ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ILK
Approved Name	integrin-linked kinase
Location	11p15.4
Position	chr11:6624961-6632102, 1
External Links	HGNC: 6040 Entrez Gene: 3611 Ensembl: ENSG00000166333 UCSC: uc001mef.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_29	chr11:5582423-7488751 (NCBI Build 36.1 (hg18))	1859865	11p15.4	Loss	De novo

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 53)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 53)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0048812	neuron projection morphogenesis	biological process	IEA	8
GO:0007569	cell aging	biological process	IEA	5
GO:0007160	cell-matrix adhesion	biological process	NAS	16
GO:0051897	positive regulation of protein kinase B signaling cascade	biological process	IEA	17
GO:0043195	terminal bouton	cellular component	IEA	11
GO:0030017	sarcomere	cellular component	IEA	4
GO:0042327	positive regulation of phosphorylation	biological process	IMP	5
GO:0030335	positive regulation of cell migration	biological process	IEA	28
GO:0005524	ATP binding	molecular function	NAS	265
GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	biological process	IEA	2
GO:0045663	positive regulation of myoblast differentiation	biological process	IEA	1
GO:0005911	cell-cell junction	cellular component	IEA	21
GO:0007229	integrin-mediated signaling pathway	biological process	IDA[9366252]; NAS	10
GO:0005178	integrin binding	molecular function	IEA	15
GO:0010667	negative regulation of cardiac muscle cell apoptotic process	biological process	IEA	3
GO:0005925	focal adhesion	cellular component	IEA	26
GO:0032956	regulation of actin cytoskeleton organization	biological process	IEA	8
GO:0043025	neuronal cell body	cellular component	IEA	56
GO:0051291	protein heterooligomerization	biological process	IEA	13
GO:0030513	positive regulation of BMP signaling pathway	biological process	IEA	5
GO:0043206	extracellular fibril organization	biological process	IEA	2
GO:0043198	dendritic shaft	cellular component	IEA	11
GO:0004674	protein serine/threonine kinase activity	molecular function	IDA[9366252]	65
GO:0032288	myelin assembly	biological process	IEA	2
GO:0001658	branching involved in ureteric bud morphogenesis	biological process	IEA	8
GO:0004871	signal transducer activity	molecular function	IEA	56
GO:0017124	SH3 domain binding	molecular function	IEA	22
GO:0006468	protein phosphorylation	biological process	IDA[10871859]	58
GO:0005515	protein binding	molecular function	IPI	1015
GO:0008283	cell proliferation	biological process	NAS[10871859]	66
GO:0001954	positive regulation of cell-matrix adhesion	biological process	IEA	3
GO:0045669	positive regulation of osteoblast differentiation	biological process	IEA	7
GO:0043406	positive regulation of MAP kinase activity	biological process	IEA	10
GO:0045893	positive regulation of transcription, DNA-dependent	biological process	IMP	89
GO:0034329	cell junction assembly	biological process	TAS	18
GO:0008284	positive regulation of cell proliferation	biological process	IEA	75
GO:0043524	negative regulation of neuron apoptotic process	biological process	IEA	18
GO:0018105	peptidyl-serine phosphorylation	biological process	IEA	13
GO:0043034	costamere	cellular component	IEA	4
GO:0007050	cell cycle arrest	biological process	IEA	28
GO:0006469	negative regulation of protein kinase activity	biological process	IEA	17
GO:0090263	positive regulation of canonical Wnt receptor signaling pathway	biological process	IMP	9
GO:0030027	lamellipodium	cellular component	IEA	29
GO:0005737	cytoplasm	cellular component	NAS	781
GO:0048662	negative regulation of smooth muscle cell proliferation	biological process	IEA	7
GO:0034446	substrate adhesion-dependent cell spreading	biological process	IMP[19118217]	4
GO:0045773	positive regulation of axon extension	biological process	IEA	9
GO:0019901	protein kinase binding	molecular function	IPI[19118217]	59
GO:0050775	positive regulation of dendrite morphogenesis	biological process	IEA	2
GO:0043234	protein complex	cellular component	IEA	47
GO:0005829	cytosol	cellular component	TAS	485
GO:0014912	negative regulation of smooth muscle cell migration	biological process	IEA	2
GO:0005886	plasma membrane	cellular component	IEA	839

