ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0042803
Name protein homodimerization activity
Type molecular function
No. of Genes in ADHDgene  128
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 128)

Literature-origin genes (count: 19)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
ADRB2 adrenoceptor beta 2, surface 5q31-q32 2(1/1/0) IDA[15123695]
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9 2q37 1(0/0/1) IPI
VEGFA vascular endothelial growth factor A 6p12 1(0/1/0) ISS
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) 2p16.1 1(0/0/1) TAS[19616629]
ADRA2A adrenoceptor alpha 2A 10q25.2 13(4/9/0) IDA[16605244]
NPPC natriuretic peptide C 2q37.1 1(0/1/0) IEA
FOXP2 forkhead box P2 7q31 1(1/0/0) IDA[16407075]
MAOB monoamine oxidase B Xp11.4-p11.3 6(2/4/0) IEA
TENM4 teneurin transmembrane protein 4 11q13 1(0/1/0) ISS
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) 15q13.3 2(0/1/1) IDA[8145738]
ADRA2C adrenoceptor alpha 2C 4p16.3 7(2/4/1) IDA[16605244]
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 9q22.1 1(1/0/0) ISS
ASMT acetylserotonin O-methyltransferase Xp22.3 and Yp11.3 1(1/0/0) IPI
HES1 hes family bHLH transcription factor 1 3q28-q29 1(1/0/0) ISS
ADRB3 adrenoceptor beta 3 8p12 2(0/2/0) IDA[15123695]
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 17q11.2 26(13/13/0) IEA
FOXP1 forkhead box P1 3p14.1 1(0/0/1) IBA
GDNF glial cell derived neurotrophic factor 5p13.1-p12 2(1/1/0) IDA[8988018]
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta) 6p12 1(1/0/0) IPI[11505339]

Genes from other sources Help (count: 109)

