ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	NTRK2
Symbol Alias	TRKB
Approved Name	neurotrophic tyrosine kinase, receptor, type 2
Location	9q22.1
Position	chr9:87283466-87638505, +
External Links	HGNC: 8032 Entrez Gene: 4915 Ensembl: ENSG00000148053 UCSC: uc004anz.1
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Ribases M, 2008	a four-marker haplotype(rs7816-rs11795386-rs1387926-rs1586681) global P-value=2.1e-04, Best Haplotype P-value=1.5e-04, adjusted P-value=0.0030, OR=1.52 (1.16-1.98) in children; Haplotype-Specific (ACGA) P-value=0.0084; OR(CI)=1.52 (1.17-1.98), Haplotype-Specific(ATAA) P-value=1.5e-04; OR(CI)=3.92 (1.85-8.32) in children	Significant

Gene related SNPs (count: 19)

Literature-origin SNPs (count: 5)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs1387926	Chr9:87632663(Fwd)	intron_variant	1(1/0/0)
rs1073049	Chr9:87647100(Fwd)		1(1/0/0)
rs10780695	Chr9:87644233(Fwd)		1(1/0/0)
rs1545285	Chr9:87542369(Fwd)	intron_variant	1(1/0/0)
rs11795386	Chr9:87602898(Fwd)	intron_variant	1(1/0/0)

LD-proxies (count: 14)

rs_ID	Location	Functional Annotation
rs12378021	Chr9:87635540(Fwd)	intron_variant
rs2165892	Chr9:87559707(Fwd)	intron_variant
rs6559838	Chr9:87553563(Fwd)	intron_variant
rs17418241	Chr9:87625848(Fwd)	intron_variant
rs1443442	Chr9:87576842(Fwd)	intron_variant
rs995861	Chr9:87541642(Fwd)	intron_variant
rs7047427	Chr9:87578464(Fwd)	intron_variant
rs2808707	Chr9:87558294(Fwd)	intron_variant
rs2034107	Chr9:87580367(Fwd)	intron_variant
rs4394479	Chr9:87618543(Fwd)	intron_variant
rs3860945	Chr9:87585624(Fwd)	intron_variant
rs4615661	Chr9:87594400(Fwd)	intron_variant
rs4314726	Chr9:87589244(Fwd)	intron_variant
rs13440094	Chr9:87619071(Fwd)	intron_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 51)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 51)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0007190	activation of adenylate cyclase activity	Biological Process		9
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	Biological Process		16
GO:0005887	integral to plasma membrane	Cellular Component	IDA[15494731]	220
GO:0005829	cytosol	Cellular Component		447
GO:0007631	feeding behavior	Biological Process		9
GO:0007616	long-term memory	Biological Process		4
GO:0007612	learning	Biological Process		13
GO:0007568	aging	Biological Process		29
GO:0005524	ATP binding	Molecular Function		228
GO:0001764	neuron migration	Biological Process		21
GO:0001570	vasculogenesis	Biological Process		10
GO:0030426	growth cone	Cellular Component		20
GO:0031547	brain-derived neurotrophic factor receptor signaling pathway	Biological Process	IMP[15494731]	1
GO:0032314	regulation of Rac GTPase activity	Biological Process		4
GO:0035584	calcium-mediated signaling using intracellular calcium source	Biological Process		2
GO:0014069	postsynaptic density	Cellular Component		23
GO:0021954	central nervous system neuron development	Biological Process		3
GO:0021987	cerebral cortex development	Biological Process		11
GO:0030182	neuron differentiation	Biological Process		9
GO:0010976	positive regulation of neuron projection development	Biological Process		9
GO:0010996	response to auditory stimulus	Biological Process		1
GO:0014047	glutamate secretion	Biological Process		7
GO:0014068	positive regulation of phosphatidylinositol 3-kinase cascade	Biological Process		5
GO:0008284	positive regulation of cell proliferation	Biological Process		69
GO:0009986	cell surface	Cellular Component		70
GO:0010008	endosome membrane	Cellular Component		27
GO:0010628	positive regulation of gene expression	Biological Process		28
GO:0048709	oligodendrocyte differentiation	Biological Process		1
GO:0048403	brain-derived neurotrophic factor binding	Molecular Function		1
GO:0048935	peripheral nervous system neuron development	Biological Process		2
GO:0048786	presynaptic active zone	Cellular Component		4
GO:0046875	ephrin receptor binding	Molecular Function		3
GO:0046777	protein autophosphorylation	Biological Process		23
GO:0048011	nerve growth factor receptor signaling pathway	Biological Process		42
GO:0046928	regulation of neurotransmitter secretion	Biological Process		5
GO:0043410	positive regulation of MAPK cascade	Biological Process		17
GO:0043195	terminal bouton	Cellular Component		11
GO:0046548	retinal rod cell development	Biological Process		2
GO:0043524	negative regulation of neuron apoptotic process	Biological Process		19
GO:0042803	protein homodimerization activity	Molecular Function		113
GO:0042490	mechanoreceptor differentiation	Biological Process		3
GO:0043121	neurotrophin binding	Molecular Function	IDA[11738045]	1
GO:0043025	neuronal cell body	Cellular Component		51
GO:0060291	long-term synaptic potentiation	Biological Process		5
GO:2000811	negative regulation of anoikis	Biological Process		1
GO:0060076	excitatory synapse	Cellular Component		3
GO:0060175	brain-derived neurotrophic factor-activated receptor activity	Molecular Function	IMP[15494731]	1
GO:0051896	regulation of protein kinase B signaling cascade	Biological Process		3
GO:0051968	positive regulation of synaptic transmission, glutamatergic	Biological Process		8
GO:0050772	positive regulation of axonogenesis	Biological Process		3
GO:0050773	regulation of dendrite development	Biological Process		3

