of transcription, DNA-dependent; positive regulation of fat cell differentiation; protein binding;
FGF10	5	positive regulation of transcription, DNA-dependent; mesonephros development; nucleus; negative regulation of cell proliferation; embryonic pattern specification;
CREBBP	5	positive regulation of transcription, DNA-dependent; nucleus; nuclear body; protein binding; zinc ion binding;
KAT5	5	positive regulation of transcription, DNA-dependent; transcription, DNA-dependent; nucleus; negative regulation of transcription, DNA-dependent; protein binding;
CIITA	5	positive regulation of transcription, DNA-dependent; transcription, DNA-dependent; DNA binding; negative regulation of transcription, DNA-dependent; protein binding;
GLIS2	5	positive regulation of transcription, DNA-dependent; nucleus; negative regulation of transcription, DNA-dependent; nuclear speck; zinc ion binding;
RSF1	5	positive regulation of transcription, DNA-dependent; nucleus; negative regulation of transcription, DNA-dependent; protein binding; zinc ion binding;
MYB	5	positive regulation of transcription, DNA-dependent; transcription, DNA-dependent; DNA binding; negative regulation of transcription, DNA-dependent; protein binding;
CBX3	5	transcription, DNA-dependent; nucleus; negative regulation of transcription, DNA-dependent; identical protein binding; protein binding;
ZNF174	5	transcription, DNA-dependent; nucleus; negative regulation of transcription, DNA-dependent; protein homodimerization activity; zinc ion binding;
IGHMBP2	5	transcription, DNA-dependent; nucleus; DNA binding; protein binding; zinc ion binding;
BCL11A	5	transcription, DNA-dependent; nucleus; hemopoiesis; protein homodimerization activity; zinc ion binding;
CREBZF	5	transcription, DNA-dependent; nucleus; DNA binding; negative regulation of transcription, DNA-dependent; protein binding;
ZNF263	5	transcription, DNA-dependent; nucleus; DNA binding; negative regulation of transcription, DNA-dependent; zinc ion binding;
BRMS1	5	transcription, DNA-dependent; nucleus; negative regulation of transcription, DNA-dependent; apoptotic process; protein binding;
ZNF646	5	transcription, DNA-dependent; nucleus; DNA binding; protein binding; zinc ion binding;
TRIM22	5	transcription, DNA-dependent; nucleus; nuclear speck; zinc ion binding; protein ubiquitination;
HOXA9	5	transcription, DNA-dependent; nucleus; anterior/posterior pattern specification; negative regulation of myeloid cell differentiation; protein binding;
BIRC2	5	transcription, DNA-dependent; nucleus; apoptotic process; protein binding; zinc ion binding;
EED	5	transcription, DNA-dependent; nucleus; negative regulation of transcription, DNA-dependent; identical protein binding; protein binding;
NDN	5	transcription, DNA-dependent; nucleus; DNA binding; central nervous system development; negative regulation of cell proliferation;
TRAF7	5	transcription, DNA-dependent; apoptotic process; protein binding; zinc ion binding; protein ubiquitination;
XRCC5	5	transcription, DNA-dependent; nucleus; DNA binding; negative regulation of transcription, DNA-dependent; protein binding;
RNF2	5	transcription, DNA-dependent; nucleus; nuclear body; protein binding; zinc ion binding;
E4F1	5	transcription, DNA-dependent; DNA binding; protein binding; zinc ion binding; protein ubiquitination;
ZNF205	5	transcription, DNA-dependent; nucleus; DNA binding; protein binding; zinc ion binding;
MAP1S	5	nucleus; DNA binding; identical protein binding; apoptotic process; protein binding;
GATA6	5	nucleus; negative regulation of transcription, DNA-dependent; apoptotic process; protein binding; zinc ion binding;
KLF11	5	nucleus; negative regulation of cell proliferation; positive regulation of apoptotic process; apoptotic process; zinc ion binding;
BNIP3	5	nucleus; identical protein binding; apoptotic process; protein binding; protein homodimerization activity;
PRPF19	5	nucleus; DNA binding; identical protein binding; nuclear speck; protein binding;
TRIM5	5	nucleus; identical protein binding; protein binding; protein homodimerization activity; zinc ion binding;
KLF13	5	nucleus; DNA binding; negative regulation of cell proliferation; protein binding; zinc ion binding;
NIPBL	5	nucleus; positive regulation of ossification; negative regulation of transcription, DNA-dependent; forelimb morphogenesis; protein binding;
ESRRA	5	nucleus; DNA binding; cartilage development; protein binding; zinc ion binding;
HES1	5	nucleus; DNA binding; negative regulation of transcription, DNA-dependent; protein binding; protein homodimerization activity;
TOP3A	5	nucleus; DNA binding; PML body; protein binding; zinc ion binding;
SQSTM1	5	identical protein binding; apoptotic process; protein binding; protein homodimerization activity; zinc ion binding;

Genes shared at least 2 KEGG pathways with ZBTB16 (count: 0)

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Region: chr11:113930315..114121398 View in gBrowse