ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	NTRK2
Symbol Alias	TRKB
Approved Name	neurotrophic tyrosine kinase, receptor, type 2
Location	9q22.1
Position	chr9:87283466-87638505, 1
External Links	HGNC: 8032 Entrez Gene: 4915 Ensembl: ENSG00000148053 UCSC: uc004anz.1
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin; Mapped by Literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Ribases M, 2008	a four-marker haplotype(rs7816-rs11795386-rs1387926-rs1586681) global P-value=2.1e-04, Best Haplotype P-value=1.5e-04, adjusted P-value=0.0030, OR=1.52 (1.16-1.98) in children; Haplotype-Specific (ACGA) P-value=0.0084; OR(CI)=1.52 (1.17-1.98), Haplotype-Specific(ATAA) P-value=1.5e-04; OR(CI)=3.92 (1.85-8.32) in children	Significant

Gene related SNPs (count: 17)

Literature-origin SNPs (count: 3)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs11795386	chr9:87602898(Fwd)	intron_variant	1(1/0/0)
rs1545285	chr9:87542369(Fwd)	intron_variant	1(1/0/0)
rs1387926	chr9:87632663(Fwd)	intron_variant	1(1/0/0)

LD-proxies (count: 14)

rs_ID	Location	Functional Annotation
rs12378021	chr9:87635540(Fwd)	intron_variant
rs3860945	chr9:87585624(Fwd)	intron_variant
rs2808707	chr9:87558294(Fwd)	intron_variant
rs17418241	chr9:87625848(Fwd)	intron_variant
rs2165892	chr9:87559707(Fwd)	intron_variant
rs1443442	chr9:87576842(Fwd)	intron_variant
rs7047427	chr9:87578464(Fwd)	intron_variant
rs6559838	chr9:87553563(Fwd)	intron_variant
rs2034107	chr9:87580367(Fwd)	intron_variant
rs995861	chr9:87541642(Fwd)	intron_variant
rs4314726	chr9:87589244(Fwd)	intron_variant
rs4615661	chr9:87594400(Fwd)	intron_variant
rs4394479	chr9:87618543(Fwd)	intron_variant
rs13440094	chr9:87619071(Fwd)	intron_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 51)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 51)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0050773	regulation of dendrite development	biological process	IEA	3
GO:0010008	endosome membrane	cellular component	IEA	31
GO:0051968	positive regulation of synaptic transmission, glutamatergic	biological process	IEA	8
GO:0048011	nerve growth factor receptor signaling pathway	biological process	TAS	51
GO:0043410	positive regulation of MAPK cascade	biological process	ISS	19
GO:0046875	ephrin receptor binding	molecular function	IEA	3
GO:0043121	neurotrophin binding	molecular function	IDA[11738045]; ISS	1
GO:0005524	ATP binding	molecular function	IEA	265
GO:0046928	regulation of neurotransmitter secretion	biological process	IEA	5
GO:0010976	positive regulation of neuron projection development	biological process	ISS	10
GO:0043025	neuronal cell body	cellular component	IEA	56
GO:0048403	brain-derived neurotrophic factor binding	molecular function	ISS	1
GO:0014068	positive regulation of phosphatidylinositol 3-kinase cascade	biological process	ISS	5
GO:0008284	positive regulation of cell proliferation	biological process	ISS	75
GO:0060175	brain-derived neurotrophic factor-activated receptor activity	molecular function	IMP[15494731]	1
GO:0010996	response to auditory stimulus	biological process	IEA	1
GO:0014047	glutamate secretion	biological process	IEA	7
GO:0031547	brain-derived neurotrophic factor receptor signaling pathway	biological process	IMP[15494731]	1
GO:0046548	retinal rod cell development	biological process	IEA	2
GO:0005829	cytosol	cellular component	IEA	485
GO:0043195	terminal bouton	cellular component	IEA	11
GO:0030182	neuron differentiation	biological process	ISS	10
GO:0007190	activation of adenylate cyclase activity	biological process	TAS	10
GO:0048786	presynaptic active zone	cellular component	IEA	4
GO:0048709	oligodendrocyte differentiation	biological process	IEA	3
GO:0007612	learning	biological process	ISS	13
GO:0010628	positive regulation of gene expression	biological process	ISS	29
GO:0046777	protein autophosphorylation	biological process	ISS	26
GO:0060076	excitatory synapse	cellular component	IEA	3
GO:0021987	cerebral cortex development	biological process	ISS	11
GO:0030426	growth cone	cellular component	IEA	23
GO:0014069	postsynaptic density	cellular component	IEA	26
GO:0050772	positive regulation of axonogenesis	biological process	ISS	5
GO:0007616	long-term memory	biological process	IEA	4
GO:0060291	long-term synaptic potentiation	biological process	IEA	5
GO:0048935	peripheral nervous system neuron development	biological process	IEA	2
GO:0042490	mechanoreceptor differentiation	biological process	IEA	3
GO:0001764	neuron migration	biological process	ISS	22
GO:0032314	regulation of Rac GTPase activity	biological process	ISS	5
GO:0035584	calcium-mediated signaling using intracellular calcium source	biological process	IEA	2
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	biological process	TAS	16
GO:2000811	negative regulation of anoikis	biological process	IEA	2
GO:0001570	vasculogenesis	biological process	IEA	10
GO:0021954	central nervous system neuron development	biological process	ISS	3
GO:0051896	regulation of protein kinase B signaling cascade	biological process	IEA	4
GO:0043524	negative regulation of neuron apoptotic process	biological process	ISS	18
GO:0007568	aging	biological process	IEA	29
GO:0042803	protein homodimerization activity	molecular function	ISS	128
GO:0009986	cell surface	cellular component	IEA	75
GO:0005887	integral to plasma membrane	cellular component	IDA[15494731]	236
GO:0007631	feeding behavior	biological process	IEA	10

