ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	RPS6KA4
Symbol Alias	RSK-B, MSK2
Approved Name	ribosomal protein S6 kinase, 90kDa, polypeptide 4
Previous Name	ribosomal protein S6 kinase, 90kD, polypeptide 4
Location	11q11-q13
Position	chr11:64126620-64139687, +
External Links	HGNC: 10433 Entrez Gene: 8986 Ensembl: ENSG00000162302 UCSC: uc001oae.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 24)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 24)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004711	ribosomal protein S6 kinase activity	Molecular Function	NAS[11035004]	2
GO:0005515	protein binding	Molecular Function	IPI[9792677]	910
GO:0001818	negative regulation of cytokine production	Biological Process	TAS[18508628]	2
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IDA[9792677]; IMP[12773393]	61
GO:0005730	nucleolus	Cellular Component		243
GO:0005737	cytoplasm	Cellular Component		690
GO:0005524	ATP binding	Molecular Function	IDA[9792677]	228
GO:0005634	nucleus	Cellular Component		770
GO:0006954	inflammatory response	Biological Process		51
GO:0007243	intracellular protein kinase cascade	Biological Process	IDA[9792677]	19
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IDA[9792677]	158
GO:0006468	protein phosphorylation	Biological Process	IDA[9792677]	53
GO:0032793	positive regulation of CREB transcription factor activity	Biological Process	TAS[18508628]	6
GO:0033129	positive regulation of histone phosphorylation	Biological Process		2
GO:0007411	axon guidance	Biological Process		65
GO:0016572	histone phosphorylation	Biological Process		1
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process		131
GO:0043988	histone H3-S28 phosphorylation	Biological Process	IMP[12773393]	1
GO:0043987	histone H3-S10 phosphorylation	Biological Process	IMP[12773393]	1
GO:0035066	positive regulation of histone acetylation	Biological Process		3
GO:0070498	interleukin-1-mediated signaling pathway	Biological Process		2
GO:0051092	positive regulation of NF-kappaB transcription factor activity	Biological Process	TAS[18508628]	27
GO:0048273	mitogen-activated protein kinase p38 binding	Molecular Function	IGI[11035004]	1
GO:0000287	magnesium ion binding	Molecular Function		28

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04722	Neurotrophin signaling pathway	24	Neurotrophins are a family of trophic factors involved in di...... Neurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), and neurotrophin 4 (NT-4). Neurotrophins exert their functions through engagement of Trk tyrosine kinase receptors or p75 neurotrophin receptor (p75NTR). Neurotrophin/Trk signaling is regulated by connecting a variety of intracellular signaling cascades, which include MAPK pathway, PI-3 kinase pathway, and PLC pathway, transmitting positive signals like enhanced survival and growth. On the other hand, p75NTR transmits both positive and nagative signals. These signals play an important role for neural development and additional higher-order activities such as learning and memory. More...
hsa04010	MAPK signaling pathway	69	The mitogen-activated protein kinase (MAPK) cascade is a hig...... The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. More...

Genes shared at least 5 GO terms with RPS6KA4 (count: 64)