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene
hsa04510	Focal adhesion	40
hsa03320	PPAR signaling pathway	13
hsa05213	Endometrial cancer	14

Genes shared at least 5 GO terms with ILK (count: 111)

Gene Symbol	Pathway Count	Pathway List
GSK3B	13	ATP binding; integrin binding; neuronal cell body; dendritic shaft; protein serine/threonine kinase activity; protein phosphorylation; protein binding; positive regulation of cell-matrix adhesion; peptidyl-serine phosphorylation; cytoplasm; protein kinase binding; cytosol; plasma membrane;
PAK1	12	neuron projection morphogenesis; ATP binding; cell-cell junction; focal adhesion; protein serine/threonine kinase activity; protein phosphorylation; protein binding; cytoplasm; protein kinase binding; protein complex; cytosol; plasma membrane;
MAPK1	11	positive regulation of cell migration; ATP binding; focal adhesion; protein serine/threonine kinase activity; protein binding; positive regulation of transcription, DNA-dependent; positive regulation of cell proliferation; peptidyl-serine phosphorylation; cytoplasm; protein complex; cytosol;
BCAR1	11	positive regulation of cell migration; integrin-mediated signaling pathway; focal adhesion; signal transducer activity; SH3 domain binding; protein binding; cell proliferation; cytoplasm; protein kinase binding; cytosol; plasma membrane;
PRKD1	11	ATP binding; cell-cell junction; integrin-mediated signaling pathway; protein serine/threonine kinase activity; protein binding; cell proliferation; positive regulation of osteoblast differentiation; peptidyl-serine phosphorylation; cytoplasm; cytosol; plasma membrane;
PDPK1	11	ATP binding; negative regulation of cardiac muscle cell apoptotic process; focal adhesion; protein serine/threonine kinase activity; protein phosphorylation; protein binding; negative regulation of protein kinase activity; cytoplasm; protein kinase binding; cytosol; plasma membrane;
TGFBR1	10	positive regulation of protein kinase B signaling cascade; ATP binding; protein serine/threonine kinase activity; protein phosphorylation; protein binding; positive regulation of transcription, DNA-dependent; positive regulation of cell proliferation; peptidyl-serine phosphorylation; cell cycle arrest; plasma membrane;
ADAM17	9	positive regulation of cell migration; cell-cell junction; integrin binding; focal adhesion; SH3 domain binding; protein binding; positive regulation of cell proliferation; cytoplasm; plasma membrane;
STK11	9	ATP binding; protein heterooligomerization; protein serine/threonine kinase activity; protein phosphorylation; protein binding; cell cycle arrest; cytoplasm; protein complex; cytosol;
SYK	9	ATP binding; integrin-mediated signaling pathway; integrin binding; protein phosphorylation; protein binding; cell proliferation; protein kinase binding; cytosol; plasma membrane;
TSC1	8	cell-matrix adhesion; protein heterooligomerization; protein binding; cell cycle arrest; lamellipodium; cytoplasm; protein complex; cytosol;
PIK3CG	8	positive regulation of protein kinase B signaling cascade; ATP binding; protein serine/threonine kinase activity; protein binding; positive regulation of MAP kinase activity; cytoplasm; cytosol; plasma membrane;
APC	8	positive regulation of cell migration; protein binding; cell cycle arrest; lamellipodium; cytoplasm; protein kinase binding; cytosol; plasma membrane;
PLK1	8	ATP binding; protein serine/threonine kinase activity; protein phosphorylation; protein binding; cell proliferation; peptidyl-serine phosphorylation; protein kinase binding; cytosol;
NEK6	8	ATP binding; protein serine/threonine kinase activity; signal transducer activity; protein phosphorylation; protein binding; peptidyl-serine phosphorylation; cytoplasm; protein kinase binding;
DNAJA3	7	cell aging; ATP binding; protein binding; negative regulation of protein kinase activity; cytoplasm; protein kinase binding; cytosol;
SNCA	7	terminal bouton; extracellular fibril organization; protein binding; negative regulation of neuron apoptotic process; cytoplasm; cytosol; plasma membrane;
ADRA2A	7	positive regulation of cell migration; protein binding; positive regulation of MAP kinase activity; positive regulation of cell proliferation; cytoplasm; protein kinase binding; plasma membrane;
