ADHDgene Database
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  • Large-scale studies
  • Data Summary
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

KEGG Pathway Report

Basic Info
ID hsa04010
Name MAPK signaling pathway
Description  The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
No. of Genes in ADHDgene  69
Source Pathway by Database Search

Pathway related genes in ADHDgene (count: 69)

Literature-origin genes (count: 11)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend)
FGF10 fibroblast growth factor 10 5p13-p12 1(0/1/0)
FLNC filamin C, gamma 7q32-q35 1(0/0/1)
MAP2K3 mitogen-activated protein kinase kinase 3 17q11.2 1(0/1/0)
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 12p13.3 1(0/1/0)
ARRB1 arrestin, beta 1 11q13 2(1/1/0)
NTF3 neurotrophin 3 12p13 3(1/2/0)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 9q22.1 1(1/0/0)
NGF nerve growth factor (beta polypeptide) 1p13.1 2(2/0/0)
ARRB2 arrestin, beta 2 17p13 1(1/0/0)
BDNF brain-derived neurotrophic factor 11p14.1 14(8/6/0)
DUSP1 dual specificity phosphatase 1 5q35.1 1(0/1/0)

Genes from other sources Help(count: 58)

Approved Symbol Approved Name Location Source
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 11q11-q13 Mapped by significant region
PRKCB protein kinase C, beta 16p12 Mapped by significant region
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 1p35 Mapped by PBA pathway
PLA2G1B phospholipase A2, group IB (pancreas) 12q23-qter Mapped by PBA pathway
FGF4 fibroblast growth factor 4 11q13.3 Mapped by significant region
PLA2G2E phospholipase A2, group IIE 1p36.13 Mapped by PBA pathway
FGF9 fibroblast growth factor 9 (glia-activating factor) 13q11-q12 Mapped by significant region
PLA2G2D phospholipase A2, group IID 1p36.12 Mapped by PBA pathway
PLA2G4B phospholipase A2, group IVB (cytosolic) 15q11.2-q21.3 Mapped by PBA pathway
PLA2G3 phospholipase A2, group III 22q12.2 Mapped by PBA pathway
PLA2G5 phospholipase A2, group V 1p36-p34 Mapped by PBA pathway
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit 22q13.1 Mapped by CNV
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) 22q13.1 Mapped by PBA pathway
MAP3K5 mitogen-activated protein kinase kinase kinase 5 6q22.33 Mapped by LD-proxy; Mapped by significant region
MAPK1 mitogen-activated protein kinase 1 22q11.2 Mapped by LD-proxy
DAXX death-domain associated protein 6p21.3 Mapped by LD-proxy; Mapped by PBA pathway
MAPT microtubule-associated protein tau 17q21 Mapped by LD-proxy; Mapped by PBA pathway
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit Xp11.23 Mapped by LD-proxy; Mapped by PBA pathway; Mapped by literature SNP
PPP3R2 protein phosphatase 3, regulatory subunit B, beta 9q31 Mapped by significant region
MAPK9 mitogen-activated protein kinase 9 5q35 Mapped by CNV
RASA1 RAS p21 protein activator (GTPase activating protein) 1 5q13 Mapped by PBA pathway
MAPK3 mitogen-activated protein kinase 3 16p11.2 Mapped by CNV
FGF3 fibroblast growth factor 3 11q13 Mapped by significant region
CDC25B cell division cycle 25 homolog B (S. pombe) 20p13 Mapped by CNV
FGF19 fibroblast growth factor 19 11q13.1 Mapped by significant region
DUSP2 dual specificity phosphatase 2 2q11 Mapped by LD-proxy
TAOK2 TAO kinase 2 16p11.2 Mapped by CNV
CACNG5 calcium channel, voltage-dependent, gamma subunit 5 17q24 Mapped by PBA pathway
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated) 11q13 Mapped by significant region
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 14q11.2 Mapped by significant region
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 2q22-q23 Mapped by PBA pathway
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 17q24 Mapped by PBA pathway
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 22q13.1 Mapped by PBA pathway
STMN1 stathmin 1 1p36.11 Mapped by PBA pathway
CACNG4 calcium channel, voltage-dependent, gamma subunit 4 17q24 Mapped by PBA pathway
MAP3K11 mitogen-activated protein kinase kinase kinase 11 11q13.1-q13.3 Mapped by significant region
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 11q13.1 Mapped by significant region
MAPK7 mitogen-activated protein kinase 7 17p11.2 Mapped by significant region
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 11q13 Mapped by significant region
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit 9q34 Mapped by PBA pathway
HSPA8 heat shock 70kDa protein 8 11q24.1 Mapped by significant region
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 19p13 Mapped by PBA pathway
CACNB1 calcium channel, voltage-dependent, beta 1 subunit 17q21-q22 Mapped by PBA pathway
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 7q21-q22 Mapped by PBA pathway
CACNB3 calcium channel, voltage-dependent, beta 3 subunit 12q13 Mapped by PBA pathway
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 10p12 Mapped by PBA pathway
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit 17q22 Mapped by PBA pathway
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 22q11.21 Mapped by CNV
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 3p14.3 Mapped by PBA pathway
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 1q32 Mapped by PBA pathway
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit 16p13.3 Mapped by PBA pathway
TGFBR1 transforming growth factor, beta receptor 1 9q22 Mapped by significant region
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit 1q25-q31 Mapped by PBA pathway; Mapped by significant region
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 11q13-q14 Mapped by significant region
PLA2G10 phospholipase A2, group X 16p13.1-p12 Mapped by PBA pathway; Mapped by significant region
DUSP14 dual specificity phosphatase 14 17q12 Mapped by CNV
HSPA6 heat shock 70kDa protein 6 (HSP70B') 1q23.3 Mapped by CNV
GADD45G growth arrest and DNA-damage-inducible, gamma 9q22.1-q22.2 Mapped by significant region

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014