ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ROR2
Previous Symbol	NTRKR2, BDB, BDB1
Approved Name	receptor tyrosine kinase-like orphan receptor 2
Location	9q22
Position	chr9:94325373-94712444, -
External Links	HGNC: 10257 Entrez Gene: 4920 Ensembl: ENSG00000169071 UCSC: uc004arj.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q22	chr9:90400000-102600000	3 (1/1/1)

Gene related GO terms (count: 22)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 22)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0030538	embryonic genitalia morphogenesis	Biological Process		2
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	Biological Process		16
GO:0042472	inner ear morphogenesis	Biological Process		6
GO:0007223	Wnt receptor signaling pathway, calcium modulating pathway	Biological Process		2
GO:0030154	cell differentiation	Biological Process		51
GO:0005887	integral to plasma membrane	Cellular Component	TAS[1334494]	220
GO:0030335	positive regulation of cell migration	Biological Process	IDA[19486338]	29
GO:0007165	signal transduction	Biological Process	TAS[1334494]	171
GO:0090090	negative regulation of canonical Wnt receptor signaling pathway	Biological Process		14
GO:0008285	negative regulation of cell proliferation	Biological Process	IMP[19486338]	59
GO:0090263	positive regulation of canonical Wnt receptor signaling pathway	Biological Process		9
GO:0017147	Wnt-protein binding	Molecular Function	IPI[19486338]	3
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process		80
GO:0007254	JNK cascade	Biological Process		11
GO:0060071	Wnt receptor signaling pathway, planar cell polarity pathway	Biological Process		3
GO:0007275	multicellular organismal development	Biological Process	TAS[1334494]	71
GO:0001502	cartilage condensation	Biological Process		5
GO:0001756	somitogenesis	Biological Process		7
GO:0005515	protein binding	Molecular Function		910
GO:0005524	ATP binding	Molecular Function		228
GO:0004714	transmembrane receptor protein tyrosine kinase activity	Molecular Function		5
GO:0005109	frizzled binding	Molecular Function		3

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with ROR2 (count: 7)

Gene Symbol	Pathway Count	Pathway List
ERBB2	5	transmembrane receptor protein tyrosine kinase signaling pathway; signal transduction; protein binding; ATP binding; transmembrane receptor protein tyrosine kinase activity;
FLT4	5	transmembrane receptor protein tyrosine kinase signaling pathway; integral to plasma membrane; protein binding; ATP binding; transmembrane receptor protein tyrosine kinase activity;
MUSK	5	transmembrane receptor protein tyrosine kinase signaling pathway; integral to plasma membrane; protein binding; ATP binding; transmembrane receptor protein tyrosine kinase activity;
TFAP2A	5	inner ear morphogenesis; positive regulation of cell migration; negative regulation of cell proliferation; positive regulation of transcription, DNA-dependent; protein binding;
FZD4	5	Wnt receptor signaling pathway, calcium modulating pathway; integral to plasma membrane; Wnt-protein binding; positive regulation of transcription, DNA-dependent; protein binding;
ILK	5	positive regulation of cell migration; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of transcription, DNA-dependent; protein binding; ATP binding;
MAPK1	5	positive regulation of cell migration; signal transduction; positive regulation of transcription, DNA-dependent; protein binding; ATP binding;

Genes shared at least 2 KEGG pathways with ROR2 (count: 0)

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Region: chr9:94325373..94712444 View in gBrowse