ROCK2	7	ATP binding; regulation of actin cytoskeleton organization; protein serine/threonine kinase activity; protein phosphorylation; protein binding; cytosol; plasma membrane;
PRKAA1	7	ATP binding; protein heterooligomerization; protein phosphorylation; protein binding; positive regulation of cell proliferation; cell cycle arrest; cytosol;
CTNND1	7	cell-cell junction; protein binding; cell junction assembly; lamellipodium; cytoplasm; cytosol; plasma membrane;
TSC2	7	neuronal cell body; protein heterooligomerization; protein binding; cell cycle arrest; negative regulation of protein kinase activity; cytoplasm; cytosol;
AXIN1	7	signal transducer activity; protein binding; positive regulation of transcription, DNA-dependent; cytoplasm; protein kinase binding; cytosol; plasma membrane;
ADORA2A	6	neuron projection morphogenesis; neuronal cell body; protein binding; negative regulation of neuron apoptotic process; negative regulation of protein kinase activity; plasma membrane;
MIF	6	cell aging; positive regulation of phosphorylation; protein binding; cell proliferation; positive regulation of MAP kinase activity; cytoplasm;
CTGF	6	cell-matrix adhesion; integrin-mediated signaling pathway; integrin binding; positive regulation of cell proliferation; cytosol; plasma membrane;
PKD1	6	cell-matrix adhesion; protein binding; peptidyl-serine phosphorylation; cell cycle arrest; cytoplasm; protein kinase binding;
NTRK2	6	terminal bouton; ATP binding; neuronal cell body; positive regulation of cell proliferation; negative regulation of neuron apoptotic process; cytosol;
CORO1A	6	positive regulation of cell migration; protein binding; lamellipodium; cytoplasm; protein complex; plasma membrane;
LATS1	6	ATP binding; protein serine/threonine kinase activity; protein phosphorylation; protein binding; protein kinase binding; cytosol;
FES	6	ATP binding; focal adhesion; protein phosphorylation; cell proliferation; cytoplasm; cytosol;
BMPR1B	6	ATP binding; protein serine/threonine kinase activity; protein phosphorylation; protein binding; positive regulation of osteoblast differentiation; plasma membrane;
MYO10	6	ATP binding; neuronal cell body; lamellipodium; cytoplasm; cytosol; plasma membrane;
RIPK3	6	ATP binding; protein heterooligomerization; protein serine/threonine kinase activity; protein binding; cytosol; plasma membrane;
PRKG1	6	ATP binding; protein phosphorylation; protein binding; cytoplasm; cytosol; plasma membrane;
ADRBK1	6	ATP binding; protein binding; peptidyl-serine phosphorylation; cytoplasm; cytosol; plasma membrane;
MAP2K3	6	ATP binding; protein serine/threonine kinase activity; protein binding; positive regulation of transcription, DNA-dependent; protein kinase binding; cytosol;
SMG1	6	ATP binding; protein serine/threonine kinase activity; protein binding; peptidyl-serine phosphorylation; cytoplasm; cytosol;
MARK2	6	ATP binding; establishment or maintenance of epithelial cell apical/basal polarity; protein serine/threonine kinase activity; protein phosphorylation; protein binding; plasma membrane;
ERBB2	6	ATP binding; protein phosphorylation; protein binding; cell proliferation; positive regulation of MAP kinase activity; plasma membrane;
CSNK1E	6	ATP binding; protein serine/threonine kinase activity; protein phosphorylation; protein binding; positive regulation of canonical Wnt receptor signaling pathway; cytosol;
CAMK2D	6	ATP binding; neuronal cell body; protein phosphorylation; peptidyl-serine phosphorylation; cytosol; plasma membrane;
MAP3K11	6	ATP binding; protein serine/threonine kinase activity; protein phosphorylation; protein binding; cell proliferation; cytoplasm;
FZD4	6	cell-cell junction; protein binding; positive regulation of transcription, DNA-dependent; cytoplasm; substrate adhesion-dependent cell spreading; plasma membrane;
THY1	6	integrin binding; protein binding; negative regulation of protein kinase activity; protein kinase binding; cytosol; plasma membrane;
DIXDC1	6	focal adhesion; neuronal cell body; signal transducer activity; protein binding; positive regulation of canonical Wnt receptor signaling pathway; cytosol;