Gene Symbol	Pathway Count	Pathway List
MAPK3	10	protein binding; nucleolus; ATP binding; nucleus; protein phosphorylation; positive regulation of histone phosphorylation; axon guidance; positive regulation of transcription from RNA polymerase II promoter; positive regulation of histone acetylation; interleukin-1-mediated signaling pathway;
PRKD1	10	protein binding; protein serine/threonine kinase activity; cytoplasm; ATP binding; nucleus; inflammatory response; intracellular protein kinase cascade; positive regulation of CREB transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of NF-kappaB transcription factor activity;
GSK3B	9	protein binding; protein serine/threonine kinase activity; nucleolus; cytoplasm; ATP binding; nucleus; protein phosphorylation; axon guidance; positive regulation of transcription from RNA polymerase II promoter;
SIK2	8	protein binding; protein serine/threonine kinase activity; cytoplasm; ATP binding; nucleus; intracellular protein kinase cascade; protein phosphorylation; magnesium ion binding;
MAPK1	7	protein binding; protein serine/threonine kinase activity; nucleolus; cytoplasm; ATP binding; nucleus; axon guidance;
MARK2	7	protein binding; protein serine/threonine kinase activity; ATP binding; nucleus; intracellular protein kinase cascade; protein phosphorylation; magnesium ion binding;
NEK6	7	protein binding; protein serine/threonine kinase activity; cytoplasm; ATP binding; nucleus; protein phosphorylation; magnesium ion binding;
PRKCB	7	protein binding; protein serine/threonine kinase activity; cytoplasm; ATP binding; nucleus; protein phosphorylation; positive regulation of NF-kappaB transcription factor activity;
STK36	7	protein binding; protein serine/threonine kinase activity; cytoplasm; ATP binding; nucleus; protein phosphorylation; magnesium ion binding;
CDC42BPG	6	protein binding; protein serine/threonine kinase activity; cytoplasm; ATP binding; protein phosphorylation; magnesium ion binding;
LATS2	6	protein binding; protein serine/threonine kinase activity; ATP binding; nucleus; intracellular protein kinase cascade; protein phosphorylation;
PAK1	6	protein binding; protein serine/threonine kinase activity; cytoplasm; ATP binding; protein phosphorylation; axon guidance;
RELA	6	protein binding; cytoplasm; nucleus; inflammatory response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of NF-kappaB transcription factor activity;
ROCK2	6	protein binding; protein serine/threonine kinase activity; ATP binding; nucleus; protein phosphorylation; axon guidance;
SIK3	6	protein binding; protein serine/threonine kinase activity; cytoplasm; ATP binding; protein phosphorylation; magnesium ion binding;
TSSK2	6	protein binding; protein serine/threonine kinase activity; cytoplasm; ATP binding; protein phosphorylation; magnesium ion binding;
TSSK4	6	protein binding; protein serine/threonine kinase activity; ATP binding; protein phosphorylation; positive regulation of CREB transcription factor activity; magnesium ion binding;
AATF	5	protein binding; nucleolus; cytoplasm; nucleus; positive regulation of transcription from RNA polymerase II promoter;
APBB1	5	protein binding; cytoplasm; nucleus; regulation of transcription, DNA-dependent; axon guidance;
ARRB1	5	protein binding; cytoplasm; nucleus; positive regulation of transcription from RNA polymerase II promoter; positive regulation of histone acetylation;
ATXN1	5	protein binding; nucleolus; cytoplasm; nucleus; positive regulation of transcription from RNA polymerase II promoter;
BMPR1B	5	protein binding; protein serine/threonine kinase activity; ATP binding; inflammatory response; protein phosphorylation;
CFL1	5	protein binding; cytoplasm; nucleus; protein phosphorylation; axon guidance;
CHD1L	5	protein binding; nucleolus; cytoplasm; ATP binding; nucleus;
CSNK1E	5	protein binding; protein serine/threonine kinase activity; ATP binding; nucleus; protein phosphorylation;
DAXX	5	protein binding; nucleolus; cytoplasm; nucleus; regulation of transcription, DNA-dependent;
DHX9	5	protein binding; nucleolus; cytoplasm; ATP binding; nucleus;
ERBB2	5	protein binding; ATP binding; nucleus; protein phosphorylation; axon guidance;
FLII	5	protein binding; nucleolus; cytoplasm; nucleus; regulation of transcription, DNA-dependent;
FRK	5	protein binding; cytoplasm; ATP binding; nucleus; protein phosphorylation;
IARS	5	protein binding; nucleolus; cytoplasm; ATP binding; nucleus;
IGHMBP2	5	protein binding; cytoplasm; ATP binding; nucleus; regulation of transcription, DNA-dependent;
ILK	5	protein binding; protein serine/threonine kinase activity; cytoplasm; ATP binding; protein phosphorylation;