Approved Symbol Approved Name Source Evidence[PMID]
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3 Mapped by LD-proxy IPI
GOLGA5 golgin A5 Mapped by PBA pathway IPI[9915833]
PDE2A phosphodiesterase 2A, cGMP-stimulated Mapped by significant region IPI[19828435]
MAP3K5 mitogen-activated protein kinase kinase kinase 5 Mapped by LD-proxy; Mapped by significant region IDA[11920685]
AMBP alpha-1-microglobulin/bikunin precursor Mapped by significant region IPI[11883904]
MAP3K11 mitogen-activated protein kinase kinase kinase 11 Mapped by significant region IPI[9829970]
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase Mapped by CNV IPI[19483087]
JAM3 junctional adhesion molecule 3 Mapped by significant region IEA
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein Mapped by significant region ISS
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 Mapped by significant region IDA[8537108]
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1 Mapped by CNV; Mapped by significant region IEA
CEP57 centrosomal protein 57kDa Mapped by significant region IPI[12717444]
PRLR prolactin receptor Mapped by significant region NAS[10585417]
ACHE acetylcholinesterase (Yt blood group) Mapped by PBA pathway IPI[12524166]; NAS[1517212]
SCARB1 scavenger receptor class B, member 1 Mapped by CNV IEA
TPD52L1 tumor protein D52-like 1 Mapped by significant region IDA[9484778]
CORO1A coronin, actin binding protein, 1A Mapped by CNV IDA[15601263]
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 Mapped by significant region IDA[16870176]
MVD mevalonate (diphospho) decarboxylase Mapped by significant region IDA[8626466]
VEGFB vascular endothelial growth factor B Mapped by significant region IEA
SEPT12 septin 12 Mapped by significant region IPI[18443421]; ISS
DAB2IP DAB2 interacting protein Mapped by significant region IPI[12813029]
SDCBP2 syndecan binding protein (syntenin) 2 Mapped by Literature SNP IDA[11152476]
AXIN1 axin 1 Mapped by significant region ISS
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) Mapped by PBA pathway ISS
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 Mapped by Literature SNP IPI
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 Mapped by LD-proxy IPI
KMT2A lysine (K)-specific methyltransferase 2A Mapped by significant region IDA[11313484]
UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4 Mapped by LD-proxy IPI
APOC2 apolipoprotein C-II Mapped by PBA pathway IMP[8245722]
MTMR2 myotubularin related protein 2 Mapped by significant region IEA
NUDT16L1 nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1 Mapped by significant region IDA[18820299]
TRIM5 tripartite motif containing 5 Mapped by CNV IPI[11331580]
DSCAML1 Down syndrome cell adhesion molecule like 1 Mapped by significant region IDA[11453658]
CCDC88A coiled-coil domain containing 88A Mapped by PBA pathway IPI[16139227]
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) Mapped by significant region IEA
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7 Mapped by LD-proxy IPI
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase Mapped by significant region ISS
TERT telomerase reverse transcriptase Mapped by significant region IDA[11432839]
CRYBA2 crystallin, beta A2 Mapped by significant region IEA
CRYL1 crystallin, lambda 1 Mapped by significant region IPI[15809331]
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 Mapped by Literature SNP IPI[11402072]
NPR3 natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) Mapped by significant region IEA
HSF2 heat shock transcription factor 2 Mapped by significant region IEA
OXCT1 3-oxoacid CoA transferase 1 Mapped by significant region NAS[10964512]
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 Mapped by Literature SNP IPI
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 Mapped by CNV IDA[16870176]
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 Mapped by LD-proxy IPI
ACTN3 actinin, alpha 3 (gene/pseudogene) Mapped by significant region TAS[15841212]
CHKA choline kinase alpha Mapped by significant region IEA
CUBN cubilin (intrinsic factor-cobalamin receptor) Mapped by CNV IDA[10552972]
ABAT 4-aminobutyrate aminotransferase Mapped by significant region IPI[15528998]
THRSP thyroid hormone responsive Mapped by significant region IEA
VIL1 villin 1 Mapped by significant region IDA[17606613]
OLFML2A olfactomedin-like 2A Mapped by significant region IEA
MGLL monoglyceride lipase Mapped by PBA pathway IPI[19957260]
ACAT1 acetyl-CoA acetyltransferase 1 Mapped by CNV; Mapped by significant region IEA
ANKS6 ankyrin repeat and sterile alpha motif domain containing 6 Mapped by significant region IEA
SHMT1 serine hydroxymethyltransferase 1 (soluble) Mapped by significant region IDA[9753690]
GHR growth hormone receptor Mapped by CNV; Mapped by significant region IDA[8137822]
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) Mapped by significant region IEA
QPRT quinolinate phosphoribosyltransferase Mapped by CNV IDA[17868694]
APOA4 apolipoprotein A-IV Mapped by significant region IDA[1935934]
KLHL7 kelch-like family member 7 Mapped by significant region IDA
SQSTM1 sequestosome 1 Mapped by CNV IEA
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Mapped by significant region IPI[14966129]
SNRPC small nuclear ribonucleoprotein polypeptide C Mapped by PBA pathway IPI[8532530]
CADM1 cell adhesion molecule 1 Mapped by significant region ISS[12826663]
SLC39A13 solute carrier family 39 (zinc transporter), member 13 Mapped by LD-proxy IPI
CACYBP calcyclin binding protein Mapped by significant region IPI[16085652]
KCNN2 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 Mapped by LD-proxy IPI[17110593]
DGAT2 diacylglycerol O-acyltransferase 2 Mapped by significant region ISS
FZD4 frizzled class receptor 4 Mapped by significant region IPI[14688793]
ZNF174 zinc finger protein 174 Mapped by significant region IPI[15629724]
PTS 6-pyruvoyltetrahydropterin synthase Mapped by significant region IEA
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) Mapped by significant region IEA
FBXO4 F-box protein 4 Mapped by significant region IPI
NADK2 NAD kinase 2, mitochondrial Mapped by significant region IDA
TBX1 T-box 1 Mapped by CNV IDA[11111039]
BARD1 BRCA1 associated RING domain 1 Mapped by significant region IPI[15265711]
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) Mapped by significant region IPI[16387659]
GOPC golgi-associated PDZ and coiled-coil motif containing Mapped by significant region IEA
HNF1B HNF1 homeobox B Mapped by CNV IEA; IPI[1677179]
NRBP1 nuclear receptor binding protein 1 Mapped by PBA pathway ISS
CRYAB crystallin, alpha B Mapped by significant region IPI[19646995]
TARS threonyl-tRNA synthetase Mapped by significant region NAS[2033077]
RNF40 ring finger protein 40, E3 ubiquitin protein ligase Mapped by CNV IPI[10944455]
SUMF1 sulfatase modifying factor 1 Mapped by CNV IEA
CRYM crystallin, mu Mapped by significant region IDA[12590647]
NR6A1 nuclear receptor subfamily 6, group A, member 1 Mapped by significant region ISS
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) Mapped by significant region IEA
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) Mapped by significant region ISS
TSC2 tuberous sclerosis 2 Mapped by significant region IPI[10585443]
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 Mapped by significant region IDA[7830796]
XPA xeroderma pigmentosum, complementation group A Mapped by significant region IPI[8197175]
SETMAR SET domain and mariner transposase fusion gene Mapped by CNV IPI
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 Mapped by CNV IDA[9396766]
SYT10 synaptotagmin X Mapped by CNV IEA
TYR tyrosinase Mapped by significant region ISS
PLD6 phospholipase D family, member 6 Mapped by significant region IDA[17028579]
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4) Mapped by significant region IPI[2123466]
PYCARD PYD and CARD domain containing Mapped by CNV IDA[15030775]
PDCD6 programmed cell death 6 Mapped by significant region IEA
PEX7 peroxisomal biogenesis factor 7 Mapped by Literature SNP; Mapped by significant region IDA[11931631]
DARS2 aspartyl-tRNA synthetase 2, mitochondrial Mapped by significant region IPI[15779907]
DAXX death-domain associated protein Mapped by PBA pathway IDA[10698492]
PDCD10 programmed cell death 10 Mapped by CNV IPI
RAB11FIP3 RAB11 family interacting protein 3 (class II) Mapped by significant region IDA[17030804]
ZBTB16 zinc finger and BTB domain containing 16 Mapped by significant region IDA[8622986]