BAIAP2	6	regulation of actin cytoskeleton organization; SH3 domain binding; protein binding; cytoplasm; cytosol; plasma membrane;
CBL	6	signal transducer activity; SH3 domain binding; protein binding; cytoplasm; cytosol; plasma membrane;
MALT1	6	signal transducer activity; protein binding; cytoplasm; protein complex; cytosol; plasma membrane;
MAPT	6	SH3 domain binding; protein binding; positive regulation of axon extension; protein kinase binding; cytosol; plasma membrane;
INPPL1	6	SH3 domain binding; protein binding; lamellipodium; cytoplasm; cytosol; plasma membrane;
RELA	6	protein binding; positive regulation of transcription, DNA-dependent; positive regulation of cell proliferation; cytoplasm; protein kinase binding; cytosol;
APBB1	6	protein binding; positive regulation of transcription, DNA-dependent; cell cycle arrest; lamellipodium; cytoplasm; plasma membrane;
FLNC	6	protein binding; cell junction assembly; costamere; cytoplasm; cytosol; plasma membrane;
YAP1	6	protein binding; cell proliferation; positive regulation of cell proliferation; positive regulation of canonical Wnt receptor signaling pathway; cytoplasm; cytosol;
MEN1	6	protein binding; positive regulation of osteoblast differentiation; cell cycle arrest; cytoplasm; protein complex; cytosol;
GJA1	5	neuron projection morphogenesis; signal transducer activity; SH3 domain binding; protein binding; plasma membrane;
ITGA1	5	cell-matrix adhesion; integrin-mediated signaling pathway; integrin binding; protein binding; plasma membrane;
IL6	5	positive regulation of protein kinase B signaling cascade; positive regulation of osteoblast differentiation; positive regulation of transcription, DNA-dependent; positive regulation of cell proliferation; negative regulation of protein kinase activity;
ARRB2	5	positive regulation of protein kinase B signaling cascade; protein binding; cytoplasm; cytosol; plasma membrane;
PTPRJ	5	positive regulation of protein kinase B signaling cascade; cell-cell junction; protein binding; protein kinase binding; plasma membrane;
ADAM8	5	positive regulation of protein kinase B signaling cascade; protein binding; negative regulation of neuron apoptotic process; cytoplasm; plasma membrane;
DRD4	5	terminal bouton; neuronal cell body; SH3 domain binding; protein binding; plasma membrane;
TRPC1	5	sarcomere; protein binding; costamere; protein complex; plasma membrane;
GRB10	5	positive regulation of phosphorylation; protein binding; cytoplasm; cytosol; plasma membrane;
PIK3R1	5	positive regulation of cell migration; protein phosphorylation; protein binding; cytosol; plasma membrane;
WNT11	5	positive regulation of cell migration; protein phosphorylation; positive regulation of transcription, DNA-dependent; cytoplasm; plasma membrane;
DAB2	5	positive regulation of cell migration; integrin binding; protein binding; cell proliferation; positive regulation of transcription, DNA-dependent;
ROR2	5	positive regulation of cell migration; ATP binding; protein binding; positive regulation of transcription, DNA-dependent; positive regulation of canonical Wnt receptor signaling pathway;
IKBKAP	5	positive regulation of cell migration; signal transducer activity; protein phosphorylation; protein binding; cytoplasm;
CDH13	5	positive regulation of cell migration; positive regulation of cell-matrix adhesion; cell junction assembly; cytoplasm; plasma membrane;
VEGFA	5	positive regulation of cell migration; protein binding; positive regulation of MAP kinase activity; positive regulation of cell proliferation; cytoplasm;
LATS2	5	ATP binding; protein serine/threonine kinase activity; protein phosphorylation; protein binding; cytosol;
SIK3	5	ATP binding; protein serine/threonine kinase activity; protein phosphorylation; protein binding; cytoplasm;
TWF2	5	ATP binding; regulation of actin cytoskeleton organization; lamellipodium; cytoplasm; positive regulation of axon extension;
FLT4	5	ATP binding; protein binding; positive regulation of cell proliferation; cytoplasm; plasma membrane;
CDC42BPG	5	ATP binding; protein serine/threonine kinase activity; protein phosphorylation; protein binding; cytoplasm;
