ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PDCD10
Previous Symbol	CCM3
Symbol Alias	TFAR15
Approved Name	programmed cell death 10
Previous Name	cerebral cavernous malformations 3
Location	3q26.1
Position	chr3:167401086-167452727, -
External Links	HGNC: 8761 Entrez Gene: 11235 Ensembl: ENSG00000114209 UCSC: uc003fez.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 2)

ID	Location	Size	Band	Type	Inheritance
CNV_Lesch[2011]_1	chr3:166944967-168896272 (NCBI Build 35 (hg17))	1951305	3q26.1	Deletion	De novo
CNV_Elia[2010]_31	chr3:168483422-169118601 (NCBI Build 35 (hg17))	635180	3q26.1	Duplication	Maternal

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 11)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005886	plasma membrane	Cellular Component		772
GO:0006915	apoptotic process	Biological Process		111
GO:0005515	protein binding	Molecular Function	IPI[18782753]	910
GO:0005829	cytosol	Cellular Component	IDA[17360971]	447
GO:0043066	negative regulation of apoptotic process	Biological Process	IDA[17360971]	77
GO:0043406	positive regulation of MAP kinase activity	Biological Process	IDA[17360971]	10
GO:0008284	positive regulation of cell proliferation	Biological Process	IDA[17360971]	69
GO:0042803	protein homodimerization activity	Molecular Function		113
GO:0047485	protein N-terminus binding	Molecular Function		23
GO:0000139	Golgi membrane	Cellular Component		95
GO:0001525	angiogenesis	Biological Process		35

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with PDCD10 (count: 12)

Gene Symbol	Pathway Count	Pathway List
PIK3CG	6	plasma membrane; protein binding; cytosol; negative regulation of apoptotic process; positive regulation of MAP kinase activity; angiogenesis;
TGFBR1	6	plasma membrane; apoptotic process; protein binding; negative regulation of apoptotic process; positive regulation of cell proliferation; angiogenesis;
VEGFA	6	protein binding; negative regulation of apoptotic process; positive regulation of MAP kinase activity; positive regulation of cell proliferation; protein homodimerization activity; angiogenesis;
ADRA2A	5	plasma membrane; protein binding; positive regulation of MAP kinase activity; positive regulation of cell proliferation; protein homodimerization activity;
APC	5	plasma membrane; apoptotic process; protein binding; cytosol; negative regulation of apoptotic process;
CRYAB	5	plasma membrane; protein binding; cytosol; negative regulation of apoptotic process; protein homodimerization activity;
ILK	5	plasma membrane; protein binding; cytosol; positive regulation of MAP kinase activity; positive regulation of cell proliferation;
PRKD1	5	plasma membrane; apoptotic process; protein binding; cytosol; angiogenesis;
SNCA	5	plasma membrane; protein binding; cytosol; negative regulation of apoptotic process; protein N-terminus binding;
BIRC2	5	apoptotic process; protein binding; cytosol; negative regulation of apoptotic process; protein N-terminus binding;
DAXX	5	apoptotic process; protein binding; cytosol; protein homodimerization activity; protein N-terminus binding;
RELA	5	protein binding; cytosol; negative regulation of apoptotic process; positive regulation of cell proliferation; protein N-terminus binding;

Genes shared at least 2 KEGG pathways with PDCD10 (count: 0)

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Region: chr3:167401086..167452727 View in gBrowse