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04010	MAPK signaling pathway	68

Genes shared at least 5 GO terms with NTRK2 (count: 15)

Gene Symbol	Pathway Count	Pathway List
ADORA2A	9	positive regulation of synaptic transmission, glutamatergic; nerve growth factor receptor signaling pathway; neuronal cell body; activation of adenylate cyclase activity; presynaptic active zone; postsynaptic density; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of neuron apoptotic process; integral to plasma membrane;
NGF	6	nerve growth factor receptor signaling pathway; regulation of neurotransmitter secretion; positive regulation of gene expression; positive regulation of axonogenesis; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of neuron apoptotic process;
FLT4	6	positive regulation of MAPK cascade; ATP binding; positive regulation of cell proliferation; protein autophosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; integral to plasma membrane;
ILK	6	ATP binding; neuronal cell body; positive regulation of cell proliferation; cytosol; terminal bouton; negative regulation of neuron apoptotic process;
PAFAH1B1	6	neuronal cell body; cytosol; cerebral cortex development; growth cone; neuron migration; protein homodimerization activity;
SNCA	6	cytosol; terminal bouton; growth cone; long-term synaptic potentiation; negative regulation of neuron apoptotic process; aging;
SLC6A4	5	endosome membrane; cytosol; positive regulation of gene expression; protein homodimerization activity; integral to plasma membrane;
TSC2	5	nerve growth factor receptor signaling pathway; neuronal cell body; cytosol; growth cone; protein homodimerization activity;
GSK3B	5	nerve growth factor receptor signaling pathway; ATP binding; neuronal cell body; cytosol; growth cone;
ADRB3	5	positive regulation of MAPK cascade; activation of adenylate cyclase activity; aging; protein homodimerization activity; integral to plasma membrane;
STK11	5	ATP binding; cytosol; protein autophosphorylation; positive regulation of axonogenesis; regulation of protein kinase B signaling cascade;
MUSK	5	ATP binding; positive regulation of gene expression; protein autophosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; integral to plasma membrane;
PRKD1	5	ATP binding; positive regulation of neuron projection development; cytosol; protein autophosphorylation; integral to plasma membrane;
VEGFA	5	positive regulation of cell proliferation; positive regulation of gene expression; vasculogenesis; protein homodimerization activity; cell surface;
FZD4	5	neuron differentiation; vasculogenesis; protein homodimerization activity; cell surface; integral to plasma membrane;

Genes shared at least 2 KEGG pathways with NTRK2 (count: 0)

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Region: chr9:87283466..87638505 View in gBrowse