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04722	Neurotrophin signaling pathway	24	Neurotrophins are a family of trophic factors involved in di...... Neurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), and neurotrophin 4 (NT-4). Neurotrophins exert their functions through engagement of Trk tyrosine kinase receptors or p75 neurotrophin receptor (p75NTR). Neurotrophin/Trk signaling is regulated by connecting a variety of intracellular signaling cascades, which include MAPK pathway, PI-3 kinase pathway, and PLC pathway, transmitting positive signals like enhanced survival and growth. On the other hand, p75NTR transmits both positive and nagative signals. These signals play an important role for neural development and additional higher-order activities such as learning and memory. More...
hsa04010	MAPK signaling pathway	69	The mitogen-activated protein kinase (MAPK) cascade is a hig...... The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. More...

Genes shared at least 5 GO terms with NTRK2 (count: 13)

Gene Symbol	Pathway Count	Pathway List
ADORA2A	9	activation of adenylate cyclase activity; transmembrane receptor protein tyrosine kinase signaling pathway; integral to plasma membrane; postsynaptic density; presynaptic active zone; nerve growth factor receptor signaling pathway; negative regulation of neuron apoptotic process; neuronal cell body; positive regulation of synaptic transmission, glutamatergic;
FLT4	6	transmembrane receptor protein tyrosine kinase signaling pathway; integral to plasma membrane; ATP binding; positive regulation of cell proliferation; protein autophosphorylation; positive regulation of MAPK cascade;
NGF	6	transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of gene expression; nerve growth factor receptor signaling pathway; regulation of neurotransmitter secretion; negative regulation of neuron apoptotic process; positive regulation of axonogenesis;
ILK	6	cytosol; ATP binding; positive regulation of cell proliferation; terminal bouton; negative regulation of neuron apoptotic process; neuronal cell body;
PAFAH1B1	6	cytosol; neuron migration; growth cone; cerebral cortex development; protein homodimerization activity; neuronal cell body;
SNCA	6	cytosol; aging; growth cone; terminal bouton; negative regulation of neuron apoptotic process; long-term synaptic potentiation;
ADRB3	5	activation of adenylate cyclase activity; integral to plasma membrane; aging; positive regulation of MAPK cascade; protein homodimerization activity;
MUSK	5	transmembrane receptor protein tyrosine kinase signaling pathway; integral to plasma membrane; ATP binding; positive regulation of gene expression; protein autophosphorylation;
FZD4	5	integral to plasma membrane; vasculogenesis; neuron differentiation; cell surface; protein homodimerization activity;
PRKD1	5	integral to plasma membrane; cytosol; ATP binding; positive regulation of neuron projection development; protein autophosphorylation;
SLC6A4	5	integral to plasma membrane; cytosol; endosome membrane; positive regulation of gene expression; protein homodimerization activity;
GSK3B	5	cytosol; ATP binding; growth cone; nerve growth factor receptor signaling pathway; neuronal cell body;
VEGFA	5	vasculogenesis; positive regulation of cell proliferation; cell surface; positive regulation of gene expression; protein homodimerization activity;

Genes shared at least 2 KEGG pathways with NTRK2 (count: 11)

Gene Symbol	Pathway Count	Pathway List
BDNF	2	Neurotrophin signaling pathway; MAPK signaling pathway;
CRKL	2	Neurotrophin signaling pathway; MAPK signaling pathway;
MAP3K5	2	Neurotrophin signaling pathway; MAPK signaling pathway;
MAPK1	2	Neurotrophin signaling pathway; MAPK signaling pathway;
MAPK3	2	Neurotrophin signaling pathway; MAPK signaling pathway;
MAPK7	2	Neurotrophin signaling pathway; MAPK signaling pathway;
MAPK9	2	Neurotrophin signaling pathway; MAPK signaling pathway;
NGF	2	Neurotrophin signaling pathway; MAPK signaling pathway;
NTF3	2	Neurotrophin signaling pathway; MAPK signaling pathway;
RELA	2	Neurotrophin signaling pathway; MAPK signaling pathway;
RPS6KA4	2	Neurotrophin signaling pathway; MAPK signaling pathway;

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Region: chr9:87283466..87638505 View in gBrowse