PRKAG2	5	ATP binding; cell cycle arrest; negative regulation of protein kinase activity; protein kinase binding; cytosol;
ATM	5	ATP binding; protein serine/threonine kinase activity; protein binding; peptidyl-serine phosphorylation; cell cycle arrest;
NUBP1	5	ATP binding; protein binding; cytoplasm; cytosol; plasma membrane;
GAK	5	ATP binding; focal adhesion; protein serine/threonine kinase activity; protein binding; cytoplasm;
RPS6KA4	5	ATP binding; protein serine/threonine kinase activity; protein phosphorylation; protein binding; cytoplasm;
FRK	5	ATP binding; protein phosphorylation; protein binding; cytoplasm; plasma membrane;
STK36	5	ATP binding; protein serine/threonine kinase activity; protein phosphorylation; protein binding; cytoplasm;
TNNI3K	5	ATP binding; protein serine/threonine kinase activity; protein phosphorylation; protein binding; cytoplasm;
SIK2	5	ATP binding; protein serine/threonine kinase activity; protein phosphorylation; protein binding; cytoplasm;
TSSK2	5	ATP binding; protein serine/threonine kinase activity; protein phosphorylation; protein binding; cytoplasm;
WNK2	5	ATP binding; protein serine/threonine kinase activity; protein phosphorylation; cytoplasm; plasma membrane;
MAPK3	5	ATP binding; focal adhesion; protein phosphorylation; protein binding; cytosol;
RDX	5	focal adhesion; protein binding; lamellipodium; cytoplasm; plasma membrane;
CACNA1C	5	neuronal cell body; dendritic shaft; protein binding; cytoplasm; plasma membrane;
STRN3	5	neuronal cell body; protein binding; cytoplasm; protein complex; plasma membrane;
PAFAH1B1	5	neuronal cell body; protein binding; cytoplasm; positive regulation of axon extension; cytosol;
MAGI2	5	protein heterooligomerization; signal transducer activity; protein binding; cytoplasm; plasma membrane;
SQSTM1	5	protein heterooligomerization; protein serine/threonine kinase activity; protein binding; protein kinase binding; cytosol;
STXBP3	5	protein heterooligomerization; protein binding; cytoplasm; cytosol; plasma membrane;
HTR2A	5	dendritic shaft; positive regulation of MAP kinase activity; positive regulation of cell proliferation; cytosol; plasma membrane;
AIP	5	signal transducer activity; protein binding; cytoplasm; cytosol; plasma membrane;
IRF7	5	protein phosphorylation; protein binding; positive regulation of transcription, DNA-dependent; cytoplasm; cytosol;
ID2	5	protein binding; positive regulation of transcription, DNA-dependent; cytoplasm; protein complex; cytosol;
GAB2	5	protein binding; positive regulation of cell proliferation; cytoplasm; cytosol; plasma membrane;
CUL5	5	protein binding; cell proliferation; cell cycle arrest; cytosol; plasma membrane;
PARK2	5	protein binding; negative regulation of neuron apoptotic process; cytoplasm; protein kinase binding; cytosol;
PLCE1	5	protein binding; cell proliferation; cytoplasm; cytosol; plasma membrane;
NF2	5	protein binding; negative regulation of protein kinase activity; lamellipodium; cytoplasm; plasma membrane;
GOLPH3	5	protein binding; cell proliferation; cytoplasm; cytosol; plasma membrane;
CDK5RAP2	5	protein binding; positive regulation of transcription, DNA-dependent; cytoplasm; protein kinase binding; cytosol;
AKAP7	5	protein binding; protein kinase binding; protein complex; cytosol; plasma membrane;
RPTOR	5	protein binding; cell cycle arrest; cytoplasm; protein kinase binding; cytosol;
SOCS1	5	protein binding; negative regulation of protein kinase activity; cytoplasm; protein kinase binding; cytosol;
PDCD10	5	protein binding; positive regulation of MAP kinase activity; positive regulation of cell proliferation; cytosol; plasma membrane;

Genes shared at least 2 KEGG pathways with ILK (count: 9)

Gene Symbol	Pathway Count	Pathway List
PDPK1	3	Focal adhesion; PPAR signaling pathway; Endometrial cancer;
PIK3R1	2	Focal adhesion; Endometrial cancer;
BAD	2	Focal adhesion; Endometrial cancer;
MAPK1	2	Focal adhesion; Endometrial cancer;
PIK3CG	2	Focal adhesion; Endometrial cancer;
MAPK3	2	Focal adhesion; Endometrial cancer;
CCND1	2	Focal adhesion; Endometrial cancer;
ERBB2	2	Focal adhesion; Endometrial cancer;
GSK3B	2	Focal adhesion; Endometrial cancer;

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Region: chr11:6624961..6632102 View in gBrowse