IRF7	5	protein binding; cytoplasm; nucleus; protein phosphorylation; positive regulation of transcription from RNA polymerase II promoter;
LATS1	5	protein binding; protein serine/threonine kinase activity; ATP binding; protein phosphorylation; magnesium ion binding;
MALT1	5	protein binding; nucleolus; cytoplasm; nucleus; positive regulation of NF-kappaB transcription factor activity;
MAML1	5	protein binding; nucleolus; nucleus; protein phosphorylation; positive regulation of transcription from RNA polymerase II promoter;
MAP3K11	5	protein binding; protein serine/threonine kinase activity; cytoplasm; ATP binding; protein phosphorylation;
MAP4K2	5	protein binding; protein serine/threonine kinase activity; ATP binding; intracellular protein kinase cascade; protein phosphorylation;
MEN1	5	protein binding; nucleolus; cytoplasm; nucleus; positive regulation of transcription from RNA polymerase II promoter;
NCK1	5	protein binding; cytoplasm; nucleus; axon guidance; positive regulation of transcription from RNA polymerase II promoter;
NFRKB	5	protein binding; nucleolus; nucleus; inflammatory response; regulation of transcription, DNA-dependent;
PIK3CG	5	protein binding; protein serine/threonine kinase activity; cytoplasm; ATP binding; inflammatory response;
PLK1	5	protein binding; protein serine/threonine kinase activity; ATP binding; nucleus; protein phosphorylation;
POU2F3	5	protein binding; nucleolus; cytoplasm; nucleus; positive regulation of transcription from RNA polymerase II promoter;
PRKAA1	5	protein binding; ATP binding; nucleus; regulation of transcription, DNA-dependent; protein phosphorylation;
PSPC1	5	protein binding; nucleolus; cytoplasm; nucleus; regulation of transcription, DNA-dependent;
PYCARD	5	protein binding; cytoplasm; nucleus; inflammatory response; positive regulation of NF-kappaB transcription factor activity;
RBPJ	5	protein binding; nucleolus; cytoplasm; nucleus; positive regulation of transcription from RNA polymerase II promoter;
SMC1A	5	protein binding; nucleolus; cytoplasm; ATP binding; nucleus;
SMG1	5	protein binding; protein serine/threonine kinase activity; cytoplasm; ATP binding; nucleus;
SSRP1	5	protein binding; nucleolus; cytoplasm; nucleus; regulation of transcription, DNA-dependent;
TDP2	5	protein binding; nucleolus; cytoplasm; nucleus; magnesium ion binding;
TERF2IP	5	protein binding; cytoplasm; nucleus; regulation of transcription, DNA-dependent; positive regulation of NF-kappaB transcription factor activity;
TFAP2A	5	protein binding; nucleolus; cytoplasm; nucleus; positive regulation of transcription from RNA polymerase II promoter;
TGFBR1	5	protein binding; protein serine/threonine kinase activity; ATP binding; regulation of transcription, DNA-dependent; protein phosphorylation;
THRAP3	5	protein binding; nucleolus; ATP binding; nucleus; positive regulation of transcription from RNA polymerase II promoter;
TRIM5	5	protein binding; nucleolus; cytoplasm; nucleus; positive regulation of NF-kappaB transcription factor activity;
XRCC5	5	protein binding; nucleolus; cytoplasm; ATP binding; nucleus;
AURKC	5	protein serine/threonine kinase activity; cytoplasm; ATP binding; nucleus; protein phosphorylation;
TAOK2	5	protein serine/threonine kinase activity; nucleolus; cytoplasm; ATP binding; nucleus;
WNK2	5	protein serine/threonine kinase activity; cytoplasm; ATP binding; intracellular protein kinase cascade; protein phosphorylation;
HOXB1	5	nucleolus; cytoplasm; nucleus; regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
CAMK1D	5	cytoplasm; ATP binding; nucleus; inflammatory response; positive regulation of CREB transcription factor activity;

Genes shared at least 2 KEGG pathways with RPS6KA4 (count: 11)

Gene Symbol	Pathway Count	Pathway List
BDNF	2	Neurotrophin signaling pathway; MAPK signaling pathway;
CRKL	2	Neurotrophin signaling pathway; MAPK signaling pathway;
MAP3K5	2	Neurotrophin signaling pathway; MAPK signaling pathway;
MAPK1	2	Neurotrophin signaling pathway; MAPK signaling pathway;
MAPK3	2	Neurotrophin signaling pathway; MAPK signaling pathway;
MAPK7	2	Neurotrophin signaling pathway; MAPK signaling pathway;
MAPK9	2	Neurotrophin signaling pathway; MAPK signaling pathway;
NGF	2	Neurotrophin signaling pathway; MAPK signaling pathway;
NTF3	2	Neurotrophin signaling pathway; MAPK signaling pathway;
NTRK2	2	Neurotrophin signaling pathway; MAPK signaling pathway;
RELA	2	Neurotrophin signaling pathway; MAPK signaling pathway;

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Region: chr11:64126620..64139687 View in gBrowse