ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MUSK
Approved Name	muscle, skeletal, receptor tyrosine kinase
Location	9q31.3-q32
Position	chr9:113431051-113563859, +
External Links	HGNC: 7525 Entrez Gene: 4593 Ensembl: ENSG00000030304 UCSC: uc004bey.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q31.1-33.1	chr9:102600000-122500000	1 (1/0/0)

Gene related GO terms (count: 19)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 19)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0031594	neuromuscular junction	Cellular Component		7
GO:0030054	cell junction	Cellular Component		77
GO:0010628	positive regulation of gene expression	Biological Process		28
GO:0008582	regulation of synaptic growth at neuromuscular junction	Biological Process		1
GO:0007613	memory	Biological Process		18
GO:0007528	neuromuscular junction development	Biological Process		8
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	Biological Process	TAS[7546737]	16
GO:0006355	regulation of transcription, DNA-dependent	Biological Process		158
GO:0005887	integral to plasma membrane	Cellular Component		220
GO:0005524	ATP binding	Molecular Function		228
GO:0005515	protein binding	Molecular Function		910
GO:0004714	transmembrane receptor protein tyrosine kinase activity	Molecular Function		5
GO:0004713	protein tyrosine kinase activity	Molecular Function		10
GO:0001934	positive regulation of protein phosphorylation	Biological Process		22
GO:2000541	positive regulation of protein geranylgeranylation	Biological Process		1
GO:0046777	protein autophosphorylation	Biological Process		23
GO:0071340	skeletal muscle acetylcholine-gated channel clustering	Biological Process		1
GO:0043525	positive regulation of neuron apoptotic process	Biological Process		9
GO:0045211	postsynaptic membrane	Cellular Component		41

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with MUSK (count: 8)

Gene Symbol	Pathway Count	Pathway List
ERBB2	8	neuromuscular junction development; transmembrane receptor protein tyrosine kinase signaling pathway; ATP binding; protein binding; transmembrane receptor protein tyrosine kinase activity; protein tyrosine kinase activity; positive regulation of protein phosphorylation; protein autophosphorylation;
FLT4	7	transmembrane receptor protein tyrosine kinase signaling pathway; integral to plasma membrane; ATP binding; protein binding; transmembrane receptor protein tyrosine kinase activity; positive regulation of protein phosphorylation; protein autophosphorylation;
GRIN2A	5	cell junction; memory; integral to plasma membrane; protein binding; postsynaptic membrane;
GRIN2B	5	cell junction; memory; integral to plasma membrane; protein binding; postsynaptic membrane;
NTRK2	5	positive regulation of gene expression; transmembrane receptor protein tyrosine kinase signaling pathway; integral to plasma membrane; ATP binding; protein autophosphorylation;
ADORA2A	5	transmembrane receptor protein tyrosine kinase signaling pathway; regulation of transcription, DNA-dependent; integral to plasma membrane; protein binding; postsynaptic membrane;
ROR2	5	transmembrane receptor protein tyrosine kinase signaling pathway; integral to plasma membrane; ATP binding; protein binding; transmembrane receptor protein tyrosine kinase activity;
MAP3K11	5	ATP binding; protein binding; protein tyrosine kinase activity; protein autophosphorylation; positive regulation of neuron apoptotic process;

Genes shared at least 2 KEGG pathways with MUSK (count: 0)

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Region: chr9:113431051..113563859 View in gBrowse